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38,995 Research products, page 1 of 3,900

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  • Other research product . Other ORP type . 2020
    Open Access English
    Authors: 
    CARLETTI, Elena; PAGANO, Marco; PELIZZON, Loriana; SUBRAHMANYAM, Marti G.;
    Publisher: Bloomberg L.P.
    Country: Italy

    Published on April 9, 2020 Fiscally sound governments will be able to pump money into their companies unhindered by state aid rules. The EU needs an equity fund to level things up. All great economic crises pose two equally important challenges: they drain the liquidity necessary for the functioning of businesses, large and small, and burn up their equity capital, or a substantial part of it. Of the two, the former is the immediate challenge amid the coronavirus-induced lockdowns. Providing liquidity to companies is the top priority to ensure their survival. Yet this doesn’t guarantee their healing, or their ultimate durability and growth. Equity capital, the stuff that’s needed to invest and thrive, is essential to the second stage of recovery.

  • Other research product . 2021
    Open Access
    Authors: 
    Kruisbergen, E.; Haas, M.; Es, L. van; Snijders, J.; Coomans, A.; Deuren, S. van; Dijk, M. van; Weijer, S. van de; Blokland, A.; Baak, C.; +18 more
    Publisher: Boom juridisch
    Country: Netherlands

    CONTENT: 1. The pandemic as a criminological experiment. The development of crime during one year of corona measures - Edwin Kruisbergen, Marco Haas, Lisa van Es and Joanieke Snijders 2. Stay home, stay safe? The consequences of Covid-19 measures on domestic violence in the Netherlands - Anne Coomans, Sjoukje van Deuren, Meintje van Dijk, Steve van de Weijer, Arjan Blokland, Carlijn van Baak, David Kühling, Rosanne Bombeld and Veroni Eichelsheim 3. Compliance with COVID-19 mitigating measures in the Netherlands - Joska Appelman, Kiki Bijleveld, Peter Ejbye-Ernst, Evelien Hoeben, Lasse Liebst, Cees Snoek, Dennis Koelma and Marie Rosenkrantz Lindegaard 4. Deception during the corona pandemic. On fake news, conspiracy thinking and social receptivity - Peter Klerks 5. Administration of justice in youth protection cases during the COVID pandemic. A report of ongoing research - Eddy Bauw, Yasemin Glasgow, Anne Janssen and Marc Simon Thomas 6. Sex work in times of corona. The impact of the lockdown on sex workers - Roos de Wildt

  • Open Access English
    Authors: 
    Krasnopjorovs, Oļegs;

    The aim of the article is to study both the magnitude and structure of internal labour reserves in the Baltic countries as well as to discuss potential policy measures that might help to activate these reserves. despite the record-high employment rates recently posted by Estonia, Latvia and Lithuania, considerable internal labour reserves can still be found in some population groups. Among upper-middle-aged men, low employment might reflect a low incidence of lifelong learning, inadequate digital skills and rapidly deteriorating health condition. Low employment of youth mirrors the low prevalence of apprenticeships. in Lithuania and Latvia, there is also a postponed entry of young women into the labour market. These internal labour reserves total more than 25,000 people in Estonia, 55,000 in Latvia and 85,000 in Lithuania, corresponding to 4–7% of the total employment. The recent outbreak of the Covid-19 pandemic may somewhat increase and change the structure of these labour reserves.

  • Open Access Russian
    Country: Russian Federation

    При лечении пациентов, инфицированных SARS-CoV-2, важной задачей является проведение эффективной патогенетической и симптоматической терапии до развития угрожающих жизни осложнений, таких как пневмония, острый респираторный дистресс-синдром, сепсис. В настоящее время в схемах лечения COVID-19 широко используют ремдесивир и тоцилизумаб, однако сведений о безопасности данных препаратов недостаточно. В связи с этим экспертами Управления экспертизы безопасности лекарственных средств ФГБУ «НЦЭСМП» Минздрава России был проведен анализ нежелательных реакций при применении ремдесивира и тоцилизумаба по информации глобальной базы данных нежелательных реакций VigiBase (по состоянию на 27 августа 2020 г.).

  • Other research product . 2020
    Open Access Portuguese
    Authors: 
    Silva, João Paulo Miranda da;
    Country: Portugal

    This Report is the result of the Internship carried out within the scope of Sports Training in Football aiming to obtain a master’s degree in Sports Sciences, at the University of Beira Interior. The deepening and development of knowledge, within the scope of the Football training methodology, and its practical application in the context of an Internship, was carried out with the Under-16 Football team of Gil Vicente Futebol Clube (GVFC), a football Club in the city of Barcelos. We started this Report with the presentation of the Club where the Internship took place, it’s history and the human and material resources available to the GVFC under-16 level. Then we present and reflect on the implementation of the ideas transmitted by the Superiors for the training teams, especially for the under-16 level, from the intervention strategies during the Internship, the diagnosis, control, work performed, and function played in the Club and team. The Report also contemplates an investigation work, the objective of which was the training and evaluation of the evolution of the precision of the launch with the hand of the ball by the Goalkeepers of the under-16 level and in which the two Goalkeepers of the level have participated. Due to the cancellation of training and games because of the declared state of emergency (pandemic covid-19), it was not possible to complete the work in the manner prescribed, so the conclusions regarding the evolution of Goalkeepers in this capacity through the proposed situations were left committed, this work should be continued in the near future. O presente Relatório resulta do Estágio realizado no âmbito do Treino Desportivo em Futebol visando a obtenção do Grau de Mestre em Ciências do Desporto, na Universidade da Beira Interior. O aprofundamento e desenvolvimento do conhecimento, no âmbito da metodologia de treino em Futebol, e sua aplicação prática em contexto de Estágio, foi realizado com a equipa de Futebol Sub-16 do Gil Vicente Futebol Clube (GVFC), Clube da cidade de Barcelos. Iniciamos este Relatório pela apresentação do Clube onde decorreu o Estágio, a sua história e recursos humanos e materiais disponíveis para o escalão de sub-16 do GVFC. Seguidamente apresentamos e refletimos sobre a implementação das ideias transmitidas pela Coordenação para as equipas da Formação, em especial para o escalão de sub-16, desde as estratégias intervenção no decorrer do Estágio, o diagnóstico, controlo, trabalhos realizados, e função desempenhada no Clube e equipa. O Relatório contempla ainda um trabalho de investigação, cujo objetivo foi o treino e a avaliação da evolução da precisão do lançamento com a mão da bola pelos Guarda-Redes do escalão de sub-16 e no qual, participarão os dois Guarda-Redes do escalão. Devido ao cancelamento dos treinos e jogos por conta do estado de emergência declarado (pandemia covid-19), não foi possível a conclusão do trabalho nos moldes previstos, pelo que as conclusões relativas à evolução dos Guarda-Redes nesta capacidade através das situações propostas ficaram comprometidas devendo este trabalho ser continuado num futuro próximo.

