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173 Research products, page 1 of 18

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  • Open Access
    Authors: 
    Bilde, Basthiann A.; Andersen, Morten L.; Steven Harrod;
    Country: Denmark

    Offentlig transport er en kritisk service i København, fordi mange beboere ikke ejer en bil, og under mange omstændigheder er bilkørsel ikke praktisk i byens centrum på grund af smalle veje og manglende parkering. Som svar på COVID-19 har de danske sundhedsmyndigheder fastlagt en minimumspolitik for social afstand på 1 meter i det offentlige rum. Følgende undersøgelse simulerer passagerernes flow på tre repræsentative stationer i den københavnske metro for at afgøre, om disse afstandskrav kan overholdes, samt om eventuelle fysiske ændringer bør foretages. Undersøgelsen udføres med en mikrosimulering i Bentley Legion af passagerstrømmen på tre stationer med små, mellemstore og store trafikstrømme. Simuleringen er agentbaseret, og den individuelle objektive funktion er minimering af omkostninger i henhold til gåafstand, komfort og frustration. Resultaterne viser, at for de fleste stationer, er den fysiske infrastruktur og den forventede trafikstrøm forenelige med målene for social afstand. For nogle få af de mest efterspurgte stationer, især dem, der fungerer som intermodale knudepunkter, er der imidlertid store vanskeligheder med at opnå de ønskede sociale afstandsforanstaltninger. Især den intermodale hubstation, Nørreport, har ikke korridorer og rulletrapper, der fordeles korrekt i henhold til fodgængerstrømmen. Denne station er under jorden, og det er desværre ikke let at ændre i infrastrukturen for dette knudepunkt.

  • Publication . Conference object . Contribution for newspaper or weekly magazine . 2020
    Open Access English
    Authors: 
    Niels Jeppesen; Anders Christensen; Vedrana Andersen Dahl; Anders Bjorholm Dahl;
    Publisher: IEEE
    Country: Denmark

    We introduce the novel concept of a Sparse Layered Graph (SLG) for s-t graph cut segmentation of image data. The concept is based on the widely used Ishikawa layered technique for multi-object segmentation, which allows explicit object interactions, such as containment and exclusion with margins. However, the spatial complexity of the Ishikawa technique limits its use for many segmentation problems. To solve this issue, we formulate a general method for adding containment and exclusion interaction constraints to layered graphs. Given some prior knowledge, we can create a SLG, which is often orders of magnitude smaller than traditional Ishikawa graphs, with identical segmentation results. This allows us to solve many problems that could previously not be solved using general graph cut algorithms. We then propose three algorithms for further reducing the spatial complexity of SLGs, by using ordered multi-column graphs. In our experiments, we show that SLGs, and in particular ordered multi-column SLGs, can produce high-quality segmentation results using extremely simple data terms. We also show the scalability of ordered multi-column SLGs, by segmenting a high-resolution volume with several hundred interacting objects.

  • Authors: 
    Avila Flavio; Amir Hossein Poorjam; Deepak Mittal; Charles Dognin; Ananya Muguli; Rohit Kumar; Srikanth Raj Chetupalli; Sriram Ganapathy; Maneesh Singh;
    Publisher: ISCA

    In this paper, we propose an approach to automatically classify COVID-19 and non-COVID-19 cough samples based on the combination of both feature engineering and deep learning models. In the feature engineering approach, we develop a support vector machine classifier over high dimensional (6373D) space of acoustic features. In the deep learning-based approach, on the other hand, we apply a convolutional neural network trained on the log-mel spectrograms. These two methodologically diverse models are then combined by fusing the probability scores of the models. The proposed system, which ranked 9th on the 2021 Diagnosing COVID-19 using Acoustics (Di- COVA) challenge leaderboard, obtained an area under the receiver operating characteristic curve (AUC) of 0:81 on the blind test data set, which is a 10:9% absolute improvement compared to the baseline. Moreover, we analyze the explainability of the deep learning-based model when detecting COVID-19 from cough signals. Copyright © 2021 ISCA.

