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description Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Springer Science and Business Media LLC Funded by:NIH | HARVARD-MIT-NEMC RESEARCH..., NIH | UCLA Clinical Translation..., EC | PERISCOPE +17 projectsNIH| HARVARD-MIT-NEMC RESEARCH TRAINING IN HEALTH INFORMATICS ,NIH| UCLA Clinical Translational Science Institute ,EC| PERISCOPE ,NIH| The role of angiotensin-(1-7) in hypertension and hypertension-induced heart and kidney damage ,NIH| Modeling the Incompleteness and Biases of Health Data ,NIH| A framework to stratify patient cohorts for clinical management ,NIH| Frontiers: University of Kansas Clinical and Translational Science Institute ,NIH| Kentucky Center for Clinical and Translational Science ,NIH| Wake forest Clinical and Translational Science Award ,NIH| Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) ,NIH| Integrating EHR and Genomics to Predict Multiple Sclerosis Drug Response ,NIH| The Harvard Clinical and Translational Science Center ,NIH| University of Michigan Proteogenomics Data Analysis Center ,NIH| Michigan Institute for Clinical and Health Research (MICHR) ,NIH| University of Pittsburgh Clinical and Translational Science Institute ,NIH| University of Pittsburgh Clinical and Translational Science Institute ,NIH| The LungMAP Data Coordination Center for Next Gen Systems Biology of Respiration ,NIH| Biases introduced by filtering electronic health records for patients with "complete data" ,NIH| Developing i2b2 into a Health Innovation Platform for Clinical Decision Support in the Genomics Era ,NIH| eMERGE Phase IV Clinical Center at Partners HealthCareHarrison G. Zhang; Arianna Dagliati; Zahra Shakeri Hossein Abad; Xin Xiong; Clara-Lea Bonzel; Zongqi Xia; Bryce W. Q. Tan; Paul Avillach; Gabriel A. Brat; Chuan Hong; Michele Morris; Shyam Visweswaran; Lav P. Patel; Alba Gutiérrez-Sacristán; David A. Hanauer; John H. Holmes; Malarkodi Jebathilagam Samayamuthu; Florence T. Bourgeois; Sehi L’Yi; Sarah E. Maidlow; Bertrand Moal; Shawn N. Murphy; Zachary H. Strasser; Antoine Neuraz; Kee Yuan Ngiam; Ne Hooi Will Loh; Gilbert S. Omenn; Andrea Prunotto; Lauren A. Dalvin; Jeffrey G. Klann; Petra Schubert; Fernando J. Sanz Vidorreta; Vincent Benoit; Guillaume Verdy; Ramakanth Kavuluru; Hossein Estiri; Yuan Luo; Alberto Malovini; Valentina Tibollo; Riccardo Bellazzi; Kelly Cho; Yuk-Lam Ho; Amelia L. M. Tan; Byorn W. L. Tan; Nils Gehlenborg; Sara Lozano-Zahonero; Vianney Jouhet; Luca Chiovato; Bruce J. Aronow; Emma M. S. Toh; Wei Gen Scott Wong; Sara Pizzimenti; Kavishwar B. Wagholikar; Mauro Bucalo; The Consortium for Clinical Characterization of COVID-19 by EHR (4CE); Tianxi Cai; Andrew M. South; Isaac S. Kohane; Griffin M. Weber;AbstractThe risk profiles of post-acute sequelae of COVID-19 (PASC) have not been well characterized in multi-national settings with appropriate controls. We leveraged electronic health record (EHR) data from 277 international hospitals representing 414,602 patients with COVID-19, 2.3 million control patients without COVID-19 in the inpatient and outpatient settings, and over 221 million diagnosis codes to systematically identify new-onset conditions enriched among patients with COVID-19 during the post-acute period. Compared to inpatient controls, inpatient COVID-19 cases were at significant risk for angina pectoris (RR 1.30, 95% CI 1.09–1.55), heart failure (RR 1.22, 95% CI 1.10–1.35), cognitive dysfunctions (RR 1.18, 95% CI 1.07–1.31), and fatigue (RR 1.18, 95% CI 1.07–1.30). Relative to outpatient controls, outpatient COVID-19 cases were at risk for pulmonary embolism (RR 2.10, 95% CI 1.58–2.76), venous embolism (RR 1.34, 95% CI 1.17–1.54), atrial fibrillation (RR 1.30, 95% CI 1.13–1.50), type 2 diabetes (RR 1.26, 95% CI 1.16–1.36) and vitamin D deficiency (RR 1.19, 95% CI 1.09–1.30). Outpatient COVID-19 cases were also at risk for loss of smell and taste (RR 2.42, 95% CI 1.90–3.06), inflammatory neuropathy (RR 1.66, 95% CI 1.21–2.27), and cognitive dysfunction (RR 1.18, 95% CI 1.04–1.33). The incidence of post-acute cardiovascular and pulmonary conditions decreased across time among inpatient cases while the incidence of cardiovascular, digestive, and metabolic conditions increased among outpatient cases. Our study, based on a federated international network, systematically identified robust conditions associated with PASC compared to control groups, underscoring the multifaceted cardiovascular and neurological phenotype profiles of PASC.
