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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Arash Khorrami Jahromi; Roozbeh Siavash Moakhar; Sripadh Guptha Yedire; Hamed Shieh; +7 Authors

    AbstractPortable sample-to-answer devices with applications in point-of-care settings have emerged to obviate the necessity of centralized laboratories for biomarker analysis. In this work, a smartphone-operated and additively manufactured multiplexed electrochemical device (AMMED) is presented for the portable detection of biomarkers in blood and saliva. AMMED is comprised of a customized portable potentiostat with a multiplexing feature, a 3D-printed sample collection cartridge to handle three samples of saliva and blood at the same time, a smartphone application to remotely control the potentiostat, and a 3D-printed-based multiplexed microfluidic electrochemical biosensor (test chip). Here, by employing additive manufacturing techniques, a simple, cleanroom-free, and scalable approach was proposed for the fabrication of the test chip. Moreover, these techniques can bring about easy integration of AMMED components. Additionally, the test chip can be compatible with different affinity-based bioassays which can be implemented in a multiplexed manner for detection. The AMMED components were successfully characterized in terms of electrochemical and fluidic performance. Particularly, to demonstrate the biosensing capabilities of the device, the spike protein of the SARS-CoV-2 omicron variant and a well-established aptameric assay were selected as the representative biomarker and the bioassay, respectively. The proposed device accurately and selectively detected the target of interest in a rapid (5 min) and multiplex manner with a dynamic detection range of 1–10,000 pg. ml-1in different media; and the clinical feasibility was assessed by several saliva patient samples. AMMED offers a versatile sample-to-answer platform that can be used for the detection of various biomarkers present in biofluids.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Lab on a Chiparrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Lab on a Chip
    Article . 2023 . Peer-reviewed
    License: Royal Society of Chemistry Licence to Publish
    Data sources: Crossref
    Lab on a Chip
    Article . 2023
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Lab on a Chiparrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Lab on a Chip
      Article . 2023 . Peer-reviewed
      License: Royal Society of Chemistry Licence to Publish
      Data sources: Crossref
      Lab on a Chip
      Article . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Wayne Vuong; Conrad Fischer; Muhammad Bashir Khan; Marco J. van Belkum; +12 Authors

    Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (Mpro) to cleave viral proteins. Consequently, Mpro is a target for antiviral agents. We and others previously demonstrated that GC376, a bisulfite prodrug with efficacy as an anti-coronaviral agent in animals, is an effective inhibitor of Mpro in SARS-CoV-2. Here, we report structure-activity studies of improved GC376 derivatives with nanomolar affinities and therapeutic indices >200. Crystallographic structures of inhibitor-Mpro complexes reveal that an alternative binding pocket in Mpro, S4, accommodates the P3 position. Alternative binding is induced by polar P3 groups or a nearby methyl. NMR and solubility studies with GC376 show that it exists as a mixture of stereoisomers and forms colloids in aqueous media at higher concentrations, a property not previously reported. Replacement of its Na+ counter ion with choline greatly increases solubility. The physical, biochemical, crystallographic, and cellular data reveal new avenues for Mpro inhibitor design. Graphical abstract Image 1

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ European Journal of ...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    European Journal of Medicinal Chemistry
    Article . 2021 . Peer-reviewed
    License: Elsevier TDM
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ European Journal of ...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      European Journal of Medicinal Chemistry
      Article . 2021 . Peer-reviewed
      License: Elsevier TDM
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Raiden Skala; Mohamed Ahmed T. A. Elgalhud; Katarina Grolinger; Syed Mir;