  • Publication . Conference object . 2021
    Restricted Danish
    Authors: 
    Aida Hougaard Andersen; Dorte Toudal Viftrup; Mads Bank;
    Country: Denmark
  • Restricted English
    Authors: 
    Woodward, Ian; Banke, Signe;
    Country: Denmark

    On March 6, Danish Prime Minister Mette Frederiksen declared that all gatherings over 1000 people would be banned until at least August 31, 2020. This announcement, and subsequent further reductions in gathering numbers, effectively ‘cancelled the summer’ of music festivals and much more in 2020. In this paper, based on a study of three music festivals in Denmark, we focus on the un-making of music festivals and their creative re-making across diverse social spaces and contexts by multiple agents in response to the trauma of cancellation. The absence of music festivals points actors to a Corona-induced social and cultural lack, an emblematic fact referring to the loss of spaces of intense sociality and connection which we interpret via literatures on compressed cultural trauma. Our field research shows that lack and loss are not the defining features of this event. Instead, a suite of strategies is enacted to protect and repair the festival ritual, its history, community, and commercial interests in the wake of Corona’s attack. The paper draws upon extensive ethnographic and qualitative research, including a 7-month ongoing longitudinal phase of interviews with audiences and various types of organisers associated with three cancelled Danish music festivals, as well as a 9-month ongoing large-scale longitudinal media and netnographic analysis. We examine how agents of festivalisation - festival organisers, musicians, audiences, local entrepreneurs, and festival spaces – have gone about remembering, commemorating, and mobilising festivals in the wake of Corona. We explore the ways festival agents use materials, spaces, symbolic resources and creative strategies to respond to the external threat of the virus and reflect on who these festival agents are acting for, what they end up making, and why. Specificities of responses differ depending on festival type, history and context. Further, responses are also relationally and temporo-spatially anchored to interpretation of wider Corona developments. However, we observe widespread evidence of creative re-materialisations of festival experiences, pointing to processes of remembrance, repair, and the ongoing constructive re-making of ritual festival experience in novel contexts.

  • Closed Access English
    Authors: 
    Glintborg, B.; Jensen, D. V.; Engel, S.; Terslev, L.; Jensen, M. Pfeiffer; Hendricks, O.; Ostergaard, M.; Rasmussen, S. H.; Adelsten, T.; Danebod, K.; +11 more
    Country: Denmark
  • Restricted English
    Authors: 
    Bollig, Georg;
    Country: Denmark

    1. Background and GoalsA major challenge for public palliative care is to support all people who want to die at home. Last Aid Courses (LAC) have been started in 2015 to educate citizens and to empower them to participate in end-of-life care. The main goals of the International Last Aid project were to establish an International Last Aid working group and to provide and evaluate public palliative care education for citizens. 2. MethodsBetween 2017 and 2019 an International Last Aid working group with representatives from different countries and national organisations from e.g. palliative care, health-services, and the church as cooperation partners has been established. The curriculum and contents of the International Last Aid course are revised every other year by the International Last Aid working group. Scientific evaluation of LAC is coordinated by the international Last Aid Research Group Europe (LARGE) that was founded in September 2019. The experiences from he implementation process and the findings from the scientific evaluation will be summarised and presented during the Zoominar. 3. Results and ConclusionWork on LAC has been started in 17 countries as Denmark, Germany, Slovenia, Lithuania, Scotland, Ireland, Australia, Brasil, etc. The overall results show that the LAC is feasible and very well accepted in many different countries, cultures and groups. It has been used for adults, children and groups as hospital employees and policemen. LAC are even possible as online course format that was tested during the COVID-19 pandemic. Scientific work on cultural issues and the effects of Last aid Courses are ongoing in a number of countries. In conclusion Last Aid Courses are feasible and well accepted by citizens in different countries. The courses can contribute to a public debate on death, dying and palliative care and may contribute to empower citizens to provide end-of-life care. Keywords: Palliative care, public palliative care education, end-of-life care, home death, compassionate communities, Last Aid Course Biography: Dr. med. Georg Bollig, PhD, MAS, DEAA is a physician and researcher. He is a specialist in anaesthesiology, emergency medicine and palliative medicine with scientific work in various fields. He works as consultant in palliative medicine at the Medical Center Sønderjylland in Sønderborg, South Jutland Hospital, Denmark. Georg is a clinical associate professor in palliative care at the University of Southern Denmark. He invented Last Aid Courses and is the leader of Last Aid International and the international Last Aid working group. At present he is working on research projects about ethics, telemedicine and the effects of Last Aid Courses. The presented research has been performed without external funding.Presenting author details that will be used for Certificates and Id cardsDr. Georg Bollig, PhD, MAS, DEAA; Clin. Assoc. Prof. in Palliative Care Palliative Care Team, Medical Department Sønderborg/Tønder, South Jutland Hospital, Sønderborg, Denmark b Palliative Care research group, Medical Research Unit, Institute of Regional Health Research, University of Southern Denmarkc Last Aid International, Schleswig, GermanyEmail 1(Work): georg.bollig@rsyd.dkEmail 2(Personal): bollig.georg@gmx.deMobile: +49-17634747059Office Tel: +45-20168303ORCID iD: https://orcid.org/0000-0002-0367-5295

