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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yeung, Jonas; DeYoung, Taylor; Spring, Shoshana; de Guzman, A. Elizabeth; +5 Authors

    Description Biological sex influences prevalence of developmental disorders through sex hormones and sex chromosomes. However, our understanding of their impacts in neurodevelopment and response to injury remains limited. In this project, we use high resolution magnetic resonance imaging (MRI) to investigate the four core genotype mouse model (FCG) that separates the influences of sex hormones and sex chromosomes during normal brain development and after cranial radiation therapy. Sex differences are attributed to either sex hormones or sex chromosomes. This can be distinguished by the FCG model which decouples the sex determining region (SRY) from the Y chromosome by moving SRY onto an autosome. This gives us four core sex genotypes: XX NULL, XY NULL, XX SRY, and XY SRY. This dataset represents the most comprehensive mouse brain imaging study employing the FCG model to date with 5 timepoints (P14, P23, P42, P63, P98), Ccl2 wildtype (+/+) and knockouts (-/-), irradiation (7Gy) and sham (0Gy) mice. All in all, a total of 1071 images! The dataset presented here is for an upcoming manuscript to be published. In vivo MRI scans were obtained using a 7-T MRI scanner (Bruker BioSpin, Ettlingen, Germany) equipped with four cryocoils for simultaneous imaging of four mice. The scans were performed with the following settings: T1-weighted, 3D-gradient echo sequence, 75μm isotropic resolution, TR=26ms, TE=8.25ms, flip angle=26°, field of view=25×22×22mm, and matrix size=334×294×294. All structural MR images are stored in images.tar.gz. Images were segmented and registered using an automated pipeline which are stored in labels.tar.gz. The consensus average and labels are final_average.mnc and final_labels.mnc, respectively. Extracted structure volumes alongside the metadata are included in df_micevolumes.csv. Structural MRIs are in MINC format and the readme.txt provides further information on this dataset. The authors express their sincere gratitude for the research funding recieved from the Canadian Institutes of Health Research (158622, 168037) and the Ontario Institute for Cancer Research (IA-024) with funding from the Government of Ontario and Restracomp from the SIckKids Research Training Centre. Code/Software MINChttps://www.bic.mni.mcgill.ca/ServicesSoftware/MINC RMINChttps://github.com/Mouse-Imaging-Centre/RMINC PydPiperhttps://github.com/Mouse-Imaging-Centre/pydpiper/tree/v2.0.19.1

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    ZENODO
    Dataset . 2024
    License: CC BY
    Data sources: ZENODO
    ZENODO
    Dataset . 2024
    License: CC BY
    Data sources: Datacite
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      ZENODO
      Dataset . 2024
      License: CC BY
      Data sources: ZENODO
      ZENODO
      Dataset . 2024
      License: CC BY
      Data sources: Datacite
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  • Authors: Toutant, Darion;

    This thesis introduces a novel investigation into the morphological characteristics of epileptiform spikes across various sleep-wake states. A gold-standard database of spikes was created, offering insights into their variations across wakefulness, non-rapid-eye-movement (NREM) sleep stages 1-3, and particularly rapid-eye-movement (REM) sleep, and hypothesizing on the dynamics regulating its suppressive ability towards spikes. The study employed lab-developed software to categorize sleep states and validate spikes using data from 7 epilepsy monitoring unit patients. A computational pipeline was developed to assess nine morphological spike features throughout Laplacian, Referential, and Raw montages. Due to non-normal data distribution, statistical analysis was performed using the Kruskal-Wallis test, followed by Dunn's post-hoc testing and Bonferroni correction. Results revealed that the spike features of REM sleep are significantly different from those of other sleep-wake states. In particular, spikes during REM sleep had the shallowest ascending and descending slopes by nearly 50% of the other states, which were nearly symmetrical, blunter peaks with roughly twice the angle of other states and exhibited lower peak amplitudes less than 50% of the voltage of other states. Wakefulness was the most different state concerning duration while being, on average, 15% shorter. Finally, the spike area during REM was roughly twice as small as all other states. This study shows significant spike feature differences throughout sleep-wake states, with REM drastically different in most features. The driving factors for changes in spike morphology throughout the sleep-wake states are unknown. However, this thesis explores the effects of ionic, neurotransmitter, astrocytic and network dynamic processes to help shed light on these changes. Notably, this thesis provides glimpses into the roles of astrocytic involvement, orexinergic systems, and network dynamics as potential contributors to the observed morphological differences within REM. Further investigations are necessary to fully understand these complex electrobiological interactions, which may be responsible for the observed anti-epileptic properties during REM sleep. This study paves the way for future work to expose and leverage the unique anti-epileptic mechanisms of REM sleep, potentially leading to the development of REM-specific therapeutic strategies for epilepsy management.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Tremblay, Pascale; Gagnon, Lydia; Roy, Johanna-Pascale; Arseneault, Alison;

