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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
31 Research products, page 1 of 4

  • COVID-19
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  • Open Access English
    Authors: 
    Reiter, R.; Sharma, Ramaswamy; Castillo, Rafael; Marik, Paul E.; Domínguez Rodriguez, Alberto; Cardinali, Daniel Pedro; Tesarik, Jan;
    Country: Argentina

    Abstract: Two highly relevant studies related to SARS-CoV-2 and coronavirus disease (COVID-19) and supporting the use of melatonin to prevent and treat this serious infection were published recently. Campos-Codo and colleagues [1] documented experimentally their claim that drugs which specifically target hypoxia inducible factor-1α (HIF-1α) would likely have great therapeutic value in treating COVID-19. The second report is a retrospective analysis based on the clinical experience at the Columbia University Irving Medical Center with the use of drugs to treat respiratory distress in COVID-19-infected patients who required endotracheal intubation [2]. Hyperinflammatory monocytes/macrophages accumulate in abundance in the lower respiratory tract where they play a key role in determining the severity of SARS-CoV-2 infections. Campos-Codo, et al. [1] found that monocytes/macrophages infected with the SARSCoV-2 virus reprogram their metabolism from the conventional mitochondrial oxidative phosphorylation (OXPHOS) to the (usually) pathological cytosolic glycolysis. This so-called Warburg-type metabolism is aided by the inadequately controlled elevated blood glucose levels of diabetic patients, which enhances cellular glycolysis, viral replication and hastens development of a severe respiratory infection resulting from the elevated cytokine release (“cytokine storm”).

  • Open Access English
    Authors: 
    Cardinali, Daniel Pedro; Brown, Gregory M.; Reiter, R.; Pandi Perumal, Seithikurippu R.;
    Country: Argentina

    Abstract: The association of age with a higher vulnerability to COVID-19 infection is a subject of major importance. Several factors, including higher stress due to social isolation, diminished melatonin levels with age, and higher exposure of individuals to light at the evening, which reduces melatonin levels and disrupts circadian rhythmicity are relevant for maintaining the circadian health in aged individuals. Properly administered, chronotherapy restores the optimal circadian pattern of the sleep–wake cycle in the elderly. It involves adequate sleep hygiene, timed light exposure, and the use of a chronobiotic medication like melatonin, which affects the output phase of circadian rhythms thus controlling the biological clock. Besides, the therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections has been advocated due to its wide-ranging effects as an antioxidant, anti-inflammatory, and as an immunomodulatory agent, as well as to a possible antiviral action. This article discusses how chronotherapy may reverse the detrimental circadian condition of the elderly in the COVID-19 pandemic.

  • Other research product . Other ORP type . 2020
    Open Access English
    Authors: 
    Otero Losada, Matilde; Kobiec, Tamara; Udovin, Lucas Daniel; Chevalier, Guenson; Quarracino, Cecilia; Menéndez Maissonave, Camila Belén; Bordet, Sofía; Capani, Francisco; Pérez Lloret, Santiago;
    Country: Argentina

    Abstract: Humankind has gone through major airborne virus pandemics in the modern era. Coronavirus outbreaks have been registered in 2003 [severe acute respiratory syndrome (SARS)], 2009 [Middle East respiratory syndrome (MERS)], and 2019/2020 ongoing [CoV disease (COVID-19)]. Influenza outbreaks were documented in 1918 (post-World War I Spanish flu, H1N1 virus), 1957–1958 (Asian flu, H2N2 virus), 1968 (the Hong Kong flu, H3N2 virus), and 2009 (the swine flu, H1N1 virus).