  • Authors: 
    Antonella Arcadu; Silvia Puglisi; Alessandra Dubini; Sara Piciucchi; Fabio Sultani; Sabrina Martinello; Lara Bertolovic; Stefano Oldani; Luca Donati; Christian Gurioli; +2 more
    Publisher: European Respiratory Society

    Objectives: We sought to evaluate the association between age and presentation of SARS-COV2 infection Methods: Clinical presentation and radiological data of all consecutive COVID19 patients admitted to our Hospital between 01-03-2020 and 30-04-2020 were analyzed SARS-CoV-2 positive patients were diagnosed by either swab test or bronchoalveolar lavage Patients without proved SARS-CoV-2 infection or without HRCT scan were excluded All HRCT were reviewed and classified according to RSNA Classification of SARS-CoV-2 pneumonia(l) Results: Over the study period, 179 patients met the inclusion criteria Mean age was 67 years (SD 15 1, range 19-96);55 8% (N= 100) were male Of them, 22 patients (12%) had atypical clinical presentation The more frequent atypical presentations were cardiovascular, including syncope (N= 5, 22%) and heart failure (N= 5, 22%) HRCT was Typical in 151 (84 4%) patients, Indeterminate in 14 (7 8%), Atypical in 12 (6 7%), and Negative in 2 (0 01%) Among elderly patients (>70 years old) accounting for 44% of the total population (N=80), HRTC was more frequently Atypical (11/80 patients, 13 75%) compared to younger patients (<70 year of age, 1/99 patients, 1%) (p-value= 0 001) Similarly, the clinical presentation was more frequently atypical in the elderly (19/80, 23%) compared to the younger (3/99, 3 0%) (p-value <0 0001) Conclusions: Our study demonstrated that SARS-CoV-2 infections in elderly can results in atypical clinical and radiological presentation, potentially leading to misdiagnosis and unrecognized cases (1)Simpson S, et al Radiology 2020 doi: 10 1148/ryct 2020200152

  • Open Access English
    Authors: 
    Bjorgvinsdottir, Unnur Jona; Carstensen, Laura Stentoft; Colliander, Anna; Jaehger, Ditte Elisabeth; Veiga, Gael Clergeaud; Halldorsdottir, Holmfriour Rosa; Jorgensen, Matilde Smaerup; Christensen, Esben; Vangsgaard, Sara; Koukos, Aristeidis; +3 more
    Country: Denmark

