International audience; The SARS-CoV-2 pandemic has led to the implementation of unprecedented public health intervention measures, not least the lockdown of countries worldwide. In our hyperconnected world exemplified by social media, it is now possible to derive quant...

The SARS-CoV-2 coronavirus infects human cells through the interaction of the viral envelope Spike protein (IPR044366) with the human Angiotensin-Converting Enzyme 2 (ACE2), expressed at the surface of target cells. Here, we describe a detailed protocol to measure the b...

To control the evolution of a pandemic such as COVID-19, knowing the conditions under which the pathogen is being transmitted represents a critical issue, especially when implementing protection strategies like social distancing and face masks wearing. For viruses and b...

AbstractThe present chapter concerns arguments whose conclusions take the form of a prescription such as you ought to do such-and-such, which have driven much public discussion and policy since the beginning of the COVID-19 pandemic. We aim to tackle a hitherto under-ex...

International audience; The SARS-CoV-2 outbreak has highlighted the need for broad-spectrum antivirals against coronaviruses (CoVs). Here, pheophorbide a (Pba) was identified as a highly active antiviral molecule against HCoV-229E after bioguided fractionation of plant ...

The need for personal protective equipment increased exponentially in response to the Covid-19 pandemic. To cope with the mask shortage during springtime 2020, a French consortium was created to find ways to reuse medical and respiratory masks in healthcare departments....

SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain (RBD) with the host's cellular receptor. Vaccines seek to block this interaction by eliciting neutralizing antibodies, most of which are directed toward ...

International audience; This multicenter study evaluated the IMMY Aspergillus Galactomannan Lateral Flow Assay (LFA) with automated reader for diagnosis of pulmonary aspergillosis in patients with COVID-19 associated acute respiratory failure (ARF) requiring intensive c...

Objectives In the early stages of the coronavirus disease 2019 (COVID-19) pandemic, chloroquine and its derivatives such as hydroxychloroquine (HCQ) were widely commented upon both within the scientific community and in the media. This paper explores the different facto...

International audience; This article shares findings on COVID-19 in Africa across 2020 to examine concepts and practices of epidemic preparedness and response. Amidst uncertainties about the trajectory of COVID-19, the stages of emergency response emerge in practice as ...