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  • Open Access English
    Authors: 
    Júlia Vergara-Alert; Enric Vidal; Albert Bensaid; Joaquim Segalés;
    Publisher: Elsevier BV
    Country: Spain
    Project: EC | ZAPI (115760)

    Emerging and re-emerging pathogens represent a substantial threat to public health, as demonstrated with numerous outbreaks over the past years, including the 2013–2016 outbreak of Ebola virus in western Africa. Coronaviruses are also a threat for humans, as evidenced in 2002/2003 with infection by the severe acute respiratory syndrome coronavirus (SARS-CoV), which caused more than 8000 human infections with 10% fatality rate in 37 countries. Ten years later, a novel human coronavirus (Middle East respiratory syndrome coronavirus, MERS-CoV), associated with severe pneumonia, arose in the Kingdom of Saudi Arabia. Until December 2016, MERS has accounted for more than 1800 cases and 35% fatality rate. Finding an animal model of disease is key to develop vaccines or antivirals against such emerging pathogens and to understand its pathogenesis. Knowledge of the potential role of domestic livestock and other animal species in the transmission of pathogens is of importance to understand the epidemiology of the disease. Little is known about MERS-CoV animal host range. In this paper, experimental data on potential hosts for MERS-CoV is reviewed. Advantages and limitations of different animal models are evaluated in relation to viral pathogenesis and transmission studies. Finally, the relevance of potential new target species is discussed.

  • Open Access English
    Authors: 
    Blanca León-Nabal; Cristina Zhang-Yu; José Luis Lalueza;
    Publisher: Frontiers Media S.A.
    Country: Spain

    The COVID-19 pandemic has sharpened the inequalities in our societies. In Spain, we observed that the impact on schooling varied according to socioeconomic, gender and sociocultural variables. In this article, we present a case analysis illustrating the impact of the COVID-19 pandemic on schooling in early educational grades (ages 3–6), which leads us to focus on school-family relationship. First, we present some studies that show the inequalities in education during the lockdown period, the digital divide faced by both schools and families and how digital mediation impacts school-family relationships. Then we will introduce our study, which aims to explore the uses, potentials and limitations of an app intended to facilitate the relationship. Our study took place during September 2020-January 2021, when social restriction persisted. It took the form of a telematic ethnography in which we monitored the meetings of the Early Childhood Education teachers and their interaction with the families via an app-based communication tool. Results have allowed us to identify that most conversations are initiated by the school and their aim is to show families the classroom activities. We have also observed some advantages regarding the use of this app: communication can become more direct and immediate, and teachers have developed strategies to foster proximity in this relationship, as well as to respond inclusively to diversity. Regarding the challenges, we identified the lack of involvement of some families, the need to transform the roles played by families and children, and the difficulty to maintain personalized relationships This research was funded by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO), the Spanish State Research Agency (AEI), and the European Regional Development Funds (European Union), grant number EDU2017-83363-R

  • Open Access English
    Authors: 
    Albiol, Nil; Aso, Olga; Gómez-Pérez, Lucía; Triquell, Mercè; Roch, Nerea; Lázaro, Elisabeth; Esquirol, Albert; González, Iria; López-Contreras, Joaquín; Sierra, Jorge; +3 more
    Country: Spain
  • Open Access English
    Authors: 
    Aguilar-Martínez, Alicia; Bosque Prous, Marina; González-Casals, Helena; Colillas-Malet, Ester; Puigcorbé, Susanna; Esquius, Laura; Espelt, Albert; Universitat Central de Catalunya;
    Country: Spain

    Adolescence is a critical period in the consolidation of healthy lifestyles that can last into adulthood. To analyze changes in food consumption and eating behaviors in high-school adolescents during the first confinement, a cross-sectional study was conducted at the end of confinement in Spain. Changes in the frequency or quantity of consumption of different types of food and food-related behaviors were analyzed. Socioeconomic and health-related variables were also considered. To determine whether dietary changes were related to socioeconomic position (SEP), Poisson regression models with robust variance were estimated. Overall, there were some changes towards a healthier diet such as an increase in fruit consumption (38.9%) and a decrease in the consumption of soft drinks (49.8%), sweets and pastries (39.3%), and convenience foods (49.2%). Some changes, however, were related to less healthy behaviors, such as a more irregular pattern of meal distribution (39.9%) or an increase in snacking between meals (56.4%). Changes towards less healthy eating were also related to students’ SEP. The risk of worsening the diet was found to be 21% higher in adolescents from a more disadvantaged SEP. Future public policies could be adapted to avoid increasing nutritional and health inequalities.

  • Open Access English
    Authors: 
    López Monteiro, Marcial;
    Country: Spain

    En el siguiente trabajo de investigación se analizan una serie de aspectos relacionados con la motivación en la educación secundaria y se propone una acción educativa con unas metas, métodos, tareas y evaluación diferentes con respecto a la metodología tradicional, con el objetivo de comparar el valor motivador de ambas. La primera parte de este estudio refleja algunas de las ideas recogidas en trabajos llevados a cabo por expertos en la materia, como J. Alonso Tapia o Miguel Ángel Broc Cavero, entre otros. Estos autores intentan explicar, entre otras cuestiones, qué es la motivación, qué distingue a un alumno motivado de un alumno no motivado o cuáles son los rasgos propios de los alumnos motivados. En la segunda parte del estudio se propone una acción educativa de seis meses (dos trimestres) orientada a medir la motivación de los alumnos en comparación con las metodologías tradicionales. La acción educativa se caracteriza por establecer unas metas claras, así como una serie de tareas que pretender emocionar al alumno e identificarlo mucho más con los contenidos. El trabajo se centrará en alumnos de 2.º de ESO del Institut Baix a Mar de Vilanova i la Geltrú. Se pretende que los alumnos puedan trabajar tanto de forma autónoma como en equipo, usando su imaginación y creatividad, y desarrollando su espíritu crítico. Asimismo, el fruto de su trabajo se irá plasmando en una página web para que puedan ver resultados inmediatos. Si bien esta última parte no ha podido ser llevada a la práctica debido a la situación excepcional provocada por la COVID-19, la intención es hacerlo en cuanto la situación se normalice. En el següent treball de recerca s’analitzen una sèrie d’aspectes relacionats amb la motivació en l’educació secundària i es proposa una acció educativa amb unes metes, mètodes, tasques i avaluació diferents respecte a la metodologia tradicional, amb l’objectiu de comparar el valor motivador d’ambdues. La primera part d’aquest estudi reflecteix algunes de les idees recollides en treballs duts a terme per experts en la matèria, com a J. Alonso Tapia o Miguel Ángel Broc Cavero, entre altres. Aquests autors intenten explicar, entre altres qüestions, què és la motivació, què distingeix a un alumne motivat d’un alumne no motivat o quins són els trets propis dels alumnes motivats. En la segona part de l’estudi es proposa una acció educativa de sis mesos (dos trimestres) orientada a mesurar la motivació dels alumnes en comparació amb les metodologies tradicionals. L’acció educativa es caracteritza per establir unes metes clares, així com una sèrie de tasques que pretenen emocionar a l’alumne i identificar-lo molt més amb els continguts. El treball se centrarà en alumnes de 2n d’ESO del Institut Baix a Mar de Vilanova i la Geltrú. Es pretén que els alumnes puguin treballar tant de manera autònoma com en equip, usant la seva imaginació i creativitat, i desenvolupant el seu esperit crític. Així mateix, el fruit del seu treball s’anirà plasmant en una pàgina web perquè puguin veure resultats immediats. Si bé aquesta última part no ha pogut ser portada a la pràctica a causa de la situació excepcional provocada per la COVID-19, la intenció és fer-ho quan la situació es normalitzi. The following research paper analyses a series of aspects related to motivation in secondary education and proposes an educational action with different goals, methods, tasks and evaluation with respect to traditional methodology, with the aim of comparing the motivational value of both. The first part of this study reflects some of the ideas gathered in works carried out by experts in the field, such as J. Alonso Tapia or Miguel Ángel Broc Cavero, among others. These authors try to define the concept of motivation, what distinguishes a motivated student from an unmotivated student, or what are the traits of motivated students. The second part of the study proposes a six months educational action (two terms) aimed at measuring the motivation of students in comparison with traditional methodologies. The educational action is characterised by establishing clear goals, as well as a series of tasks that aim to move the students and identify them much more with the contents. The work will be focused on 2nd year students of the Institut Baix a Mar in Vilanova i la Geltrú. The aim is for the students to be able to work both independently and in a team, using their imagination and creativity, and developing their critical spirit. Likewise, the fruit of their work will be reflected in a web page so that they can see immediate results. Due to the exceptional situation caused by COVID-19, it was not possible to implement these measures, and their application will be postponed until the situation is normalised.

