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  • Publication . Article . 2022
    Open Access English
    Authors: 
    Maryam Kakovan; Samaneh Ghorbani Shirkouhi; Mojtaba Zarei; Sasan Andalib;
    Country: Denmark

    Objectives: Development of safe and effective vaccines against coronavirus disease 2019 (COVID-19) remains the cornerstone of controlling this pandemic. However, there are increasing reports of various types of stroke including ischemic stroke, and hemorrhagic stroke, as well as cerebral venous sinus thrombosis (CVST) after COVID-19 vaccination. This paper aims to review reports of stroke associated with COVID-19 vaccines and provide a coherent clinical picture of this condition. Materials and methods: A literature review was performed with a focus on data from recent studies. Results: Most of such patients are women under 60 years of age and who had received ChAdOx1 nCoV-19 vaccine. Most studies reported CVST with or without secondary ischemic or hemorrhagic stroke, and some with Vaccine-induced Thrombotic Thrombocytopenia (VITT). The most common clinical symptom of CVST seen after COVID-19 vaccination was headache. The clinical course of CVST after COVID-19 vaccination may be more severe than CVST not associated with COVID vaccination. Management of CVST following COVID-19 vaccination is challenging and may differ from the standard treatment of CVST. Low molecular weight heparin is commonly used in the treatment of CVST; however, it may worsen outcomes in CVST associated with VITT. Furthermore, administration of intravenous immunoglobulin and high-dose glucocorticoids have been recommended with various success rates. Conclusion: These contradictory observations are a source of confusion in clinical decision-making and warrant further study and development of clinical guidelines. Clinicians should be aware of clinical presentation, diagnosis, and management of stroke associated with COVID-19 vaccination.

  • Open Access English
    Authors: 
    Manuel Fernández Cruz; José Álvarez Rodríguez; Inmaculada Ávalos Ruiz; Mercedes Cuevas López; Claudia de Barros Camargo; Francisco Díaz Rosas; Esther González Castellón; Daniel González González; Antonio Hernández Fernández; Pilar Ibáñez Cubillas; +1 more
    Publisher: FRONTIERS MEDIA SA
    Country: Spain

    Background: In a situation of compulsory home isolation enacted by governments at the spreading of the Covid-19 pandemic, the emotional health and well-being of students became a key factor in the successful implementation of distance teaching methodologies in face-to-face education universities. Psychological well-being, an essential factor in preventing academic failure, has been threatened in this serious situation of unprecedented and stressful isolation. The aim of this study is to analyze the students’ cognitive-emotional regulation as well as their beliefs and perceptions about the pandemic and this lockdown situation. With this extensive study we are carrying out, want to describe the extent to which the lockdown situation is a risk factor, and, in the future, make proposals for preventive and palliative actions, if necessary, to minimize this potential risk. Method: We applied the CERQ Cognitive Emotion Regulation Questionnaire by means of an online application together with a questionnaire, CC/covid-19, of objective description and subjective perception of the lockdown situation of the students, their conditions to study, general opinions about the pandemic and specific opinions about the real possibilities of implementing online education in the middle of the academic year at the university. 1910 valid responses from more than 80 universities in 13 different Spanish-speaking countries were obtained and submitted to descriptive analysis and modeling using structural equations. Results: Most of them consider that the lockdown decision is correct, that health systems are not prepared to deal with the pandemic, and that although the universities have adequate means, the teaching staff is not competent to implement online teaching methodologies. They have a good perception of the conditions of isolation, however, the time devoted to studying has not increased. One of the results of our study is the students’ self-evaluation about their digital competence and their capacity to perform in online interactive communication. This is key to rejecting a feeling of loneliness or social isolation, even if there is momentary physical separation with friends and classmates which is consistent with the results of emotional well-being the surveyed students present. The cognitive strategies used by the students surveyed have allowed them coping with events arising from the pandemic, mandatory isolation and university closure, certainly adaptive and functional, while maintaining a positive perception of their new living and learning situation. FEDER/Junta de AndaluciaConsejeria de Economia y Conocimiento/Proyecto B-SEJ-516-UGR18

  • Open Access English
    Authors: 
    Kenneth Lundstrom; Debmalya Barh; Bruce D. Uhal; Kazuo Takayama; Alaa A. A. Aljabali; Tarek Mohamed Abd El-Aziz; Amos Lal; Elrashdy M. Redwan; Parise Adadi; Gaurav Chauhan; +16 more
    Publisher: Uppsala universitet, Materialteori
    Countries: Denmark, Sweden

    Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies. Similar findings have been reported for several viral diseases after vaccine administration. In addition, immunological mechanisms elicited by viral vectors related to cellular delivery could play a relevant role in individuals with certain genetic backgrounds. Although rare, the potential COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) requires immediate validation, especially in risk groups, such as the elderly, chronic smokers, and individuals with pre-existing incidences of thrombocytopenia; and if necessary, a reformulation of existing vaccines.

