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12,966 Research products, page 1 of 1,297

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  • COVID-19

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  • Embargo English
    Authors: 
    Meza Miranda, Eliana Romina; Parra Soto, Solange Liliana; Durán Agüero, Samuel; Gómez, Georgina; Carpio Arias, Valeria; Ríos Castillo, Israel; Murillo, Ana Gabriela; Araneda, Jacqueline; Morales, Gladys; Cavagnari, Brian M.; +6 more
    Country: Argentina

    Abstract: Introduction: Short sleep, physical inactivity, and being locked up are risk factors for weight gain. Objective: We evaluated weight gain according to sex, age, hours of sleep and physical activity in university students from 10 Latin American countries during the COVID-19 pandemic. Methods: Cross-sectional and multicenter study (n = 4880). Results: The average age was 22.5 ± 4.4 years. 60.2% were currently locked up. 73.6% were women, 48.2% increased their body weight, 66% reported insufficient sleep hours, and 65.9% were inactive. Women gained more weight than men (73.2%) and younger students gained more weight (85.1%). Those who had insufficient sleep hours gained most weight (67.6%). Inactive participants gained most weight (74.7%). Students who have insufficient sleep are 21% more likely to have changes in body weight compared to students who have optimal sleep. Conclusion: The increase in body weight and its risk factors during confinement should be considered as emerging from public health.

  • Embargo English
    Authors: 
    Otero Losada, Matilde; Petrovsky, Nikolai; Alami, Abdallah; Crispo, James A.; Mattison, Donald; Capani, Francisco; Goetz, Christopher; Krewski, Daniel; Pérez Lloret, Santiago;
    Country: Argentina

    Abstract: Background: Information on neurological and psychiatric adverse events following immunization (AEFIs) with COVID-19 vaccines is limited. Research design & methods: We examined and compared neurological and psychiatric AEFIS reports related to BNT162b2 (Pfizer-BioNTech) and ChAdOx1 (Oxford-AstraZeneca) COVID-19 vaccines and recorded in the United Kingdom Medicines and Healthcare products Regulatory Agency between 9 December 2020 and 30 June 2021. Results: As of 30 June 2021, 46.1 million doses of ChAdOx1 and 30.3 million doses of BNT162b2 had been administered. The most frequently reported AEFI was headache with 1,686 and 575 cases per million doses of ChAdOx1 and BNT162b2, respectively. AEFIs more frequently reported after CHAdOx1 compared with BNT162b2 vaccination were Guillain-Barré syndrome (OR, 95% CI = 2.53, 1.82–3.51), freezing (6.66, 3.12–14.22), cluster headache (1.53, 1.28–1.84), migraine (1.23,1.17–1.30), postural dizziness (1.24,1.13–1.37), tremor (2.86, 2.68–3.05), headache (1.40, 1.38–1.43), paresthesia (1.11, 1.06–1.16), delirium (1.85, 1.45–2.36), hallucination (2.20, 1.82–2.66), poor quality sleep (1.53, 1.26–1.85), and nervousness (1.54, 1.26–1.89) Reactions less frequently reported with ChAdOx1 than with BNT162b2 were Bell’s palsy (0.47, 0.41–0.55), anosmia (0.58, 0.47–0.71), facial paralysis (0.35, 0.29– 0.41), dysgeusia (0.68, 0.62–0.73), presyncope (0.48, 0.42–0.55), syncope (0.63, 0.58–0.67), and anxiety (0.75 (0.67–0.85). Conclusion: Neurological and psychiatric AEFIs were relatively infrequent, but each vaccine was associated with a distinctive toxic profile. Plain Language Summary We examined reports on adverse neurological and psychiatric effects following immunization with BNT162b2 (Pfizer-BioNTech) and ChAdOx1 (Oxford-AstraZeneca) for COVID-19 to the United Kingdom Medicines and Healthcare products Regulatory Agency between 9 December 2020 and 30 June 2021. Adverse effects following immunization (AEFIs) were relatively infrequent. Compared to BNT162b2, Guillain-Barré syndrome, freezing phenomenon, cluster headache, migraine, postural dizziness, tremor, headache, paresthesia, delirium, hallucination, poor quality sleep, and nervousness were more frequently reported for ChAdOx1. Reactions less frequently reported for ChAdOx1 than for BNT162b2 were Bell’s palsy, anosmia, facial paralysis, dysgeusia, presyncope, syncope, and anxiety.