    Purpose: Amateur singing is a universal, accessible, and enjoyable musical activity that may have positive impacts on human communication. However, evidence of an impact of singing on speech articulation is still scarce, yet, understanding the effects of vocal training on speech production could provide a model for treating people with speech deficits. The aim of this study was to examine speech production in younger and older adults with or without amateur singing experience. Method: 38 amateur singers (aged 20–87 years, 23 females) and 40 non-musician controls (aged 23–88 years, 19 females) were recruited. A set of tasks were used to evaluate the oral motor sphere: two voice production tasks, a passage reading task and a modified diadochokinetic rates task (DDK) performed at a natural rhythm and as fast as possible. Results: Our results show that older age was associated with lower reading rate, lower articulation rate and articulation rate variability in the DDK task, as well as reduced accuracy for the phonologically complex stimuli. Most importantly, our results show an advantage for singers over cognitively active non-singers in terms of articulatory accuracy in the most challenging situations. Conclusions: This result suggests extended maximal performance capacities in amateur singers perhaps resulting from the articulatory efforts required during singing.

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    CorpusUL
    Other ORP type . 2023
    Data sources: CorpusUL
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      CorpusUL
      Other ORP type . 2023
      Data sources: CorpusUL
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: McAllister, Zachary;

    Transcranial direct current stimulation (tDCS) applied to the dorsolateral prefrontal cortex (DLPFC) has been shown to have asymmetric behavioral effects, but the underlaying neurophysiological mechanisms causing these asymmetric behavioral differences are poorly understood. Functional magnetic resonance imaging (fMRI) can be used in conjunction with a behavioral measurement to better understand these mechanisms. To measure the hemispheric laterality of neurophysiological and behavioral effects of anodal tDCS applied to the left and right DLPFC using fMRI and Stroop test interference, 11 male and 28 female healthy participants were randomized into three treatment groups of 1.5mA anodal tDCS applied to sham or the left or right the DLPFC, with the cathode placed on the contralateral supraorbital region. Before and after tDCS application participants took the Stroop test and underwent resting-state fMRI. Seed-to-voxel functional connectivity and voxel-to-voxel whole brain intrinsic connectivity (IC) analyses were performed on the fMRI data. All fMRI analysis was done by using two sets of 2×2 factorial analyses between groups (real vs. sham) and time (pre- vs. post-tDCS) for each left and right tDCS, separately, while Stroop interference was measured using a repeated measures general linear model. tDCS to the left DLPFC in the voxel-to-voxel analysis resulted in three significant clusters of changed IC, with one of the clusters being an increase of IC in the left prefrontal region. tDCS to the right DLPFC in the voxel-to-voxel analysis resulted in only one significant cluster of decreased IC in the right prefrontal region. For Stroop interference, only tDCS to the right DLPFC improved Stroop interference performance with left and sham causing no significant changes. No significant changes were found for seed-to-voxel analysis. This study shows that tDCS applied to the left and right DLPFC causes asymmetric changes to IC, as well as providing further support that the DLPFC is asymmetric in interference control, with only tDCS to the right DLPFC having a significant effect on interference.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Parent, Camille; Rousseau, Louis-Simon; Predovan, David; Duchesne, Simon; +1 Authors

