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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: José Filipe;

    Covid-19 appeared in Wuhan (China), by December 2019 and rapidly spread to the rest of the world. Many countries adopted measures against its spread to protect people and national healthcare services. However, at the moment, more than 2.5 million people got infected and more than 175 thousand died in the 213 countries, areas and territories reached by the disease (official records at April 23, 2020). Countries began to adopt also measures to protect the economy and to prepare the economic recovery, once the effects are tremendous worldwide. In Portugal, measures allowed a flattered curve for Covid-19 spread. In this paper, we use an analogy to the 'drop of honey effect' to show how this curve develops. The 'drop of honey effect' is studied in terms of chaos theory and dynamic systems and is used as a framework to the way systems change in social phenomena.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ International Journa...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ International Journa...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    AbstractIn the spreading of infectious diseases, an important number to determine is how many other people will be infected on average by anyone who has become infected themselves. This is known as the reproduction number. This paper describes a non-parametric inverse method for extracting the full transfer function of infection, of which the reproduction number is the integral. The method is demonstrated by applying it to the timeline of hospitalisation admissions for covid-19 in the Netherlands up to May 20 2020, which is publicly available from the site of the Dutch National Institute of Public Health and the Environment (rivm.nl).

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ NARCIS; Journal of M...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Journal of Mathematical Biology
    Article
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Europe PubMed Central
    Article . 2021
    Data sources: PubMed Central
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ NARCIS; Journal of M...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Journal of Mathematical Biology
      Article
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Europe PubMed Central
      Article . 2021
      Data sources: PubMed Central
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Jacopo Marazzato; Fabio Angeli; Paolo Verdecchia; Sergio Masnaghetti; +4 Authors

    Abstract Aims Although the new coronavirus (SARS-CoV-2) may cause an acute multiorgan syndrome (COVID-19), data are emerging on mid- and long-term sequelae of COVID-19 pneumonia. Since no study has hitherto investigated the role of both cardiac and pulmonary ultrasound techniques in detecting such sequelae, this study aimed at evaluating these simple diagnostic tools to appraise the cardiopulmonary involvement occurring after COVID-19 pneumonia. Methods and results Twenty-nine patients fully recovered from COVID-19 pneumonia were considered at our centre. On admission, all patients underwent 12-lead electrocardiogram (ECG) and transthoracic echocardiography (TTE) evaluation. Compression ultrasound (CUS) and lung ultrasound (LUS) were also performed. Finally, in each patient, pathological findings detected on LUS were correlated with the pulmonary involvement occurring after COVID-19 pneumonia as assessed on thoracic computed tomography (CT). Out of 29 patients (mean age 70 ± 10 years old; M 69%), prior cardiovascular and pulmonary comorbidities were recorded in 22 (76%). Twenty-seven patients (93%) were in sinus rhythm and two (7%) in atrial fibrillation. ECG repolarization abnormalities were extremely common (93%) and reflected the high prevalence of pericardial involvement on TTE (86%). Likewise, pleural abnormalities were frequently observed (66%). TTE signs of left and right ventricular dysfunction were reported in two patients only, but values of systolic pulmonary artery pressure were abnormal in 16 (55%) despite absence of prior comorbidities in 44% of them. Regarding LUS evaluation, most patients displayed abnormal values of diaphragmatic thickness and excursion (93%) which well correlated with the high prevalence (76%) of on pathological findings on CT scan. CUS ruled out deep vein thrombosis in all patients. Conclusions Data on cardiopulmonary sequelae after COVID-19 pneumonia are scarce. In our study, simple diagnostic tools (TTE and LUS) proved clinically useful for detection of cardiopulmonary involvement after COVID-19 pneumonia.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ European Heart Journ...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ European Heart Journ...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Jon Hafan Sutawardana; Yustika Dian Pawesti; Murtaqib Murtaqib;