    Background Therapeutic cancer vaccines represent an intriguing approach to cancer immunotherapy and they have been widely explored for the last decade. As opposed to standard modalities, such as surgery and chemotherapy, an effective vaccine-based immune response may provide protection against metastatic disease. Peptide based vaccines can elicit a highly targeted immune response and include a simple, fast and cost-effective production due to recent developments in solid phase peptide synthesis. Recent development within the field of COVID-19 vaccines has highlighted the use of lipid nanoparticles as an effective drug delivery system for vaccination. Incorporation of peptide antigens into engineered micro- and nanoparticles enables induction of a potent T cell response, partly attributed to prolonged and improved antigen presentation by dendritic cells after particle internalization. Peptide-based vaccines are often based on delivery of high-affinity T cell model epitopes. However, the therapeutic relevance of vaccination with low-affinity epitopes is gaining increasing support following the observation that high-affinity epitopes can promote T cell exhaustion resulting from excessive T cell receptor stimulation. Here, we characterize and evaluate a novel lipid nanoparticle (LNP) vaccine platform that is suited for delivery of both high- and low-affinity epitopes in the setting of therapeutic cancer vaccination.Methods LNPs were formulated to carry high- or low-affinity peptide epitopes from Ovalbumin (OVA) in conjunction with the TLR7 agonist 1V270. The peptides were anchored to the surface of the LNPs via a reducible DSPE-PEG2000 linker system. The therapeutic vaccine platform was evaluated in vivo both as a monotherapy and in combination with adoptive transfer of OT-I T cells in the syngeneic B16-OVA murine melanoma model.Results The LNP vaccine promotes efficient antigen-release and ensures high, continuous antigen-presentation by antigen-presenting cells. While the LNPs can be administered via multiple routes, intratumoral vaccination favors enhanced particle uptake in dendritic cells in the tumor. Formulated with either high- or low-affinity epitopes, intratumorally delivered vaccine particles promote superior tumor-infiltration of adoptively transferred T cells, which translates into potent anti-tumor efficacy in vivo. Finally, we show that vaccination with both CD8+ and CD4+ epitopes can delay tumor growth and prolong survival in an antigen-dependent manner.Conclusions This study presents a versatile and multi-purpose LNP vaccine platform that ensures effective delivery of high- and low-affinity epitopes. Intratumoral administration promotes vaccine particle uptake by intratumoral dendritic cells, which is followed by T cell infiltration and anti-tumor efficacy in vivo.

  • Publication . Contribution for newspaper or weekly magazine . Conference object . 2021
    Open Access English
    Authors: 
    Javad Najafi; Javad Mahmoudi; Amjad Anvari-Moghaddam;
    Publisher: IEEE Press
    Country: Denmark

    The reliability of power distribution networks can be threatened due to the health of repair crews. Covid-19 is a nowadays challenge that affects the health and the availability of repair crews. Monte Carlo simulation is implemented in this paper to evaluate the reliability of power distribution networks considering Covid-19. This paper alerts the power distribution companies to consider some strategies to prevent the growth of expected energy not served (EENS) during the pandemics era such as Covid-19.

Advanced search in Research products
Research products
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Searching FieldsTerms
Any field
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includes
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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
173 Research products, page 1 of 18
  • Open Access
    Authors: 
    Bilde, Basthiann A.; Andersen, Morten L.; Steven Harrod;
    Country: Denmark

    Offentlig transport er en kritisk service i København, fordi mange beboere ikke ejer en bil, og under mange omstændigheder er bilkørsel ikke praktisk i byens centrum på grund af smalle veje og manglende parkering. Som svar på COVID-19 har de danske sundhedsmyndigheder fastlagt en minimumspolitik for social afstand på 1 meter i det offentlige rum. Følgende undersøgelse simulerer passagerernes flow på tre repræsentative stationer i den københavnske metro for at afgøre, om disse afstandskrav kan overholdes, samt om eventuelle fysiske ændringer bør foretages. Undersøgelsen udføres med en mikrosimulering i Bentley Legion af passagerstrømmen på tre stationer med små, mellemstore og store trafikstrømme. Simuleringen er agentbaseret, og den individuelle objektive funktion er minimering af omkostninger i henhold til gåafstand, komfort og frustration. Resultaterne viser, at for de fleste stationer, er den fysiske infrastruktur og den forventede trafikstrøm forenelige med målene for social afstand. For nogle få af de mest efterspurgte stationer, især dem, der fungerer som intermodale knudepunkter, er der imidlertid store vanskeligheder med at opnå de ønskede sociale afstandsforanstaltninger. Især den intermodale hubstation, Nørreport, har ikke korridorer og rulletrapper, der fordeles korrekt i henhold til fodgængerstrømmen. Denne station er under jorden, og det er desværre ikke let at ændre i infrastrukturen for dette knudepunkt.