    This systematic review examined the longitudinal association between amyloid-b (Ab) accumulation and cognitive decline in cognitively healthy adults. It was conducted using the PubMed, Embase, PsycInfo, and Web of Science databases. The methodological quality of the selected articles was assessed. In fine, seventeen longitudinal clinical studies were included in this review. A minority (seven out of 17) of studies reported a statistically significant association or prediction of cognitive decline with Ab change, measured by positron emission tomography (PET; n = 6) and lumbar puncture (n = 1), with a mean follow-up duration of 3.17 years for cognition and 2.99 years for Ab. The studies reporting significant results with PET found differences in the frontal, posterior cingular, lateral parietal and global (whole brain) cortices as well as in the precuneus. Significant associations were found with episodic memory (n = 6) and global cognition (n = 1). Five of the seven studies using a composite cognitive score found significant results. A quality assessment revealed widespread methodological biases, such as failure to report or account for loss to follow up and missing data, and failure to report p-values and effect sizes of nonsignificant results. Overall, the longitudinal association between Ab accumulation and cognitive decline in preclinical Alzheimer’s disease remains unclear. The discrepancy in results between studies may be explained in part by the choice of neuroimaging technique used to measure Ab change, the duration of longitudinal studies, the heterogeneity of the healthy preclinical population, and importantly, the use of a composite score to capture cognitive changes with increased sensitivity. More longitudinal studies with larger sample sizes are needed to elucidate this relationship.

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    CorpusUL
    Other ORP type . 2023
    Data sources: CorpusUL
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      CorpusUL
      Other ORP type . 2023
      Data sources: CorpusUL
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Harel, Yann; Cyr, André; Boyle, Julie; Pinsard, Basile; +7 Authors

    {"references": ["Harel et al., (2023). Open design and validation of a reproducible videogame controller for MRI and MEG."]} Full documentation and files required to build the CNeuromod controller.

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    ZENODO
    PhysicalObject . 2023
    License: CC BY
    Data sources: Datacite
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    ZENODO
    PhysicalObject . 2023
    License: CC BY
    Data sources: ZENODO
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      ZENODO
      PhysicalObject . 2023
      License: CC BY
      Data sources: Datacite
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      ZENODO
      PhysicalObject . 2023
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      Data sources: ZENODO
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    Authors: Young, Christina B.; Johns, Emily; Kennedy, Gabriel; Belloy, Michael E.; +6 Authors

    Abstract Background APOE variants are strongly associated with abnormal amyloid aggregation and additional direct effects of APOE on tau aggregation are reported in animal and human cell models. The degree to which these effects are present in humans when individuals are clinically unimpaired (CU) but have abnormal amyloid (Aβ+) remains unclear. Methods We analyzed data from CU individuals in the Anti-Amyloid Treatment in Asymptomatic AD (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies. Amyloid PET data were available for 4486 participants (3163 Aβ-, 1323 Aβ+) and tau PET data were available for a subset of 447 participants (55 Aβ-, 392 Aβ+). Linear models examined APOE (number of e2 and e4 alleles) associations with global amyloid and regional tau burden in medial temporal lobe (entorhinal, amygdala) and early neocortical regions (inferior temporal, inferior parietal, precuneus). Consistency of APOE4 effects on regional tau were examined in 220 Aβ + CU and mild cognitive impairment (MCI) participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Results APOE2 and APOE4 were associated with lower and higher amyloid positivity rates, respectively. Among Aβ+ CU, e2 and e4 were associated with reduced (−12 centiloids per allele) and greater (+15 centiloids per allele) continuous amyloid burden, respectively. APOE2 was associated with reduced regional tau in all regions (-0.05 to -0.09 SUVR per allele), whereas APOE4 was associated with greater regional tau (+0.02 to +0.07 SUVR per allele). APOE differences were confirmed by contrasting e3/e3 with e2/e3 and e3/e4. Mediation analyses among Aβ+ s showed that direct effects of e2 on regional tau were present in medial temporal lobe and early neocortical regions, beyond an indirect pathway mediated by continuous amyloid burden. For e4, direct effects on regional tau were only significant in medial temporal lobe. The magnitude of protective e2 effects on regional tau was consistent across brain regions, whereas detrimental e4 effects were greatest in medial temporal lobe. APOE4 patterns were confirmed in Aβ+ ADNI participants. Conclusions APOE influences early regional tau PET burden, above and beyond effects related to cross-sectional amyloid PET burden. Therapeutic strategies targeting underlying mechanisms related to APOE may modify tau accumulation among Aβ+ individuals.