    A sedentary lifestyle is any type of activity that only expends a small amount of energy with an energy expenditure of not more than 1.5 METs when sitting or lying down. this has a very bad impact on health. These activities have a very bad impact on health. During the COVID-19 pandemic, people face many big challenges, one of which is social distancing in a sedentary lifestyle. The objective of this study is to describe changes in sedentary lifestyles among cardiovascular disease patients during the COVID-19 pandemic. The research design used was a literature review using 3 databases (Pubmed, Proquest, and Science Direct). The process of searching for articles using keywords and Boolean operators (AND, OR, or NOT) aims to define and expand the literature. The review found that the sedentary lifestyle increased up to 8 hours/day. In addition to what has been mentioned 4 other articles also mention an increase in sedentary lifestyle time and an increase in sitting time, this is in accordance with research conducted on the average daily duration of sedentary behaviour is 8.3 hours between Koreans and 7, 7 hours among American adults due to government regulations during the pandemic. All articles show that people who tend to be older and male have a higher risk of developing cardiovascular cases that lead to death during the COVID-19 pandemic. So it is necessary to expand the scope of information about the importance of physical activity so that all people with cardiovascular disease have high vigilance.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Media Keperawatan In...arrow_drop_down
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Media Keperawatan In...arrow_drop_down
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    Обґрунтування. Запровадження карантину з приводу COVID-19 може призвести до зниження виявлення хворих на туберкульоз, зростання захворюваності та смертності від цього захворювання. На тлі виснаження імунної системи населення дедалі частіше трапляється поєднана туберкульозна патологія, зокрема поєднання туберкульозу легень і туберкульозного отиту. Туберкульоз середнього вуха виникає як вторинний процес у хворих на дисеміновані й інші форми легеневого туберкульозу. Діагностика поєднаної патології значно утруднена, коли специфічний процес перебігає на тлі хронічної неспецифічної патології легень. У таких випадках актуальності набуває застосування додаткових методів дослідження, а саме комп’ютерної томографії (КТ) скроневих кісток та органів грудної порожнини (ОГП). Клінічний випадок. Хвора Т., 1982 р. н., в анамнезі має всі календарні щеплення БЦЖ. Із 2008 р. cпостерігається в пульмонолога з приводу бронхоектатичної хвороби нижньої частки лівої легені. Неодноразово лікувалася стаціонарно й амбулаторно. З березня 2018 р. cпостерігається в оториноларинголога з приводу хронічного лівобічного гнійного середнього отиту. Останнє загострення було в лютому 2020 р. Виконано пункцію та шунтування барабанної порожнини. Тоді ж з’явилися загальна кволість, нежить, біль і пирхота в горлі, підвищення температури тіла до 37,5 ° С, потім – кашель із гнійним мокротинням, осиплість голосу. Отримувала декілька курсів неспецифічної антибактеріальної терапії, але без позитивного ефекту. З метою уточнення діагнозу та лікування направлена до Національного інституту фтизіатрії і пульмонології. Проведено КТ скроневих кісток, у ході якої виявлено ознаки лівобічного середнього отиту та мастоїдиту (рис. 1). На аудіограмі – погіршення слуху за типом слухопроведення (кістково-повітряний розрив на частоті 4000 Гц дорівнював 50 дБ). Виділення з лівого зовнішнього слухового проходу відсутні. На КТ ОГП – ознаки дисемінованого туберкульозу легень, сегментарний ателектаз нижньої частки зліва (рис. 2). Мікроскопія мокротиння: КСП не виявлено, GenXpert МТВ + RIF-. Розпочато основний курс антимікобактеріальної терапії за I категорією. Місцево – офлоксацин (вушні краплі). У результаті призначеного лікування отримано позитивну динаміку поєднаної патології (рис. 3). Висновки. Незважаючи на своєчасне звернення по медичну допомогу, у хворої на хронічний середній отит і бронхоектатичну хворобу, що не піддавалися неспецифічній антибактеріальній терапії, не було своєчасно діагностовано туберкульоз. Проведення КТ скроневих кісток та ОГП у пацієнтів із хронічними захворюваннями легень у поєднанні з хронічним середнім отитом має високу інформативність у виявленні туберкульозного процесу й оцінки ефективності лікування.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Infusion & Chemother...arrow_drop_down
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    Infusion & Chemotherapy
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Infusion & Chemother...arrow_drop_down
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      Infusion & Chemotherapy
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    Authors: Kacper Łoś; Joanna Kulikowska; Napoleon Waszkiewicz;