    The transition to Electric Vehicles (EV) in place of traditional internal combustion engines is increasing societal demand for electricity. The ability to integrate the additional demand from EV charging into forecasting electricity demand is critical for maintaining the reliability of electricity generation and distribution. Load forecasting studies typically exclude households with home EV charging, focusing on offices, schools, and public charging stations. Moreover, they provide point forecasts which do not offer information about prediction uncertainty. Consequently, this paper proposes the Long Short-Term Memory Bayesian Neural Networks (LSTM-BNNs) for household load forecasting in presence of EV charging. The approach takes advantage of the LSTM model to capture the time dependencies and uses the dropout layer with Bayesian inference to generate prediction intervals. Results show that the proposed LSTM-BNNs achieve accuracy similar to point forecasts with the advantage of prediction intervals. Moreover, the impact of lockdowns related to the COVID-19 pandemic on the load forecasting model is examined, and the analysis shows that there is no major change in the model performance as, for the considered households, the randomness of the EV charging outweighs the change due to pandemic.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Energiesarrow_drop_down
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    Energies
    Other literature type . Article . 2023 . Peer-reviewed
    License: CC BY
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    arXiv.org e-Print Archive
    Other literature type . Preprint . 2023
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Energies
    Article . 2023
    Data sources: DOAJ
    https://doi.org/10.48550/arxiv...
    Article . 2023
    License: arXiv Non-Exclusive Distribution
    Data sources: Datacite
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Energiesarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Energies
      Other literature type . Article . 2023 . Peer-reviewed
      License: CC BY
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      arXiv.org e-Print Archive
      Other literature type . Preprint . 2023
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Energies
      Article . 2023
      Data sources: DOAJ
      https://doi.org/10.48550/arxiv...
      Article . 2023
      License: arXiv Non-Exclusive Distribution
      Data sources: Datacite
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Ortega, I.; Gaubert, B.; Hannigan, J.; Brasseur, G. ; https://orcid.org/0000-0001-6794-9497; +17 Authors

    Anomalies of tropospheric columns of ozone (O$_3$), carbon monoxide (CO), acetylene (C$_2$H$_2$), formaldehyde (H$_2$CO), and ethane (C$_2$H$_6$) are quantified during the 2020 stringent COVID-19 world-wide lockdown using multiple ground-based Fourier-transform infrared spectrometers covering urban and remote conditions. We applied an exponential smoothing forecasting approach to the data sets to estimate business-as-usual values for 2020, which are then contrasted with actual observations. The Community Atmosphere Model with chemistry (CAM-chem) is used to simulate the same gases using lockdown-adjusted and business-as-usual emissions. The role of meteorology, or natural variability, is assessed with additional CAM-chem simulations. The tropospheric column of O$_3$ declined between March and May 2020 for most sites with a mean decrease of 9.2% ± 4.7%. Simulations reproduce these anomalies, especially under background conditions where natural variability explains up to 80% of the decline for sites in the Northern Hemisphere. While urban sites show a reduction between 1% and 12% in tropospheric CO, the remote sites do not show a significant change. Overall, CAM-chem simulations capture the magnitude of the anomalies and in many cases natural variability and lockdowns have opposite effects. We further used the long-term record of the Measurements of Pollution in the Troposphere (MOPITT) satellite instrument to capture global anomalies of CO. Reductions of CO vary highly across regions but North America and Europe registered lower values in March 2020. The absence of CO reduction in April and May, concomitant with reductions of anthropogenic emissions, is explained by a negative anomaly in the hydroxyl radical (OH) found with CAM-chem. The implications of these findings are discussed for methane (CH$_4$), which shows a positive lifetime anomaly during the COVID-19 lockdown period. The fossil fuel combustion by-product tracer C2H2 shows a mean drop of 13.6% ± 8.3% in urban Northern Hemisphere sites due to the reduction in emissions and in some sites exacerbated by natural variability. For some sites with anthropogenic influence there is a decrease in C$_2$H$_6$. The simulations capture the anomalies but the main cause may be related to natural variability. H$_2$CO declined during the stringent 2020 lockdown in all urban sites explained by reductions in emissions of precursors.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Elementa: Science of...arrow_drop_down
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    Elementa: Science of the Anthropocene
    Article . 2023 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    MPG.PuRe
    Article . 2023
    Data sources: MPG.PuRe
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    KITopen
    Article . 2023
    License: CC BY
    Data sources: KITopen
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    https://doi.org/10.5445/ir/100...
    Article . 2023
    License: CC BY
    Data sources: Datacite
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    MPG.PuRe
    Article . 2023
    License: CC BY
    Data sources: MPG.PuRe
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Elementa: Science of...arrow_drop_down
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      Elementa: Science of the Anthropocene
      Article . 2023 . Peer-reviewed
      License: CC BY
      Data sources: Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      Article . 2023
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      KITopen
      Article . 2023
      License: CC BY
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      https://doi.org/10.5445/ir/100...
      Article . 2023
      License: CC BY
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      MPG.PuRe
      Article . 2023
      License: CC BY
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Xi He; Jennie Rogers; Johes Bater; Ashwin Machanavajjhala; +2 Authors