  • Open Access Portuguese
    Authors: 
    Conde, Olga Lucía Mosquera;
    Country: Brazil

    Trabalho de Conclusão de Residência apresentado ao Programa de Pós-graduação em Saúde da Família (Residência Multiprofissional), do Instituto Latino-americano de Ciências da Vida e da Natureza da Universidade Federal da Integração Latino Americana, como requisito parcial para obtenção do título de Especialista em Saúde da Família. Trata-se de um estudo ecológico, realizado no município de Foz do Iguaçu-PR, com o objetivo de analisar os efeitos da implantação das medidas restritivas no enfrentamento da COVID-19. Foram analisados decretos publicados no ano de 2020 e no primeiro quadrimestre de 2021. Após análise primária dos decretos, foram criadas nove categorias de medidas restritivas. Posteriormente, foram elaboradas e analisadas as seguintes variáveis: número de casos novos; número de óbitos; taxa de mortalidade; taxa de incidência e letalidade. Os resultados permitiram compreender a implantação das medidas restritivas no município de Foz do IguaçuPR, como ferramenta de redução dos casos, hospitalizações, e, consequentemente, dos óbitos. Foi possível observar a implementação de medidas restritivas em tempo oportuno e o impacto das flexibilizações no aumento dos casos, principalmente nas primeiras semanas epidemiológicas de 2021, em que se observou o maior pico de casos. Ministério da Educação

  • Open Access English
    Authors: 
    Al-Luhaibi Zaid Isam Issa;
    Country: Hungary

    Autophagy is an intracellular catabolic process that controls infections both directly and indirectly via its multifaceted effects on the innate and adaptive immune responses. It has been reported that LPS stimulates this cellular process, whereas the effect of IL-36α on autophagy remains largely unknown. We, therefore, investigated how IL-36α modulates the endogenous and LPS-induced autophagy in THP-1 cells. The levels of LC3B-II and autophagic flux were determined by western blotting. The intracellular localization of LC3B was measured by immunofluorescence assay. The activation levels of signaling pathways implicated in autophagy regulation were evaluated by using a phosphokinase array. Our results showed that combined IL-36α and LPS treatment cooperatively increased the levels of LC3B-II and Beclin-1, stimulated the autophagic flux, facilitated intracellular redistribution of LC3B, and increased the average number of autophagosomes per cell. The IL36α/LPS combined treatment increased phosphorylation of STAT5a/b, had minimal effect on the Akt/PRAS40/mTOR pathway, and reduced the levels of phospho-Yes, phospho-FAK, and phospho-WNK1. Thus, this cytokine/PAMP combination triggers pro-autophagic biased signaling by several mechanisms and thus cooperatively stimulates the autophagic cascade. An increased autophagic activity of innate immune cells simultaneously exposed to IL-36α and LPS may play an important role in the pathogenesis of Gram-negative bacterial infections. SARS-CoV-2 can infect and replicate in esophageal cells and enterocytes, leading to direct damage to the intestinal epithelium. The infection decreases the level of angiotensin converting enzyme 2 receptors, thereby altering the composition of the gut microbiota. SARS-CoV-2 elicits a cytokine storm, which contributes to gastrointestinal inflammation. The direct cytopathic effects of SARS-CoV-2, gut dysbiosis, and aberrant immune response result in increased intestinal permeability, which may exacerbate existing symptoms and worsen the prognosis. By exploring the elements of pathogenesis, several therapeutic options have emerged for the treatment of COVID-19 patients, such as biologics and biotherapeutic agents. However, the presence of SARS-CoV-2 in the feces may facilitate the spread of COVID-19 through fecal-oral transmission and contaminate the environment. Thus, gastrointestinal SARS-CoV-2 infection has important epidemiological significance. The development of new therapeutic and preventive options is necessary to treat and restrict the spread of this severe and widespread infection more effectively.