  • Open Access English
    Authors: 
    Rosati, Germán; Domenech, Laia; Chazarreta, Adriana Silvina; Maguire, Tomás;
    Country: Argentina

    We present a first approximation to the quantification of social representations about the COVID-19, using news comments. A web crawler was developed to construct the dataset of reader’s comments. We detect relevant topics in the dataset using Latent Dirichlet Allocation, and analyze its evolution during time. Finally, we show a first prototype to the prediction of the majority topics, using FastText. Sociedad Argentina de Informática

  • Open Access English
    Authors: 
    Paez Maggio, M.; Rossi, M.; Fazzito, L.; Merello, M.;
    Country: Argentina

    Abstract: Most of the validated ‘events exposure’ questionnaires are focused on lifetime burden and are hardly applicable to Argentina owing to its sociocultural and natural conditions, where corruption and economic crises have been hitting middle-class people’s lives in a cyclic manner. This prompted us to develop a new questionnaire, validated in Argentina, to assess the occurrence of exposure to events and their severity over a limited period. Deductive (bibliographic search) and inductive (by a Delphi group) selection was used to create an initial group of 24 questions, which were condensed into a final 14-item questionnaire. After administration to 512 inhabitants of the metropolitan area of Buenos Aires and other major cities in Argentina, the questionnaire was shown to have an intraclass correlation coefficient of 0.996 and an internal consistency, measured by the omega coefficient, of 0.86. Because this study was conducted during the coronavirus disease 2019 (COVID-19) pandemic, an additional question on how this situation affected individuals was included. The time span used to measure event exposure was 1 year prior to the study. In the case of an affirmative event exposure, the responder selected the severity of the stress perception generated on a Likert-like scale, ranging from 0 (nothing) to 5 (severe). Fifty-eight per cent of the responders were women, and the mean age was 47.14 years (SD: 13.97). The average annual event incidence per person was 2.5 events (SD: 1.88). Thirty-two per cent (164/512) reported at least one 5-point event on the severity scale. Ten per cent (51/512) responded that the COVID-19 pandemic affected them in a different manner than events related to personal or family disease, or the death of a close family member or friend.

  • Open Access English
    Authors: 
    Perdomo, Luciano; Ordinez, Leonardo;
    Country: Argentina

    In Argentina there was a great growth of e-commerce due to the COVID-19 pandemic. With the aim of helping local companies to understand the market and help them in decision making, data were obtained from online shoe sales sites and with them Machine Learning models were implemented to make price predictions in sneakers. It was concluded that higher-tier companies have greater competitive advantage over lower-tier companies. Nonetheless, the cost-effective methodology used would aid local companies scale up. Workshop: WBDMD - Base de Datos y Minería de Datos Red de Universidades con Carreras en Informática

  • Open Access English
    Authors: 
    Menéndez, Sebastián García; Martín Giménez, Virna Margarita; Holick, Michael F.; Barrantes, Francisco José; Manucha, Walter;
    Country: Argentina

    Abstract: SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, belongs to a broad family of coronaviruses that also affect humans. SARS-CoV-2 infection usually leads to bilateral atypical pneumonia with significant impairment of respiratory function. However, the infectious capacity of SARS-CoV-2 is not limited to the respiratory system, but may also affect other vital organs such as the brain. The central nervous system is vulnerable to cell damage via direct invasion or indirect virus-related effects leading to a neuroinflammatory response, processes possibly associated with a decrease in the activity of angiotensin II converting enzyme (ACE2), the canonical cell-surface receptor for SARS-CoV-2. This enzyme regulates neuroprotective and neuroimmunomodulatory functions and can neutralize both inflammation and oxidative stress generated at the cellular level. Furthermore, there is evidence of an association between vitamin D deficiency and predisposition to the development of severe forms of COVID-19, with its possible neurological and neuropsychiatric sequelae: vitamin D has the ability to down-modulate the effects of neuroinflammatory cytokines, among other anti-inflammatory/immunomodulatory effects, thus attenuating harmful consequences of COVID-19. This review critically analyzes current evidence supporting the notion that vitamin D may act as a neuroprotective and neuroreparative agent against the neurological sequelae of COVID-19.