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    Collection . 2023
    License: CC BY
    Data sources: Datacite
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    Collection . 2023
    License: CC BY
    Data sources: Datacite
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Duarte-Guterman, P.; Richard, J. E.; Lieblich, S. E.; Eid, R. S.; +2 Authors

    Data used for this publication

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Ippolitov, Danyyl;

    Introduction: HER2+ (ErbB2+) breast cancer (BC) patients demonstrate a high incidence (30%) of brain metastases (BM). Regardless of the effectiveness of ErbB2 targeting therapies in the therapy of primary HER2+ BC, BM remains a fatal complication. Restricted drug permeability across the blood-brain barrier and specific tumor- and/or brain tumor microenvironment (TME)-derived factors determine the low effectiveness of ErbB targeted drugs in the brain. Neuregulin-1 (NRG-1) is a member of the EGF family which is commonly expressed by cells in the brain TME. NRG1 can bind to ErbB3 and/or ErbB4 receptors and potentially promote activation of alternative signaling pathways under ErbB2 inhibition. Results: The newly established patient-derived HER2+ BC model (BCBM94) that metastasizes to the brain in mice forms well-circumscribed proliferative tumors that are vascularized and surrounded by activated astrocytes. BCBM94 cells are sensitive to the pro-apoptotic actions of the reversible EGFR/ErbB2 small molecule tyrosine kinase inhibitor Lapatinib. NRG1 mitigated cytotoxicity induced by Lapatinib, as shown by higher viability in WST-1 assays and the preserved ability for long-term cell propagation in clonogenicity assays. NRG-1 blocked Lapatinib-driven PARP cleavage and activation of the pro-apoptotic caspases-3/7 and caspase-9. NRG-1 also prevented Lapatinib-induced mitochondrial damage. rhNRG1 rescued phosphorylation of kinase-impaired ErbB3 under combined Lapatinib/rhNRG1 treatment suggesting the involvement of ErbB3 in maintaining the viability of BCBM94 under Lapatinib. The essential role of ErbB3 in the apoptosis inhibiting action of rhNRG1 was confirmed by siRNA-mediated silencing (KD) of the receptor. Upon ErbB3 knockdown, rhNRG1 was no longer able to attenuate the Lapatinib-mediated apoptosis in BCBM94 and this coincided with the mitigated rescue of Survivin and XIAP expression and BAD phosphorylation in BCBM94. These rhNRG1-mediated anti-apoptotic actions were also prevented with exposure to the multi-targeted PI3K-Akt and mTORC1/C2 inhibitor (PI-103) confirming the role of the ErbB3-Akt-mTOR signaling axis in the cell viability rescue. Conclusion: The findings identify BCBM94 as a valuable brain metastasis cell model to study resistance mechanisms under ErbB2 inhibition and demonstrate an important role of NRG1 as a powerful brain TME-derived anti-apoptotic factor that can facilitate resistance of BC brain metastases to ErbB2 targeting therapies.

