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212 Research products, page 1 of 22

  • COVID-19
  • Publications
  • Open Access
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  • MX
  • COVID-19

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  • Open Access English
    Authors: 
    Sk. Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Alaa A. A. Aljabali; Bruce D. Uhal; Kenneth Lundstrom; Nima Rezaei; Vladimir N. Uversky; Murat Seyran; +14 more
    Publisher: MDPI AG

    393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species. Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22&ndash 84, and aa 330&ndash 42, aa 79&ndash

  • Open Access
    Authors: 
    Arturo Galindo-Fraga; Ana A Ortiz-Hernández; Alejandra Ramírez-Venegas; Rafael Valdez Vázquez; Sarbelio Moreno-Espinosa; Beatriz Llamosas-Gallardo; Santiago Pérez-Patrigeon; Maggie Salinger; Laura Freimanis; Chiung Yu Huang; +4 more
    Publisher: Elsevier BV

    Summary Background Influenza-like illnesses (ILI) are estimated to cause millions of deaths annually. Despite this disease burden, the etiologic causes of ILI are poorly described for many geographical regions. Methods Beginning in April 2010, we conducted an observational cohort study at five hospitals in Mexico City, enrolling subjects who met the criteria for ILI. Evaluations were conducted at enrollment and on day 28, with the collection of clinical data and a nasopharyngeal swab (or nasal aspirate in children). Swabs were tested by multiplex PCR for 15 viral pathogens and real-time PCR for influenza. Results During the first year, 1065 subjects were enrolled in this study, 55% of whom were hospitalized; 24% of all subjects were children. One or more pathogens were detected by PCR in 64% of subjects, most commonly rhinovirus (25% of all isolates) and influenza (24% of isolates). Six percent of subjects died, and of those, 54% had no pathogen identified. Rhinovirus was the most common pathogen among those who died, although it did not have the highest case fatality rate. Conclusions Multiple respiratory viruses beyond influenza are associated with significant morbidity and mortality among adults and children in Mexico City. Detection of these agents could be useful for the adjustment of antibiotic treatment in severe cases.

  • Publication . Article . Other literature type . 2020
    Open Access English
    Authors: 
    Blanca Taboada; Joel A. Vazquez-Perez; José Esteban Muñoz-Medina; Pilar Ramos-Cervantes; Marina Escalera-Zamudio; Celia Boukadida; Alejandro Sanchez-Flores; Pavel Isa; Edgar Mendieta-Condado; José Arturo Martínez-Orozco; +21 more
    Publisher: American Society for Microbiology
    Country: United Kingdom

    The coronavirus disease 2019 (COVID-19) pandemic has affected most countries in the world. Studying the evolution and transmission patterns in different countries is crucial to enabling implementation of effective strategies for disease control and prevention. In this work, we present the full genome sequence for 17 SARS-CoV-2 isolates corresponding to the earliest sampled cases in Mexico. Global and local phylogenomics, coupled with mutational analysis, consistently revealed that these viral sequences are distributed within 2 known lineages, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage A/G, containing mostly sequences from North America, and lineage B/S, containing mainly sequences from Europe. Based on the exposure history of the cases and on the phylogenomic analysis, we characterized 14 independent introduction events. Additionally, three cases with no travel history were identified. We found evidence that two of these cases represented local transmission cases occurring in Mexico during mid-March 2020, denoting the earliest events described for the country. Within this local transmission cluster, we also identified an H49Y amino acid change in the Spike protein. This mutation represents a homoplasy occurring independently through time and space and may function as a molecular marker to follow any further spread of these viral variants throughout the country. Our results provide a general picture of the SARS-CoV-2 variants introduced at the beginning of the outbreak in Mexico, setting the foundation for future surveillance efforts. IMPORTANCE Understanding the introduction, spread, and establishment of SARS-CoV-2 within distinct human populations as well as the evolution of the pandemics is crucial to implement effective control strategies. In this work, we report that the initial virus strains introduced in Mexico came from Europe and the United States and that the virus was circulating locally in the country as early as mid-March. We also found evidence for early local transmission of strains with a H49Y mutation in the Spike protein, which could be further used as a molecular marker to follow viral spread within the country and the region.

