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SepsEast is an enthusiastic intensivists group initiative launched in 2012, with the aim to facilitate clinical and research activities in the region. Through its actions and with the motto « Together we win, divided we are slow! » several joint research projects in the fields of perioperative medicine, fluid therapy, cardiovascular monitoring and support have been conducted. In the light of the COVID- 19 pandemic, the SepsEast community is aware of its mission and is ready to take the challenge. This is mirrored by several educational, clinical and research activities including the development of a COVID-19 Registry ; and an observational clinical study on cytokine adsorption in COVID-19 patients. The current pandemic should be our lesson on how to manage the global threat of infectious disease and to develop strategies for effective diagnostic and therapeutic procedures. Hopefully, the SepsEast community will contribute to these developments and scientific advances in general.

The attached compressed file package supplements our research article. It comprises SARS-CoV-2 variant timemaps SVG files for 2020 and 2021, updated with data submitted to GISAID as of February 10th 2021 (inclusive). It is a snapshot of the webpage hosting these maps (https://bcgsc.github.io/SARS2) on that day and includes the script and single nucleotide variation (SNV) report files used to generate these and could be used by anyone to generate additional and custom interactive SVG maps. The frequently updated and comprehensive SARS-CoV-2 genome SNV reports (https://www.bcgsc.ca/downloads/btl/SARS-CoV-2/mutations) represent a wealth of variant information that could be mined to gain further insights into the rapid SARS-CoV-2 coronavirus evolution in human hosts.

This Update reports from a webinar on the impacts of lockdown measures put in place globally amid the Covid-19 pandemic on the right to housing and linked political struggles. Three main threads emerged from the conversation: the impacts of the pandemic are deepening pre-existing housing inequalities, while governments’ responses are largely insufficient; activists and contentious actors worldwide are changing their framings and repertoires to adapt to lockdown measures and attempt to radicalize their action; possibilities, albeit limited, are opening for the construction of global networks of struggle.

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Activitats; Contenció; Mesures de seguretat Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Actividades; Contención; Medidas de seguridad Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Activities; Containment; Security measures Cartell adreçat a la ciutadania informant de les mesures de protecció destinades a la contenció de la COVID-19 que seran d'aplicació a partir del 8 de març a Catalunya. Cartel dirigido a la ciudadanía informando de las medidas de protección destinadas a la contención de la Covid-19 que serán de aplicación a partir del 8 de marzo en Catalunya. Poster addressed to the public informing of the protection measures intended for the containment of the COVID-19 that will be applicable from March 8 in Catalonia.

As year 2020 came to a close, several new strains have been reported for the SARS-CoV-2 coronavirus, the agent responsible for the COVID-19 pandemic that has afflicted us all this past year. However, it is difficult to comprehend the scale, in sequence space, geographical location and time, at which SARS-CoV-2 mutates and evolves in its human hosts. To get an appreciation for the rapid evolution of the coronavirus, we built interactive scalable vector graphics (SVG) maps that show daily nucleotide variations in genomes from the six most populated continents compared to that of the initial, ground-zero SARS-CoV-2 isolate sequenced at the beginning of the year. The attached compressed file package comprises SARS-CoV-2 mutation timemaps for 2020 and 2021, updated with data submitted to GISAID (gisaid.org) as of January 25th 2021 (inclusive). It is a snapshot of the webpage hosting these maps (https://bcgsc.github.io/SARS2) on that day.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) not only affects the respiratory tract but also causes neurological symptoms such as loss of smell and taste, headache, fatigue or severe cerebrovascular complications. Using transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) we investigated the spatiotemporal distribution and pathomorphological features in the CNS following intranasal infection with SARS-CoV-2 variants, also after prior influenza A virus infection. Apart from Omicron, we found all variants to frequently spread to and within the CNS. Infection was restricted to neurons and appeared to spread from the olfactory bulb mainly in basally orientated regions in the brain and into the spinal cord, independent of ACE2 expression and without evidence of neuronal cell death, axonal damage or demyelination. However, microglial activation, microgliosis and a mild macrophage and T cell dominated inflammatory response was consistently observed, accompanied by apoptotic death of endothelial, microglial and immune cells, without their apparent infection. Microgliosis and immune cell apoptosis indicate a potential role of microglia for pathogenesis and viral effect in COVID-19 and possible impairment of neurological functions, especially in long COVID. These data may also be informative for the selection of therapeutic candidates, and broadly support investigation of agents with adequate penetration into relevant regions of the CNS.

As the year 2020 came to a close, several new strains have been reported for the SARS-CoV-2 coronavirus, the agent responsible for the COVID-19 pandemic that has afflicted us all this past year. However, it is difficult to comprehend the scale, in sequence space, geographical location and time, at which SARS-CoV-2 mutates and evolves in its human hosts. To get an appreciation for the rapid evolution of the coronavirus, we built interactive scalable vector graphics (SVG) maps that show daily nucleotide variations in genomes from the six most populated continents compared to that of the initial, ground-zero SARS-CoV-2 isolate sequenced at the beginning of the year. The attached compressed file package comprises SARS-CoV-2 mutation timemaps SVG files for 2020 and 2021, updated with data submitted to GISAID as of February 5th 2021 (inclusive). It is a snapshot of the webpage hosting these maps (https://bcgsc.github.io/SARS2) on that day and includes the script and single nucleotide variation (SNV) report files used to generate these and could be used by anyone to generate additional and custom interactive SVG maps. It supplements our F1000research article. The frequently updated and comprehensive SARS-CoV-2 genome SNV reports (https://www.bcgsc.ca/downloads/btl/SARS-CoV-2/mutations) represent a wealth of information that could be mined to gain further insights into the rapid SARS-CoV-2 coronavirus evolution in human hosts.