  • Open Access English
    Authors: 
    McLean, K A; Kamarajah, S K; Chaudhry, D; Gujjuri, R R; Raubenheimer, K; Trout, I; Al Ameer, E; Creagh-Brown, B; Harrison, E M; Nepogodiev, D; +202 more
    Publisher: Oxford University Press
    Countries: Netherlands, United Kingdom, United Kingdom, Denmark, Italy, Italy, Italy, Italy, Italy, Finland ...

    Association of Surgeons in Training Surgical Summit, online, 17 Oct 2020 - 17 Oct 2020 2021 Virtual Annual Meeting / Surgical Research Society, online, 24 Mar 2021 - 25 Mar 2021, National Research Collaborative Meeting, online, 10 Dec 2020 - 10 Dec 2020, Royal Australasian College of Surgeons Annual Academic Surgery Conference, online, 5 Nov 2020 - 5 Nov 2020; The British journal of surgery : BJS 108(12), 1448-1464 (2021). doi:10.1093/bjs/znab336 Published by Wiley, New York, NY [u.a.]

  • Open Access English
    Authors: 
    Heimbürger, Balder Nehring;
    Country: Denmark

    Coral reefs across the world are at imminent risk of irreversible degradation due to warming climate, ocean acidification, and nutrient pollution. Recently, dissolved inorganic nitrogen has been determined to be a key stressor of coral reefs and has been directly associated with and linked to bleaching in stony corals. However, as stony corals bleach, die and disappear on the reefs, soft corals have been observed to remain present and thriving on even the most eutrophic reefs. This thesis sets out to investigate the background for the observed phase shift in community composure from hard coral dominated reefs to soft coral dominated, by first investigating the scientific literature on coral physiology and the effects of elevated nitrogen concentrations on corals in laboratory experiments, and later by conducting a similar and representable experiment on soft corals, in the order Alcyonacea. The thesis continues with a thorough description of the pilot experiment that came to be as a consequence of the initial experiment being stopped due to a variety of factors, including COVID-19 lockdowns. The data from the pilot experiment is reflected upon and used to improve the final experiment that was resumed after lockdown restrictions were eased. The final experiment is thus written as a draft for a publishable scientific article. The experiment investigated the impact on the growth rates of six species of soft corals to severely elevated levels of nitrogen, 10 and 20 times higher than what similar experiments on stony corals have tested, as well as testing the photosynthetic yield and maximum electron transfer rate of their symbiotic zooxanthellae, under these conditions. The study found that five out of six species of soft corals showed no changes in growth rates attributable to the elevated nitrogen levels, and that the photosynthetic yield and maximum electron transfer rate of the zooxanthellae did not change across treatments. Based on these findings, it is argued that important distinctions are made when correlating nitrogen enrichment to soft coral health. The study concludes that the data presented can contribute to a better understanding of soft coral resistance to nitrogen enrichment and serve as the base of future research into this scientifically underrepresented family of corals. Koralrev verden over er i overhængende risiko for uoprettelig tilbagegang, grundet global opvarmning, forsuring af havet og forurening med næringsstoffer. For nylig er opløst uorganisk nitrogen blevet bekræftet som værende en primær stresskilde for koralrev, og er blevet direkte forbundet med “blegning” hos stenkoraller. Trods dette, når disse stenkoraller blegner, dør og forsvinder, er det imidlertid observeret, at blødkoraller forbliver tilstede og trives, på selv de mest eutrofiske rev.Denne afhandling forsøger således at undersøge baggrunden for det observerede faseskift i disse koralrevs biodiversitet fra rev domineret af stenkoraller, til rev domineret af blødkoraller, ved først at undersøge den eksisterende videnskabelige litteratur om virkningerne af forhøjede nitrogenkoncentrationer på stenkoraller i laboratorieforsøg, og senere ved at udføre et lignende og repræsentativt eksperiment på blødkoraller i ordenen Alcyonacea. Specialet indeholder et afsnit om et pilotforsøg, der opstod som en konsekvens af, at det første forsøg måtte standses på grund af COVID-19-nedlukninger. Dataen fra pilotforsøget reflekteres over og bruges til at forbedre det sidste eksperiment, der blev genoptaget efter at restriktionerne og nedlukningen af universitetet blev lettet. Det sidste eksperiment er således skrevet som et udkast til en videnskabelig artikel, der kan udgives. Forsøget undersøgte seks arter af blødkorallers resistens over for ekstreme niveauer af opløst nitrogen, 10 og 20 gange højere end lignende eksperimenter på stenkoraller, samt testede det fotosyntetiske udbytte og den maksimale elektronoverførselshastighed for deres symbiotiske zooxantheller, under disse betingelser. Experimentet viste, at fem ud af de seks testede arter af blødkoraller ikke oplevede nogen ændringer i vækstrate, fotosyntetisk udbytte, eller maksimale elektronoverførselshastighed, på tværs af nitrogenniveauer. Undersøgelsen konkluderer, at de præsenterede data kan bidrage til en bedre forståelse af blødkorallers resistens overfor nitrogenberigelse og fortsatte tilstedeværelse på eutrofiske rev, og tjene som grundlag for fremtidig forskning i denne videnskabeligt underrepræsenterede orden af koraller.