  • Embargo English
    Authors: 
    Barrantes, Francisco José;
    Country: Argentina

    Abstract: Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a hijacking mechanism perfected over the course of evolution. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has successfully adopted this strategy using its spike glycoprotein to dock on the membraneboundmetalloprotease angiotensin-converting enzyme 2 (ACE2). The crystal structures of several SARS-CoV-2 proteins alone or in complex with their receptors or other ligands were recently solved at an unprecedented pace. This accomplishment is partly due to the increasing availability of data on other coronaviruses and ACE2 over the past 18 years. Likewise, other key intervening actors and mechanisms of viral infection were elucidated with the aid of biophysical approaches. An understanding of the various structurally important motifs of the interacting partners provides key mechanistic information for the development of structure-based designer drugs able to inhibit various steps of the infective cycle, including neutralizing antibodies, small organic drugs, and vaccines. This review analyzes current progress and the outlook for future structural studies.

  • Research data . 2025
    English
    Authors: 
    MATTOTEIA, Daiana; FORNERIS, Federico;
    Publisher: European Synchrotron Radiation Facility

    This BAG application builds on the development of single particle cryoEM in the Italian Structural Biology community, as in Italy there is no top-end instrument is yet available. The groups in this application have acquired know-how in cryoEM through international collaborations or by acquiring medium-level in-house equipment. Access to the CM01 beamline at the ESRF from August 2020 has allowed the development of projects from groups that do not have in-house equipment that will most likely result in high top level publications in 2021. The three screening microscopes presently installed in Italy boosted sample production in 2020 in spite of the Covid-19 pandemic and the number of samples foreseen for 2021 has greatly increased. The BAG from Italian institutions is nurturing the expansion of the field in Italy and will result in a high-level scientific production.

  • Research data . 2025
    English
    Authors: 
    Matar KRAVICAS; BECK-BARKAI, Roy; RAVIV, Uri;
    Publisher: European Synchrotron Radiation Facility

    The BAG is quite large with 24 principal investigators covering almost all groups in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades. There are several projects that are directed towards molecular recognition with implementation towards drug design. In addition, we still have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. Since Covid-19 is still a relevant topic as are other viral infections BAG members are and have been involved in the understanding of the infection process and the means to hinder it.

  • Research data . 2025
    English
    Authors: 
    Yarden OPATOWSKY;
    Publisher: European Synchrotron Radiation Facility

    The BAG includes numerous principal investigators which are the majority of structural biologists in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades, Thermodynamics of proteolytic reaction. In addition, we have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. The current events promote several Covid-19 related projects but BAG members are and have been involved and virus infection and inhibitory strategies including Hepatitis C virus, arthropod borne viruses (e.g .dengue, West Nile, Zika, Israel Turkey Meningoencephalitis), chikungunya virus and more.

  • English
    Authors: 
    STELLATO, Francesco; COSTANZI, Pietro; MORANTE, Silvia;
    Publisher: European Synchrotron Radiation Facility

    The most supported hypothesis for the orf7a function is the interference with virion budding operated by cellular antigens, while the orf8 function is still unknown. We aim at studying the interaction of orf7a and orf8 with the bone marrow stromal antigen 2 (BST2). BST2 dimerization and oligomerization involve intermolecular disulfide bonds between cysteine residues and are strongly influenced by the presence of divalent cations, such as Zn2+. We want to test the hypothesis [7] that the orf7a and orf8 proteins have been selected to counteract BST2 antiviral activity by bringing in situ Zn2+ cations owing to the presence of multiple Zn-finger domains. The formation of orf7a/BST2 and orf8/BST2 complexes assisted by the presence of Zn2+ may enable the virus to evade the antiviral activity of BST2. In this proposal we aim at determining the Zn2+coordination mode in orf7a, orf8 and BST2 to check the possible formation of orf7a/BST2 and orf8/BST2 complexes.

