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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
9 Research products, page 1 of 1

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  • Open Access English
    Authors: 
    Nilima Dinesh Kumar; Bram M. ter Ellen; Ellen M Bouma; Berit Troost; Denise P. I. van de Pol; Heidi van der Ende-Metselaar; Djoke van Gosliga; Leonie Apperloo; Orestes A Carpaij; Maarten van den Berge; +4 more
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660)

    AbstractAntiviral therapies are urgently needed to treat and limit the development of severe COVID-19 disease. Ivermectin, a broad-spectrum anti-parasitic agent, has been shown to have anti-SARS-CoV-2 activity in Vero cells at a concentration of 5 µM. These in vitro res...

  • Open Access English
    Authors: 
    Parej Nath; Nishant Ranjan Chauhan; Kautilya Kumar Jena; Ankita Datey; Nilima Dinesh Kumar; Subhash Mehto; Saikat De; Tapas Kumar Nayak; Swatismita Priyadarsini; Kshitish Rout; +8 more
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660)

    Abstract The type I interferon (IFN) response is the major host arsenal against invading viruses. IRGM is a negative regulator of IFN responses under basal conditions. However, the role of human IRGM during viral infection has remained unclear. In this study, we show th...

  • Open Access English
    Authors: 
    Bram M. ter Ellen; Nilima Dinesh Kumar; Ellen M Bouma; Berit Troost; Denise P. I. van de Pol; Heidi van der Ende-Metselaar; Leonie Apperloo; Djoke van Gosliga; Maarten van den Berge; Martijn C. Nawijn; +4 more
    Country: Netherlands
    Project: EC | EVA-GLOBAL (871029), EC | PRONKJEWAIL (713660)

    The current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has an enormous impact on human health and economy. In search for therapeutic options, researchers have proposed resveratrol, a food supplement with known antivir...

  • Open Access English
    Authors: 
    I. Margineanu; Zohar Mor; D. Garcia; C. Gilpin; S. Dhawan; Nicole Ritz; Dominik Zenner;
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660)
  • Open Access English
    Authors: 
    Rick Oerlemans; Angel J Ruiz-Moreno; Yingying Cong; Nilima Dinesh Kumar; Marco A. Velasco-Velázquez; Constantinos G. Neochoritis; Jolanda Smith; Fulvio Reggiori; Matthew Groves; Alexander Dömling;
    Country: Netherlands
    Project: EC | DRIVE (765912), EC | PRONKJEWAIL (713660)

    The rapid growth of COVID-19 cases is causing an increasing death toll and also paralyzing the world economy. De novo drug discovery takes years to move from idea and/or pre-clinic to market, and it is not a short-term solution for the current SARS-CoV-2 pandemic. Drug ...

  • Open Access English
    Authors: 
    Ong, Catherine Wei Min; Migliori, Giovanni Battista; Raviglione, Mario; MacGregor-Skinner, Gavin; Sotgiu, Giovanni; Alffenaar, Jan-Willem; Tiberi, Simon; Adlhoch, Cornelia; Alonzi, Tonino; Archuleta, Sophia; +37 more
    Publisher: European Respiratory Society
    Project: EC | PRONKJEWAIL (713660)

    Major epidemics, including some that qualify as pandemics, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A (H1N1)pdm/09 and most recently COVID-19, affect the lung. Tuberculosis (TB) remains the top infectious ...

  • Open Access English
    Authors: 
    Mario Mauthe; Idil Orhon; Cecilia Rocchi; Xingdong Zhou; Morten Luhr; Kerst-Jan Hijlkema; Robert P. Coppes; Nikolai Engedal; Muriel Mari; Fulvio Reggiori;
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and...

  • Open Access English
    Authors: 
    Xingdong Zhou; Yingying Cong; Tineke Veenendaal; Judith Klumperman; Dongfang Shi; Muriel Mari; Fulvio Reggiori;
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771)

    The porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) belonging to the alpha-CoV genus and it causes high mortality in infected sucking piglets, resulting in substantial losses in the farming industry. CoV trigger a drastic reorganization of host cell membra...

  • Other research product . Other ORP type . 2017
    Open Access English
    Authors: 
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...