  • Open Access English
    Authors: 
    Jireh, Ejoku; Ngalyuka Nzau, Julius;
    Country: Spain

    The article compares the way COVID-19 has been managed in the East African Community and in the EU. How were the initial measures in each of the regions and what have been the consequences of the measures adopted, especially those related to confinement and vaccination. It discusses how the strength of European integration and the notable economic and technological development of its member states have provided a comparative advantage over the resources available to the East African Community. They conclude that, in addition to the undoubted importance of advancing in economic development, continuing to deepen regional cooperation in African territory would be an opportunity to better manage future threats. L'article compara la manera com s'ha gestionat la COVID-19 a la Comunitat d'Àfrica Oriental ia la UE. Com van ser les mesures inicials a cadascuna de les regions i quines han estat les conseqüències que han tingut les mesures adoptades, especialment les relacionades amb el confinament i la vacunació. Planteja com la solidesa de la integració europea i el notable desenvolupament econòmic i tecnològic dels seus Estats membres han suposat un avantatge comparatiu respecte als recursos amb què han comptat la Comunitat de l'Àfrica Oriental. Conclouen que, a més de la importància indubtable d'avançar en el desenvolupament econòmic, continuar aprofundint en la cooperació regional en territori africà suposaria una oportunitat per poder gestionar millor amenaces futures. El artículo compara la forma en que se ha gestionado la COVID-19 en la Comunidad de África Oriental y en la UE. Cómo fueron las medidas iniciales en cada una de las regiones y cuáles han sido las consecuencias que han tenido las medidas adoptadas, especialmente las relacionadas con el confinamiento y la vacunación. Plantea cómo la solidez de la integración europea y el notable desarrollo económico y tecnológico de sus Estados miembros han supuesto una ventaja comparativa, respecto a los recursos con los que han contado la Comunidad de África Oriental. Concluyen que, además de la indudable importancia de avanzar en el desarrollo económico, seguir profundizando en la cooperación regional en territorio africano supondría una oportunidad para poder gestionar mejor futuras amenazas.

  • Publication . Article . 2021
    Open Access English
    Authors: 
    Liu, Yuyu; Aliagas, Cristina; Llompart Esbert, Julia; Pascual, Mariona; Salas, Naymé; Vallejo Rubinstein, Claudia;
    Country: Spain

    Cristina Aliagas, Júlia Llompart, Mariona Pascual, Naymé Salas and Claudia Vallejo are Early Career Researchers in the Department of Language and Literature Education and Social Science Education at the Universitat Autònoma de Barcelona. In this interview they were asked to reflect on their experiences as researchers in times of the COVID-19 pandemic. Cristina Aliagas, Júlia Llompart, Mariona Pascual, Naymé Salas i Claudia Vallejo són investigadores en etapes inicials o de consolidació de la seva carrera acadèmica del Departament de Didàctica de la Llengua, la Literatura i de les Ciències Socials de la Universitat Autònoma de Barcelona. En aquesta entrevista se'ls va demanar que reflexionessin sobre les seves experiències com a investigadores en temps de la pandèmia de la COVID-19. Cristina Aliagas, Júlia Llompart, Mariona Pascual, Naymé Salas y Claudia Vallejo son investigadoras en etapas iniciales o de consolidación de su carrera académica del Departamento de Didáctica de la Lengua, la Literatura y de las Ciencias Sociales de la Universitat Autònoma de Barcelona. En esta entrevista se les pidió que reflexionaran sobre sus experiencias como investigadoras en tiempos de la pandemia de la COVID-19. Cristina Aliagas, Júlia Llompart, Mariona Pascual, Naymé Salas et Claudia Vallejo sont des chercheures en phase initiale ou de consolidation de leur carrière académique au Département de Didactique du Langue, de la Littérature et des Sciences Sociales de l'Universitat Autònoma de Barcelona. Dans cet entretien, on leur a demandé de réfléchir à leurs expériences en tant que chercheures pendant la pandémie COVID-19.