  • Publication . Conference object . Contribution for newspaper or weekly magazine . 2020
    Open Access English
    Authors: 
    Niels Jeppesen; Anders Christensen; Vedrana Andersen Dahl; Anders Bjorholm Dahl;
    Publisher: IEEE
    Country: Denmark

    We introduce the novel concept of a Sparse Layered Graph (SLG) for s-t graph cut segmentation of image data. The concept is based on the widely used Ishikawa layered technique for multi-object segmentation, which allows explicit object interactions, such as containment and exclusion with margins. However, the spatial complexity of the Ishikawa technique limits its use for many segmentation problems. To solve this issue, we formulate a general method for adding containment and exclusion interaction constraints to layered graphs. Given some prior knowledge, we can create a SLG, which is often orders of magnitude smaller than traditional Ishikawa graphs, with identical segmentation results. This allows us to solve many problems that could previously not be solved using general graph cut algorithms. We then propose three algorithms for further reducing the spatial complexity of SLGs, by using ordered multi-column graphs. In our experiments, we show that SLGs, and in particular ordered multi-column SLGs, can produce high-quality segmentation results using extremely simple data terms. We also show the scalability of ordered multi-column SLGs, by segmenting a high-resolution volume with several hundred interacting objects.

  • Authors: 
    Avila Flavio; Amir Hossein Poorjam; Deepak Mittal; Charles Dognin; Ananya Muguli; Rohit Kumar; Srikanth Raj Chetupalli; Sriram Ganapathy; Maneesh Singh;
    Publisher: ISCA

    In this paper, we propose an approach to automatically classify COVID-19 and non-COVID-19 cough samples based on the combination of both feature engineering and deep learning models. In the feature engineering approach, we develop a support vector machine classifier over high dimensional (6373D) space of acoustic features. In the deep learning-based approach, on the other hand, we apply a convolutional neural network trained on the log-mel spectrograms. These two methodologically diverse models are then combined by fusing the probability scores of the models. The proposed system, which ranked 9th on the 2021 Diagnosing COVID-19 using Acoustics (Di- COVA) challenge leaderboard, obtained an area under the receiver operating characteristic curve (AUC) of 0:81 on the blind test data set, which is a 10:9% absolute improvement compared to the baseline. Moreover, we analyze the explainability of the deep learning-based model when detecting COVID-19 from cough signals. Copyright © 2021 ISCA.

  • Publication . Conference object . 2021
    Restricted Danish
    Authors: 
    Aida Hougaard Andersen; Dorte Toudal Viftrup; Mads Bank;
    Country: Denmark
  • Restricted English
    Authors: 
    Woodward, Ian; Banke, Signe;
    Country: Denmark

    On March 6, Danish Prime Minister Mette Frederiksen declared that all gatherings over 1000 people would be banned until at least August 31, 2020. This announcement, and subsequent further reductions in gathering numbers, effectively ‘cancelled the summer’ of music festivals and much more in 2020. In this paper, based on a study of three music festivals in Denmark, we focus on the un-making of music festivals and their creative re-making across diverse social spaces and contexts by multiple agents in response to the trauma of cancellation. The absence of music festivals points actors to a Corona-induced social and cultural lack, an emblematic fact referring to the loss of spaces of intense sociality and connection which we interpret via literatures on compressed cultural trauma. Our field research shows that lack and loss are not the defining features of this event. Instead, a suite of strategies is enacted to protect and repair the festival ritual, its history, community, and commercial interests in the wake of Corona’s attack. The paper draws upon extensive ethnographic and qualitative research, including a 7-month ongoing longitudinal phase of interviews with audiences and various types of organisers associated with three cancelled Danish music festivals, as well as a 9-month ongoing large-scale longitudinal media and netnographic analysis. We examine how agents of festivalisation - festival organisers, musicians, audiences, local entrepreneurs, and festival spaces – have gone about remembering, commemorating, and mobilising festivals in the wake of Corona. We explore the ways festival agents use materials, spaces, symbolic resources and creative strategies to respond to the external threat of the virus and reflect on who these festival agents are acting for, what they end up making, and why. Specificities of responses differ depending on festival type, history and context. Further, responses are also relationally and temporo-spatially anchored to interpretation of wider Corona developments. However, we observe widespread evidence of creative re-materialisations of festival experiences, pointing to processes of remembrance, repair, and the ongoing constructive re-making of ritual festival experience in novel contexts.