  • Other research product . Other ORP type . 2022
    Open Access Lithuanian
    Authors: 
    Barštytė, Rūta;
    Country: Lithuania

    Prekės ženklų komunikacija atlieką svarbų vaidmenį ypatingai šiandieninėje aplinkoje. Įvykiai tokie kaip Covid-19 pandemija bei Rusijos invazija į Ukrainą paveikė tiek vartotojus tiek jų įpročius. Prekės ženklų komunikacija taip pat turėjo reaguoti į įvykius aplinkoje. Ypatingą svarbą prekės ženklų komunikacija įgauna neapibrėžtumo laikotarpiu. Prekės ženklų komunikacijos pagalba gali būti tiek užmezgamas ryšys su vartotoju, tiek palaikomas jau esamas. Prekės ženklų komunikacija neapibrėžtumo laikotarpiu gali veikti vartotojus raminančiai, suteikti jiems aktualią informaciją bei parodyti palaikymą ir empatiją. Siekiant išnagrinėti prekės ženklų komunikaciją neapibrėžtumo laikotarpiu išsikelta tyrimo problema - koks prekių ženklų komunikacijos turinys dominavo Covid-19 pandemijos ir Rusijos agresijos Ukrainoje laikotarpiu? Išsikeltas tyrimo tikslas - ištirti prekės ženklų komunikaciją neapibrėžtumo laikotarpiu. Išsikeltam tyrimo tikslui pasiekti naudoti tyrimo metodai antrinių duomenų analizė bei pusiau struktūruotas ekspertų interviu. Antrinių duomenų analizė atskleidė atliktų tyrimų susijusių su neapibrėžtumo laikotarpiu rezultatus bei Lietuvos marketingo ir komunikacijos ekspertų pastebėjimus, nuomones pozicijas apie prekės ženklų komunikaciją neapibrėžtumo laikotarpiu. Pusiau struktūruotas ekspertų interviu leido pagrįsti informaciją gautą antrinių duomenų analizės metu. Tyrimai atskleidė, kad prekės ženklai neapibrėžtumo laikotarpiu neturėtų stabdyti savo komunikacijos. Prekės ženklų komunikacijoje neapibrėžtumo laikotarpiu vartotojams turėtų būti pateikiama aktuali informacija aiškiai ir visiems suprantamai. Prekės ženklų komunikacijoje neapibrėžtumo laikotarpiu turėtų būti skiriamas dėmesys naudojamiems žodžiams, ne visi žodžiai gali būti tinkami kontekste. Tyrimai atskleidė, kad vartotojų naudojimasis socialiniais kanalais išaugo, prekės ženklų komunikacija neapibrėžtumo laikotarpiu turėtų atkreipti dėmesį į tai norint pasiekti vartotoją. Šis darbas yra projektinis magistro baigiamasis darbas. Brand communication plays an important role especially in today’s environment. Events such as the Covid-19 pandemic and the Russian invasion of Ukraine have affected both consumers and their habits. Brand communication also has to respond to events in the environment. Brand communication is gaining in importance during the times of uncertainty. Brand communication can be used to connect with the user and also maintain an existing relationship. Brand communication can reassure consumers, provide them with relevant information, demonstrate support and empathy in times of uncertainty, In order to research brand communication in times of uncertainty, the research problem was raised - what content of brand communication dominated during the Covid-19 pandemic and the Russian aggression in Ukraine? Research aim is to investigate brand communication in times of uncertainty. The research methods used to achieve the research aim is secondary data analysis and semi-structured expert interview. Secondary data analysis revealed the results of the performed studies related to the time of uncertainty observations and opinions of Lithuanian marketing and communication experts on brand communication during the period of uncertainty. Semi-structured expert interviews allowed to substantiate the information obtained during secondary data analysis. Research has shown that brands should not stop their communication during a period of uncertainty. The consumer should be provided with relevant information clearly and comprehensibly during brand communication in times of uncertainty. In times of uncertainty, brand communication should focus on the words used, not all words may be appropriate in the context. Research has revealed that consumer use of social channels increased, and brand communication in times of uncertainty should pay attention to this to reach the consumer. This paper is projected solutions oriented final master thesis.

  • Open Access Finnish
    Authors: 
    Anttila, Teija;
    Country: Finland

    Maailmanlaajuisen COVID-19-pandemian jälkeen työympäristöstandardeja määritellään kriittisesti uudelleen kaikilla aloilla. Kriisi on pakottanut yritykset pohtimaan työtapojaan ja turvautumaan teknologiaan uusien vuorovaikutustapojen toteuttamiseksi. Tämän digitaalisen harppauksen tunnusmerkkinä oleva siirtyminen etätyökäytäntöihin kyseenalaistaa toimitilojen tarkoituksen. Keskellä tätä muutosta työympäristösuunnittelu on nyt uusien haasteiden edessä luodakseen toimivia ja mielekkäitä toimistotiloja, jotka vastaavat tämän päivän ja huomisen tarpeisiin. Opinnäytetyö on tehty osana PES-Arkkitehdit Oy:n toimeksiantoa palvelumuotoilun kehittämiseksi yrityksessä (2022). Tavoitteena on kohdentaa tilaajaorganisaation toimintaa asiakaslähtöisemmäksi, kehittää palvelumuotoilua ja luoda siihen liittyvä prosessi työympäristön suunnitteluun. Oleellinen nosto työstä on työympäristön fasilitoijan työnkuvan tunnistaminen ja määrittäminen. Opinnäytetyö vastaa tutkimuksensa kautta (ja myöhemmin testaamalla ja jatkuvalla kehittämisellä) seuraavaan tutkimuskysymykseen: Millainen palveluprosessi tuottaa onnistuneita työympäristön yhteiskehitysprojekteja? Tässä työssä kehittämismenetelmänä on palvelumuotoilun viitekehys. Palvelumuotoilun avulla voidaan hyödyntää käyttäjäkeskeistä lähestymistä, prosessia, testaamista ja työkaluja - sitoen ne kehitettävään työympäristön kehitysprosessiin. Viitekehyksen sisälle asettuvat palvelumuotoilu, työympäristöhankkeen projektinhallinta, yhteiskehittämisen menetelmät, sidosryhmät ja oma katsontakulma sekä työn toimeksianto. Tutkimusosaan kuuluu erilaisten kehitysprosessien tutkiminen, analysointi ja vertailu. Tutkimusosassa tavoitteena on yhdistää tutkimuskehitystyö ja palvelumuotoilu sekä lisätä ymmärrystä palvelumuotoilusta. Kyselytutkimuksissa (yhteistyössä YAMK-opiskelija Raisa Hämäläisen kanssa) kerättiin mielipiteitä osallistavasta suunnittelusta työympäristösuunnittelun ammattilaisten ja siihen osallistuvien loppukäyttäjien keskuudessa. Arkkitehdin haastattelu antoi yrityksen sisäisen näkökulman osallistavan suunnittelun prosessien integroinnista strategisiin tavoitteisiin ja projektien johtamiseen. Kyselyissä ja haastattelussa selvitettiin työympäristön kehittämisen haasteita ja yhteisymmärryksen tärkeyttä yhteisissä kehittämishankkeissa. Lopputuloksena syntyy kymmenvaiheinen palveluprosessi toimeksiantajalle. Tämän palveluprosessin tavoitteena on vastata realistisesti arkkitehtitoimiston arvoja, huomioida eri sidosryhmät ja olla räätälöitävissä. Työssä selvitetään myös palvelumuotoilun tuomaa arvoa asiakkaille ja yritykselle. Opinnäytetyön tavoitteena on toimia runkona uniikkien asiakasprojektien osallistamisprosessien laadinnalle ja rakentaa ymmärryksen siltaa projektin osallisten välillä kohti palvelumuotoilun laajempaa hyödyntämistä.