  • Open Access English
    Authors: 
    Alvarado, Yoselie; Rodríguez, Graciela; Jofré, Nicolás; Fernández, Jacqueline; Guerrero, Roberto A.;
    Country: Argentina

    Some time ago Virtual Reality and Augmented Reality were exclusively devoted to the gaming industry. Nowadays, both technologies are experiencing a deep interest from various spheres, including healthcare sector. The new infectious disease COVID-19 has had a catastrophic effect on the world’s demographics. Many patients with mild or severe COVID- 19 do not recover completely and present with a wide variety of chronic symptoms after infection, often of a neurological, cognitive or psychiatric nature. The most common signs of cognitive disorder can be summarized as mental fog, memory problems and concentration problems. The aim of this study was to analyze the opportunities for Virtual and Augmented Reality in the cognitive interventions related to mentioned disorders by searching for articles in scientific databases. We conclude that as these technologies and devices become cheaper and accessible worldwide, can at least be regarded as a rehabilitation therapy as effective as traditional training, and to some extent better than it. Workshop: WCGIV - Computación Gráfica, Imágenes y Visualización Red de Universidades con Carreras en Informática

  • Open Access English
    Authors: 
    Brusco, Luis I.; Cruz, Pablo; Cangas, Alicia V.; González Rojas, Carmen; Vigo, Daniel Eduardo; Cardinali, Daniel Pedro;
    Country: Argentina

    Abstract: The association of sleep disruption with a higher vulnerability to COVID-19 infection is a subject of major clinical importance. In patients with pneumonia associated with COVID-19 admitted to non-intensive care unit (NICU) several factors, like the disrupting influence of respiratory distress, medication, greater stress due to social isolation, and lack of appropriate exposure to environmental light can be instrumental to disrupt sleep/wake cycle. The therapeutic potential of melatonin to counteract the consequences of COVID-19 infection has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. Properly administered, melatonin may restore the optimal circadian pattern of the sleep-wake cycle and improve clinical condition in pneumonia associated with COVID-19 patients. The present review article discusses the importance of maintaining normal sleep and circadian rhythmicity in NICU patients and provides preliminary data suggesting the efficacy of melatonin (9 mg/day) to reduce length of stay of pneumonia patients associated with COVID-19 in NICU.

  • Open Access English
    Authors: 
    Barrantes, Francisco José;
    Country: Argentina

    Abstract: At the time of reception of this article (April 2, 2020), efforts to develop a specific vaccine against SARS-Cov-2, the causative agent of the coronavirus disease 2019 (COVID-19), had just begun trial phase 1, but full validation of this and other current developments is likely to take many more months to reach completion. The ongoing pandemic constitutes a major health burden of world proportions that is also having a devastating impact on whole economies worldwide, the knock-on effects of which could be catastrophic especially in poorer countries. Alternative measures to ameliorate the impact and hamper or minimally slow down disease progression are urgently called for. This review discusses past and currently evolving data on the etiological agent of the current pandemic, SARS-CoV-2, and its host cell receptors with a view to disclosing alternative drugs for palliative or therapeutic approaches. Firstly, SARS-CoV-2 exhibits marked tropism for cells that harbor the membrane-bound metalloprotease angiotensin-converting enzyme 2 (ACE2) at their plasmalemma, predominantly in cells lining the oral cavity, upper respiratory tract, and bronchoalveolar cells, making these epithelial mucosae the most likely viral receptor cell targets and entry routes. Secondly, the crystal structures of several coronavirus spike proteins in complex with their cell host target receptors, and of SARS-Cov-2 in complex with an inhibitor, are now available at atomic resolution through X-ray diffraction and cryo-electron microscopy studies. Thirdly, viral entry of other viruses has been successfully blocked by inhibiting viral endogenous proteases or clathrin/dynamin-dependent endocytosis, the same internalization pathway followed by ACE2 and some viruses. Fourthly, the target cell-surface receptor molecules and SARS-CoV-2 possess other putative sites for drugs potentially modulating receptor activity or virus processing. A multi-pronged pharmacological approach attacking more than one flank of the viral-receptor interactions is worth considering as a front-line strategy.