    The effects of COVID-19 on the human body are not yet understood enough. Medical history provides information on cases of psychiatric symptoms during viral infections in the 20th century, such as the influenza pandemic. Currently, it is observed that there is an increasing number of new psychiatric disorders in previously healthy individuals. In addition, because of the decreased amount of reporting to health care providers, including psychiatrists, many physicians suggest that the number of neuropsychiatric disorders may be underestimated. In this paper, we review available studies on the occurrence of first-time psychotic spectrum disorder (PSD) in individuals related to SARS-CoV-2 infection. The reviewed studies suggest that first-time psychotic disorder in COVID-19 patients is statistically significantly more frequent compared to influenza, as well as to other respiratory infections. The emergence of new PSDs is explained by direct neurotropism of the virus on the one hand and by immunological mechanisms on the other. The main conclusions of this review should be treated with caution, and future research on this topic is needed. The authors recognize the particular need to develop standardized laboratory panels that include inflammatory markers (IL-6, TNF-α), cerebrospinal fluid (CSF) testing, and SARS-CoV-2 antibody assays to entirely understand the etiology of neuropsychiatric complications of SARS-CoV-2 infections and the pandemic itself. In addition, public health efforts are required to promote mental health, especially during COVID-19.

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    Authors: Janusz Marcinkiewicz; Grzegorz Majka;
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    Authors: G James Rubin; Louise E Smith; Richard Amlot; Nicola T Fear; +2 Authors

    ObjectivesTo assess the percentage of people in the UK with cough, fever or loss of taste or smell who have not had a positive COVID-19 test result who had been to work, to shops, socialised or provided care to a vulnerable person in the 10 days after developing symptoms. To investigate whether these rates differed according to the type of symptom, what the participant thought the cause of their symptoms was and whether they had taken a COVID-19 test.DesignFour online cross-sectional surveys using non-probability quota sampling method (n=8547).SettingData were collected across the UK from 20 September to 3 November 2021, via a market research company.ParticipantsAged over 16 years living in the UK.Primary outcome measuresOut-of-home activity.Results498 participants reported one or more symptoms and had not had a positive COVID-19 test result. Within that group, about half of employed participants had attended work while symptomatic (51.2%–56.3% depending on the symptom, 95% CIs 42.2% to 65.6%). Rates of other contact behaviours ranged from 31.4% (caring for a vulnerable person after developing a cough: 95% CI 24.3% to 38.4%) to 61.5% (shopping for groceries or pharmacy after developing a cough: 95% CI 54.1% to 68.9%). There were no differences according to type of symptom experienced or what the participant felt might be the cause. People who had taken a COVID-19 test were less likely to go out shopping for non-essentials than people who had not taken a test.ConclusionMany people in the UK with symptoms of an infectious disease were not following government advice to stay at home if they believed they had an infectious illness. Reducing these rates may require a shift in our national attitude to the acceptability of people attending work with infectious illnesses.

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    Article . 2022
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      Article . 2022
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    Метою дослідження є узагальнення найкращих практик корпоративної соціальної відповідальності міжнародних компаній, особливо під впливом глобальної пандемії COVID-19. У дослідженні використано методи логічного узагальнення, аналізу, порівняння, групування, графічні та табличні. Особливістю корпоративної соціальної відповідальності є її приналежність до суспільного або квазісуспільного блага, що поєднує корпоративне управління й економіку публічного сектора. Низка сучасних досліджень указує на прямий зв'язок соціальної відповідальності та репутації компаній, оскільки її найбільш важливими факторами визнаються якість товарів та послуг (20,1 %), якість управління (14,8 %), громадянство (14,4 %), фінансовий успіх (13,2 %) та інновації (13,1 %).У статті наголошено, що глобальний уплив пандемії COVID-19 сприяв тому, що організації в прискореному режимі почали розвивати власну стратегічну гнучкість та різні моделі корпоративної соціальної відповідальності. Відтак у 2022 р. рейтинг соціально відповідальних компаній очолили: Rolex, Ferrari, Lego Group, Rolls-Royce, Mercedes-Benz, Harley-Davidson, The Bosch Group, PayPal, Netflix, Intel. Визначено, що пандемія COVID-19 сприяла появі нових соціальних ініціатив: від створення інноваційного фонду кліматичних рішень, відмови від використання пластику до забезпечення дітей із малозабезпечених сімей безкоштовним доступом до Інтернету та гаджетами. У статті доведено, що зростання лояльності споживачів, підвищення репутації корпорацій як привабливих роботодавців безпосередньо впливають на збільшення обсягів продажів, мотивацію співробітників, бажання держави та суспільства взаємодіяти із соціально відповідальними компаніями, зростання ринкової вартості компаній.