  • English
    Authors: 
    Kohnert, Dirk;
    Country: Germany

    ABSTRACT & RÉSUMÉ & ZUSAMMENFASSUNG : Dark clouds over the EU-Africa Summit 2021 in view of Brexit and Corona ---- Every three years, the AU-EU summit reunites African and EU leaders to outline the future direction of cooperation. The 6th summit had been to reaffirm and renew the partnership between the two blocks already in October 2020, but it was pushed back to the first quarter of 2021 or even later due to COVID-19 crisis. Besides, Brussels had to deal with its own post-Brexit situation and its repercussions on EU-Africa relations, excluding the UK. African states, for their part, wanted to renegotiate the EU-Africa partnership and to balance it with new promising Post-Brexit visions of the British premier Johnson about increased economic ties with the African Angloshere. China and other global players compete with the EU and its member states in the new scramble for African resources. Given that Africa is increasingly courted by other partners it could be inclined to successively limit its relations with the EU and see it as a mere provider of aid and security against Islamic terrorism. This trend was reinforced by the fact that the new EU-Africa strategy still hasn't been approved by EU member states. And a timely replacement of the Cotonou Agreement, which expires in November 2021, is open to question. ___________________________________________________________________________ RÉSUMÉ : Tous les trois ans, le sommet UA-UE réunit les dirigeants africains et européens pour définir l'orientation future de la coopération. Le 6e sommet devait réaffirmer et renouveler le partenariat entre les deux blocs déjà en octobre 2020, mais il a été repoussé au premier trimestre 2021, ou même plus tard, en raison de la crise du COVID-19. En outre, Bruxelles a dû faire face à sa propre situation post-Brexit, compte tenu l'exclusion du Royaume-Uni, et à ses répercussions sur les relations UE-Afrique. Les États africains, pour leur part, souhaitaient renégocier le partenariat UE-Afrique, et l'équilibrer avec les nouvelles visions post-Brexit prometteuses du Premier ministre britannique Johnson sur le renforcement des liens économiques avec l'Anglosphère africaine. La Chine et d'autres acteurs mondiaux sont en concurrence avec l'UE et ses États membre dans la nouvelle ruée vers les ressources africaines. Étant donné que l'Afrique est de plus en plus courtisée par d'autres partenaires, elle pourrait être encline à limiter successivement ses relations avec l'UE et à la considérer comme un simple fournisseur d'aide et de sécurité contre le terrorisme islamique. Cette tendance a été renforcée par le fait que la nouvelle stratégie UE-Afrique n'a toujours pas été approuvée par les États membres de l'UE. Et un remplacement opportun de l'accord de Cotonou, qui expire en novembre 2021, est sujet à caution. _____________________________________________________________________ ZUSAMMENFASSUNG : Alle drei Jahre bringt der AU-EU Gipfel afrikanische und EU-Staats- und Regierungschefs zusammen, um die künftige Richtung der Zusammenarbeit zu skizzieren. Der 6. Gipfel hatte sich zum Ziel gesetzt, die Partnerschaft zwischen den beiden Blöcken bereits im Oktober 2020 zu bekräftigen und zu erneuern, er wurde jedoch aufgrund der COVID-19-Krise auf das erste Quartal 2021 verschoben. Davon unabhängig mußte sich Brüssel erst einmal über seine eigene Situation nach dem Brexit und dessen Auswirkungen auf die Beziehungen zwischen der EU und Afrika klar werden. Die afrikanischen Staaten ihrerseits wollen die Partnerschaft zwischen der EU und Afrika neu verhandeln und sie mit den vielversprechenden Visionen des britischen Premierministers Boris Johnson über verstärkte wirtschaftliche Beziehungen zur afrikanischen Anglosphäre in Einklang bringen. Zudem konkurrieren China und andere Global Player mit der EU und ihren Mitgliedstaaten im Kampf um afrikanische Ressourcen. Angesichts der Tatsache, daß Afrika zunehmend von anderen Partnern umworben wird, könnten seine Führer dazu neigen, ihre Beziehungen zur EU sukzessive einzuschränken und die EU auf ihre Funktion als Anbieter von Hilfe und Sicherheit gegen den islamischen Terrorismus zu begrenzen. Dieser Trend wird noch dadurch verstärkt, daß eine gemeinsame EU-Afrika-Strategie von den EU-Mitgliedstaaten noch nicht einmal verabschiedet wurde. Selbst der rechtzeitige Ersatz des Cotonou-Abkommens, das im November 2021 ausläuft, ist fraglich.