  • Open Access English
    Authors: 
    Nakanishi, Tomoko; Pigazzini, Sara; Degenhardt, Frauke; Cordioli, Mattia; Butler-Laporte, Guillaume; Maya-Miles, Douglas; Nafría-Jiménez, Beatriz; Bouysran, Youssef; Niemi, Mari; Palom, Adriana; +55 more
    Publisher: American Society for Clinical Investigation
    Countries: Denmark, Spain, Germany, Italy, Spain, Spain, Spain, Belgium, Belgium
    Project: EC | LITMUS (777377)

    AG has received support by NordForsk Nordic Trial Alliance (NTA) grant, by Academy of Finland Fellow grant N. 323116 and the Academy of Finland for PREDICT consortium N. 340541. The Richards research group is supported by the Canadian Institutes of Health Research (CIHR) (365825 and 409511), the Lady Davis Institute of the Jewish General Hospital, the Canadian Foundation for Innovation (CFI), the NIH Foundation, Cancer Research UK, Genome Québec, the Public Health Agency of Canada, the McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé (FRQS). TN is supported by a research fellowship of the Japan Society for the Promotion of Science for Young Scientists. GBL is supported by a CIHR scholarship and a joint FRQS and Québec Ministry of Health and Social Services scholarship. JBR is supported by an FRQS Clinical Research Scholarship. Support from Calcul Québec and Compute Canada is acknowledged. TwinsUK is funded by the Welcome Trust, the Medical Research Council, the European Union, the National Institute for Health Research-funded BioResource and the Clinical Research Facility and Biomedical Research Centre based at Guy’s and St. Thomas’ NHS Foundation Trust in partnership with King’s College London. The Biobanque Québec COVID19 is funded by FRQS, Genome Québec and the Public Health Agency of Canada, the McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé. These funding agencies had no role in the design, implementation or interpretation of this study. The COVID19-Host(a)ge study received infrastructure support from the DFG Cluster of Excellence 2167 “Precision Medicine in Chronic Inflammation (PMI)” (DFG Grant: “EXC2167”). The COVID19-Host(a)ge study was supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the Computational Life Sciences funding concept (CompLS grant 031L0165). Genotyping in COVID19-Host(a)ge was supported by a philantropic donation from Stein Erik Hagen. The COVID GWAs, Premed COVID-19 study (COVID19-Host(a)ge_3) was supported by "Grupo de Trabajo en Medicina Personalizada contra el COVID-19 de Andalucia"and also by the Instituto de Salud Carlos III (CIBERehd and CIBERER). Funding comes from COVID-19-GWAS, COVID-PREMED initiatives. Both of them are supported by "Consejeria de Salud y Familias" of the Andalusian Government. DMM is currently funded by the the Andalussian government (Proyectos Estratégicos-Fondos Feder PE-0451-2018). The Columbia University Biobank was supported by Columbia University and the National Center for Advancing Translational Sciences, NIH, through Grant Number UL1TR001873. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or Columbia University. The SPGRX study was supported by the Consejería de Economía, Conocimiento, Empresas y Universidad #CV20-10150. The GEN-COVID study was funded by: the MIUR grant “Dipartimenti di Eccellenza 2018-2020” to the Department of Medical Biotechnologies University of Siena, Italy; the “Intesa San Paolo 2020 charity fund” dedicated to the project NB/2020/0119; and philanthropic donations to the Department of Medical Biotechnologies, University of Siena for the COVID-19 host genetics research project (D.L n.18 of March 17, 2020). Part of this research project is also funded by Tuscany Region “Bando Ricerca COVID-19 Toscana” grant to the Azienda Ospedaliero Universitaria Senese (CUP I49C20000280002). Authors are grateful to: the CINECA consortium for providing computational resources; the Network for Italian Genomes (NIG) (http://www.nig.cineca.it) for its support; the COVID-19 Host Genetics Initiative (https://www.covid19hg.org/); the Genetic Biobank of Siena, member of BBMRI-IT, Telethon Network of Genetic Biobanks (project no. GTB18001), EuroBioBank, and RD-Connect, for managing specimens. Genetics against coronavirus (GENIUS), Humanitas University (COVID19-Host(a)ge_4) was supported by Ricerca Corrente (Italian Ministry of Health), intramural funding (Fondazione Humanitas per la Ricerca). The generous contribution of Banca Intesa San Paolo and of the Dolce&Gabbana Fashion Firm is gratefully acknowledged. Data acquisition and sample processing was supported by COVID-19 Biobank, Fondazione IRCCS Cà Granda Milano; LV group was supported by MyFirst Grant AIRC n.16888, Ricerca Finalizzata Ministero della Salute RF-2016-02364358, Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, the European Union (EU) Programme Horizon 2020 (under grant agreement No. 777377) for the project LITMUS- “Liver Investigation: Testing Marker Utility in Steatohepatitis”, Programme “Photonics” under grant agreement “101016726” for the project “REVEAL: Neuronal microscopy for cell behavioural examination and manipulation”, Fondazione Patrimonio Ca’ Granda “Liver Bible” PR-0361. DP was supported by Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, CV PREVITAL “Strategie di prevenzione primaria nella popolazione Italiana” Ministero della Salute, and Associazione Italiana per la Prevenzione dell’Epatite Virale (COPEV). Genetic modifiers for COVID-19 related illness (BeLCovid_1) was supported by the "Fonds Erasme". The Host genetics and immune response in SARS-Cov-2 infection (BelCovid_2) study was supported by grants from Fondation Léon Fredericq and from Fonds de la Recherche Scientifique (FNRS). The INMUNGEN-CoV2 study was funded by the Consejo Superior de Investigaciones Científicas. KUL is supported by the German Research Foundation (LU 1944/3-1) SweCovid is funded by the SciLifeLab/KAW national COVID-19 research program project grant to Michael Hultström (KAW 2020.0182) and the Swedish Research Council to Robert Frithiof (2014-02569 and 2014-07606). HZ is supported by Jeansson Stiftelser, Magnus Bergvalls Stiftelse. The COMRI cohort is funded by Technical University of Munich, Munich, Germany. Genotyping for the COMRI cohort was performed and funded by the Genotyping Laboratory of Institute for Molecular Medicine Finland FIMM Technology Centre, University of Helsinki, Helsinki, Finland. These funding agencies had no role in the design, implementation or interpretation of this study. Background: There is considerable variability in COVID-19 outcomes amongst younger adults—and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium. Method: The major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by age and were independent from known clinical COVID-19 risk factors. Findings: We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (hazard ratio [HR] 1·4, 95% confidence interval [CI] 1·2–1·6) and COVID-19 related mortality (HR 1·5, 95%CI 1·3–1·8). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (odds ratio [OR] 2·0, 95%CI 1·6-2·6), venous thromboembolism (OR 1·7, 95%CI 1·2-2·4), and hepatic injury (OR 1·6, 95%CI 1·2-2·0). Risk allele carriers ≤ 60 years had higher odds of death or severe respiratory failure (OR 2·6, 95%CI 1·8-3·9) compared to those > 60 years OR 1·5 (95%CI 1·3-1·9, interaction p-value=0·04). Amongst individuals ≤ 60 years who died or experienced severe respiratory COVID-19 outcome, we found that 31·8% (95%CI 27·6-36·2) were risk variant carriers, compared to 13·9% (95%CI 12·6-15·2%) of those not experiencing these outcomes. Prediction of death or severe respiratory failure among those ≤ 60 years improved when including the risk allele (AUC 0·82 vs 0·84, p=0·016) and the prediction ability of rs10490770 risk allele was similar to, or better than, most established clinical risk factors. Interpretation: The major common COVID-19 risk locus on chromosome 3 is associated with increased risks of morbidity and mortality—and these are more pronounced amongst individuals ≤ 60 years. The effect on COVID-19 severity was similar to, or larger than most established risk factors, suggesting potential implications for clinical risk management. CV PREVITAL “Strategie di prevenzione primaria nella popolazione Italiana” Ministero della Salute, and Associazione Italiana per la Prevenzione dell’Epatite Virale (COPEV) Genotyping Laboratory of Institute for Molecular Medicine Finland FIMM Technology Centre, University of Helsinki, Helsinki, Finland Clinical Research Facility and Biomedical Research Centre based at Guy’s and St. Thomas’ NHS Foundation Trust McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé (FRQS) CIHR scholarship and a joint FRQS and Québec Ministry of Health and Social Services scholarship European Union (EU) Programme Horizon 2020 (under grant agreement No. 777377) "Grupo de Trabajo en Medicina Personalizada contra el COVID-19 de Andalucia" “Intesa San Paolo 2020 charity fund” dedicated to the project NB/2020/0119 Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico SciLifeLab/KAW national COVID-19 research program project (KAW 2020.0182) Andalusian government (Proyectos Estratégicos-Fondos Feder PE-0451-2018) Consejería de Economía, Conocimiento, Empresas y Universidad #CV20-10150 Canadian Institutes of Health Research (CIHR) (365825 and 409511) Japan Society for the Promotion of Science for Young Scientists "Consejeria de Salud y Familias" of the Andalusian Government McGill Interdisciplinary Initiative in Infection and Immunity Ricerca Finalizzata Ministero della Salute RF-2016-02364358 National Institute for Health Research-funded BioResource Fondazione Patrimonio Ca’ Granda “Liver Bible” PR-0361 Swedish Research Council (2014-02569 and 2014-07606) Instituto de Salud Carlos III (CIBERehd and CIBERER) National Center for Advancing Translational Sciences Academy of Finland for PREDICT consortium N. 340541. Lady Davis Institute of the Jewish General Hospital MIUR grant “Dipartimenti di Eccellenza 2018-2020” Technical University of Munich, Munich, Germany Jeansson Stiftelser, Magnus Bergvalls Stiftelse Tuscany Region “Bando Ricerca COVID-19 Toscana” Consejo Superior de Investigaciones Científicas Ricerca Corrente (Italian Ministry of Health) Academy of Finland Fellow grant N. 323116 Fonds de la Recherche Scientifique (FNRS) German Research Foundation (LU 1944/3-1) Canadian Foundation for Innovation (CFI) Fondazione Humanitas per la Ricerca FRQS Clinical Research Scholarship Fondazione IRCCS Cà Granda Milano Network for Italian Genomes (NIG) COVID-19 Host Genetics Initiative Fonds de Recherche Québec Santé Public Health Agency of Canada NIH Grant Number UL1TR001873 Dolce&Gabbana Fashion Firm MyFirst Grant AIRC n.16888 COVID-PREMED initiatives Genetic Biobank of Siena Fondation Léon Fredericq “Photonics” “101016726” (CompLS grant 031L0165) Banca Intesa San Paolo Medical Research Counc (DFG Grant: “EXC2167”) King’s College London Columbia University Cancer Research UK CINECA consortium COVID-19 Biobank Stein Erik Hagen Compute Canada "Fonds Erasme" NIH Foundation European Union Genome Québec COVID-19-GWAS Calcul Québec Welcome Trust EuroBioBank RD-Connect