    Computing technology has enabled massive digital traces of our personal lives to be collected and stored. These datasets play an important role in numerous real-life applications and research analysis, such as contact tracing for COVID 19, but they contain sensitive information about individuals. When managing these datasets, privacy is usually addressed as an afterthought, engineered on top of a database system optimized for performance and usability. This has led to a plethora of unexpected privacy attacks in the news. Specialized privacy-preserving solutions usually require a group of privacy experts and they are not directly transferable to other domains. There is an urgent need for a generally trustworthy database system that offers end-to-end security and privacy guarantees. In this tutorial, we will first describe the security and privacy requirements for database systems in different settings and cover the state-of-the-art tools that achieve these requirements. We will also show challenges in integrating these techniques together and demonstrate the design principles and optimization opportunities for these security and privacy-aware database systems. This is designed to be a three hour tutorial.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://dl.acm.org/d...arrow_drop_down
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    https://dl.acm.org/doi/pdf/10....
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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    https://doi.org/10.1145/344801...
    Conference object . 2021 . Peer-reviewed
    License: ACM Copyright Policies
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://dl.acm.org/d...arrow_drop_down
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      https://doi.org/10.1145/344801...
      Conference object . 2021 . Peer-reviewed
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  • Authors: Gil Robern; Alvaro Uribe-Quevedo; Mahadeo Sukhai; Peter Coppin; +2 Authors

    According to the World Health Organization, there are more than one billion people with moderate or severe distance vision impairment or blindness worldwide in 2020. Due to recent COVID-19 safety measures, online events have moved to online platforms in order to maintain physical distancing. The transition towards online gatherings have shown gaps associated with technology and internet access, along with lacking accessibility, which has resulted in reactive responses to improve usability by adding captioning, compatibility with screen readers, and image captioning to cite some examples. However, traditional video conference lacks immersion and presence otherwise found in virtual reality (VR), for example Mozilla Hubs, Engage VR, AltspaceVR, and Virbela amongst others. Although these services and consumer-level hardware are becoming ubiquitous, there are still accessibility challenges to be met when designing VR experiences. In this work-in-progress paper we explore the design of an inclusive web-based VR application that simulates registering at a virtual conference and navigating to a presentation room. Our preliminary study focused on usability and engagement by inviting participants to experience the demo eyes closed. Our preliminary results show the audio cues were helpful to navigate the environment without visual feedback.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Sharma, Divya Khandige; Bressler, Kamiko; Patel, Harshil; Balasingam, Nirujah; +1 Authors

    Protein synthesis can be segmented into distinct phases comprising mRNA translation initiation, elongation, and termination. Translation initiation is a highly regulated and rate-limiting step of protein synthesis that requires more than 12 eukaryotic initiation factors (eIFs). Extensive evidence shows that the transcriptome and corresponding proteome do not invariably correlate with each other in a variety of contexts. In particular, translation of mRNAs specific to angiogenesis, tumor development, and apoptosis is altered during physiological and pathophysiological stress conditions. In cancer cells, the expression and functions of eIFs are hampered, resulting in the inhibition of global translation and enhancement of translation of subsets of mRNAs by alternative mechanisms. A precise understanding of mechanisms involving eukaryotic initiation factors leading to differential protein expression can help us to design better strategies to diagnose and treat cancer. The high spatial and temporal resolution of translation control can have an immediate effect on the microenvironment of the cell in comparison with changes in transcription. The dysregulation of mRNA translation mechanisms is increasingly being exploited as a target to treat cancer. In this review, we will focus on this context by describing both canonical and noncanonical roles of eIFs, which alter mRNA translation.