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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
38,995 Research products, page 1 of 3,900
  • Other research product . Other ORP type . 2020
    Open Access English
    Authors: 
    CARLETTI, Elena; PAGANO, Marco; PELIZZON, Loriana; SUBRAHMANYAM, Marti G.;
    Publisher: Bloomberg L.P.
    Country: Italy

    Published on April 9, 2020 Fiscally sound governments will be able to pump money into their companies unhindered by state aid rules. The EU needs an equity fund to level things up. All great economic crises pose two equally important challenges: they drain the liquidity necessary for the functioning of businesses, large and small, and burn up their equity capital, or a substantial part of it. Of the two, the former is the immediate challenge amid the coronavirus-induced lockdowns. Providing liquidity to companies is the top priority to ensure their survival. Yet this doesn’t guarantee their healing, or their ultimate durability and growth. Equity capital, the stuff that’s needed to invest and thrive, is essential to the second stage of recovery.

  • Other research product . 2021
    Open Access
    Authors: 
    Kruisbergen, E.; Haas, M.; Es, L. van; Snijders, J.; Coomans, A.; Deuren, S. van; Dijk, M. van; Weijer, S. van de; Blokland, A.; Baak, C.; +18 more
    Publisher: Boom juridisch
    Country: Netherlands

    CONTENT: 1. The pandemic as a criminological experiment. The development of crime during one year of corona measures - Edwin Kruisbergen, Marco Haas, Lisa van Es and Joanieke Snijders 2. Stay home, stay safe? The consequences of Covid-19 measures on domestic violence in the Netherlands - Anne Coomans, Sjoukje van Deuren, Meintje van Dijk, Steve van de Weijer, Arjan Blokland, Carlijn van Baak, David Kühling, Rosanne Bombeld and Veroni Eichelsheim 3. Compliance with COVID-19 mitigating measures in the Netherlands - Joska Appelman, Kiki Bijleveld, Peter Ejbye-Ernst, Evelien Hoeben, Lasse Liebst, Cees Snoek, Dennis Koelma and Marie Rosenkrantz Lindegaard 4. Deception during the corona pandemic. On fake news, conspiracy thinking and social receptivity - Peter Klerks 5. Administration of justice in youth protection cases during the COVID pandemic. A report of ongoing research - Eddy Bauw, Yasemin Glasgow, Anne Janssen and Marc Simon Thomas 6. Sex work in times of corona. The impact of the lockdown on sex workers - Roos de Wildt

  • Open Access English
    Authors: 
    Krasnopjorovs, Oļegs;

    The aim of the article is to study both the magnitude and structure of internal labour reserves in the Baltic countries as well as to discuss potential policy measures that might help to activate these reserves. despite the record-high employment rates recently posted by Estonia, Latvia and Lithuania, considerable internal labour reserves can still be found in some population groups. Among upper-middle-aged men, low employment might reflect a low incidence of lifelong learning, inadequate digital skills and rapidly deteriorating health condition. Low employment of youth mirrors the low prevalence of apprenticeships. in Lithuania and Latvia, there is also a postponed entry of young women into the labour market. These internal labour reserves total more than 25,000 people in Estonia, 55,000 in Latvia and 85,000 in Lithuania, corresponding to 4–7% of the total employment. The recent outbreak of the Covid-19 pandemic may somewhat increase and change the structure of these labour reserves.

  • Open Access Russian
    Country: Russian Federation

    При лечении пациентов, инфицированных SARS-CoV-2, важной задачей является проведение эффективной патогенетической и симптоматической терапии до развития угрожающих жизни осложнений, таких как пневмония, острый респираторный дистресс-синдром, сепсис. В настоящее время в схемах лечения COVID-19 широко используют ремдесивир и тоцилизумаб, однако сведений о безопасности данных препаратов недостаточно. В связи с этим экспертами Управления экспертизы безопасности лекарственных средств ФГБУ «НЦЭСМП» Минздрава России был проведен анализ нежелательных реакций при применении ремдесивира и тоцилизумаба по информации глобальной базы данных нежелательных реакций VigiBase (по состоянию на 27 августа 2020 г.).

  • Other research product . 2020
    Open Access Portuguese
    Authors: 
    Silva, João Paulo Miranda da;
    Country: Portugal

    This Report is the result of the Internship carried out within the scope of Sports Training in Football aiming to obtain a master’s degree in Sports Sciences, at the University of Beira Interior. The deepening and development of knowledge, within the scope of the Football training methodology, and its practical application in the context of an Internship, was carried out with the Under-16 Football team of Gil Vicente Futebol Clube (GVFC), a football Club in the city of Barcelos. We started this Report with the presentation of the Club where the Internship took place, it’s history and the human and material resources available to the GVFC under-16 level. Then we present and reflect on the implementation of the ideas transmitted by the Superiors for the training teams, especially for the under-16 level, from the intervention strategies during the Internship, the diagnosis, control, work performed, and function played in the Club and team. The Report also contemplates an investigation work, the objective of which was the training and evaluation of the evolution of the precision of the launch with the hand of the ball by the Goalkeepers of the under-16 level and in which the two Goalkeepers of the level have participated. Due to the cancellation of training and games because of the declared state of emergency (pandemic covid-19), it was not possible to complete the work in the manner prescribed, so the conclusions regarding the evolution of Goalkeepers in this capacity through the proposed situations were left committed, this work should be continued in the near future. O presente Relatório resulta do Estágio realizado no âmbito do Treino Desportivo em Futebol visando a obtenção do Grau de Mestre em Ciências do Desporto, na Universidade da Beira Interior. O aprofundamento e desenvolvimento do conhecimento, no âmbito da metodologia de treino em Futebol, e sua aplicação prática em contexto de Estágio, foi realizado com a equipa de Futebol Sub-16 do Gil Vicente Futebol Clube (GVFC), Clube da cidade de Barcelos. Iniciamos este Relatório pela apresentação do Clube onde decorreu o Estágio, a sua história e recursos humanos e materiais disponíveis para o escalão de sub-16 do GVFC. Seguidamente apresentamos e refletimos sobre a implementação das ideias transmitidas pela Coordenação para as equipas da Formação, em especial para o escalão de sub-16, desde as estratégias intervenção no decorrer do Estágio, o diagnóstico, controlo, trabalhos realizados, e função desempenhada no Clube e equipa. O Relatório contempla ainda um trabalho de investigação, cujo objetivo foi o treino e a avaliação da evolução da precisão do lançamento com a mão da bola pelos Guarda-Redes do escalão de sub-16 e no qual, participarão os dois Guarda-Redes do escalão. Devido ao cancelamento dos treinos e jogos por conta do estado de emergência declarado (pandemia covid-19), não foi possível a conclusão do trabalho nos moldes previstos, pelo que as conclusões relativas à evolução dos Guarda-Redes nesta capacidade através das situações propostas ficaram comprometidas devendo este trabalho ser continuado num futuro próximo.