  • Open Access English
    Authors: 
    Charalampos Attipa; Kyriaki Neofytou; Christos Yiapanis; Pamela Martínez-Orellana; Gad Baneth; Yaarit Nachum-Biala; Harriet Brooks-Brownlie; Laia Solano-Gallego; Séverine Tasker;
    Publisher: SAGE Publications
    Countries: United Kingdom, United Kingdom, Spain

    Case summary A 6-year-old female neutered domestic shorthair cat from Cyprus was presented with multiple ulcerated skin nodules. Cytology and histopathology of the lesions revealed granulomatous dermatitis with intracytoplasmic organisms, consistent with amastigotes of Leishmania species. Biochemistry identified a mild hyperproteinaemia. Blood extraction and PCR detected Leishmania species, Hepatozoon species and ‘ Candidatus Mycoplasma haemominutum’ (CMhm) DNA. Subsequent sequencing identified Hepatozoon felis. Additionally, the rRNA internal transcribed spacer 1 locus of Leishmania infantum was partially sequenced and phylogeny showed it to cluster with species derived from dogs in Italy and Uzbekistan, and a human in France. Allopurinol treatment was administered for 6 months. Clinical signs resolved in the second month of treatment with no deterioration 8 months post-treatment cessation. Quantitative PCR and ELISA were used to monitor L infantum blood DNA and antibody levels. The cat had high L infantum DNA levels pretreatment that gradually declined during treatment but increased 8 months post-treatment cessation. Similarly, ELISA revealed high levels of antibodies pretreatment, which gradually declined during treatment and increased slightly 8 months post-treatment cessation. The cat remained PCR positive for CMhm and Hepatozoon species throughout the study. There was no clinical evidence of relapse 24 months post-treatment. Relevance and novel information To our knowledge, this is the first clinical report of a cat with leishmaniosis with H felis and CMhm coinfections. The high L infantum DNA levels post-treatment cessation might indicate that although the lesions had resolved, prolonged or an alternative treatment could have been considered.

  • Open Access English
    Authors: 
    Leira Fernández-Bastit; Núria Roca; Miguel Romero-Durana; Jordi Rodon; Guillermo Cantero; Óscar García; Carlos López; Mònica Pérez; Rosa López; Jorge Carrillo; +7 more
    Publisher: Multidisciplinary Digital Publishing Institute
    Country: Spain

    A wide range of animal species are susceptible to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Natural and/or experimental infections have been reported in pet, zoo, farmed and wild animals. Interestingly, some SARS-CoV-2 variants, such as B.1.1.7/Alpha, B.1.351/Beta, and B.1.1.529/Omicron, were demonstrated to infect some animal species not susceptible to classical viral variants. The present study aimed to elucidate if goats (Capra aegagrus hircus) are susceptible to the B.1.351/Beta variant. First, an in silico approach was used to predict the affinity between the receptor-binding domain of the spike protein of SARS-CoV-2 B.1.351/Beta variant and angiotensin-converting enzyme 2 from goats. Moreover, we performed an experimental inoculation with this variant in domestic goat and showed evidence of infection. SARS-CoV-2 was detected in nasal swabs and tissues by RT-qPCR and/or immunohistochemistry, and seroneutralisation was confirmed via ELISA and live virus neutralisation assays. However, the viral amount and tissue distribution suggest a low susceptibility of goats to the B.1.351/Beta variant. Therefore, although monitoring livestock is advisable, it is unlikely that goats play a role as SARS-CoV-2 reservoir species, and they are not useful surrogates to study SARS-CoV-2 infection in farmed animals.