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    Journal of Nucleic Acids
    Article . 2016 . Peer-reviewed
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    Journal of Nucleic Acids
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      Journal of Nucleic Acids
      Article . 2016 . Peer-reviewed
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Zheng, Wang; Chunjiang, An; Kenneth, Lee; Xiujuan, Chen; +3 Authors

    The explosive growth of disposable gloves usage in cities around the world has posed a considerable risk to municipal solid management and disposal during the COVID-19 pandemic. The lack of the environmental awareness leads to glove waste being discarded randomly and ending up in the soil and/or the ocean ecosystem. To explore the physicochemical changes and environmental behaviors of disposable glove wastes in the aqueous environment, three kinds of glove (latex, nitrile and vinyl) were investigated. The results showed that the physicochemical characteristics of disposable gloves made of different materials were altered to different degrees by UV weathering. Nitrile gloves were more stable than latex and vinyl gloves after being exposed to weathering conditions. Although the chemical structures were not clearly demonstrated through FTIR after weathering, the SEM results showed significant microscopic changes on the surfaces of the gloves. Analysis of the leachate results showed that UV weathered gloves released leachable substances, including microparticles, organic matter, and heavy metals. Latex gloves were more likely to release microparticles and other substances into the water after UV weathering. The release of microparticles from gloves can also be impacted by sand abrasion. The appropriate strategy needs to be developed to mitigate the environmental impact caused by the discarded gloves.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao The Science of The T...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    The Science of The Total Environment
    Article . 2022 . Peer-reviewed
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      The Science of The Total Environment
      Article . 2022 . Peer-reviewed
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    Authors: Taha Azad; Reza Rezaei; Ragunath Singaravelu; Taylor R Jamieson; +7 Authors

    High-throughput detection strategies for antibodies against SARS-CoV-2 in patients recovering from COVID-19, or in vaccinated individuals, are urgently required during this ongoing pandemic. Serological assays are the most widely used method to measure antibody responses in patients. However, most of the current methods lack the speed, stability, sensitivity, and specificity to be selected as a test for worldwide serosurveys. Here, we demonstrate a novel NanoBiT-based serological assay for fast and sensitive detection of SARS-CoV-2 RBD-specific antibodies in sera of COVID-19 patients. This assay can be done in high-throughput manner at 384 samples per hour and only requires a minimum of 5 μL of serum or 10 ng of antibody. The stability of our NanoBiT reporter in various temperatures (4–42 °C) and pH (4–12) settings suggests the assay will be able to withstand imperfect shipping and handling conditions for worldwide seroepidemiologic surveillance in the post-vaccination period of the pandemic. Our newly developed rapid assay is highly accessible and may facilitate a more cost-effective solution for seroconversion screening as vaccination efforts progress.

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    Nanomaterials
    Other literature type . Article . 2021 . Peer-reviewed
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    DOAJ
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    Nanomaterials
    Article . 2021
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    Nanomaterials
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      Nanomaterials
      Other literature type . Article . 2021 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Dmytro Chumachenko; Tetiana Dudkina; Tetyana Chumachenko; Plinio Pelegrini Morita;

    Background: The COVID-19 pandemic has profoundly transformed the global scenario, marked by overwhelming infections, fatalities, overburdened healthcare infrastructures, economic upheavals, and significant lifestyle modifications. Concurrently, the Russian full-scale invasion of Ukraine on 24 February 2022, triggered a severe humanitarian and public health crisis, leading to healthcare disruptions, medical resource shortages, and heightened emergency care needs. Italy emerged as a significant refuge for displaced Ukrainians during this period. Aim: This research aims to discern the impact of the Russian full-scale invasion of Ukraine on the COVID-19 transmission dynamics in Italy. Materials and Methods: The study employed advanced simulation methodologies, particularly those integrating machine learning, to model the pandemic’s trajectory. The XGBoost algorithm was adopted to construct a predictive model for the COVID-19 epidemic trajectory in Italy. Results: The model demonstrated a commendable accuracy of 86.03% in forecasting new COVID-19 cases in Italy over 30 days and an impressive 96.29% accuracy in estimating fatalities. When applied to the initial 30 days following the escalation of the conflict (24 February 2022, to 25 March 2022), the model’s projections suggested that the influx of Ukrainian refugees into Italy did not significantly alter the country’s COVID-19 epidemic course. Discussion: While simulation methodologies have been pivotal in the pandemic response, their accuracy is intrinsically linked to data quality, assumptions, and modeling techniques. Enhancing these methodologies can further their applicability in future public health emergencies. The findings from the model underscore that external geopolitical events, such as the mass migration from Ukraine, did not play a determinative role in Italy’s COVID-19 epidemic dynamics during the study period. Conclusion: The research provides empirical evidence negating a substantial influence of the Ukrainian refugee influx due to the Russian full-scale invasion on the COVID-19 epidemic trajectory in Italy. The robust performance of the developed model affirms its potential value in public health analyses.