  • Open Access Portuguese
    Authors: 
    Conde, Olga Lucía Mosquera;
    Country: Brazil

    Trabalho de Conclusão de Residência apresentado ao Programa de Pós-graduação em Saúde da Família (Residência Multiprofissional), do Instituto Latino-americano de Ciências da Vida e da Natureza da Universidade Federal da Integração Latino Americana, como requisito parcial para obtenção do título de Especialista em Saúde da Família. Trata-se de um estudo ecológico, realizado no município de Foz do Iguaçu-PR, com o objetivo de analisar os efeitos da implantação das medidas restritivas no enfrentamento da COVID-19. Foram analisados decretos publicados no ano de 2020 e no primeiro quadrimestre de 2021. Após análise primária dos decretos, foram criadas nove categorias de medidas restritivas. Posteriormente, foram elaboradas e analisadas as seguintes variáveis: número de casos novos; número de óbitos; taxa de mortalidade; taxa de incidência e letalidade. Os resultados permitiram compreender a implantação das medidas restritivas no município de Foz do IguaçuPR, como ferramenta de redução dos casos, hospitalizações, e, consequentemente, dos óbitos. Foi possível observar a implementação de medidas restritivas em tempo oportuno e o impacto das flexibilizações no aumento dos casos, principalmente nas primeiras semanas epidemiológicas de 2021, em que se observou o maior pico de casos. Ministério da Educação

  • Open Access English
    Authors: 
    Al-Luhaibi Zaid Isam Issa;
    Country: Hungary

    Autophagy is an intracellular catabolic process that controls infections both directly and indirectly via its multifaceted effects on the innate and adaptive immune responses. It has been reported that LPS stimulates this cellular process, whereas the effect of IL-36α on autophagy remains largely unknown. We, therefore, investigated how IL-36α modulates the endogenous and LPS-induced autophagy in THP-1 cells. The levels of LC3B-II and autophagic flux were determined by western blotting. The intracellular localization of LC3B was measured by immunofluorescence assay. The activation levels of signaling pathways implicated in autophagy regulation were evaluated by using a phosphokinase array. Our results showed that combined IL-36α and LPS treatment cooperatively increased the levels of LC3B-II and Beclin-1, stimulated the autophagic flux, facilitated intracellular redistribution of LC3B, and increased the average number of autophagosomes per cell. The IL36α/LPS combined treatment increased phosphorylation of STAT5a/b, had minimal effect on the Akt/PRAS40/mTOR pathway, and reduced the levels of phospho-Yes, phospho-FAK, and phospho-WNK1. Thus, this cytokine/PAMP combination triggers pro-autophagic biased signaling by several mechanisms and thus cooperatively stimulates the autophagic cascade. An increased autophagic activity of innate immune cells simultaneously exposed to IL-36α and LPS may play an important role in the pathogenesis of Gram-negative bacterial infections. SARS-CoV-2 can infect and replicate in esophageal cells and enterocytes, leading to direct damage to the intestinal epithelium. The infection decreases the level of angiotensin converting enzyme 2 receptors, thereby altering the composition of the gut microbiota. SARS-CoV-2 elicits a cytokine storm, which contributes to gastrointestinal inflammation. The direct cytopathic effects of SARS-CoV-2, gut dysbiosis, and aberrant immune response result in increased intestinal permeability, which may exacerbate existing symptoms and worsen the prognosis. By exploring the elements of pathogenesis, several therapeutic options have emerged for the treatment of COVID-19 patients, such as biologics and biotherapeutic agents. However, the presence of SARS-CoV-2 in the feces may facilitate the spread of COVID-19 through fecal-oral transmission and contaminate the environment. Thus, gastrointestinal SARS-CoV-2 infection has important epidemiological significance. The development of new therapeutic and preventive options is necessary to treat and restrict the spread of this severe and widespread infection more effectively.