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244 Research products, page 1 of 25
  • Open Access English
    Authors: 
    Júlia Vergara-Alert; Enric Vidal; Albert Bensaid; Joaquim Segalés;
    Publisher: Elsevier BV
    Country: Spain
    Project: EC | ZAPI (115760)

    Emerging and re-emerging pathogens represent a substantial threat to public health, as demonstrated with numerous outbreaks over the past years, including the 2013–2016 outbreak of Ebola virus in western Africa. Coronaviruses are also a threat for humans, as evidenced in 2002/2003 with infection by the severe acute respiratory syndrome coronavirus (SARS-CoV), which caused more than 8000 human infections with 10% fatality rate in 37 countries. Ten years later, a novel human coronavirus (Middle East respiratory syndrome coronavirus, MERS-CoV), associated with severe pneumonia, arose in the Kingdom of Saudi Arabia. Until December 2016, MERS has accounted for more than 1800 cases and 35% fatality rate. Finding an animal model of disease is key to develop vaccines or antivirals against such emerging pathogens and to understand its pathogenesis. Knowledge of the potential role of domestic livestock and other animal species in the transmission of pathogens is of importance to understand the epidemiology of the disease. Little is known about MERS-CoV animal host range. In this paper, experimental data on potential hosts for MERS-CoV is reviewed. Advantages and limitations of different animal models are evaluated in relation to viral pathogenesis and transmission studies. Finally, the relevance of potential new target species is discussed.

  • Open Access English
    Authors: 
    Blanca León-Nabal; Cristina Zhang-Yu; José Luis Lalueza;
    Publisher: Frontiers Media S.A.
    Country: Spain

    The COVID-19 pandemic has sharpened the inequalities in our societies. In Spain, we observed that the impact on schooling varied according to socioeconomic, gender and sociocultural variables. In this article, we present a case analysis illustrating the impact of the COVID-19 pandemic on schooling in early educational grades (ages 3–6), which leads us to focus on school-family relationship. First, we present some studies that show the inequalities in education during the lockdown period, the digital divide faced by both schools and families and how digital mediation impacts school-family relationships. Then we will introduce our study, which aims to explore the uses, potentials and limitations of an app intended to facilitate the relationship. Our study took place during September 2020-January 2021, when social restriction persisted. It took the form of a telematic ethnography in which we monitored the meetings of the Early Childhood Education teachers and their interaction with the families via an app-based communication tool. Results have allowed us to identify that most conversations are initiated by the school and their aim is to show families the classroom activities. We have also observed some advantages regarding the use of this app: communication can become more direct and immediate, and teachers have developed strategies to foster proximity in this relationship, as well as to respond inclusively to diversity. Regarding the challenges, we identified the lack of involvement of some families, the need to transform the roles played by families and children, and the difficulty to maintain personalized relationships This research was funded by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO), the Spanish State Research Agency (AEI), and the European Regional Development Funds (European Union), grant number EDU2017-83363-R

  • Open Access English
    Authors: 
    Albiol, Nil; Aso, Olga; Gómez-Pérez, Lucía; Triquell, Mercè; Roch, Nerea; Lázaro, Elisabeth; Esquirol, Albert; González, Iria; López-Contreras, Joaquín; Sierra, Jorge; +3 more
    Country: Spain
  • Open Access English
    Authors: 
    Aguilar-Martínez, Alicia; Bosque Prous, Marina; González-Casals, Helena; Colillas-Malet, Ester; Puigcorbé, Susanna; Esquius, Laura; Espelt, Albert; Universitat Central de Catalunya;
    Country: Spain

    Adolescence is a critical period in the consolidation of healthy lifestyles that can last into adulthood. To analyze changes in food consumption and eating behaviors in high-school adolescents during the first confinement, a cross-sectional study was conducted at the end of confinement in Spain. Changes in the frequency or quantity of consumption of different types of food and food-related behaviors were analyzed. Socioeconomic and health-related variables were also considered. To determine whether dietary changes were related to socioeconomic position (SEP), Poisson regression models with robust variance were estimated. Overall, there were some changes towards a healthier diet such as an increase in fruit consumption (38.9%) and a decrease in the consumption of soft drinks (49.8%), sweets and pastries (39.3%), and convenience foods (49.2%). Some changes, however, were related to less healthy behaviors, such as a more irregular pattern of meal distribution (39.9%) or an increase in snacking between meals (56.4%). Changes towards less healthy eating were also related to students’ SEP. The risk of worsening the diet was found to be 21% higher in adolescents from a more disadvantaged SEP. Future public policies could be adapted to avoid increasing nutritional and health inequalities.

  • Open Access English
    Authors: 
    López Monteiro, Marcial;
    Country: Spain

    En el siguiente trabajo de investigación se analizan una serie de aspectos relacionados con la motivación en la educación secundaria y se propone una acción educativa con unas metas, métodos, tareas y evaluación diferentes con respecto a la metodología tradicional, con el objetivo de comparar el valor motivador de ambas. La primera parte de este estudio refleja algunas de las ideas recogidas en trabajos llevados a cabo por expertos en la materia, como J. Alonso Tapia o Miguel Ángel Broc Cavero, entre otros. Estos autores intentan explicar, entre otras cuestiones, qué es la motivación, qué distingue a un alumno motivado de un alumno no motivado o cuáles son los rasgos propios de los alumnos motivados. En la segunda parte del estudio se propone una acción educativa de seis meses (dos trimestres) orientada a medir la motivación de los alumnos en comparación con las metodologías tradicionales. La acción educativa se caracteriza por establecer unas metas claras, así como una serie de tareas que pretender emocionar al alumno e identificarlo mucho más con los contenidos. El trabajo se centrará en alumnos de 2.º de ESO del Institut Baix a Mar de Vilanova i la Geltrú. Se pretende que los alumnos puedan trabajar tanto de forma autónoma como en equipo, usando su imaginación y creatividad, y desarrollando su espíritu crítico. Asimismo, el fruto de su trabajo se irá plasmando en una página web para que puedan ver resultados inmediatos. Si bien esta última parte no ha podido ser llevada a la práctica debido a la situación excepcional provocada por la COVID-19, la intención es hacerlo en cuanto la situación se normalice. En el següent treball de recerca s’analitzen una sèrie d’aspectes relacionats amb la motivació en l’educació secundària i es proposa una acció educativa amb unes metes, mètodes, tasques i avaluació diferents respecte a la metodologia tradicional, amb l’objectiu de comparar el valor motivador d’ambdues. La primera part d’aquest estudi reflecteix algunes de les idees recollides en treballs duts a terme per experts en la matèria, com a J. Alonso Tapia o Miguel Ángel Broc Cavero, entre altres. Aquests autors intenten explicar, entre altres qüestions, què és la motivació, què distingeix a un alumne motivat d’un alumne no motivat o quins són els trets propis dels alumnes motivats. En la segona part de l’estudi es proposa una acció educativa de sis mesos (dos trimestres) orientada a mesurar la motivació dels alumnes en comparació amb les metodologies tradicionals. L’acció educativa es caracteritza per establir unes metes clares, així com una sèrie de tasques que pretenen emocionar a l’alumne i identificar-lo molt més amb els continguts. El treball se centrarà en alumnes de 2n d’ESO del Institut Baix a Mar de Vilanova i la Geltrú. Es pretén que els alumnes puguin treballar tant de manera autònoma com en equip, usant la seva imaginació i creativitat, i desenvolupant el seu esperit crític. Així mateix, el fruit del seu treball s’anirà plasmant en una pàgina web perquè puguin veure resultats immediats. Si bé aquesta última part no ha pogut ser portada a la pràctica a causa de la situació excepcional provocada per la COVID-19, la intenció és fer-ho quan la situació es normalitzi. The following research paper analyses a series of aspects related to motivation in secondary education and proposes an educational action with different goals, methods, tasks and evaluation with respect to traditional methodology, with the aim of comparing the motivational value of both. The first part of this study reflects some of the ideas gathered in works carried out by experts in the field, such as J. Alonso Tapia or Miguel Ángel Broc Cavero, among others. These authors try to define the concept of motivation, what distinguishes a motivated student from an unmotivated student, or what are the traits of motivated students. The second part of the study proposes a six months educational action (two terms) aimed at measuring the motivation of students in comparison with traditional methodologies. The educational action is characterised by establishing clear goals, as well as a series of tasks that aim to move the students and identify them much more with the contents. The work will be focused on 2nd year students of the Institut Baix a Mar in Vilanova i la Geltrú. The aim is for the students to be able to work both independently and in a team, using their imagination and creativity, and developing their critical spirit. Likewise, the fruit of their work will be reflected in a web page so that they can see immediate results. Due to the exceptional situation caused by COVID-19, it was not possible to implement these measures, and their application will be postponed until the situation is normalised.