  • Research data . 2025
    English
    Authors: 
    YECHEZKEL, Itai Gershon ITAI GERSHON; TZARUM, Netanel; FRAENKEL, Rina;
    Publisher: European Synchrotron Radiation Facility

    The BAG is quite large with 24 principal investigators covering almost all groups in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades. There are several projects that are directed towards molecular recognition with implementation towards drug design. In addition, we still have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. Since Covid-19 is still a relevant topic as are other viral infections BAG members are and have been involved in the understanding of the infection process and the means to hinder it.

  • Research data . 2025
    English
    Authors: 
    ROUVINSKI, Alexander; TZARUM, Netanel; WIENER, Reuven;
    Publisher: European Synchrotron Radiation Facility

    The BAG is quite large with 24 principal investigators covering almost all groups in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades. There are several projects that are directed towards molecular recognition with implementation towards drug design. In addition, we still have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. Since Covid-19 is still a relevant topic as are other viral infections BAG members are and have been involved in the understanding of the infection process and the means to hinder it.

  • English
    Authors: 
    PLEWKA, Jacek;
    Publisher: European Synchrotron Radiation Facility

    Coronaviruses protect their ssRNA genome with a methylated cap. The methylation is performed by two methyltransferases, nsp14 and nsp16. Additionally, nsp14 carries an exonuclease domain, which operates in the proofreading system. nsp14 and nsp16 were reported to independently bind nsp10, but the available structural information suggests that the concomitant interaction between these three proteins should be impossible due to steric clashes. In our work (https://www.biorxiv.org/content/10.1101/2022.01.25.477673v1 ), we show that nsp14, nsp10, and nsp16 can form a ternary complex (MST, enzymatic assays, SAXS, TEM). This interaction is expected to encourage formation of mature capped viral mRNA, modulating the nsp14 exonuclease activity, and protecting the viral RNA. A high-resolution structure of the triplex would greatly improve the understanding of how the component proteins are undergoing the structural changes upon the ternary complex formation.

Advanced search in Research products
Research products
arrow_drop_down
Searching FieldsTerms
Any field
arrow_drop_down
includes
arrow_drop_down
Include:
The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
12,966 Research products, page 1 of 1,297
  • Embargo English
    Authors: 
    Meza Miranda, Eliana Romina; Parra Soto, Solange Liliana; Durán Agüero, Samuel; Gómez, Georgina; Carpio Arias, Valeria; Ríos Castillo, Israel; Murillo, Ana Gabriela; Araneda, Jacqueline; Morales, Gladys; Cavagnari, Brian M.; +6 more
    Country: Argentina

    Abstract: Introduction: Short sleep, physical inactivity, and being locked up are risk factors for weight gain. Objective: We evaluated weight gain according to sex, age, hours of sleep and physical activity in university students from 10 Latin American countries during the COVID-19 pandemic. Methods: Cross-sectional and multicenter study (n = 4880). Results: The average age was 22.5 ± 4.4 years. 60.2% were currently locked up. 73.6% were women, 48.2% increased their body weight, 66% reported insufficient sleep hours, and 65.9% were inactive. Women gained more weight than men (73.2%) and younger students gained more weight (85.1%). Those who had insufficient sleep hours gained most weight (67.6%). Inactive participants gained most weight (74.7%). Students who have insufficient sleep are 21% more likely to have changes in body weight compared to students who have optimal sleep. Conclusion: The increase in body weight and its risk factors during confinement should be considered as emerging from public health.

  • Embargo English
    Authors: 
    Otero Losada, Matilde; Petrovsky, Nikolai; Alami, Abdallah; Crispo, James A.; Mattison, Donald; Capani, Francisco; Goetz, Christopher; Krewski, Daniel; Pérez Lloret, Santiago;
    Country: Argentina