  • Other research product . Other ORP type . 2022
    Open Access Lithuanian
    Authors: 
    Barštytė, Rūta;
    Country: Lithuania

    Prekės ženklų komunikacija atlieką svarbų vaidmenį ypatingai šiandieninėje aplinkoje. Įvykiai tokie kaip Covid-19 pandemija bei Rusijos invazija į Ukrainą paveikė tiek vartotojus tiek jų įpročius. Prekės ženklų komunikacija taip pat turėjo reaguoti į įvykius aplinkoje. Ypatingą svarbą prekės ženklų komunikacija įgauna neapibrėžtumo laikotarpiu. Prekės ženklų komunikacijos pagalba gali būti tiek užmezgamas ryšys su vartotoju, tiek palaikomas jau esamas. Prekės ženklų komunikacija neapibrėžtumo laikotarpiu gali veikti vartotojus raminančiai, suteikti jiems aktualią informaciją bei parodyti palaikymą ir empatiją. Siekiant išnagrinėti prekės ženklų komunikaciją neapibrėžtumo laikotarpiu išsikelta tyrimo problema - koks prekių ženklų komunikacijos turinys dominavo Covid-19 pandemijos ir Rusijos agresijos Ukrainoje laikotarpiu? Išsikeltas tyrimo tikslas - ištirti prekės ženklų komunikaciją neapibrėžtumo laikotarpiu. Išsikeltam tyrimo tikslui pasiekti naudoti tyrimo metodai antrinių duomenų analizė bei pusiau struktūruotas ekspertų interviu. Antrinių duomenų analizė atskleidė atliktų tyrimų susijusių su neapibrėžtumo laikotarpiu rezultatus bei Lietuvos marketingo ir komunikacijos ekspertų pastebėjimus, nuomones pozicijas apie prekės ženklų komunikaciją neapibrėžtumo laikotarpiu. Pusiau struktūruotas ekspertų interviu leido pagrįsti informaciją gautą antrinių duomenų analizės metu. Tyrimai atskleidė, kad prekės ženklai neapibrėžtumo laikotarpiu neturėtų stabdyti savo komunikacijos. Prekės ženklų komunikacijoje neapibrėžtumo laikotarpiu vartotojams turėtų būti pateikiama aktuali informacija aiškiai ir visiems suprantamai. Prekės ženklų komunikacijoje neapibrėžtumo laikotarpiu turėtų būti skiriamas dėmesys naudojamiems žodžiams, ne visi žodžiai gali būti tinkami kontekste. Tyrimai atskleidė, kad vartotojų naudojimasis socialiniais kanalais išaugo, prekės ženklų komunikacija neapibrėžtumo laikotarpiu turėtų atkreipti dėmesį į tai norint pasiekti vartotoją. Šis darbas yra projektinis magistro baigiamasis darbas. Brand communication plays an important role especially in today’s environment. Events such as the Covid-19 pandemic and the Russian invasion of Ukraine have affected both consumers and their habits. Brand communication also has to respond to events in the environment. Brand communication is gaining in importance during the times of uncertainty. Brand communication can be used to connect with the user and also maintain an existing relationship. Brand communication can reassure consumers, provide them with relevant information, demonstrate support and empathy in times of uncertainty, In order to research brand communication in times of uncertainty, the research problem was raised - what content of brand communication dominated during the Covid-19 pandemic and the Russian aggression in Ukraine? Research aim is to investigate brand communication in times of uncertainty. The research methods used to achieve the research aim is secondary data analysis and semi-structured expert interview. Secondary data analysis revealed the results of the performed studies related to the time of uncertainty observations and opinions of Lithuanian marketing and communication experts on brand communication during the period of uncertainty. Semi-structured expert interviews allowed to substantiate the information obtained during secondary data analysis. Research has shown that brands should not stop their communication during a period of uncertainty. The consumer should be provided with relevant information clearly and comprehensibly during brand communication in times of uncertainty. In times of uncertainty, brand communication should focus on the words used, not all words may be appropriate in the context. Research has revealed that consumer use of social channels increased, and brand communication in times of uncertainty should pay attention to this to reach the consumer. This paper is projected solutions oriented final master thesis.

  • Open Access Finnish
    Authors: 
    Anttila, Teija;
    Country: Finland

    Maailmanlaajuisen COVID-19-pandemian jälkeen työympäristöstandardeja määritellään kriittisesti uudelleen kaikilla aloilla. Kriisi on pakottanut yritykset pohtimaan työtapojaan ja turvautumaan teknologiaan uusien vuorovaikutustapojen toteuttamiseksi. Tämän digitaalisen harppauksen tunnusmerkkinä oleva siirtyminen etätyökäytäntöihin kyseenalaistaa toimitilojen tarkoituksen. Keskellä tätä muutosta työympäristösuunnittelu on nyt uusien haasteiden edessä luodakseen toimivia ja mielekkäitä toimistotiloja, jotka vastaavat tämän päivän ja huomisen tarpeisiin. Opinnäytetyö on tehty osana PES-Arkkitehdit Oy:n toimeksiantoa palvelumuotoilun kehittämiseksi yrityksessä (2022). Tavoitteena on kohdentaa tilaajaorganisaation toimintaa asiakaslähtöisemmäksi, kehittää palvelumuotoilua ja luoda siihen liittyvä prosessi työympäristön suunnitteluun. Oleellinen nosto työstä on työympäristön fasilitoijan työnkuvan tunnistaminen ja määrittäminen. Opinnäytetyö vastaa tutkimuksensa kautta (ja myöhemmin testaamalla ja jatkuvalla kehittämisellä) seuraavaan tutkimuskysymykseen: Millainen palveluprosessi tuottaa onnistuneita työympäristön yhteiskehitysprojekteja? Tässä työssä kehittämismenetelmänä on palvelumuotoilun viitekehys. Palvelumuotoilun avulla voidaan hyödyntää käyttäjäkeskeistä lähestymistä, prosessia, testaamista ja työkaluja - sitoen ne kehitettävään työympäristön kehitysprosessiin. Viitekehyksen sisälle asettuvat palvelumuotoilu, työympäristöhankkeen projektinhallinta, yhteiskehittämisen menetelmät, sidosryhmät ja oma katsontakulma sekä työn toimeksianto. Tutkimusosaan kuuluu erilaisten kehitysprosessien tutkiminen, analysointi ja vertailu. Tutkimusosassa tavoitteena on yhdistää tutkimuskehitystyö ja palvelumuotoilu sekä lisätä ymmärrystä palvelumuotoilusta. Kyselytutkimuksissa (yhteistyössä YAMK-opiskelija Raisa Hämäläisen kanssa) kerättiin mielipiteitä osallistavasta suunnittelusta työympäristösuunnittelun ammattilaisten ja siihen osallistuvien loppukäyttäjien keskuudessa. Arkkitehdin haastattelu antoi yrityksen sisäisen näkökulman osallistavan suunnittelun prosessien integroinnista strategisiin tavoitteisiin ja projektien johtamiseen. Kyselyissä ja haastattelussa selvitettiin työympäristön kehittämisen haasteita ja yhteisymmärryksen tärkeyttä yhteisissä kehittämishankkeissa. Lopputuloksena syntyy kymmenvaiheinen palveluprosessi toimeksiantajalle. Tämän palveluprosessin tavoitteena on vastata realistisesti arkkitehtitoimiston arvoja, huomioida eri sidosryhmät ja olla räätälöitävissä. Työssä selvitetään myös palvelumuotoilun tuomaa arvoa asiakkaille ja yritykselle. Opinnäytetyön tavoitteena on toimia runkona uniikkien asiakasprojektien osallistamisprosessien laadinnalle ja rakentaa ymmärryksen siltaa projektin osallisten välillä kohti palvelumuotoilun laajempaa hyödyntämistä.