  • Open Access English
    Authors: 
    Alfonso Gastelum Strozzi; Claudia Infante-Castañeda; Juan Guillermo Figueroa-Perea; Ingris Peláez-Ballestas;
    Publisher: Multidisciplinary Digital Publishing Institute

    The perception of risk has been a key element in the experiences, containment and differential impact of the COVID-19 pandemic worldwide. The complexity of this phenomenon requires the interdisciplinary integration of theoretical and methodological aspects, as this integration informs the objective of developing a mathematical proposal based on a conceptual model located within the social theory of risk at the micro-social level. The mathematical risk model used here was developed from a secondary analysis of a study of 12,649 individuals on the experiences of the COVID-19 pandemic in a population in which the quantity and quality of the information made it possible to define a risk factor and its relationship to emotions and the sources of information used. Four sequential strategies were used to construct the model: choosing the variables for the questionnaire that theoretically corresponded to the conceptual model, constructing the risk vector and initial grouping of individuals by perception of risk, modeling by using principal component analysis and applying network methods. The theoretical model of risk, proposed and constructed through the analysis of groupings by quartiles and by networks in the studied population from a social and mathematical perspective, demonstrates the heterogeneity of risk perception as manifested by differences in perception by age, gender, expression of feelings and media consulted in a university community. The knowledge and methodology generated in these analyses contribute to the body of knowledge informing the response to future epidemiological contingencies.

  • Open Access English
    Authors: 
    Ana E. Gonzalez-Santiago; Luz A. Mendoza-Topete; Francisco Sánchez-Llamas; Rogelio Troyo-Sanromán; Carmen M. Gurrola-Díaz;
    Publisher: Wiley Subscription Services, Inc., A Wiley Company

    Lung cancer is a malignant disease with increasing mortality rates. Cytokines play a role in normal cell growth regulation and differentiation and are also implicated in malignant disease. Among these cytokines, Transforming Growth Factor β type 1 (TGF-β1) acts as a tumor promoter in malignant cells. Several clinical studies have found high levels of TGF-β1 in various cancer types. The aim of this study was to establish a TGF-β1 cut-off point as a complementary diagnostic tool in lung cancer detection. Therefore, 72 clinically well-characterized individuals were studied, 41 lung cancer patients and 31 healthy subjects. Serum TGF-β1 concentration was measured by an enzyme-linked immunosorbent assay (ELISA). We compared statistically the serum TGF-β1 concentration between both groups with analysis of variance, linear regression and receiver operating curve analysis. We observed that lung cancer patients produced higher TGF-β1 levels than healthy individuals (37,225±9,436 vs. 28,416±9,324 pg/ml, P<0.001). The cut-point diagnostic value was 30,500 pg/ml with 80.5% sensitivity, 64.5% specificity and odds ratio: 7.5, 95% CI: 2.6–21.8. Conclusions: We found significantly higher TGF-β1 levels in lung cancer patients than in healthy individuals. We propose the measurement of serum TGF-β1 levels as a complementary diagnostic test in lung cancer detection. J. Clin. Lab. Anal. 25:238–243, 2011. © 2011 Wiley-Liss, Inc.

  • Publication . Article . Other literature type . Preprint . 2020
    Open Access English
    Authors: 
    Xyoli Pérez-Campos; Victor Hugo Espíndola; Daniel González-Ávila; Betty Zanolli Fabila; Victor H. Márquez-Ramírez; Raphael S. M. De Plaen; Juan C. Montalvo-Arrieta; Luis Quintanar;