    Abstract: Background: Information on neurological and psychiatric adverse events following immunization (AEFIs) with COVID-19 vaccines is limited. Research design & methods: We examined and compared neurological and psychiatric AEFIS reports related to BNT162b2 (Pfizer-BioNTech) and ChAdOx1 (Oxford-AstraZeneca) COVID-19 vaccines and recorded in the United Kingdom Medicines and Healthcare products Regulatory Agency between 9 December 2020 and 30 June 2021. Results: As of 30 June 2021, 46.1 million doses of ChAdOx1 and 30.3 million doses of BNT162b2 had been administered. The most frequently reported AEFI was headache with 1,686 and 575 cases per million doses of ChAdOx1 and BNT162b2, respectively. AEFIs more frequently reported after CHAdOx1 compared with BNT162b2 vaccination were Guillain-Barré syndrome (OR, 95% CI = 2.53, 1.82–3.51), freezing (6.66, 3.12–14.22), cluster headache (1.53, 1.28–1.84), migraine (1.23,1.17–1.30), postural dizziness (1.24,1.13–1.37), tremor (2.86, 2.68–3.05), headache (1.40, 1.38–1.43), paresthesia (1.11, 1.06–1.16), delirium (1.85, 1.45–2.36), hallucination (2.20, 1.82–2.66), poor quality sleep (1.53, 1.26–1.85), and nervousness (1.54, 1.26–1.89) Reactions less frequently reported with ChAdOx1 than with BNT162b2 were Bell’s palsy (0.47, 0.41–0.55), anosmia (0.58, 0.47–0.71), facial paralysis (0.35, 0.29– 0.41), dysgeusia (0.68, 0.62–0.73), presyncope (0.48, 0.42–0.55), syncope (0.63, 0.58–0.67), and anxiety (0.75 (0.67–0.85). Conclusion: Neurological and psychiatric AEFIs were relatively infrequent, but each vaccine was associated with a distinctive toxic profile. Plain Language Summary We examined reports on adverse neurological and psychiatric effects following immunization with BNT162b2 (Pfizer-BioNTech) and ChAdOx1 (Oxford-AstraZeneca) for COVID-19 to the United Kingdom Medicines and Healthcare products Regulatory Agency between 9 December 2020 and 30 June 2021. Adverse effects following immunization (AEFIs) were relatively infrequent. Compared to BNT162b2, Guillain-Barré syndrome, freezing phenomenon, cluster headache, migraine, postural dizziness, tremor, headache, paresthesia, delirium, hallucination, poor quality sleep, and nervousness were more frequently reported for ChAdOx1. Reactions less frequently reported for ChAdOx1 than for BNT162b2 were Bell’s palsy, anosmia, facial paralysis, dysgeusia, presyncope, syncope, and anxiety.

  • Embargo English
    Authors: 
    Barrantes, Francisco José;
    Country: Argentina

    Abstract: Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a hijacking mechanism perfected over the course of evolution. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has successfully adopted this strategy using its spike glycoprotein to dock on the membraneboundmetalloprotease angiotensin-converting enzyme 2 (ACE2). The crystal structures of several SARS-CoV-2 proteins alone or in complex with their receptors or other ligands were recently solved at an unprecedented pace. This accomplishment is partly due to the increasing availability of data on other coronaviruses and ACE2 over the past 18 years. Likewise, other key intervening actors and mechanisms of viral infection were elucidated with the aid of biophysical approaches. An understanding of the various structurally important motifs of the interacting partners provides key mechanistic information for the development of structure-based designer drugs able to inhibit various steps of the infective cycle, including neutralizing antibodies, small organic drugs, and vaccines. This review analyzes current progress and the outlook for future structural studies.

  • Research data . 2025
    English
    Authors: 
    MATTOTEIA, Daiana; FORNERIS, Federico;
    Publisher: European Synchrotron Radiation Facility

    This BAG application builds on the development of single particle cryoEM in the Italian Structural Biology community, as in Italy there is no top-end instrument is yet available. The groups in this application have acquired know-how in cryoEM through international collaborations or by acquiring medium-level in-house equipment. Access to the CM01 beamline at the ESRF from August 2020 has allowed the development of projects from groups that do not have in-house equipment that will most likely result in high top level publications in 2021. The three screening microscopes presently installed in Italy boosted sample production in 2020 in spite of the Covid-19 pandemic and the number of samples foreseen for 2021 has greatly increased. The BAG from Italian institutions is nurturing the expansion of the field in Italy and will result in a high-level scientific production.