  • Closed Access English
    Authors: 
    Glintborg, B.; Jensen, D. V.; Engel, S.; Terslev, L.; Jensen, M. Pfeiffer; Hendricks, O.; Ostergaard, M.; Rasmussen, S. H.; Adelsten, T.; Danebod, K.; +11 more
    Country: Denmark
  • Restricted English
    Authors: 
    Bollig, Georg;
    Country: Denmark

    1. Background and GoalsA major challenge for public palliative care is to support all people who want to die at home. Last Aid Courses (LAC) have been started in 2015 to educate citizens and to empower them to participate in end-of-life care. The main goals of the International Last Aid project were to establish an International Last Aid working group and to provide and evaluate public palliative care education for citizens. 2. MethodsBetween 2017 and 2019 an International Last Aid working group with representatives from different countries and national organisations from e.g. palliative care, health-services, and the church as cooperation partners has been established. The curriculum and contents of the International Last Aid course are revised every other year by the International Last Aid working group. Scientific evaluation of LAC is coordinated by the international Last Aid Research Group Europe (LARGE) that was founded in September 2019. The experiences from he implementation process and the findings from the scientific evaluation will be summarised and presented during the Zoominar. 3. Results and ConclusionWork on LAC has been started in 17 countries as Denmark, Germany, Slovenia, Lithuania, Scotland, Ireland, Australia, Brasil, etc. The overall results show that the LAC is feasible and very well accepted in many different countries, cultures and groups. It has been used for adults, children and groups as hospital employees and policemen. LAC are even possible as online course format that was tested during the COVID-19 pandemic. Scientific work on cultural issues and the effects of Last aid Courses are ongoing in a number of countries. In conclusion Last Aid Courses are feasible and well accepted by citizens in different countries. The courses can contribute to a public debate on death, dying and palliative care and may contribute to empower citizens to provide end-of-life care. Keywords: Palliative care, public palliative care education, end-of-life care, home death, compassionate communities, Last Aid Course Biography: Dr. med. Georg Bollig, PhD, MAS, DEAA is a physician and researcher. He is a specialist in anaesthesiology, emergency medicine and palliative medicine with scientific work in various fields. He works as consultant in palliative medicine at the Medical Center Sønderjylland in Sønderborg, South Jutland Hospital, Denmark. Georg is a clinical associate professor in palliative care at the University of Southern Denmark. He invented Last Aid Courses and is the leader of Last Aid International and the international Last Aid working group. At present he is working on research projects about ethics, telemedicine and the effects of Last Aid Courses. The presented research has been performed without external funding.Presenting author details that will be used for Certificates and Id cardsDr. Georg Bollig, PhD, MAS, DEAA; Clin. Assoc. Prof. in Palliative Care Palliative Care Team, Medical Department Sønderborg/Tønder, South Jutland Hospital, Sønderborg, Denmark b Palliative Care research group, Medical Research Unit, Institute of Regional Health Research, University of Southern Denmarkc Last Aid International, Schleswig, GermanyEmail 1(Work): georg.bollig@rsyd.dkEmail 2(Personal): bollig.georg@gmx.deMobile: +49-17634747059Office Tel: +45-20168303ORCID iD: https://orcid.org/0000-0002-0367-5295

  • Authors: 
    Antonella Arcadu; Silvia Puglisi; Alessandra Dubini; Sara Piciucchi; Fabio Sultani; Sabrina Martinello; Lara Bertolovic; Stefano Oldani; Luca Donati; Christian Gurioli; +2 more
    Publisher: European Respiratory Society

    Objectives: We sought to evaluate the association between age and presentation of SARS-COV2 infection Methods: Clinical presentation and radiological data of all consecutive COVID19 patients admitted to our Hospital between 01-03-2020 and 30-04-2020 were analyzed SARS-CoV-2 positive patients were diagnosed by either swab test or bronchoalveolar lavage Patients without proved SARS-CoV-2 infection or without HRCT scan were excluded All HRCT were reviewed and classified according to RSNA Classification of SARS-CoV-2 pneumonia(l) Results: Over the study period, 179 patients met the inclusion criteria Mean age was 67 years (SD 15 1, range 19-96);55 8% (N= 100) were male Of them, 22 patients (12%) had atypical clinical presentation The more frequent atypical presentations were cardiovascular, including syncope (N= 5, 22%) and heart failure (N= 5, 22%) HRCT was Typical in 151 (84 4%) patients, Indeterminate in 14 (7 8%), Atypical in 12 (6 7%), and Negative in 2 (0 01%) Among elderly patients (>70 years old) accounting for 44% of the total population (N=80), HRTC was more frequently Atypical (11/80 patients, 13 75%) compared to younger patients (<70 year of age, 1/99 patients, 1%) (p-value= 0 001) Similarly, the clinical presentation was more frequently atypical in the elderly (19/80, 23%) compared to the younger (3/99, 3 0%) (p-value <0 0001) Conclusions: Our study demonstrated that SARS-CoV-2 infections in elderly can results in atypical clinical and radiological presentation, potentially leading to misdiagnosis and unrecognized cases (1)Simpson S, et al Radiology 2020 doi: 10 1148/ryct 2020200152