Advanced search in Research products
Research products
arrow_drop_down
Searching FieldsTerms
Any field
arrow_drop_down
includes
arrow_drop_down
Include:
The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
31 Research products, page 1 of 4
  • Open Access English
    Authors: 
    Reiter, R.; Sharma, Ramaswamy; Castillo, Rafael; Marik, Paul E.; Domínguez Rodriguez, Alberto; Cardinali, Daniel Pedro; Tesarik, Jan;
    Country: Argentina

    Abstract: Two highly relevant studies related to SARS-CoV-2 and coronavirus disease (COVID-19) and supporting the use of melatonin to prevent and treat this serious infection were published recently. Campos-Codo and colleagues [1] documented experimentally their claim that drugs which specifically target hypoxia inducible factor-1α (HIF-1α) would likely have great therapeutic value in treating COVID-19. The second report is a retrospective analysis based on the clinical experience at the Columbia University Irving Medical Center with the use of drugs to treat respiratory distress in COVID-19-infected patients who required endotracheal intubation [2]. Hyperinflammatory monocytes/macrophages accumulate in abundance in the lower respiratory tract where they play a key role in determining the severity of SARS-CoV-2 infections. Campos-Codo, et al. [1] found that monocytes/macrophages infected with the SARSCoV-2 virus reprogram their metabolism from the conventional mitochondrial oxidative phosphorylation (OXPHOS) to the (usually) pathological cytosolic glycolysis. This so-called Warburg-type metabolism is aided by the inadequately controlled elevated blood glucose levels of diabetic patients, which enhances cellular glycolysis, viral replication and hastens development of a severe respiratory infection resulting from the elevated cytokine release (“cytokine storm”).

  • Open Access English
    Authors: 
    Cardinali, Daniel Pedro; Brown, Gregory M.; Reiter, R.; Pandi Perumal, Seithikurippu R.;
    Country: Argentina

    Abstract: The association of age with a higher vulnerability to COVID-19 infection is a subject of major importance. Several factors, including higher stress due to social isolation, diminished melatonin levels with age, and higher exposure of individuals to light at the evening, which reduces melatonin levels and disrupts circadian rhythmicity are relevant for maintaining the circadian health in aged individuals. Properly administered, chronotherapy restores the optimal circadian pattern of the sleep–wake cycle in the elderly. It involves adequate sleep hygiene, timed light exposure, and the use of a chronobiotic medication like melatonin, which affects the output phase of circadian rhythms thus controlling the biological clock. Besides, the therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections has been advocated due to its wide-ranging effects as an antioxidant, anti-inflammatory, and as an immunomodulatory agent, as well as to a possible antiviral action. This article discusses how chronotherapy may reverse the detrimental circadian condition of the elderly in the COVID-19 pandemic.

  • Other research product . Other ORP type . 2020
    Open Access English
    Authors: 
    Otero Losada, Matilde; Kobiec, Tamara; Udovin, Lucas Daniel; Chevalier, Guenson; Quarracino, Cecilia; Menéndez Maissonave, Camila Belén; Bordet, Sofía; Capani, Francisco; Pérez Lloret, Santiago;
    Country: Argentina

    Abstract: Humankind has gone through major airborne virus pandemics in the modern era. Coronavirus outbreaks have been registered in 2003 [severe acute respiratory syndrome (SARS)], 2009 [Middle East respiratory syndrome (MERS)], and 2019/2020 ongoing [CoV disease (COVID-19)]. Influenza outbreaks were documented in 1918 (post-World War I Spanish flu, H1N1 virus), 1957–1958 (Asian flu, H2N2 virus), 1968 (the Hong Kong flu, H3N2 virus), and 2009 (the swine flu, H1N1 virus).