  • Open Access English
    Authors: 
    Sofie Rosenlund Lau; Nanna Hauge Kristensen; Bjarke Oxlund;
    Country: Denmark

    n/a

  • Open Access English
    Authors: 
    Inge K. Holden; Claus Bistrup; Anna Nilsson; Janne Fuglsang Hansen; Rozeta Abazi; Jesper Rømhild Davidsen; Mikael Kjær Poulsen; Susan Olaf Lindvig; Ulrik Stenz Justesen; Isik Somuncu Johansen;
    Country: Denmark

    Background It is currently not well described if a two-dose regimen of a Covid-19 vaccine is sufficient to elicit an immune response in SOT recipients. Results A total of 80 solid organ transplant (SOT) recipients completed a two-dose regimen with SARS-CoV-2 messenger RNA vaccine. Only 35.0% (n = 28) were able to mount a positive IgG immune response six weeks after the second dose of vaccine. Conclusion This emphasizes that SOT recipients need continued use of personal protective measures. Future studies need to closely examine the cellular immune response in patients with compromised antibody response to Covid-19 vaccination. This article is protected by copyright. All rights reserved.

  • Publication . Article . 2020
    Open Access English
    Authors: 
    Blanaid Gavin; John Lyne; Fiona McNicholas;
    Publisher: Cambridge University Press

    With the advent of the COVID-19 pandemic, we have witnessed the greatest global challenge in a generation. The full extent of the mental health impact is, as yet, unknown, but is anticipated to be severe and enduring. In this Special Issue dedicated to mental health and the COVID-19 pandemic, we aim to lay the foundation for an improved understanding of how COVID-19 is affecting mental health services both in Ireland and globally. This Special Issue highlights how the mental health effects of COVID-19 stretch to almost every element of society. The issue includes perspectives from several countries across multiple disciplines and healthcare settings. The drive for rapid innovation and service development is clearly evident throughout and provides hope that by working collaboratively we can positively impact population mental health in the months and years ahead.

  • Open Access English
    Authors: 
    Evangelos J. Giamarellos-Bourboulis; Vincenzo Bettoli; Gregor B.E. Jemec; Véronique Del Marmol; Angelo V. Marzano; Errol P. Prens; Thrasyvoulos Tzellos; Christos C. Zouboulis;
    Publisher: John Wiley and Sons Inc.
    Country: Netherlands