  • Open Access English
    Authors: 
    Bjorgvinsdottir, Unnur Jona; Carstensen, Laura Stentoft; Colliander, Anna; Jaehger, Ditte Elisabeth; Veiga, Gael Clergeaud; Halldorsdottir, Holmfriour Rosa; Jorgensen, Matilde Smaerup; Christensen, Esben; Vangsgaard, Sara; Koukos, Aristeidis; +3 more
    Country: Denmark

    Background Therapeutic cancer vaccines represent an intriguing approach to cancer immunotherapy and they have been widely explored for the last decade. As opposed to standard modalities, such as surgery and chemotherapy, an effective vaccine-based immune response may provide protection against metastatic disease. Peptide based vaccines can elicit a highly targeted immune response and include a simple, fast and cost-effective production due to recent developments in solid phase peptide synthesis. Recent development within the field of COVID-19 vaccines has highlighted the use of lipid nanoparticles as an effective drug delivery system for vaccination. Incorporation of peptide antigens into engineered micro- and nanoparticles enables induction of a potent T cell response, partly attributed to prolonged and improved antigen presentation by dendritic cells after particle internalization. Peptide-based vaccines are often based on delivery of high-affinity T cell model epitopes. However, the therapeutic relevance of vaccination with low-affinity epitopes is gaining increasing support following the observation that high-affinity epitopes can promote T cell exhaustion resulting from excessive T cell receptor stimulation. Here, we characterize and evaluate a novel lipid nanoparticle (LNP) vaccine platform that is suited for delivery of both high- and low-affinity epitopes in the setting of therapeutic cancer vaccination.Methods LNPs were formulated to carry high- or low-affinity peptide epitopes from Ovalbumin (OVA) in conjunction with the TLR7 agonist 1V270. The peptides were anchored to the surface of the LNPs via a reducible DSPE-PEG2000 linker system. The therapeutic vaccine platform was evaluated in vivo both as a monotherapy and in combination with adoptive transfer of OT-I T cells in the syngeneic B16-OVA murine melanoma model.Results The LNP vaccine promotes efficient antigen-release and ensures high, continuous antigen-presentation by antigen-presenting cells. While the LNPs can be administered via multiple routes, intratumoral vaccination favors enhanced particle uptake in dendritic cells in the tumor. Formulated with either high- or low-affinity epitopes, intratumorally delivered vaccine particles promote superior tumor-infiltration of adoptively transferred T cells, which translates into potent anti-tumor efficacy in vivo. Finally, we show that vaccination with both CD8+ and CD4+ epitopes can delay tumor growth and prolong survival in an antigen-dependent manner.Conclusions This study presents a versatile and multi-purpose LNP vaccine platform that ensures effective delivery of high- and low-affinity epitopes. Intratumoral administration promotes vaccine particle uptake by intratumoral dendritic cells, which is followed by T cell infiltration and anti-tumor efficacy in vivo.

  • Publication . Contribution for newspaper or weekly magazine . Conference object . 2021
    Open Access English
    Authors: 
    Javad Najafi; Javad Mahmoudi; Amjad Anvari-Moghaddam;
    Publisher: IEEE Press
    Country: Denmark

    The reliability of power distribution networks can be threatened due to the health of repair crews. Covid-19 is a nowadays challenge that affects the health and the availability of repair crews. Monte Carlo simulation is implemented in this paper to evaluate the reliability of power distribution networks considering Covid-19. This paper alerts the power distribution companies to consider some strategies to prevent the growth of expected energy not served (EENS) during the pandemics era such as Covid-19.