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    Article . 2023 . Peer-reviewed
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Arash Khorrami Jahromi; Roozbeh Siavash Moakhar; Sripadh Guptha Yedire; Hamed Shieh; +7 Authors

    AbstractPortable sample-to-answer devices with applications in point-of-care settings have emerged to obviate the necessity of centralized laboratories for biomarker analysis. In this work, a smartphone-operated and additively manufactured multiplexed electrochemical device (AMMED) is presented for the portable detection of biomarkers in blood and saliva. AMMED is comprised of a customized portable potentiostat with a multiplexing feature, a 3D-printed sample collection cartridge to handle three samples of saliva and blood at the same time, a smartphone application to remotely control the potentiostat, and a 3D-printed-based multiplexed microfluidic electrochemical biosensor (test chip). Here, by employing additive manufacturing techniques, a simple, cleanroom-free, and scalable approach was proposed for the fabrication of the test chip. Moreover, these techniques can bring about easy integration of AMMED components. Additionally, the test chip can be compatible with different affinity-based bioassays which can be implemented in a multiplexed manner for detection. The AMMED components were successfully characterized in terms of electrochemical and fluidic performance. Particularly, to demonstrate the biosensing capabilities of the device, the spike protein of the SARS-CoV-2 omicron variant and a well-established aptameric assay were selected as the representative biomarker and the bioassay, respectively. The proposed device accurately and selectively detected the target of interest in a rapid (5 min) and multiplex manner with a dynamic detection range of 1–10,000 pg. ml-1in different media; and the clinical feasibility was assessed by several saliva patient samples. AMMED offers a versatile sample-to-answer platform that can be used for the detection of various biomarkers present in biofluids.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Lab on a Chiparrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Lab on a Chip
    Article . 2023 . Peer-reviewed
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    Article . 2023
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Lab on a Chiparrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Lab on a Chip
      Article . 2023 . Peer-reviewed
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      Article . 2023
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    Authors: Wayne Vuong; Conrad Fischer; Muhammad Bashir Khan; Marco J. van Belkum; +12 Authors

    Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (Mpro) to cleave viral proteins. Consequently, Mpro is a target for antiviral agents. We and others previously demonstrated that GC376, a bisulfite prodrug with efficacy as an anti-coronaviral agent in animals, is an effective inhibitor of Mpro in SARS-CoV-2. Here, we report structure-activity studies of improved GC376 derivatives with nanomolar affinities and therapeutic indices >200. Crystallographic structures of inhibitor-Mpro complexes reveal that an alternative binding pocket in Mpro, S4, accommodates the P3 position. Alternative binding is induced by polar P3 groups or a nearby methyl. NMR and solubility studies with GC376 show that it exists as a mixture of stereoisomers and forms colloids in aqueous media at higher concentrations, a property not previously reported. Replacement of its Na+ counter ion with choline greatly increases solubility. The physical, biochemical, crystallographic, and cellular data reveal new avenues for Mpro inhibitor design. Graphical abstract Image 1

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    European Journal of Medicinal Chemistry
    Article . 2021 . Peer-reviewed
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      European Journal of Medicinal Chemistry
      Article . 2021 . Peer-reviewed
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    Authors: Raiden Skala; Mohamed Ahmed T. A. Elgalhud; Katarina Grolinger; Syed Mir;