    Abstract The reported incidence of COVID‐19 among cohorts of patients with inflammatory bowel and skin diseases under treatment with biologicals is low. Treatment may further modify disease severity as some biological modifiers, such as anakinra, are also proposed for the management of COVID‐19 patients potentially providing HS patients with an advantage. The above preliminary evidence suggests that hidradenitis suppurativa (HS) does probably not provide an increased susceptibility for COVID‐19 and that any susceptibility is unlikely to be modified negatively by treatment with biologicals. On the occasion of its 10th International Conference, experts of the European Hidradenitis Suppurativa Foundation e.V. have prepared a consensus statement regarding anti‐COVID‐19 measurements for HS patients. Based on the available knowledge, patients with HS may be vaccinated against SARS‐CoV2 and patients affected by metabolic syndrome constitute a high‐risk group for COVID‐19 and should be vaccinated at the earliest convenient point in time. HS patients on treatment with adalimumab can be vaccinated with non‐living virus anti‐SARS‐CoV2 vaccines. A possible suboptimal effect of the vaccine may be suspected but might not be expected universally. The management of the biological treatment in HS patients is at the discretion of the dermatologist / responsible physician.

  • Open Access English
    Authors: 
    Hans Eguia; Franco Vinciarelli; Marina Bosque-Prous; Troels Kristensen; Francesc Saigí-Rubió;
    Countries: Spain, Denmark

    (1) Background: This study aims to delineate a pattern on vaccine hesitancy in a sample of the Spanish population, considering age groups and status as healthcare workers. (2) Methods: Participants were recruited using Twitter® as a dissemination tool to reach as many respondents as possible in different parts of the Spanish territory. The participants were recruited in a cross-sectional study, which included answering an online questionnaire. Data were collected from 10 September through 23 November 2020. Respondents answered questions asking whether they intended to be vaccinated and provided the main reason for their answers. To estimate associations between vaccination hesitancy and independent variables, we fit Poisson regression models with robust variance. (3) Results: One thousand and two responses were obtained, of which only 731 were validated. One hundred and sixty-four participants stated that they would not be vaccinated (22.43%), of which 20–24% were non-health workers or unemployed, 17.5% physicians, 31.5% other health workers, and almost 35% nurses. Concerns about lack of effectiveness of the vaccination, lack of safety when vaccinating and possibly dangerous adverse effects were the main causes provided. (4) Conclusions: This study indicates that more interventions are needed to achieve better communication with the population and health professionals. Receptiveness to the message of the importance and security of the COVID-19 vaccination could be an important strategy for improving these results.

Advanced search in Research products
Research products
arrow_drop_down
Searching FieldsTerms
Any field
arrow_drop_down
includes
arrow_drop_down
Include:
The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
2,054 Research products, page 1 of 206
  • Publication . Article . 2022
    Open Access English
    Authors: 
    Maryam Kakovan; Samaneh Ghorbani Shirkouhi; Mojtaba Zarei; Sasan Andalib;
    Country: Denmark

    Objectives: Development of safe and effective vaccines against coronavirus disease 2019 (COVID-19) remains the cornerstone of controlling this pandemic. However, there are increasing reports of various types of stroke including ischemic stroke, and hemorrhagic stroke, as well as cerebral venous sinus thrombosis (CVST) after COVID-19 vaccination. This paper aims to review reports of stroke associated with COVID-19 vaccines and provide a coherent clinical picture of this condition. Materials and methods: A literature review was performed with a focus on data from recent studies. Results: Most of such patients are women under 60 years of age and who had received ChAdOx1 nCoV-19 vaccine. Most studies reported CVST with or without secondary ischemic or hemorrhagic stroke, and some with Vaccine-induced Thrombotic Thrombocytopenia (VITT). The most common clinical symptom of CVST seen after COVID-19 vaccination was headache. The clinical course of CVST after COVID-19 vaccination may be more severe than CVST not associated with COVID vaccination. Management of CVST following COVID-19 vaccination is challenging and may differ from the standard treatment of CVST. Low molecular weight heparin is commonly used in the treatment of CVST; however, it may worsen outcomes in CVST associated with VITT. Furthermore, administration of intravenous immunoglobulin and high-dose glucocorticoids have been recommended with various success rates. Conclusion: These contradictory observations are a source of confusion in clinical decision-making and warrant further study and development of clinical guidelines. Clinicians should be aware of clinical presentation, diagnosis, and management of stroke associated with COVID-19 vaccination.