  • Open Access English
    Authors: 
    Jireh, Ejoku; Ngalyuka Nzau, Julius;
    Country: Spain

    The article compares the way COVID-19 has been managed in the East African Community and in the EU. How were the initial measures in each of the regions and what have been the consequences of the measures adopted, especially those related to confinement and vaccination. It discusses how the strength of European integration and the notable economic and technological development of its member states have provided a comparative advantage over the resources available to the East African Community. They conclude that, in addition to the undoubted importance of advancing in economic development, continuing to deepen regional cooperation in African territory would be an opportunity to better manage future threats. L'article compara la manera com s'ha gestionat la COVID-19 a la Comunitat d'Àfrica Oriental ia la UE. Com van ser les mesures inicials a cadascuna de les regions i quines han estat les conseqüències que han tingut les mesures adoptades, especialment les relacionades amb el confinament i la vacunació. Planteja com la solidesa de la integració europea i el notable desenvolupament econòmic i tecnològic dels seus Estats membres han suposat un avantatge comparatiu respecte als recursos amb què han comptat la Comunitat de l'Àfrica Oriental. Conclouen que, a més de la importància indubtable d'avançar en el desenvolupament econòmic, continuar aprofundint en la cooperació regional en territori africà suposaria una oportunitat per poder gestionar millor amenaces futures. El artículo compara la forma en que se ha gestionado la COVID-19 en la Comunidad de África Oriental y en la UE. Cómo fueron las medidas iniciales en cada una de las regiones y cuáles han sido las consecuencias que han tenido las medidas adoptadas, especialmente las relacionadas con el confinamiento y la vacunación. Plantea cómo la solidez de la integración europea y el notable desarrollo económico y tecnológico de sus Estados miembros han supuesto una ventaja comparativa, respecto a los recursos con los que han contado la Comunidad de África Oriental. Concluyen que, además de la indudable importancia de avanzar en el desarrollo económico, seguir profundizando en la cooperación regional en territorio africano supondría una oportunidad para poder gestionar mejor futuras amenazas.

  • Publication . Article . 2021
    Open Access English
    Authors: 
    Liu, Yuyu; Aliagas, Cristina; Llompart Esbert, Julia; Pascual, Mariona; Salas, Naymé; Vallejo Rubinstein, Claudia;
    Country: Spain

    Cristina Aliagas, Júlia Llompart, Mariona Pascual, Naymé Salas and Claudia Vallejo are Early Career Researchers in the Department of Language and Literature Education and Social Science Education at the Universitat Autònoma de Barcelona. In this interview they were asked to reflect on their experiences as researchers in times of the COVID-19 pandemic. Cristina Aliagas, Júlia Llompart, Mariona Pascual, Naymé Salas i Claudia Vallejo són investigadores en etapes inicials o de consolidació de la seva carrera acadèmica del Departament de Didàctica de la Llengua, la Literatura i de les Ciències Socials de la Universitat Autònoma de Barcelona. En aquesta entrevista se'ls va demanar que reflexionessin sobre les seves experiències com a investigadores en temps de la pandèmia de la COVID-19. Cristina Aliagas, Júlia Llompart, Mariona Pascual, Naymé Salas y Claudia Vallejo son investigadoras en etapas iniciales o de consolidación de su carrera académica del Departamento de Didáctica de la Lengua, la Literatura y de las Ciencias Sociales de la Universitat Autònoma de Barcelona. En esta entrevista se les pidió que reflexionaran sobre sus experiencias como investigadoras en tiempos de la pandemia de la COVID-19. Cristina Aliagas, Júlia Llompart, Mariona Pascual, Naymé Salas et Claudia Vallejo sont des chercheures en phase initiale ou de consolidation de leur carrière académique au Département de Didactique du Langue, de la Littérature et des Sciences Sociales de l'Universitat Autònoma de Barcelona. Dans cet entretien, on leur a demandé de réfléchir à leurs expériences en tant que chercheures pendant la pandémie COVID-19.