    Abstract. The world experienced the beginning of the COVID-19 pandemic by the end of 2019 to the beginning of 2020. Governments implemented strategies to contain it, most based on lockdowns. Mexico was no exception. The lockdown was initiated in March 2020, and with it, a reduction in the seismic noise level was witnessed by the seismic stations of the national and Valley of Mexico networks. Stations located in municipalities with more than 50 000 people usually experience larger seismic noise levels at frequencies between 1 and 5 Hz, associated with human activity. The largest noise levels are recorded in Mexico City, which has the largest population in the country. The largest drop was observed in Hermosillo, Sonora; however, it was also the city with the fastest return to activities, which seems to correlate with a quick increase in confirmed COVID-19 cases. Mexico initiated a traffic-light system to modulate the re-opening of economic activities for each state. Therefore, since 1 June, noise levels have generally reflected the colour of the state traffic light. Furthermore, the reduction in the noise level at seismic stations has allowed identification of smaller earthquakes without signal processing. Also, people in cities have perceived smaller or more distant quakes.

  • Open Access
    Authors: 
    Gabriela Macedo-Ojeda; José Francisco Muñoz-Valle; Patricia Yokogawa-Teraoka; Andrea Carolina Machado-Sulbaran; María Guadalupe Loza-Rojas; Atziri Citlally García-Arredondo; Rafael Tejeda-Constantini; Alejandra Natali Vega-Magaña; Guillermo González-Estevez; Mariel García-Chagollán; +2 more
    Publisher: MDPI AG

    0.0001). Food intake quality was similar in both groups, except for the most consumed type of fat (p = 0.006). In conclusion, this study supports the association of diabetes as a principal risk factor for SARS-CoV-2 infection in the Mexican population. The results do not support previous associations between blood group or influenza vaccination as protective factors against SARS-CoV-2 infection. However, frequent consumption of polyunsaturated fats is highlighted as a new possible associated factor with COVID-19, which more studies should corroborate as with all novel findings. Developing countries have reported lower molecular diagnostic testing levels due to a lack of resources. Therefore, antibody tests represent an alternative to detect exposure to SARS-CoV-2 and analyze possible risk factors. We aimed to describe and compare the clinical-epidemiological characteristics and the quality of food intake in Mexican individuals with a positive or negative test to antibodies against SARS-CoV-2. We carried out antibody tests and applied a survey to 1799 individuals 0.01). No differences were identified in the blood type nor influenza vaccination between groups. Coughing, respiratory distress, muscle pain, joint pain, and anosmia were the most prevalent symptoms among seropositive cases (p < 42% were positive, and diabetes was more prevalent in these cases (p <

  • Open Access English
    Authors: 
    Gisela Pineda-García; Aracely Serrano-Medina; Estefania Ochoa-Ruíz; Ana Laura Martínez;
    Publisher: MDPI

    Background: The potential impact of the COVID-19 pandemic on weight, shape-related appearance behaviors (body image dissatisfaction), and bulimic symptoms in nonclinical participants is poorly evaluated. This study aimed to identify the relationship between labor status, confinement degree due to COVID-19, dissatisfaction with body image, and anxiety and to discover its effect on bulimic behavior in Mexican adults. Methods: A cross-sectional study was conducted with a non-probabilistic sample of 276 participants via an online survey. Questions addressed their anxiety, body image dissatisfaction, and bulimic behavior. Results: The path analysis showed direct effects on the confinement degree (β = −0.157) and dissatisfaction (β = 0.085). Conclusions: The confinement, gender, and labor status are predictors of anxiety, while anxiety and body dissatisfaction directly influence bulimic behavior. of dissatisfaction on bulimic behavior (β = 0.443) and anxiety about bulimic behavior (β = 0.184) of the labor situation (β = −0.147) and gender (β = 0.129) on anxiety

  • Open Access English
    Authors: 
    Giuseppe De Luca; Matteo Nardin; Magdy Algowhary; Berat Uguz; Dinaldo C Oliveira; Vladimir Ganyukov; Zan Zimbakov; Miha Cercek; Lisette Okkels Jensen; Poay Huan LOH; +83 more
    Countries: Croatia, Denmark, Netherlands