  • Open Access English
    Authors: 
    Manuel Fernández Cruz; José Álvarez Rodríguez; Inmaculada Ávalos Ruiz; Mercedes Cuevas López; Claudia de Barros Camargo; Francisco Díaz Rosas; Esther González Castellón; Daniel González González; Antonio Hernández Fernández; Pilar Ibáñez Cubillas; +1 more
    Publisher: FRONTIERS MEDIA SA
    Country: Spain

    Background: In a situation of compulsory home isolation enacted by governments at the spreading of the Covid-19 pandemic, the emotional health and well-being of students became a key factor in the successful implementation of distance teaching methodologies in face-to-face education universities. Psychological well-being, an essential factor in preventing academic failure, has been threatened in this serious situation of unprecedented and stressful isolation. The aim of this study is to analyze the students’ cognitive-emotional regulation as well as their beliefs and perceptions about the pandemic and this lockdown situation. With this extensive study we are carrying out, want to describe the extent to which the lockdown situation is a risk factor, and, in the future, make proposals for preventive and palliative actions, if necessary, to minimize this potential risk. Method: We applied the CERQ Cognitive Emotion Regulation Questionnaire by means of an online application together with a questionnaire, CC/covid-19, of objective description and subjective perception of the lockdown situation of the students, their conditions to study, general opinions about the pandemic and specific opinions about the real possibilities of implementing online education in the middle of the academic year at the university. 1910 valid responses from more than 80 universities in 13 different Spanish-speaking countries were obtained and submitted to descriptive analysis and modeling using structural equations. Results: Most of them consider that the lockdown decision is correct, that health systems are not prepared to deal with the pandemic, and that although the universities have adequate means, the teaching staff is not competent to implement online teaching methodologies. They have a good perception of the conditions of isolation, however, the time devoted to studying has not increased. One of the results of our study is the students’ self-evaluation about their digital competence and their capacity to perform in online interactive communication. This is key to rejecting a feeling of loneliness or social isolation, even if there is momentary physical separation with friends and classmates which is consistent with the results of emotional well-being the surveyed students present. The cognitive strategies used by the students surveyed have allowed them coping with events arising from the pandemic, mandatory isolation and university closure, certainly adaptive and functional, while maintaining a positive perception of their new living and learning situation. FEDER/Junta de AndaluciaConsejeria de Economia y Conocimiento/Proyecto B-SEJ-516-UGR18

  • Open Access English
    Authors: 
    Kenneth Lundstrom; Debmalya Barh; Bruce D. Uhal; Kazuo Takayama; Alaa A. A. Aljabali; Tarek Mohamed Abd El-Aziz; Amos Lal; Elrashdy M. Redwan; Parise Adadi; Gaurav Chauhan; +16 more
    Publisher: Uppsala universitet, Materialteori
    Countries: Denmark, Sweden

    Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies. Similar findings have been reported for several viral diseases after vaccine administration. In addition, immunological mechanisms elicited by viral vectors related to cellular delivery could play a relevant role in individuals with certain genetic backgrounds. Although rare, the potential COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) requires immediate validation, especially in risk groups, such as the elderly, chronic smokers, and individuals with pre-existing incidences of thrombocytopenia; and if necessary, a reformulation of existing vaccines.

  • Open Access English
    Authors: 
    McLean, K A; Kamarajah, S K; Chaudhry, D; Gujjuri, R R; Raubenheimer, K; Trout, I; Al Ameer, E; Creagh-Brown, B; Harrison, E M; Nepogodiev, D; +202 more
    Publisher: Oxford University Press
    Countries: Netherlands, United Kingdom, United Kingdom, Denmark, Italy, Italy, Italy, Italy, Italy, Finland ...

    Association of Surgeons in Training Surgical Summit, online, 17 Oct 2020 - 17 Oct 2020 2021 Virtual Annual Meeting / Surgical Research Society, online, 24 Mar 2021 - 25 Mar 2021, National Research Collaborative Meeting, online, 10 Dec 2020 - 10 Dec 2020, Royal Australasian College of Surgeons Annual Academic Surgery Conference, online, 5 Nov 2020 - 5 Nov 2020; The British journal of surgery : BJS 108(12), 1448-1464 (2021). doi:10.1093/bjs/znab336 Published by Wiley, New York, NY [u.a.]