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  • Authors: BIDS-contributors;

    For versions >= 1.9.0, please see this record: https://zenodo.org/doi/10.5281/zenodo.10175845 ---------- This resource defines the Brain Imaging Data Structure (BIDS) specification, including the core specification as well as many modality-specific extensions. To get started, check out the introduction. For an overview of the BIDS ecosystem, visit the BIDS homepage. The entire specification can also be browsed in an HTML version. See Appendix I for a list of the BIDS contributors who jointly created this specification.

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    ZENODO
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yeung, Jonas; DeYoung, Taylor; Spring, Shoshana; de Guzman, A. Elizabeth; +5 Authors

    Description Biological sex influences prevalence of developmental disorders through sex hormones and sex chromosomes. However, our understanding of their impacts in neurodevelopment and response to injury remains limited. In this project, we use high resolution magnetic resonance imaging (MRI) to investigate the four core genotype mouse model (FCG) that separates the influences of sex hormones and sex chromosomes during normal brain development and after cranial radiation therapy. Sex differences are attributed to either sex hormones or sex chromosomes. This can be distinguished by the FCG model which decouples the sex determining region (SRY) from the Y chromosome by moving SRY onto an autosome. This gives us four core sex genotypes: XX NULL, XY NULL, XX SRY, and XY SRY. This dataset represents the most comprehensive mouse brain imaging study employing the FCG model to date with 5 timepoints (P14, P23, P42, P63, P98), Ccl2 wildtype (+/+) and knockouts (-/-), irradiation (7Gy) and sham (0Gy) mice. All in all, a total of 1071 images! The dataset presented here is for an upcoming manuscript to be published. In vivo MRI scans were obtained using a 7-T MRI scanner (Bruker BioSpin, Ettlingen, Germany) equipped with four cryocoils for simultaneous imaging of four mice. The scans were performed with the following settings: T1-weighted, 3D-gradient echo sequence, 75μm isotropic resolution, TR=26ms, TE=8.25ms, flip angle=26°, field of view=25×22×22mm, and matrix size=334×294×294. All structural MR images are stored in images.tar.gz. Images were segmented and registered using an automated pipeline which are stored in labels.tar.gz. The consensus average and labels are final_average.mnc and final_labels.mnc, respectively. Extracted structure volumes alongside the metadata are included in df_micevolumes.csv. Structural MRIs are in MINC format and the readme.txt provides further information on this dataset. The authors express their sincere gratitude for the research funding recieved from the Canadian Institutes of Health Research (158622, 168037) and the Ontario Institute for Cancer Research (IA-024) with funding from the Government of Ontario and Restracomp from the SIckKids Research Training Centre. Code/Software MINChttps://www.bic.mni.mcgill.ca/ServicesSoftware/MINC RMINChttps://github.com/Mouse-Imaging-Centre/RMINC PydPiperhttps://github.com/Mouse-Imaging-Centre/pydpiper/tree/v2.0.19.1

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    ZENODO
    Dataset . 2024
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    ZENODO
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  • Authors: Toutant, Darion;