    Background: During the coronavirus disease 2019 (COVID-19) pandemic, concerns have been arisen on the use of renin-angiotensin system inhibitors (RASI) due to the potentially increased expression of Angiotensin-converting-enzyme (ACE)2 and patient's susceptibility to SARS-CoV2 infection. Diabetes mellitus have been recognized favoring the coronavirus infection with consequent increase mortality in COVID-19. No data have been so far reported in diabetic patients suffering from ST-elevation myocardial infarction (STEMI), a very high-risk population deserving of RASI treatment.Methods: The ISACS-STEMI COVID-19 registry retrospectively assessed STEMI patients treated with primary percutaneous coronary intervention (PPCI) in March/June 2019 and 2020 in 109 European high-volume primary PCI centers. This subanalysis assessed the prognostic impact of chronic RASI therapy at admission on mortality and SARS-CoV2 infection among diabetic patients.Results: Our population is represented by 3812 diabetic STEMI patients undergoing mechanical reperfusion, 2038 in 2019 and 1774 in 2020. Among 3761 patients with available data on chronic RASI therapy, between those ones with and without treatment there were several differences in baseline characteristics, (similar in both periods) but no difference in the prevalence of SARS-CoV2 infection (1.6% vs 1.3%, respectively, p = 0.786). Considering in-hospital medication, RASI therapy was overall associated with a significantly lower in-hospital mortality (3.3% vs 15.8%, p < 0.0001), consistently both in 2019 and in 2010.Conclusions: This is first study to investigate the impact of RASI therapy on prognosis and SARS-CoV2 infection of diabetic patients experiencing STEMI and undergoing PPCI during the COVID-19 pandemic. Both pre-admission chronic RASI therapy and in-hospital RASI did not negatively affected patients' survival during the hospitalization, neither increased the risk of SARS-CoV2 infection.Trial registration number: NCT04412655.

  • Open Access
    Authors: 
    Martínez Sierra, Pedro Daniel; Olea Uribe, Fabiola Margarita;
    Publisher: Universitat Politecnica de Valencia
    Country: Spain

    [ES] El presente artículo se desprende del webinar 2020 “Miradas de las y los adolescentes sobre el impacto de la pandemia por COVID19”, organizado por el proyecto Tejiendo Redes Infancia en colaboración con la Escuela Nacional de Trabajo Social de la Universidad Nacional Autónoma de México (UNAM). El objetivo fue analizar las experiencias de adolescentes latinoamericanos sobre la pandemia por COVID19, a través de un encuentro virtual en la plataforma zoom que permitió posicionar las voces de este sector en el contexto de la crisis sanitaria en la región de Latinoamérica y el Caribe. Participaron seis adolescentes, tres de cada sexo de 15 a 18 años provenientes de México, Panamá, Paraguay, Guatemala y Bolivia. Se desarrolló bajo una metodología cualitativa, la técnica utilizada grupos focales por considerarla la más idónea para recuperar ideas, informaciones y conocimientos respecto al tema, además del uso de imágenes diseñadas por ellas y ellos para presentar sus argumentaciones. Los hallazgos dieron cuenta de las similitudes en las realidades latinoamericanas y un sentimiento de preocupación generalizado por la ausencia de estrategias de los Estados para atender las necesidades de los sectores vulnerables, como las familias de escasos recursos y quienes no tendrán la posibilidad de regresar a las escuelas. [EN] This article is derived from the 2020 webinar "Views of adolescents on the impact of the COVID19 pandemic", organized by the (Tejiendo Redes Infancia) project in collaboration with the National School of Social Work of the National Autonomous University of Mexico (UNAM). The objective was to analyze the experiences of Latin American adolescents on the COVID19 pandemic, through a virtual meeting on the zoom platform that allowed the voices of this sector to be positioned in the context of the health crisis in the Latin American and Caribbean region. Six adolescents participated, three of each sex between 15 and 18 years old, from Mexico, Panama, Paraguay, Guatemala and Bolivia. It was developed under a qualitative methodology, the technique used by focus groups considering it the most suitable to recover ideas, information and knowledge regarding the subject, in addition to the use of images designed by them to present their arguments. The findings revealed the similarities in Latin American realities and a general feeling of concern over the absence of State strategies to address the needs of vulnerable sectors, such as low-income families and those who will not have the possibility of returning to their schools.