    The transition to Electric Vehicles (EV) in place of traditional internal combustion engines is increasing societal demand for electricity. The ability to integrate the additional demand from EV charging into forecasting electricity demand is critical for maintaining the reliability of electricity generation and distribution. Load forecasting studies typically exclude households with home EV charging, focusing on offices, schools, and public charging stations. Moreover, they provide point forecasts which do not offer information about prediction uncertainty. Consequently, this paper proposes the Long Short-Term Memory Bayesian Neural Networks (LSTM-BNNs) for household load forecasting in presence of EV charging. The approach takes advantage of the LSTM model to capture the time dependencies and uses the dropout layer with Bayesian inference to generate prediction intervals. Results show that the proposed LSTM-BNNs achieve accuracy similar to point forecasts with the advantage of prediction intervals. Moreover, the impact of lockdowns related to the COVID-19 pandemic on the load forecasting model is examined, and the analysis shows that there is no major change in the model performance as, for the considered households, the randomness of the EV charging outweighs the change due to pandemic.

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    Energies
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    arXiv.org e-Print Archive
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    Energies
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    https://doi.org/10.48550/arxiv...
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      Energies
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      Energies
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      https://doi.org/10.48550/arxiv...
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    Authors: Ortega, I.; Gaubert, B.; Hannigan, J.; Brasseur, G. ; https://orcid.org/0000-0001-6794-9497; +17 Authors

    Anomalies of tropospheric columns of ozone (O$_3$), carbon monoxide (CO), acetylene (C$_2$H$_2$), formaldehyde (H$_2$CO), and ethane (C$_2$H$_6$) are quantified during the 2020 stringent COVID-19 world-wide lockdown using multiple ground-based Fourier-transform infrared spectrometers covering urban and remote conditions. We applied an exponential smoothing forecasting approach to the data sets to estimate business-as-usual values for 2020, which are then contrasted with actual observations. The Community Atmosphere Model with chemistry (CAM-chem) is used to simulate the same gases using lockdown-adjusted and business-as-usual emissions. The role of meteorology, or natural variability, is assessed with additional CAM-chem simulations. The tropospheric column of O$_3$ declined between March and May 2020 for most sites with a mean decrease of 9.2% ± 4.7%. Simulations reproduce these anomalies, especially under background conditions where natural variability explains up to 80% of the decline for sites in the Northern Hemisphere. While urban sites show a reduction between 1% and 12% in tropospheric CO, the remote sites do not show a significant change. Overall, CAM-chem simulations capture the magnitude of the anomalies and in many cases natural variability and lockdowns have opposite effects. We further used the long-term record of the Measurements of Pollution in the Troposphere (MOPITT) satellite instrument to capture global anomalies of CO. Reductions of CO vary highly across regions but North America and Europe registered lower values in March 2020. The absence of CO reduction in April and May, concomitant with reductions of anthropogenic emissions, is explained by a negative anomaly in the hydroxyl radical (OH) found with CAM-chem. The implications of these findings are discussed for methane (CH$_4$), which shows a positive lifetime anomaly during the COVID-19 lockdown period. The fossil fuel combustion by-product tracer C2H2 shows a mean drop of 13.6% ± 8.3% in urban Northern Hemisphere sites due to the reduction in emissions and in some sites exacerbated by natural variability. For some sites with anthropogenic influence there is a decrease in C$_2$H$_6$. The simulations capture the anomalies but the main cause may be related to natural variability. H$_2$CO declined during the stringent 2020 lockdown in all urban sites explained by reductions in emissions of precursors.