  • Open Access English
    Authors: 
    Nakanishi, Tomoko; Pigazzini, Sara; Degenhardt, Frauke; Cordioli, Mattia; Butler-Laporte, Guillaume; Maya-Miles, Douglas; Nafría-Jiménez, Beatriz; Bouysran, Youssef; Niemi, Mari; Palom, Adriana; +55 more
    Publisher: American Society for Clinical Investigation
    Countries: Denmark, Spain, Germany, Italy, Spain, Spain, Spain, Belgium, Belgium
    Project: EC | LITMUS (777377)

    AG has received support by NordForsk Nordic Trial Alliance (NTA) grant, by Academy of Finland Fellow grant N. 323116 and the Academy of Finland for PREDICT consortium N. 340541. The Richards research group is supported by the Canadian Institutes of Health Research (CIHR) (365825 and 409511), the Lady Davis Institute of the Jewish General Hospital, the Canadian Foundation for Innovation (CFI), the NIH Foundation, Cancer Research UK, Genome Québec, the Public Health Agency of Canada, the McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé (FRQS). TN is supported by a research fellowship of the Japan Society for the Promotion of Science for Young Scientists. GBL is supported by a CIHR scholarship and a joint FRQS and Québec Ministry of Health and Social Services scholarship. JBR is supported by an FRQS Clinical Research Scholarship. Support from Calcul Québec and Compute Canada is acknowledged. TwinsUK is funded by the Welcome Trust, the Medical Research Council, the European Union, the National Institute for Health Research-funded BioResource and the Clinical Research Facility and Biomedical Research Centre based at Guy’s and St. Thomas’ NHS Foundation Trust in partnership with King’s College London. The Biobanque Québec COVID19 is funded by FRQS, Genome Québec and the Public Health Agency of Canada, the McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé. These funding agencies had no role in the design, implementation or interpretation of this study. The COVID19-Host(a)ge study received infrastructure support from the DFG Cluster of Excellence 2167 “Precision Medicine in Chronic Inflammation (PMI)” (DFG Grant: “EXC2167”). The COVID19-Host(a)ge study was supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the Computational Life Sciences funding concept (CompLS grant 031L0165). Genotyping in COVID19-Host(a)ge was supported by a philantropic donation from Stein Erik Hagen. The COVID GWAs, Premed COVID-19 study (COVID19-Host(a)ge_3) was supported by "Grupo de Trabajo en Medicina Personalizada contra el COVID-19 de Andalucia"and also by the Instituto de Salud Carlos III (CIBERehd and CIBERER). Funding comes from COVID-19-GWAS, COVID-PREMED initiatives. Both of them are supported by "Consejeria de Salud y Familias" of the Andalusian Government. DMM is currently funded by the the Andalussian government (Proyectos Estratégicos-Fondos Feder PE-0451-2018). The Columbia University Biobank was supported by Columbia University and the National Center for Advancing Translational Sciences, NIH, through Grant Number UL1TR001873. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or Columbia University. The SPGRX study was supported by the Consejería de Economía, Conocimiento, Empresas y Universidad #CV20-10150. The GEN-COVID study was funded by: the MIUR grant “Dipartimenti di Eccellenza 2018-2020” to the Department of Medical Biotechnologies University of Siena, Italy; the “Intesa San Paolo 2020 charity fund” dedicated to the project NB/2020/0119; and philanthropic donations to the Department of Medical Biotechnologies, University of Siena for the COVID-19 host genetics research project (D.L n.18 of March 17, 2020). Part of this research project is also funded by Tuscany Region “Bando Ricerca COVID-19 Toscana” grant to the Azienda Ospedaliero Universitaria Senese (CUP I49C20000280002). Authors are grateful to: the CINECA consortium for providing computational resources; the Network for Italian Genomes (NIG) (http://www.nig.cineca.it) for its support; the COVID-19 Host Genetics Initiative (https://www.covid19hg.org/); the Genetic Biobank of Siena, member of BBMRI-IT, Telethon Network of Genetic Biobanks (project no. GTB18001), EuroBioBank, and RD-Connect, for managing specimens. Genetics against coronavirus (GENIUS), Humanitas University (COVID19-Host(a)ge_4) was supported by Ricerca Corrente (Italian Ministry of Health), intramural funding (Fondazione Humanitas per la Ricerca). The generous contribution of Banca Intesa San Paolo and of the Dolce&Gabbana Fashion Firm is gratefully acknowledged. Data acquisition and sample processing was supported by COVID-19 Biobank, Fondazione IRCCS Cà Granda Milano; LV group was supported by MyFirst Grant AIRC n.16888, Ricerca Finalizzata Ministero della Salute RF-2016-02364358, Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, the European Union (EU) Programme Horizon 2020 (under grant agreement No. 777377) for the project LITMUS- “Liver Investigation: Testing Marker Utility in Steatohepatitis”, Programme “Photonics” under grant agreement “101016726” for the project “REVEAL: Neuronal microscopy for cell behavioural examination and manipulation”, Fondazione Patrimonio Ca’ Granda “Liver Bible” PR-0361. DP was supported by Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, CV PREVITAL “Strategie di prevenzione primaria nella popolazione Italiana” Ministero della Salute, and Associazione Italiana per la Prevenzione dell’Epatite Virale (COPEV). Genetic modifiers for COVID-19 related illness (BeLCovid_1) was supported by the "Fonds Erasme". The Host genetics and immune response in SARS-Cov-2 infection (BelCovid_2) study was supported by grants from Fondation Léon Fredericq and from Fonds de la Recherche Scientifique (FNRS). The INMUNGEN-CoV2 study was funded by the Consejo Superior de Investigaciones Científicas. KUL is supported by the German Research Foundation (LU 1944/3-1) SweCovid is funded by the SciLifeLab/KAW national COVID-19 research program project grant to Michael Hultström (KAW 2020.0182) and the Swedish Research Council to Robert Frithiof (2014-02569 and 2014-07606). HZ is supported by Jeansson Stiftelser, Magnus Bergvalls Stiftelse. The COMRI cohort is funded by Technical University of Munich, Munich, Germany. Genotyping for the COMRI cohort was performed and funded by the Genotyping Laboratory of Institute for Molecular Medicine Finland FIMM Technology Centre, University of Helsinki, Helsinki, Finland. These funding agencies had no role in the design, implementation or interpretation of this study. Background: There is considerable variability in COVID-19 outcomes amongst younger adults—and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium. Method: The major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by age and were independent from known clinical COVID-19 risk factors. Findings: We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (hazard ratio [HR] 1·4, 95% confidence interval [CI] 1·2–1·6) and COVID-19 related mortality (HR 1·5, 95%CI 1·3–1·8). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (odds ratio [OR] 2·0, 95%CI 1·6-2·6), venous thromboembolism (OR 1·7, 95%CI 1·2-2·4), and hepatic injury (OR 1·6, 95%CI 1·2-2·0). Risk allele carriers ≤ 60 years had higher odds of death or severe respiratory failure (OR 2·6, 95%CI 1·8-3·9) compared to those > 60 years OR 1·5 (95%CI 1·3-1·9, interaction p-value=0·04). Amongst individuals ≤ 60 years who died or experienced severe respiratory COVID-19 outcome, we found that 31·8% (95%CI 27·6-36·2) were risk variant carriers, compared to 13·9% (95%CI 12·6-15·2%) of those not experiencing these outcomes. Prediction of death or severe respiratory failure among those ≤ 60 years improved when including the risk allele (AUC 0·82 vs 0·84, p=0·016) and the prediction ability of rs10490770 risk allele was similar to, or better than, most established clinical risk factors. Interpretation: The major common COVID-19 risk locus on chromosome 3 is associated with increased risks of morbidity and mortality—and these are more pronounced amongst individuals ≤ 60 years. The effect on COVID-19 severity was similar to, or larger than most established risk factors, suggesting potential implications for clinical risk management. CV PREVITAL “Strategie di prevenzione primaria nella popolazione Italiana” Ministero della Salute, and Associazione Italiana per la Prevenzione dell’Epatite Virale (COPEV) Genotyping Laboratory of Institute for Molecular Medicine Finland FIMM Technology Centre, University of Helsinki, Helsinki, Finland Clinical Research Facility and Biomedical Research Centre based at Guy’s and St. Thomas’ NHS Foundation Trust McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé (FRQS) CIHR scholarship and a joint FRQS and Québec Ministry of Health and Social Services scholarship European Union (EU) Programme Horizon 2020 (under grant agreement No. 777377) "Grupo de Trabajo en Medicina Personalizada contra el COVID-19 de Andalucia" “Intesa San Paolo 2020 charity fund” dedicated to the project NB/2020/0119 Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico SciLifeLab/KAW national COVID-19 research program project (KAW 2020.0182) Andalusian government (Proyectos Estratégicos-Fondos Feder PE-0451-2018) Consejería de Economía, Conocimiento, Empresas y Universidad #CV20-10150 Canadian Institutes of Health Research (CIHR) (365825 and 409511) Japan Society for the Promotion of Science for Young Scientists "Consejeria de Salud y Familias" of the Andalusian Government McGill Interdisciplinary Initiative in Infection and Immunity Ricerca Finalizzata Ministero della Salute RF-2016-02364358 National Institute for Health Research-funded BioResource Fondazione Patrimonio Ca’ Granda “Liver Bible” PR-0361 Swedish Research Council (2014-02569 and 2014-07606) Instituto de Salud Carlos III (CIBERehd and CIBERER) National Center for Advancing Translational Sciences Academy of Finland for PREDICT consortium N. 340541. Lady Davis Institute of the Jewish General Hospital MIUR grant “Dipartimenti di Eccellenza 2018-2020” Technical University of Munich, Munich, Germany Jeansson Stiftelser, Magnus Bergvalls Stiftelse Tuscany Region “Bando Ricerca COVID-19 Toscana” Consejo Superior de Investigaciones Científicas Ricerca Corrente (Italian Ministry of Health) Academy of Finland Fellow grant N. 323116 Fonds de la Recherche Scientifique (FNRS) German Research Foundation (LU 1944/3-1) Canadian Foundation for Innovation (CFI) Fondazione Humanitas per la Ricerca FRQS Clinical Research Scholarship Fondazione IRCCS Cà Granda Milano Network for Italian Genomes (NIG) COVID-19 Host Genetics Initiative Fonds de Recherche Québec Santé Public Health Agency of Canada NIH Grant Number UL1TR001873 Dolce&Gabbana Fashion Firm MyFirst Grant AIRC n.16888 COVID-PREMED initiatives Genetic Biobank of Siena Fondation Léon Fredericq “Photonics” “101016726” (CompLS grant 031L0165) Banca Intesa San Paolo Medical Research Counc (DFG Grant: “EXC2167”) King’s College London Columbia University Cancer Research UK CINECA consortium COVID-19 Biobank Stein Erik Hagen Compute Canada "Fonds Erasme" NIH Foundation European Union Genome Québec COVID-19-GWAS Calcul Québec Welcome Trust EuroBioBank RD-Connect

