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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
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28 research outcomes, page 1 of 3
  • other research product . 2022
    Open Access English
    Authors:
    Cohen, Alexander A.; van Doremalen, Neeltje; Greaney, Allison J.; Andersen, Hanne; Sharma, Ankur; Starr, Tyler N.; Keeffe, Jennifer R.; Fan, Chengcheng; Schulz, Jonathan E.; Gnanapragasam, Priyanthi N. P.; ...
    Country: United States

    To combat future SARS-CoV-2 variants and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health, we designed mosaic nanoparticles presenting randomly-arranged sarbecovirus spike receptor-binding domains (RBDs) to elicit antibodies against c...

  • other research product . 2022
    Open Access English
    Authors:
    Winnett, Alexander Viloria; Porter, Michael K.; Romano, Anna E.; Savela, Emily S.; Akana, Reid; Shelby, Natasha; Reyes, Jessica A.; Schlenker, Noah W.; Cooper, Matthew M.; Carter, Alyssa M.; ...
    Country: United States

    Background. The analytical sensitivities of SARS-CoV-2 diagnostic tests span 6 orders of magnitude. Optimizing sample-collection methods to achieve the most reliable detection for a given sensitivity would increase the effectiveness of testing and minimize COVID-19 outb...

  • other research product . 2022
    Open Access English
    Authors:
    Nguyen, Minhphuong; Paul, Eric; Mills, Paul K.; Paul, Simon;
    Country: United States

    The probability of either testing COVID-19 positive or dying for three cohorts in Madera County, California in 2021 was compared. These cohorts included 1. those unvaccinated, 2. those vaccinated and 3. persons with a previous COVID-19 infection. The three groups were m...

  • other research product . 2021
    Open Access English
    Authors:
    Dommer, Abigail; Casalino, Lorenzo; Kearns, Fiona; Rosenfeld, Mia; Wauer, Nicholas; Ahn, Surl-Hee; Russo, John; Oliveira, Sofia; Morris, Clare; Bogetti, Anthony; ...
    Country: United States

    We seek to completely revise current models of airborne transmission of respiratory viruses by providing never-before-seen atomic-level views of the SARS-CoV-2 virus within a respiratory aerosol. Our work dramatically extends the capabilities of multiscale computational...

  • other research product . 2021
    Open Access English
    Authors:
    Cramer, Estee Y.; Huang, Yuxin; Wang, Yijin; Ray, Evan L.; Cornell, Matthew; Bracher, Johannes; Brennen, Andrea; Castro Rivadeneira, Alvaro J.; Gerding, Aaron; House, Katie; ...
    Country: United States

    Academic researchers, government agencies, industry groups, and individuals have produced forecasts at an unprecedented scale during the COVID-19 pandemic. To leverage these forecasts, the United States Centers for Disease Control and Prevention (CDC) partnered with an ...

  • other research product . 2021
    Open Access English
    Authors:
    Trifan, Anda; Gorgun, Defne; Li, Zongyi; Brace, Alexander; Zvyagin, Maxim; Ma, Heng; Clyde, Austin; Clark, David; Salim, Michael; Hardy, David J.; ...
    Country: United States

    The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) replication transcription complex (RTC) is a multi-domain protein responsible for replicating and transcribing the viral mRNA inside a human cell. Attacking RTC function with pharmaceutical compounds is a ...

  • other research product . 2021
    Open Access English
    Authors:
    Schneider, Tapio; Dunbar, Oliver R. A.; Wu, Jinlong; Burov, Dmitry; Daraio, Chiara; Böttcher, Lucas; Garbuno-Iñigo, Alfredo; Wagner, Gregory L.; Ferrari, Raffaele; Pei, Sen; ...
    Country: United States

    Testing, contact tracing, and isolation (TTI) is an epidemic management and control approach that is difficult to implement at scale. Here we demonstrate a scalable improvement to TTI that uses data assimilation (DA) on a contact network to learn about individual risks ...

  • other research product . 2021
    Open Access English
    Authors:
    Sarma, Anish A.; Sarma, Aartik; Csete, Marie; Lee, Peter P.; Doyle, John C.;
    Country: United States

    Dramatic variation in SARS-CoV-2 virulence and transmission between hosts has driven the COVID-19 pandemic. The complexity and dynamics of the immune response present a challenge to understanding variation in SARS-CoV-2 infections. To address this challenge, we apply co...

  • other research product . 2021
    Open Access English
    Authors:
    Toubat, Omar; Berg, Anders H.; Sobhani, Kimia; Mulligan, Karen; Hori, Acacia M.; Bhattacharya, Jay; Sood, Neeraj;
    Country: United States

    While SARS-CoV-2 serologic testing is used to measure cumulative incidence of COVID-19, appropriate signal-to-cut off (S/Co) thresholds remain unclear. We demonstrate S/Co thresholds based on known negative samples significantly increases seropositivity and more accurat...

  • other research product . 2021
    Open Access English
    Authors:
    Muecksch, Frauke; Weisblum, Yiska; Barnes, Christopher O.; Schmidt, Fabian; Schaefer-Babajew, Dennis; Lorenzi, Julio C. C.; Flyak, Andrew I.; DeLaitsch, Andrew T.; Huey-Tubman, Kathryn E.; Hou, Shurong; ...
    Country: United States

    Antibodies elicited in response to infection undergo somatic mutation in germinal centers that can result in higher affinity for the cognate antigen. To determine the effects of somatic mutation on the properties of SARS-CoV-2 spike receptor-binding domain (RBD)-specifi...

28 research outcomes, page 1 of 3