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    Elementa: Science of the Anthropocene
    Article . 2023 . Peer-reviewed
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    KITopen
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    https://doi.org/10.5445/ir/100...
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      Elementa: Science of the Anthropocene
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    Authors: Xi He; Jennie Rogers; Johes Bater; Ashwin Machanavajjhala; +2 Authors

    Computing technology has enabled massive digital traces of our personal lives to be collected and stored. These datasets play an important role in numerous real-life applications and research analysis, such as contact tracing for COVID 19, but they contain sensitive information about individuals. When managing these datasets, privacy is usually addressed as an afterthought, engineered on top of a database system optimized for performance and usability. This has led to a plethora of unexpected privacy attacks in the news. Specialized privacy-preserving solutions usually require a group of privacy experts and they are not directly transferable to other domains. There is an urgent need for a generally trustworthy database system that offers end-to-end security and privacy guarantees. In this tutorial, we will first describe the security and privacy requirements for database systems in different settings and cover the state-of-the-art tools that achieve these requirements. We will also show challenges in integrating these techniques together and demonstrate the design principles and optimization opportunities for these security and privacy-aware database systems. This is designed to be a three hour tutorial.

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    https://doi.org/10.1145/344801...
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  • Authors: Gil Robern; Alvaro Uribe-Quevedo; Mahadeo Sukhai; Peter Coppin; +2 Authors

    According to the World Health Organization, there are more than one billion people with moderate or severe distance vision impairment or blindness worldwide in 2020. Due to recent COVID-19 safety measures, online events have moved to online platforms in order to maintain physical distancing. The transition towards online gatherings have shown gaps associated with technology and internet access, along with lacking accessibility, which has resulted in reactive responses to improve usability by adding captioning, compatibility with screen readers, and image captioning to cite some examples. However, traditional video conference lacks immersion and presence otherwise found in virtual reality (VR), for example Mozilla Hubs, Engage VR, AltspaceVR, and Virbela amongst others. Although these services and consumer-level hardware are becoming ubiquitous, there are still accessibility challenges to be met when designing VR experiences. In this work-in-progress paper we explore the design of an inclusive web-based VR application that simulates registering at a virtual conference and navigating to a presentation room. Our preliminary study focused on usability and engagement by inviting participants to experience the demo eyes closed. Our preliminary results show the audio cues were helpful to navigate the environment without visual feedback.

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    Authors: Sharma, Divya Khandige; Bressler, Kamiko; Patel, Harshil; Balasingam, Nirujah; +1 Authors

    Protein synthesis can be segmented into distinct phases comprising mRNA translation initiation, elongation, and termination. Translation initiation is a highly regulated and rate-limiting step of protein synthesis that requires more than 12 eukaryotic initiation factors (eIFs). Extensive evidence shows that the transcriptome and corresponding proteome do not invariably correlate with each other in a variety of contexts. In particular, translation of mRNAs specific to angiogenesis, tumor development, and apoptosis is altered during physiological and pathophysiological stress conditions. In cancer cells, the expression and functions of eIFs are hampered, resulting in the inhibition of global translation and enhancement of translation of subsets of mRNAs by alternative mechanisms. A precise understanding of mechanisms involving eukaryotic initiation factors leading to differential protein expression can help us to design better strategies to diagnose and treat cancer. The high spatial and temporal resolution of translation control can have an immediate effect on the microenvironment of the cell in comparison with changes in transcription. The dysregulation of mRNA translation mechanisms is increasingly being exploited as a target to treat cancer. In this review, we will focus on this context by describing both canonical and noncanonical roles of eIFs, which alter mRNA translation.

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    Journal of Nucleic Acids
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      Journal of Nucleic Acids
      Article . 2016 . Peer-reviewed
      License: CC BY
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      Journal of Nucleic Acids
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Zheng, Wang; Chunjiang, An; Kenneth, Lee; Xiujuan, Chen; +3 Authors

    The explosive growth of disposable gloves usage in cities around the world has posed a considerable risk to municipal solid management and disposal during the COVID-19 pandemic. The lack of the environmental awareness leads to glove waste being discarded randomly and ending up in the soil and/or the ocean ecosystem. To explore the physicochemical changes and environmental behaviors of disposable glove wastes in the aqueous environment, three kinds of glove (latex, nitrile and vinyl) were investigated. The results showed that the physicochemical characteristics of disposable gloves made of different materials were altered to different degrees by UV weathering. Nitrile gloves were more stable than latex and vinyl gloves after being exposed to weathering conditions. Although the chemical structures were not clearly demonstrated through FTIR after weathering, the SEM results showed significant microscopic changes on the surfaces of the gloves. Analysis of the leachate results showed that UV weathered gloves released leachable substances, including microparticles, organic matter, and heavy metals. Latex gloves were more likely to release microparticles and other substances into the water after UV weathering. The release of microparticles from gloves can also be impacted by sand abrasion. The appropriate strategy needs to be developed to mitigate the environmental impact caused by the discarded gloves.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao The Science of The T...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    The Science of The Total Environment
    Article . 2022 . Peer-reviewed
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao The Science of The T...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      The Science of The Total Environment
      Article . 2022 . Peer-reviewed
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    Authors: Taha Azad; Reza Rezaei; Ragunath Singaravelu; Taylor R Jamieson; +7 Authors