  • Research data . 2025
    English
    Authors: 
    Matar KRAVICAS; BECK-BARKAI, Roy; RAVIV, Uri;
    Publisher: European Synchrotron Radiation Facility

    The BAG is quite large with 24 principal investigators covering almost all groups in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades. There are several projects that are directed towards molecular recognition with implementation towards drug design. In addition, we still have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. Since Covid-19 is still a relevant topic as are other viral infections BAG members are and have been involved in the understanding of the infection process and the means to hinder it.

  • Research data . 2025
    English
    Authors: 
    Yarden OPATOWSKY;
    Publisher: European Synchrotron Radiation Facility

    The BAG includes numerous principal investigators which are the majority of structural biologists in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades, Thermodynamics of proteolytic reaction. In addition, we have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. The current events promote several Covid-19 related projects but BAG members are and have been involved and virus infection and inhibitory strategies including Hepatitis C virus, arthropod borne viruses (e.g .dengue, West Nile, Zika, Israel Turkey Meningoencephalitis), chikungunya virus and more.

  • English
    Authors: 
    STELLATO, Francesco; COSTANZI, Pietro; MORANTE, Silvia;
    Publisher: European Synchrotron Radiation Facility

    The most supported hypothesis for the orf7a function is the interference with virion budding operated by cellular antigens, while the orf8 function is still unknown. We aim at studying the interaction of orf7a and orf8 with the bone marrow stromal antigen 2 (BST2). BST2 dimerization and oligomerization involve intermolecular disulfide bonds between cysteine residues and are strongly influenced by the presence of divalent cations, such as Zn2+. We want to test the hypothesis [7] that the orf7a and orf8 proteins have been selected to counteract BST2 antiviral activity by bringing in situ Zn2+ cations owing to the presence of multiple Zn-finger domains. The formation of orf7a/BST2 and orf8/BST2 complexes assisted by the presence of Zn2+ may enable the virus to evade the antiviral activity of BST2. In this proposal we aim at determining the Zn2+coordination mode in orf7a, orf8 and BST2 to check the possible formation of orf7a/BST2 and orf8/BST2 complexes.

  • Research data . 2025
    English
    Authors: 
    YECHEZKEL, Itai Gershon ITAI GERSHON; TZARUM, Netanel; FRAENKEL, Rina;
    Publisher: European Synchrotron Radiation Facility

    The BAG is quite large with 24 principal investigators covering almost all groups in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades. There are several projects that are directed towards molecular recognition with implementation towards drug design. In addition, we still have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. Since Covid-19 is still a relevant topic as are other viral infections BAG members are and have been involved in the understanding of the infection process and the means to hinder it.

  • Research data . 2025
    English
    Authors: 
    ROUVINSKI, Alexander; TZARUM, Netanel; WIENER, Reuven;
    Publisher: European Synchrotron Radiation Facility

    The BAG is quite large with 24 principal investigators covering almost all groups in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades. There are several projects that are directed towards molecular recognition with implementation towards drug design. In addition, we still have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. Since Covid-19 is still a relevant topic as are other viral infections BAG members are and have been involved in the understanding of the infection process and the means to hinder it.

  • English
    Authors: 
    PLEWKA, Jacek;
    Publisher: European Synchrotron Radiation Facility

    Coronaviruses protect their ssRNA genome with a methylated cap. The methylation is performed by two methyltransferases, nsp14 and nsp16. Additionally, nsp14 carries an exonuclease domain, which operates in the proofreading system. nsp14 and nsp16 were reported to independently bind nsp10, but the available structural information suggests that the concomitant interaction between these three proteins should be impossible due to steric clashes. In our work (https://www.biorxiv.org/content/10.1101/2022.01.25.477673v1 ), we show that nsp14, nsp10, and nsp16 can form a ternary complex (MST, enzymatic assays, SAXS, TEM). This interaction is expected to encourage formation of mature capped viral mRNA, modulating the nsp14 exonuclease activity, and protecting the viral RNA. A high-resolution structure of the triplex would greatly improve the understanding of how the component proteins are undergoing the structural changes upon the ternary complex formation.