  • English
    Authors: 
    Kohnert, Dirk;
    Country: Germany

    ABSTRACT & RÉSUMÉ & ZUSAMMENFASSUNG : Dark clouds over the EU-Africa Summit 2021 in view of Brexit and Corona ---- Every three years, the AU-EU summit reunites African and EU leaders to outline the future direction of cooperation. The 6th summit had been to reaffirm and renew the partnership between the two blocks already in October 2020, but it was pushed back to the first quarter of 2021 or even later due to COVID-19 crisis. Besides, Brussels had to deal with its own post-Brexit situation and its repercussions on EU-Africa relations, excluding the UK. African states, for their part, wanted to renegotiate the EU-Africa partnership and to balance it with new promising Post-Brexit visions of the British premier Johnson about increased economic ties with the African Angloshere. China and other global players compete with the EU and its member states in the new scramble for African resources. Given that Africa is increasingly courted by other partners it could be inclined to successively limit its relations with the EU and see it as a mere provider of aid and security against Islamic terrorism. This trend was reinforced by the fact that the new EU-Africa strategy still hasn't been approved by EU member states. And a timely replacement of the Cotonou Agreement, which expires in November 2021, is open to question. ___________________________________________________________________________ RÉSUMÉ : Tous les trois ans, le sommet UA-UE réunit les dirigeants africains et européens pour définir l'orientation future de la coopération. Le 6e sommet devait réaffirmer et renouveler le partenariat entre les deux blocs déjà en octobre 2020, mais il a été repoussé au premier trimestre 2021, ou même plus tard, en raison de la crise du COVID-19. En outre, Bruxelles a dû faire face à sa propre situation post-Brexit, compte tenu l'exclusion du Royaume-Uni, et à ses répercussions sur les relations UE-Afrique. Les États africains, pour leur part, souhaitaient renégocier le partenariat UE-Afrique, et l'équilibrer avec les nouvelles visions post-Brexit prometteuses du Premier ministre britannique Johnson sur le renforcement des liens économiques avec l'Anglosphère africaine. La Chine et d'autres acteurs mondiaux sont en concurrence avec l'UE et ses États membre dans la nouvelle ruée vers les ressources africaines. Étant donné que l'Afrique est de plus en plus courtisée par d'autres partenaires, elle pourrait être encline à limiter successivement ses relations avec l'UE et à la considérer comme un simple fournisseur d'aide et de sécurité contre le terrorisme islamique. Cette tendance a été renforcée par le fait que la nouvelle stratégie UE-Afrique n'a toujours pas été approuvée par les États membres de l'UE. Et un remplacement opportun de l'accord de Cotonou, qui expire en novembre 2021, est sujet à caution. _____________________________________________________________________ ZUSAMMENFASSUNG : Alle drei Jahre bringt der AU-EU Gipfel afrikanische und EU-Staats- und Regierungschefs zusammen, um die künftige Richtung der Zusammenarbeit zu skizzieren. Der 6. Gipfel hatte sich zum Ziel gesetzt, die Partnerschaft zwischen den beiden Blöcken bereits im Oktober 2020 zu bekräftigen und zu erneuern, er wurde jedoch aufgrund der COVID-19-Krise auf das erste Quartal 2021 verschoben. Davon unabhängig mußte sich Brüssel erst einmal über seine eigene Situation nach dem Brexit und dessen Auswirkungen auf die Beziehungen zwischen der EU und Afrika klar werden. Die afrikanischen Staaten ihrerseits wollen die Partnerschaft zwischen der EU und Afrika neu verhandeln und sie mit den vielversprechenden Visionen des britischen Premierministers Boris Johnson über verstärkte wirtschaftliche Beziehungen zur afrikanischen Anglosphäre in Einklang bringen. Zudem konkurrieren China und andere Global Player mit der EU und ihren Mitgliedstaaten im Kampf um afrikanische Ressourcen. Angesichts der Tatsache, daß Afrika zunehmend von anderen Partnern umworben wird, könnten seine Führer dazu neigen, ihre Beziehungen zur EU sukzessive einzuschränken und die EU auf ihre Funktion als Anbieter von Hilfe und Sicherheit gegen den islamischen Terrorismus zu begrenzen. Dieser Trend wird noch dadurch verstärkt, daß eine gemeinsame EU-Afrika-Strategie von den EU-Mitgliedstaaten noch nicht einmal verabschiedet wurde. Selbst der rechtzeitige Ersatz des Cotonou-Abkommens, das im November 2021 ausläuft, ist fraglich.