  • Open Access English
    Authors: 
    Heimbürger, Balder Nehring;
    Country: Denmark

    Coral reefs across the world are at imminent risk of irreversible degradation due to warming climate, ocean acidification, and nutrient pollution. Recently, dissolved inorganic nitrogen has been determined to be a key stressor of coral reefs and has been directly associated with and linked to bleaching in stony corals. However, as stony corals bleach, die and disappear on the reefs, soft corals have been observed to remain present and thriving on even the most eutrophic reefs. This thesis sets out to investigate the background for the observed phase shift in community composure from hard coral dominated reefs to soft coral dominated, by first investigating the scientific literature on coral physiology and the effects of elevated nitrogen concentrations on corals in laboratory experiments, and later by conducting a similar and representable experiment on soft corals, in the order Alcyonacea. The thesis continues with a thorough description of the pilot experiment that came to be as a consequence of the initial experiment being stopped due to a variety of factors, including COVID-19 lockdowns. The data from the pilot experiment is reflected upon and used to improve the final experiment that was resumed after lockdown restrictions were eased. The final experiment is thus written as a draft for a publishable scientific article. The experiment investigated the impact on the growth rates of six species of soft corals to severely elevated levels of nitrogen, 10 and 20 times higher than what similar experiments on stony corals have tested, as well as testing the photosynthetic yield and maximum electron transfer rate of their symbiotic zooxanthellae, under these conditions. The study found that five out of six species of soft corals showed no changes in growth rates attributable to the elevated nitrogen levels, and that the photosynthetic yield and maximum electron transfer rate of the zooxanthellae did not change across treatments. Based on these findings, it is argued that important distinctions are made when correlating nitrogen enrichment to soft coral health. The study concludes that the data presented can contribute to a better understanding of soft coral resistance to nitrogen enrichment and serve as the base of future research into this scientifically underrepresented family of corals. Koralrev verden over er i overhængende risiko for uoprettelig tilbagegang, grundet global opvarmning, forsuring af havet og forurening med næringsstoffer. For nylig er opløst uorganisk nitrogen blevet bekræftet som værende en primær stresskilde for koralrev, og er blevet direkte forbundet med “blegning” hos stenkoraller. Trods dette, når disse stenkoraller blegner, dør og forsvinder, er det imidlertid observeret, at blødkoraller forbliver tilstede og trives, på selv de mest eutrofiske rev.Denne afhandling forsøger således at undersøge baggrunden for det observerede faseskift i disse koralrevs biodiversitet fra rev domineret af stenkoraller, til rev domineret af blødkoraller, ved først at undersøge den eksisterende videnskabelige litteratur om virkningerne af forhøjede nitrogenkoncentrationer på stenkoraller i laboratorieforsøg, og senere ved at udføre et lignende og repræsentativt eksperiment på blødkoraller i ordenen Alcyonacea. Specialet indeholder et afsnit om et pilotforsøg, der opstod som en konsekvens af, at det første forsøg måtte standses på grund af COVID-19-nedlukninger. Dataen fra pilotforsøget reflekteres over og bruges til at forbedre det sidste eksperiment, der blev genoptaget efter at restriktionerne og nedlukningen af universitetet blev lettet. Det sidste eksperiment er således skrevet som et udkast til en videnskabelig artikel, der kan udgives. Forsøget undersøgte seks arter af blødkorallers resistens over for ekstreme niveauer af opløst nitrogen, 10 og 20 gange højere end lignende eksperimenter på stenkoraller, samt testede det fotosyntetiske udbytte og den maksimale elektronoverførselshastighed for deres symbiotiske zooxantheller, under disse betingelser. Experimentet viste, at fem ud af de seks testede arter af blødkoraller ikke oplevede nogen ændringer i vækstrate, fotosyntetisk udbytte, eller maksimale elektronoverførselshastighed, på tværs af nitrogenniveauer. Undersøgelsen konkluderer, at de præsenterede data kan bidrage til en bedre forståelse af blødkorallers resistens overfor nitrogenberigelse og fortsatte tilstedeværelse på eutrofiske rev, og tjene som grundlag for fremtidig forskning i denne videnskabeligt underrepræsenterede orden af koraller.

  • Open Access English
    Authors: 
    Sofie Rosenlund Lau; Nanna Hauge Kristensen; Bjarke Oxlund;
    Country: Denmark

    n/a

  • Open Access English
    Authors: 
    Inge K. Holden; Claus Bistrup; Anna Nilsson; Janne Fuglsang Hansen; Rozeta Abazi; Jesper Rømhild Davidsen; Mikael Kjær Poulsen; Susan Olaf Lindvig; Ulrik Stenz Justesen; Isik Somuncu Johansen;
    Country: Denmark

    Background It is currently not well described if a two-dose regimen of a Covid-19 vaccine is sufficient to elicit an immune response in SOT recipients. Results A total of 80 solid organ transplant (SOT) recipients completed a two-dose regimen with SARS-CoV-2 messenger RNA vaccine. Only 35.0% (n = 28) were able to mount a positive IgG immune response six weeks after the second dose of vaccine. Conclusion This emphasizes that SOT recipients need continued use of personal protective measures. Future studies need to closely examine the cellular immune response in patients with compromised antibody response to Covid-19 vaccination. This article is protected by copyright. All rights reserved.