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    Authors: Usman Usman; Iing Dwi Lestari; Sri Handayani Astuti; Nova Izanah; +3 Authors

    The Merdeka Curriculum is a curriculum that has been inaugurated since the 2021/2022 school year and will be applied to the national curriculum in the 2022/2023 school year. This curriculum is set as a form of learning recovery due to the Covid-19 pandemic which is one of the causes of students experiencing learning lags. In the implementation of the Merdeka Curriculum, there will definitely be obstacles or obstacles, both from internal and external factors. This study aims to find out the obstacles faced by biology teachers of Yuppentek 1 High School in the learning process of the Merdeka Curriculum. The type of research used is descriptive qualitative using two types of research data in the form of primary data obtained by conducting interviews, distributing questionnaires, as well as documentation and secondary data in the form of journals, books, and data from schools. Based on the research that has been carried out, it can be concluded that the obstacles for biology teachers in the implementation of the Merdeka Curriculum at Yuppentek 1 High School are: (i) in the learning process by 21,4% have difficulty determining learning models that are relevant to the Merdeka Curriculum and difficulties in time management, (ii) obstacles to teaching materials are not felt by biology teachers at Yuppentek 1 High School because the teaching materials are adequate, (iii) the process and implementation of the assessment do not experience obstacles because the evaluation materials used have measured the abilities of students, (iv) and finally there are no obstacles in obtaining information about the Merdeka Curriculum, because teachers get enough information with the socialization of the Merdeka Curriculum.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: José Filipe;

    Covid-19 appeared in Wuhan (China), by December 2019 and rapidly spread to the rest of the world. Many countries adopted measures against its spread to protect people and national healthcare services. However, at the moment, more than 2.5 million people got infected and more than 175 thousand died in the 213 countries, areas and territories reached by the disease (official records at April 23, 2020). Countries began to adopt also measures to protect the economy and to prepare the economic recovery, once the effects are tremendous worldwide. In Portugal, measures allowed a flattered curve for Covid-19 spread. In this paper, we use an analogy to the 'drop of honey effect' to show how this curve develops. The 'drop of honey effect' is studied in terms of chaos theory and dynamic systems and is used as a framework to the way systems change in social phenomena.

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    AbstractIn the spreading of infectious diseases, an important number to determine is how many other people will be infected on average by anyone who has become infected themselves. This is known as the reproduction number. This paper describes a non-parametric inverse method for extracting the full transfer function of infection, of which the reproduction number is the integral. The method is demonstrated by applying it to the timeline of hospitalisation admissions for covid-19 in the Netherlands up to May 20 2020, which is publicly available from the site of the Dutch National Institute of Public Health and the Environment (rivm.nl).

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    Journal of Mathematical Biology
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    Europe PubMed Central
    Article . 2021
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      Journal of Mathematical Biology
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      Europe PubMed Central
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    Authors: Jacopo Marazzato; Fabio Angeli; Paolo Verdecchia; Sergio Masnaghetti; +4 Authors

    Abstract Aims Although the new coronavirus (SARS-CoV-2) may cause an acute multiorgan syndrome (COVID-19), data are emerging on mid- and long-term sequelae of COVID-19 pneumonia. Since no study has hitherto investigated the role of both cardiac and pulmonary ultrasound techniques in detecting such sequelae, this study aimed at evaluating these simple diagnostic tools to appraise the cardiopulmonary involvement occurring after COVID-19 pneumonia. Methods and results Twenty-nine patients fully recovered from COVID-19 pneumonia were considered at our centre. On admission, all patients underwent 12-lead electrocardiogram (ECG) and transthoracic echocardiography (TTE) evaluation. Compression ultrasound (CUS) and lung ultrasound (LUS) were also performed. Finally, in each patient, pathological findings detected on LUS were correlated with the pulmonary involvement occurring after COVID-19 pneumonia as assessed on thoracic computed tomography (CT). Out of 29 patients (mean age 70 ± 10 years old; M 69%), prior cardiovascular and pulmonary comorbidities were recorded in 22 (76%). Twenty-seven patients (93%) were in sinus rhythm and two (7%) in atrial fibrillation. ECG repolarization abnormalities were extremely common (93%) and reflected the high prevalence of pericardial involvement on TTE (86%). Likewise, pleural abnormalities were frequently observed (66%). TTE signs of left and right ventricular dysfunction were reported in two patients only, but values of systolic pulmonary artery pressure were abnormal in 16 (55%) despite absence of prior comorbidities in 44% of them. Regarding LUS evaluation, most patients displayed abnormal values of diaphragmatic thickness and excursion (93%) which well correlated with the high prevalence (76%) of on pathological findings on CT scan. CUS ruled out deep vein thrombosis in all patients. Conclusions Data on cardiopulmonary sequelae after COVID-19 pneumonia are scarce. In our study, simple diagnostic tools (TTE and LUS) proved clinically useful for detection of cardiopulmonary involvement after COVID-19 pneumonia.