    High-throughput detection strategies for antibodies against SARS-CoV-2 in patients recovering from COVID-19, or in vaccinated individuals, are urgently required during this ongoing pandemic. Serological assays are the most widely used method to measure antibody responses in patients. However, most of the current methods lack the speed, stability, sensitivity, and specificity to be selected as a test for worldwide serosurveys. Here, we demonstrate a novel NanoBiT-based serological assay for fast and sensitive detection of SARS-CoV-2 RBD-specific antibodies in sera of COVID-19 patients. This assay can be done in high-throughput manner at 384 samples per hour and only requires a minimum of 5 μL of serum or 10 ng of antibody. The stability of our NanoBiT reporter in various temperatures (4–42 °C) and pH (4–12) settings suggests the assay will be able to withstand imperfect shipping and handling conditions for worldwide seroepidemiologic surveillance in the post-vaccination period of the pandemic. Our newly developed rapid assay is highly accessible and may facilitate a more cost-effective solution for seroconversion screening as vaccination efforts progress.

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    Nanomaterials
    Other literature type . Article . 2021 . Peer-reviewed
    License: CC BY
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    DOAJ
    Article . 2021
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    Nanomaterials
    Article . 2021
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    Nanomaterials
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      Nanomaterials
      Other literature type . Article . 2021 . Peer-reviewed
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      DOAJ
      Article . 2021
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      Nanomaterials
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      Nanomaterials
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    Authors: Dmytro Chumachenko; Tetiana Dudkina; Tetyana Chumachenko; Plinio Pelegrini Morita;

    Background: The COVID-19 pandemic has profoundly transformed the global scenario, marked by overwhelming infections, fatalities, overburdened healthcare infrastructures, economic upheavals, and significant lifestyle modifications. Concurrently, the Russian full-scale invasion of Ukraine on 24 February 2022, triggered a severe humanitarian and public health crisis, leading to healthcare disruptions, medical resource shortages, and heightened emergency care needs. Italy emerged as a significant refuge for displaced Ukrainians during this period. Aim: This research aims to discern the impact of the Russian full-scale invasion of Ukraine on the COVID-19 transmission dynamics in Italy. Materials and Methods: The study employed advanced simulation methodologies, particularly those integrating machine learning, to model the pandemic’s trajectory. The XGBoost algorithm was adopted to construct a predictive model for the COVID-19 epidemic trajectory in Italy. Results: The model demonstrated a commendable accuracy of 86.03% in forecasting new COVID-19 cases in Italy over 30 days and an impressive 96.29% accuracy in estimating fatalities. When applied to the initial 30 days following the escalation of the conflict (24 February 2022, to 25 March 2022), the model’s projections suggested that the influx of Ukrainian refugees into Italy did not significantly alter the country’s COVID-19 epidemic course. Discussion: While simulation methodologies have been pivotal in the pandemic response, their accuracy is intrinsically linked to data quality, assumptions, and modeling techniques. Enhancing these methodologies can further their applicability in future public health emergencies. The findings from the model underscore that external geopolitical events, such as the mass migration from Ukraine, did not play a determinative role in Italy’s COVID-19 epidemic dynamics during the study period. Conclusion: The research provides empirical evidence negating a substantial influence of the Ukrainian refugee influx due to the Russian full-scale invasion on the COVID-19 epidemic trajectory in Italy. The robust performance of the developed model affirms its potential value in public health analyses.

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    Computation
    Article . 2023 . Peer-reviewed
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    Article . 2023
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