  • Open Access English
    Authors: 
    Rosati, Germán; Domenech, Laia; Chazarreta, Adriana Silvina; Maguire, Tomás;
    Country: Argentina

    We present a first approximation to the quantification of social representations about the COVID-19, using news comments. A web crawler was developed to construct the dataset of reader’s comments. We detect relevant topics in the dataset using Latent Dirichlet Allocation, and analyze its evolution during time. Finally, we show a first prototype to the prediction of the majority topics, using FastText. Sociedad Argentina de Informática

  • Open Access English
    Authors: 
    Paez Maggio, M.; Rossi, M.; Fazzito, L.; Merello, M.;
    Country: Argentina

    Abstract: Most of the validated ‘events exposure’ questionnaires are focused on lifetime burden and are hardly applicable to Argentina owing to its sociocultural and natural conditions, where corruption and economic crises have been hitting middle-class people’s lives in a cyclic manner. This prompted us to develop a new questionnaire, validated in Argentina, to assess the occurrence of exposure to events and their severity over a limited period. Deductive (bibliographic search) and inductive (by a Delphi group) selection was used to create an initial group of 24 questions, which were condensed into a final 14-item questionnaire. After administration to 512 inhabitants of the metropolitan area of Buenos Aires and other major cities in Argentina, the questionnaire was shown to have an intraclass correlation coefficient of 0.996 and an internal consistency, measured by the omega coefficient, of 0.86. Because this study was conducted during the coronavirus disease 2019 (COVID-19) pandemic, an additional question on how this situation affected individuals was included. The time span used to measure event exposure was 1 year prior to the study. In the case of an affirmative event exposure, the responder selected the severity of the stress perception generated on a Likert-like scale, ranging from 0 (nothing) to 5 (severe). Fifty-eight per cent of the responders were women, and the mean age was 47.14 years (SD: 13.97). The average annual event incidence per person was 2.5 events (SD: 1.88). Thirty-two per cent (164/512) reported at least one 5-point event on the severity scale. Ten per cent (51/512) responded that the COVID-19 pandemic affected them in a different manner than events related to personal or family disease, or the death of a close family member or friend.

  • Open Access English
    Authors: 
    Perdomo, Luciano; Ordinez, Leonardo;
    Country: Argentina

    In Argentina there was a great growth of e-commerce due to the COVID-19 pandemic. With the aim of helping local companies to understand the market and help them in decision making, data were obtained from online shoe sales sites and with them Machine Learning models were implemented to make price predictions in sneakers. It was concluded that higher-tier companies have greater competitive advantage over lower-tier companies. Nonetheless, the cost-effective methodology used would aid local companies scale up. Workshop: WBDMD - Base de Datos y Minería de Datos Red de Universidades con Carreras en Informática

  • Open Access English
    Authors: 
    Menéndez, Sebastián García; Martín Giménez, Virna Margarita; Holick, Michael F.; Barrantes, Francisco José; Manucha, Walter;
    Country: Argentina

    Abstract: SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, belongs to a broad family of coronaviruses that also affect humans. SARS-CoV-2 infection usually leads to bilateral atypical pneumonia with significant impairment of respiratory function. However, the infectious capacity of SARS-CoV-2 is not limited to the respiratory system, but may also affect other vital organs such as the brain. The central nervous system is vulnerable to cell damage via direct invasion or indirect virus-related effects leading to a neuroinflammatory response, processes possibly associated with a decrease in the activity of angiotensin II converting enzyme (ACE2), the canonical cell-surface receptor for SARS-CoV-2. This enzyme regulates neuroprotective and neuroimmunomodulatory functions and can neutralize both inflammation and oxidative stress generated at the cellular level. Furthermore, there is evidence of an association between vitamin D deficiency and predisposition to the development of severe forms of COVID-19, with its possible neurological and neuropsychiatric sequelae: vitamin D has the ability to down-modulate the effects of neuroinflammatory cytokines, among other anti-inflammatory/immunomodulatory effects, thus attenuating harmful consequences of COVID-19. This review critically analyzes current evidence supporting the notion that vitamin D may act as a neuroprotective and neuroreparative agent against the neurological sequelae of COVID-19.