    This thesis introduces a novel investigation into the morphological characteristics of epileptiform spikes across various sleep-wake states. A gold-standard database of spikes was created, offering insights into their variations across wakefulness, non-rapid-eye-movement (NREM) sleep stages 1-3, and particularly rapid-eye-movement (REM) sleep, and hypothesizing on the dynamics regulating its suppressive ability towards spikes. The study employed lab-developed software to categorize sleep states and validate spikes using data from 7 epilepsy monitoring unit patients. A computational pipeline was developed to assess nine morphological spike features throughout Laplacian, Referential, and Raw montages. Due to non-normal data distribution, statistical analysis was performed using the Kruskal-Wallis test, followed by Dunn's post-hoc testing and Bonferroni correction. Results revealed that the spike features of REM sleep are significantly different from those of other sleep-wake states. In particular, spikes during REM sleep had the shallowest ascending and descending slopes by nearly 50% of the other states, which were nearly symmetrical, blunter peaks with roughly twice the angle of other states and exhibited lower peak amplitudes less than 50% of the voltage of other states. Wakefulness was the most different state concerning duration while being, on average, 15% shorter. Finally, the spike area during REM was roughly twice as small as all other states. This study shows significant spike feature differences throughout sleep-wake states, with REM drastically different in most features. The driving factors for changes in spike morphology throughout the sleep-wake states are unknown. However, this thesis explores the effects of ionic, neurotransmitter, astrocytic and network dynamic processes to help shed light on these changes. Notably, this thesis provides glimpses into the roles of astrocytic involvement, orexinergic systems, and network dynamics as potential contributors to the observed morphological differences within REM. Further investigations are necessary to fully understand these complex electrobiological interactions, which may be responsible for the observed anti-epileptic properties during REM sleep. This study paves the way for future work to expose and leverage the unique anti-epileptic mechanisms of REM sleep, potentially leading to the development of REM-specific therapeutic strategies for epilepsy management.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Tremblay, Pascale; Gagnon, Lydia; Roy, Johanna-Pascale; Arseneault, Alison;

    Purpose: Amateur singing is a universal, accessible, and enjoyable musical activity that may have positive impacts on human communication. However, evidence of an impact of singing on speech articulation is still scarce, yet, understanding the effects of vocal training on speech production could provide a model for treating people with speech deficits. The aim of this study was to examine speech production in younger and older adults with or without amateur singing experience. Method: 38 amateur singers (aged 20–87 years, 23 females) and 40 non-musician controls (aged 23–88 years, 19 females) were recruited. A set of tasks were used to evaluate the oral motor sphere: two voice production tasks, a passage reading task and a modified diadochokinetic rates task (DDK) performed at a natural rhythm and as fast as possible. Results: Our results show that older age was associated with lower reading rate, lower articulation rate and articulation rate variability in the DDK task, as well as reduced accuracy for the phonologically complex stimuli. Most importantly, our results show an advantage for singers over cognitively active non-singers in terms of articulatory accuracy in the most challenging situations. Conclusions: This result suggests extended maximal performance capacities in amateur singers perhaps resulting from the articulatory efforts required during singing.

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    CorpusUL
    Other ORP type . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: McAllister, Zachary;

    Transcranial direct current stimulation (tDCS) applied to the dorsolateral prefrontal cortex (DLPFC) has been shown to have asymmetric behavioral effects, but the underlaying neurophysiological mechanisms causing these asymmetric behavioral differences are poorly understood. Functional magnetic resonance imaging (fMRI) can be used in conjunction with a behavioral measurement to better understand these mechanisms. To measure the hemispheric laterality of neurophysiological and behavioral effects of anodal tDCS applied to the left and right DLPFC using fMRI and Stroop test interference, 11 male and 28 female healthy participants were randomized into three treatment groups of 1.5mA anodal tDCS applied to sham or the left or right the DLPFC, with the cathode placed on the contralateral supraorbital region. Before and after tDCS application participants took the Stroop test and underwent resting-state fMRI. Seed-to-voxel functional connectivity and voxel-to-voxel whole brain intrinsic connectivity (IC) analyses were performed on the fMRI data. All fMRI analysis was done by using two sets of 2×2 factorial analyses between groups (real vs. sham) and time (pre- vs. post-tDCS) for each left and right tDCS, separately, while Stroop interference was measured using a repeated measures general linear model. tDCS to the left DLPFC in the voxel-to-voxel analysis resulted in three significant clusters of changed IC, with one of the clusters being an increase of IC in the left prefrontal region. tDCS to the right DLPFC in the voxel-to-voxel analysis resulted in only one significant cluster of decreased IC in the right prefrontal region. For Stroop interference, only tDCS to the right DLPFC improved Stroop interference performance with left and sham causing no significant changes. No significant changes were found for seed-to-voxel analysis. This study shows that tDCS applied to the left and right DLPFC causes asymmetric changes to IC, as well as providing further support that the DLPFC is asymmetric in interference control, with only tDCS to the right DLPFC having a significant effect on interference.