  • Open Access English
    Authors: 
    Charalampos Attipa; Kyriaki Neofytou; Christos Yiapanis; Pamela Martínez-Orellana; Gad Baneth; Yaarit Nachum-Biala; Harriet Brooks-Brownlie; Laia Solano-Gallego; Séverine Tasker;
    Publisher: SAGE Publications
    Countries: United Kingdom, United Kingdom, Spain

    Case summary A 6-year-old female neutered domestic shorthair cat from Cyprus was presented with multiple ulcerated skin nodules. Cytology and histopathology of the lesions revealed granulomatous dermatitis with intracytoplasmic organisms, consistent with amastigotes of Leishmania species. Biochemistry identified a mild hyperproteinaemia. Blood extraction and PCR detected Leishmania species, Hepatozoon species and ‘ Candidatus Mycoplasma haemominutum’ (CMhm) DNA. Subsequent sequencing identified Hepatozoon felis. Additionally, the rRNA internal transcribed spacer 1 locus of Leishmania infantum was partially sequenced and phylogeny showed it to cluster with species derived from dogs in Italy and Uzbekistan, and a human in France. Allopurinol treatment was administered for 6 months. Clinical signs resolved in the second month of treatment with no deterioration 8 months post-treatment cessation. Quantitative PCR and ELISA were used to monitor L infantum blood DNA and antibody levels. The cat had high L infantum DNA levels pretreatment that gradually declined during treatment but increased 8 months post-treatment cessation. Similarly, ELISA revealed high levels of antibodies pretreatment, which gradually declined during treatment and increased slightly 8 months post-treatment cessation. The cat remained PCR positive for CMhm and Hepatozoon species throughout the study. There was no clinical evidence of relapse 24 months post-treatment. Relevance and novel information To our knowledge, this is the first clinical report of a cat with leishmaniosis with H felis and CMhm coinfections. The high L infantum DNA levels post-treatment cessation might indicate that although the lesions had resolved, prolonged or an alternative treatment could have been considered.

  • Open Access English
    Authors: 
    Leira Fernández-Bastit; Núria Roca; Miguel Romero-Durana; Jordi Rodon; Guillermo Cantero; Óscar García; Carlos López; Mònica Pérez; Rosa López; Jorge Carrillo; +7 more
    Publisher: Multidisciplinary Digital Publishing Institute
    Country: Spain

    A wide range of animal species are susceptible to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Natural and/or experimental infections have been reported in pet, zoo, farmed and wild animals. Interestingly, some SARS-CoV-2 variants, such as B.1.1.7/Alpha, B.1.351/Beta, and B.1.1.529/Omicron, were demonstrated to infect some animal species not susceptible to classical viral variants. The present study aimed to elucidate if goats (Capra aegagrus hircus) are susceptible to the B.1.351/Beta variant. First, an in silico approach was used to predict the affinity between the receptor-binding domain of the spike protein of SARS-CoV-2 B.1.351/Beta variant and angiotensin-converting enzyme 2 from goats. Moreover, we performed an experimental inoculation with this variant in domestic goat and showed evidence of infection. SARS-CoV-2 was detected in nasal swabs and tissues by RT-qPCR and/or immunohistochemistry, and seroneutralisation was confirmed via ELISA and live virus neutralisation assays. However, the viral amount and tissue distribution suggest a low susceptibility of goats to the B.1.351/Beta variant. Therefore, although monitoring livestock is advisable, it is unlikely that goats play a role as SARS-CoV-2 reservoir species, and they are not useful surrogates to study SARS-CoV-2 infection in farmed animals.