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    Authors: Jon Hafan Sutawardana; Yustika Dian Pawesti; Murtaqib Murtaqib;

    A sedentary lifestyle is any type of activity that only expends a small amount of energy with an energy expenditure of not more than 1.5 METs when sitting or lying down. this has a very bad impact on health. These activities have a very bad impact on health. During the COVID-19 pandemic, people face many big challenges, one of which is social distancing in a sedentary lifestyle. The objective of this study is to describe changes in sedentary lifestyles among cardiovascular disease patients during the COVID-19 pandemic. The research design used was a literature review using 3 databases (Pubmed, Proquest, and Science Direct). The process of searching for articles using keywords and Boolean operators (AND, OR, or NOT) aims to define and expand the literature. The review found that the sedentary lifestyle increased up to 8 hours/day. In addition to what has been mentioned 4 other articles also mention an increase in sedentary lifestyle time and an increase in sitting time, this is in accordance with research conducted on the average daily duration of sedentary behaviour is 8.3 hours between Koreans and 7, 7 hours among American adults due to government regulations during the pandemic. All articles show that people who tend to be older and male have a higher risk of developing cardiovascular cases that lead to death during the COVID-19 pandemic. So it is necessary to expand the scope of information about the importance of physical activity so that all people with cardiovascular disease have high vigilance.

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    Обґрунтування. Запровадження карантину з приводу COVID-19 може призвести до зниження виявлення хворих на туберкульоз, зростання захворюваності та смертності від цього захворювання. На тлі виснаження імунної системи населення дедалі частіше трапляється поєднана туберкульозна патологія, зокрема поєднання туберкульозу легень і туберкульозного отиту. Туберкульоз середнього вуха виникає як вторинний процес у хворих на дисеміновані й інші форми легеневого туберкульозу. Діагностика поєднаної патології значно утруднена, коли специфічний процес перебігає на тлі хронічної неспецифічної патології легень. У таких випадках актуальності набуває застосування додаткових методів дослідження, а саме комп’ютерної томографії (КТ) скроневих кісток та органів грудної порожнини (ОГП). Клінічний випадок. Хвора Т., 1982 р. н., в анамнезі має всі календарні щеплення БЦЖ. Із 2008 р. cпостерігається в пульмонолога з приводу бронхоектатичної хвороби нижньої частки лівої легені. Неодноразово лікувалася стаціонарно й амбулаторно. З березня 2018 р. cпостерігається в оториноларинголога з приводу хронічного лівобічного гнійного середнього отиту. Останнє загострення було в лютому 2020 р. Виконано пункцію та шунтування барабанної порожнини. Тоді ж з’явилися загальна кволість, нежить, біль і пирхота в горлі, підвищення температури тіла до 37,5 ° С, потім – кашель із гнійним мокротинням, осиплість голосу. Отримувала декілька курсів неспецифічної антибактеріальної терапії, але без позитивного ефекту. З метою уточнення діагнозу та лікування направлена до Національного інституту фтизіатрії і пульмонології. Проведено КТ скроневих кісток, у ході якої виявлено ознаки лівобічного середнього отиту та мастоїдиту (рис. 1). На аудіограмі – погіршення слуху за типом слухопроведення (кістково-повітряний розрив на частоті 4000 Гц дорівнював 50 дБ). Виділення з лівого зовнішнього слухового проходу відсутні. На КТ ОГП – ознаки дисемінованого туберкульозу легень, сегментарний ателектаз нижньої частки зліва (рис. 2). Мікроскопія мокротиння: КСП не виявлено, GenXpert МТВ + RIF-. Розпочато основний курс антимікобактеріальної терапії за I категорією. Місцево – офлоксацин (вушні краплі). У результаті призначеного лікування отримано позитивну динаміку поєднаної патології (рис. 3). Висновки. Незважаючи на своєчасне звернення по медичну допомогу, у хворої на хронічний середній отит і бронхоектатичну хворобу, що не піддавалися неспецифічній антибактеріальній терапії, не було своєчасно діагностовано туберкульоз. Проведення КТ скроневих кісток та ОГП у пацієнтів із хронічними захворюваннями легень у поєднанні з хронічним середнім отитом має високу інформативність у виявленні туберкульозного процесу й оцінки ефективності лікування.

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