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    Authors: Parent, Camille; Rousseau, Louis-Simon; Predovan, David; Duchesne, Simon; +1 Authors

    This systematic review examined the longitudinal association between amyloid-b (Ab) accumulation and cognitive decline in cognitively healthy adults. It was conducted using the PubMed, Embase, PsycInfo, and Web of Science databases. The methodological quality of the selected articles was assessed. In fine, seventeen longitudinal clinical studies were included in this review. A minority (seven out of 17) of studies reported a statistically significant association or prediction of cognitive decline with Ab change, measured by positron emission tomography (PET; n = 6) and lumbar puncture (n = 1), with a mean follow-up duration of 3.17 years for cognition and 2.99 years for Ab. The studies reporting significant results with PET found differences in the frontal, posterior cingular, lateral parietal and global (whole brain) cortices as well as in the precuneus. Significant associations were found with episodic memory (n = 6) and global cognition (n = 1). Five of the seven studies using a composite cognitive score found significant results. A quality assessment revealed widespread methodological biases, such as failure to report or account for loss to follow up and missing data, and failure to report p-values and effect sizes of nonsignificant results. Overall, the longitudinal association between Ab accumulation and cognitive decline in preclinical Alzheimer’s disease remains unclear. The discrepancy in results between studies may be explained in part by the choice of neuroimaging technique used to measure Ab change, the duration of longitudinal studies, the heterogeneity of the healthy preclinical population, and importantly, the use of a composite score to capture cognitive changes with increased sensitivity. More longitudinal studies with larger sample sizes are needed to elucidate this relationship.

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    CorpusUL
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    Authors: Harel, Yann; Cyr, André; Boyle, Julie; Pinsard, Basile; +7 Authors

    {"references": ["Harel et al., (2023). Open design and validation of a reproducible videogame controller for MRI and MEG."]} Full documentation and files required to build the CNeuromod controller.

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    Authors: Young, Christina B.; Johns, Emily; Kennedy, Gabriel; Belloy, Michael E.; +6 Authors

    Abstract Background APOE variants are strongly associated with abnormal amyloid aggregation and additional direct effects of APOE on tau aggregation are reported in animal and human cell models. The degree to which these effects are present in humans when individuals are clinically unimpaired (CU) but have abnormal amyloid (Aβ+) remains unclear. Methods We analyzed data from CU individuals in the Anti-Amyloid Treatment in Asymptomatic AD (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies. Amyloid PET data were available for 4486 participants (3163 Aβ-, 1323 Aβ+) and tau PET data were available for a subset of 447 participants (55 Aβ-, 392 Aβ+). Linear models examined APOE (number of e2 and e4 alleles) associations with global amyloid and regional tau burden in medial temporal lobe (entorhinal, amygdala) and early neocortical regions (inferior temporal, inferior parietal, precuneus). Consistency of APOE4 effects on regional tau were examined in 220 Aβ + CU and mild cognitive impairment (MCI) participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Results APOE2 and APOE4 were associated with lower and higher amyloid positivity rates, respectively. Among Aβ+ CU, e2 and e4 were associated with reduced (−12 centiloids per allele) and greater (+15 centiloids per allele) continuous amyloid burden, respectively. APOE2 was associated with reduced regional tau in all regions (-0.05 to -0.09 SUVR per allele), whereas APOE4 was associated with greater regional tau (+0.02 to +0.07 SUVR per allele). APOE differences were confirmed by contrasting e3/e3 with e2/e3 and e3/e4. Mediation analyses among Aβ+ s showed that direct effects of e2 on regional tau were present in medial temporal lobe and early neocortical regions, beyond an indirect pathway mediated by continuous amyloid burden. For e4, direct effects on regional tau were only significant in medial temporal lobe. The magnitude of protective e2 effects on regional tau was consistent across brain regions, whereas detrimental e4 effects were greatest in medial temporal lobe. APOE4 patterns were confirmed in Aβ+ ADNI participants. Conclusions APOE influences early regional tau PET burden, above and beyond effects related to cross-sectional amyloid PET burden. Therapeutic strategies targeting underlying mechanisms related to APOE may modify tau accumulation among Aβ+ individuals.