  • Open Access English
    Authors: 
    Alvarado, Yoselie; Rodríguez, Graciela; Jofré, Nicolás; Fernández, Jacqueline; Guerrero, Roberto A.;
    Country: Argentina

    Some time ago Virtual Reality and Augmented Reality were exclusively devoted to the gaming industry. Nowadays, both technologies are experiencing a deep interest from various spheres, including healthcare sector. The new infectious disease COVID-19 has had a catastrophic effect on the world’s demographics. Many patients with mild or severe COVID- 19 do not recover completely and present with a wide variety of chronic symptoms after infection, often of a neurological, cognitive or psychiatric nature. The most common signs of cognitive disorder can be summarized as mental fog, memory problems and concentration problems. The aim of this study was to analyze the opportunities for Virtual and Augmented Reality in the cognitive interventions related to mentioned disorders by searching for articles in scientific databases. We conclude that as these technologies and devices become cheaper and accessible worldwide, can at least be regarded as a rehabilitation therapy as effective as traditional training, and to some extent better than it. Workshop: WCGIV - Computación Gráfica, Imágenes y Visualización Red de Universidades con Carreras en Informática

  • Open Access English
    Authors: 
    Brusco, Luis I.; Cruz, Pablo; Cangas, Alicia V.; González Rojas, Carmen; Vigo, Daniel Eduardo; Cardinali, Daniel Pedro;
    Country: Argentina

    Abstract: The association of sleep disruption with a higher vulnerability to COVID-19 infection is a subject of major clinical importance. In patients with pneumonia associated with COVID-19 admitted to non-intensive care unit (NICU) several factors, like the disrupting influence of respiratory distress, medication, greater stress due to social isolation, and lack of appropriate exposure to environmental light can be instrumental to disrupt sleep/wake cycle. The therapeutic potential of melatonin to counteract the consequences of COVID-19 infection has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. Properly administered, melatonin may restore the optimal circadian pattern of the sleep-wake cycle and improve clinical condition in pneumonia associated with COVID-19 patients. The present review article discusses the importance of maintaining normal sleep and circadian rhythmicity in NICU patients and provides preliminary data suggesting the efficacy of melatonin (9 mg/day) to reduce length of stay of pneumonia patients associated with COVID-19 in NICU.

  • Open Access English
    Authors: 
    Barrantes, Francisco José;
    Country: Argentina

    Abstract: At the time of reception of this article (April 2, 2020), efforts to develop a specific vaccine against SARS-Cov-2, the causative agent of the coronavirus disease 2019 (COVID-19), had just begun trial phase 1, but full validation of this and other current developments is likely to take many more months to reach completion. The ongoing pandemic constitutes a major health burden of world proportions that is also having a devastating impact on whole economies worldwide, the knock-on effects of which could be catastrophic especially in poorer countries. Alternative measures to ameliorate the impact and hamper or minimally slow down disease progression are urgently called for. This review discusses past and currently evolving data on the etiological agent of the current pandemic, SARS-CoV-2, and its host cell receptors with a view to disclosing alternative drugs for palliative or therapeutic approaches. Firstly, SARS-CoV-2 exhibits marked tropism for cells that harbor the membrane-bound metalloprotease angiotensin-converting enzyme 2 (ACE2) at their plasmalemma, predominantly in cells lining the oral cavity, upper respiratory tract, and bronchoalveolar cells, making these epithelial mucosae the most likely viral receptor cell targets and entry routes. Secondly, the crystal structures of several coronavirus spike proteins in complex with their cell host target receptors, and of SARS-Cov-2 in complex with an inhibitor, are now available at atomic resolution through X-ray diffraction and cryo-electron microscopy studies. Thirdly, viral entry of other viruses has been successfully blocked by inhibiting viral endogenous proteases or clathrin/dynamin-dependent endocytosis, the same internalization pathway followed by ACE2 and some viruses. Fourthly, the target cell-surface receptor molecules and SARS-CoV-2 possess other putative sites for drugs potentially modulating receptor activity or virus processing. A multi-pronged pharmacological approach attacking more than one flank of the viral-receptor interactions is worth considering as a front-line strategy.