  • Publication . Article . 2020
    Open Access English
    Authors: 
    Blanaid Gavin; John Lyne; Fiona McNicholas;
    Publisher: Cambridge University Press

    With the advent of the COVID-19 pandemic, we have witnessed the greatest global challenge in a generation. The full extent of the mental health impact is, as yet, unknown, but is anticipated to be severe and enduring. In this Special Issue dedicated to mental health and the COVID-19 pandemic, we aim to lay the foundation for an improved understanding of how COVID-19 is affecting mental health services both in Ireland and globally. This Special Issue highlights how the mental health effects of COVID-19 stretch to almost every element of society. The issue includes perspectives from several countries across multiple disciplines and healthcare settings. The drive for rapid innovation and service development is clearly evident throughout and provides hope that by working collaboratively we can positively impact population mental health in the months and years ahead.

  • Open Access English
    Authors: 
    Evangelos J. Giamarellos-Bourboulis; Vincenzo Bettoli; Gregor B.E. Jemec; Véronique Del Marmol; Angelo V. Marzano; Errol P. Prens; Thrasyvoulos Tzellos; Christos C. Zouboulis;
    Publisher: John Wiley and Sons Inc.
    Country: Netherlands

    Abstract The reported incidence of COVID‐19 among cohorts of patients with inflammatory bowel and skin diseases under treatment with biologicals is low. Treatment may further modify disease severity as some biological modifiers, such as anakinra, are also proposed for the management of COVID‐19 patients potentially providing HS patients with an advantage. The above preliminary evidence suggests that hidradenitis suppurativa (HS) does probably not provide an increased susceptibility for COVID‐19 and that any susceptibility is unlikely to be modified negatively by treatment with biologicals. On the occasion of its 10th International Conference, experts of the European Hidradenitis Suppurativa Foundation e.V. have prepared a consensus statement regarding anti‐COVID‐19 measurements for HS patients. Based on the available knowledge, patients with HS may be vaccinated against SARS‐CoV2 and patients affected by metabolic syndrome constitute a high‐risk group for COVID‐19 and should be vaccinated at the earliest convenient point in time. HS patients on treatment with adalimumab can be vaccinated with non‐living virus anti‐SARS‐CoV2 vaccines. A possible suboptimal effect of the vaccine may be suspected but might not be expected universally. The management of the biological treatment in HS patients is at the discretion of the dermatologist / responsible physician.

  • Open Access English
    Authors: 
    Hans Eguia; Franco Vinciarelli; Marina Bosque-Prous; Troels Kristensen; Francesc Saigí-Rubió;
    Countries: Spain, Denmark

    (1) Background: This study aims to delineate a pattern on vaccine hesitancy in a sample of the Spanish population, considering age groups and status as healthcare workers. (2) Methods: Participants were recruited using Twitter® as a dissemination tool to reach as many respondents as possible in different parts of the Spanish territory. The participants were recruited in a cross-sectional study, which included answering an online questionnaire. Data were collected from 10 September through 23 November 2020. Respondents answered questions asking whether they intended to be vaccinated and provided the main reason for their answers. To estimate associations between vaccination hesitancy and independent variables, we fit Poisson regression models with robust variance. (3) Results: One thousand and two responses were obtained, of which only 731 were validated. One hundred and sixty-four participants stated that they would not be vaccinated (22.43%), of which 20–24% were non-health workers or unemployed, 17.5% physicians, 31.5% other health workers, and almost 35% nurses. Concerns about lack of effectiveness of the vaccination, lack of safety when vaccinating and possibly dangerous adverse effects were the main causes provided. (4) Conclusions: This study indicates that more interventions are needed to achieve better communication with the population and health professionals. Receptiveness to the message of the importance and security of the COVID-19 vaccination could be an important strategy for improving these results.