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    Authors: Duarte-Guterman, P.; Richard, J. E.; Lieblich, S. E.; Eid, R. S.; +2 Authors

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    Authors: Ippolitov, Danyyl;

    Introduction: HER2+ (ErbB2+) breast cancer (BC) patients demonstrate a high incidence (30%) of brain metastases (BM). Regardless of the effectiveness of ErbB2 targeting therapies in the therapy of primary HER2+ BC, BM remains a fatal complication. Restricted drug permeability across the blood-brain barrier and specific tumor- and/or brain tumor microenvironment (TME)-derived factors determine the low effectiveness of ErbB targeted drugs in the brain. Neuregulin-1 (NRG-1) is a member of the EGF family which is commonly expressed by cells in the brain TME. NRG1 can bind to ErbB3 and/or ErbB4 receptors and potentially promote activation of alternative signaling pathways under ErbB2 inhibition. Results: The newly established patient-derived HER2+ BC model (BCBM94) that metastasizes to the brain in mice forms well-circumscribed proliferative tumors that are vascularized and surrounded by activated astrocytes. BCBM94 cells are sensitive to the pro-apoptotic actions of the reversible EGFR/ErbB2 small molecule tyrosine kinase inhibitor Lapatinib. NRG1 mitigated cytotoxicity induced by Lapatinib, as shown by higher viability in WST-1 assays and the preserved ability for long-term cell propagation in clonogenicity assays. NRG-1 blocked Lapatinib-driven PARP cleavage and activation of the pro-apoptotic caspases-3/7 and caspase-9. NRG-1 also prevented Lapatinib-induced mitochondrial damage. rhNRG1 rescued phosphorylation of kinase-impaired ErbB3 under combined Lapatinib/rhNRG1 treatment suggesting the involvement of ErbB3 in maintaining the viability of BCBM94 under Lapatinib. The essential role of ErbB3 in the apoptosis inhibiting action of rhNRG1 was confirmed by siRNA-mediated silencing (KD) of the receptor. Upon ErbB3 knockdown, rhNRG1 was no longer able to attenuate the Lapatinib-mediated apoptosis in BCBM94 and this coincided with the mitigated rescue of Survivin and XIAP expression and BAD phosphorylation in BCBM94. These rhNRG1-mediated anti-apoptotic actions were also prevented with exposure to the multi-targeted PI3K-Akt and mTORC1/C2 inhibitor (PI-103) confirming the role of the ErbB3-Akt-mTOR signaling axis in the cell viability rescue. Conclusion: The findings identify BCBM94 as a valuable brain metastasis cell model to study resistance mechanisms under ErbB2 inhibition and demonstrate an important role of NRG1 as a powerful brain TME-derived anti-apoptotic factor that can facilitate resistance of BC brain metastases to ErbB2 targeting therapies.

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  • Authors: BIDS-contributors;

    For versions >= 1.9.0, please see this record: https://zenodo.org/doi/10.5281/zenodo.10175845 ---------- This resource defines the Brain Imaging Data Structure (BIDS) specification, including the core specification as well as many modality-specific extensions. To get started, check out the introduction. For an overview of the BIDS ecosystem, visit the BIDS homepage. The entire specification can also be browsed in an HTML version. See Appendix I for a list of the BIDS contributors who jointly created this specification.

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