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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
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29 research outcomes, page 1 of 3
  • other research product . 2021
    Open Access
    Authors:
    Wang, Zijun; Muecksch, Frauke; Schaefer-Babajew, Dennis; Finkin, Shlomo; Viant, Charlotte; Gaebler, Christian; Barnes, Christopher O.; Cipolla, Melissa; Ramos, Victor; Oliveira, Thiago Y.; ...

    Over one year after its inception, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several excellent vaccines. Progress in controlling the pa...

  • other research product . 2021
    Open Access
    Authors:
    Greenwald, Hannah D.; Kennedy, Lauren C.; Hinkle, Adrian; Whitney, Oscar N.; Fan, Vinson B.; Crits-Christoph, Alexander; Harris-Lovett, Sasha; Flamholz, Avi I.; Al-Shayeb, Basem; Liao, Lauren D.; ...

    Wastewater surveillance for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA can be integrated with COVID-19 case data to inform timely pandemic response. However, more research is needed to apply and develop systematic methods to interpret the true SARS...

  • other research product . 2021
    Open Access
    Authors:
    Jette, Claudia A.; Cohen, Alexander A.; Gnanapragasam, Priyanthi N. P.; Muecksch, Frauke; Lee, Yu E.; Huey-Tubman, Kathryn E.; Schmidt, Fabian; Hatziioannou, Theodora; Bieniasz, Paul D.; Nussenzweig, Michel C.; ...

    Many anti-SARS-CoV-2 neutralizing antibodies target the ACE2-binding site on viral spike receptor-binding domains (RBDs). The most potent antibodies recognize exposed variable epitopes, often rendering them ineffective against other sarbecoviruses and SARS-CoV-2 variant...

  • other research product . 2021
    Open Access
    Authors:
    Sarma, Anish A.; Sarma, Aartik; Csete, Marie; Lee, Peter P.; Doyle, John C.;

    Dramatic variation in SARS-CoV-2 virulence and transmission between hosts has driven the COVID-19 pandemic. The complexity and dynamics of the immune response present a challenge to understanding variation in SARS-CoV-2 infections. To address this challenge, we apply co...

  • other research product . 2021
    Open Access
    Authors:
    Toubat, Omar; Berg, Anders H.; Sobhani, Kimia; Mulligan, Karen; Hori, Acacia M.; Bhattacharya, Jay; Sood, Neeraj;

    While SARS-CoV-2 serologic testing is used to measure cumulative incidence of COVID-19, appropriate signal-to-cut off (S/Co) thresholds remain unclear. We demonstrate S/Co thresholds based on known negative samples significantly increases seropositivity and more accurat...

  • other research product . 2021
    Open Access
    Authors:
    Savela, Emily S.; Winnett, Alexander; Romano, Anna E.; Porter, Michael K.; Shelby, Natasha; Akana, Reid; Ji, Jenny; Cooper, Matthew M.; Schlenker, Noah W.; Reyes, Jessica A.; ...

    Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and pre-symptomatic spread of COVID-19, curb the spread of viral variants by travelers, and maximize efficacy of therapeutic treatments. We designed a study to evaluate the preferred test sensiti...

  • other research product . 2021
    Open Access
    Authors:
    Ullah, Irfan; Prevost, Jeremie; Ladinsky, Mark S.; Stone, Helen; Lu, Maolin; Anand, Sai Priya; Beaudoin-Bussieres, Guillaume; Benlarbi, Mehdi; Ding, Shilei; Gasser, Romain; ...

    Neutralizing antibodies (NAbs) are effective in treating COVID-19 but the mechanism of immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) to monitor the real-time effects of NAb treatment in prophylaxis and therapy of K18-hACE...

  • other research product . 2021
    Open Access
    Authors:
    Greaney, Allison J.; Starr, Tyler N.; Barnes, Christopher O.; Weisblum, Yiska; Schmidt, Fabian; Caskey, Marina; Gaebler, Christian; Cho, Alice; Agudelo, Marianna; Finkin, Shlomo; ...

    Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions of these different antibody classes to the polyclonal response remains unclear. Here we use a yeast-display syst...

  • other research product . 2021
    Open Access
    Authors:
    Muecksch, Frauke; Weisblum, Yiska; Barnes, Christopher O.; Schmidt, Fabian; Schaefer-Babajew, Dennis; Lorenzi, Julio C. C.; Flyak, Andrew I.; DeLaitsch, Andrew T.; Huey-Tubman, Kathryn E.; Hou, Shurong; ...

    Antibodies elicited in response to infection undergo somatic mutation in germinal centers that can result in higher affinity for the cognate antigen. To determine the effects of somatic mutation on the properties of SARS-CoV-2 spike receptor-binding domain (RBD)-specifi...

  • other research product . 2021
    Open Access
    Authors:
    West, Anthony P., Jr.; Wertheim, Joel O.; Wang, Jade C.; Vasylyeva, Tetyana I.; Havens, Jennifer L.; Chowdhury, Moinuddin A.; Gonzalez, Edimarlyn; Fang, Courtney E.; Di Lonardo, Steve S.; Hughes, Scott; ...

    Wide-scale SARS-CoV-2 genome sequencing is critical to tracking viral evolution during the ongoing pandemic. Variants first detected in the United Kingdom, South Africa, and Brazil have spread to multiple countries. We developed the software tool, Variant Database (VDB)...

29 research outcomes, page 1 of 3