npj Digital Medicine arrow_drop_down HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03722096/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41746-022-00623-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 17 citations 17 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert npj Digital Medicine arrow_drop_down HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03722096/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41746-022-00623-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:Elsevier BV Thayyil Jayakrishnan; Thejus; Haag; Aaron; Mealy; Shane; Minich; Corbyn; Attah; Abraham; Turk; Michael; Alrifai; Nada; Alhuneafat; Laith; Khoury; Fadi; Nasrullah; Adeel; Wedgeworth; Patrick; Mosley; Melissa; Vashistha; Kirtivardhan; bakalov; veli; Chaturvedi; Abhishek; Manzi; Susan; Kapetanos; Anastasios; Sangli; Swathi;pmc: PMC8503153
CHEST Journal arrow_drop_down CHEST JournalArticle . 2021Full-Text: http://europepmc.org/articles/PMC8503153Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.chest.2021.07.963&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert CHEST Journal arrow_drop_down CHEST JournalArticle . 2021Full-Text: http://europepmc.org/articles/PMC8503153Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.chest.2021.07.963&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France EnglishPublisher:HAL CCSD Authors: Dequin, Pierre-François; Heming, Nicholas; Meziani, Ferhat; Plantefève, Gaëtan; +18 AuthorsDequin, Pierre-François; Heming, Nicholas; Meziani, Ferhat; Plantefève, Gaëtan; Voiriot, Guillaume; Badié, Julio; François, Bruno; Aubron, Cécile; Ricard, Jean-Damien; Ehrmann, Stephan; Jouan, Youenn; Guillon, Antoine; Leclerc, Marie; Coffre, Carine; Bourgoin, Hélène; Lengellé, Céline; Caille-Fénérol, Caroline; Tavernier, Elsa; Zohar, Sarah; Giraudeau, Bruno; Annane, Djillali; Le Gouge, Amélie;International audience; Importance: Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.Objective: To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute respiratory failure.Design, setting, and participants: Multicenter randomized double-blind sequential trial conducted in France, with interim analyses planned every 50 patients. Patients admitted to the intensive care unit (ICU) for COVID-19-related acute respiratory failure were enrolled from March 7 to June 1, 2020, with last follow-up on June 29, 2020. The study intended to enroll 290 patients but was stopped early following the recommendation of the data and safety monitoring board.Interventions: Patients were randomized to receive low-dose hydrocortisone (n = 76) or placebo (n = 73).Main outcomes and measures: The primary outcome, treatment failure on day 21, was defined as death or persistent dependency on mechanical ventilation or high-flow oxygen therapy. Prespecified secondary outcomes included the need for tracheal intubation (among patients not intubated at baseline); cumulative incidences (until day 21) of prone position sessions, extracorporeal membrane oxygenation, and inhaled nitric oxide; Pao2:Fio2 ratio measured daily from day 1 to day 7, then on days 14 and 21; and the proportion of patients with secondary infections during their ICU stay.Results: The study was stopped after 149 patients (mean age, 62.2 years; 30.2% women; 81.2% mechanically ventilated) were enrolled. One hundred forty-eight patients (99.3%) completed the study, and there were 69 treatment failure events, including 11 deaths in the hydrocortisone group and 20 deaths in the placebo group. The primary outcome, treatment failure on day 21, occurred in 32 of 76 patients (42.1%) in the hydrocortisone group compared with 37 of 73 (50.7%) in the placebo group (difference of proportions, -8.6% [95.48% CI, -24.9% to 7.7%]; P = .29). Of the 4 prespecified secondary outcomes, none showed a significant difference. No serious adverse events were related to the study treatment.Conclusions and relevance: In this study of critically ill patients with COVID-19 and acute respiratory failure, low-dose hydrocortisone, compared with placebo, did not significantly reduce treatment failure (defined as death or persistent respiratory support) at day 21. However, the study was stopped early and likely was underpowered to find a statistically and clinically important difference in the primary outcome.Trial registration: ClinicalTrials.gov Identifier: NCT02517489.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______4254::eb2d60aac3130eb0bee645edc27e8b03&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______4254::eb2d60aac3130eb0bee645edc27e8b03&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Wiley Philippe Colson; Philippe Gautret; Jeremy Delerce; Hervé Chaudet; Pierre Pontarotti; Patrick Forterre; Raphael Tola; Marielle Bedotto; Léa Delorme; Wahiba Bader; Anthony Levasseur; Jean‐Christophe Lagier; Matthieu Million; Nouara Yahi; Jacques Fantini; Bernard La Scola; Pierre‐Edouard Fournier; Didier Raoult;The nature and dynamics of mutations associated with the emergence, spread, and vanishing of SARS-CoV-2 variants causing successive waves are complex. We determined the kinetics of the most common French variant (“Marseille-4”) for 10 months since its onset in July 2020. Here, we analyzed and classified into subvariants and lineages 7453 genomes obtained by next-generation sequencing. We identified two subvariants, Marseille-4A, which contains 22 different lineages of at least 50 genomes, and Marseille-4B. Their average lifetime was 4.1 ± 1.4 months, during which 4.1 ± 2.6 mutations accumulated. Growth rate was 0.079 ± 0.045, varying from 0.010 to 0.173. Most of the lineages exhibited a bell-shaped distribution. Several beneficial mutations at unpredicted sites initiated a new outbreak, while the accumulation of other mutations resulted in more viral heterogenicity, increased diversity and vanishing of the lineages. Marseille-4B emerged when the other Marseille-4 lineages vanished. Its ORF8 gene was knocked out by a stop codon, as reported in SARS-CoV-2 of mink and in the Alpha variant. This subvariant was associated with increased hospitalization and death rates, suggesting that ORF8 is a nonvirulence gene. We speculate that the observed heterogenicity of a lineage may predict the end of the outbreak. International audience
Journal of Medical V... arrow_drop_down Journal of Medical VirologyArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-CEA; HAL-IRDArticle . 2022License: CC BY NC NDFull-Text: https://hal.science/hal-03805866/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/jmv.28102&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of Medical V... arrow_drop_down Journal of Medical VirologyArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-CEA; HAL-IRDArticle . 2022License: CC BY NC NDFull-Text: https://hal.science/hal-03805866/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/jmv.28102&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Elsevier BV Lefrançois, Thierry; Malvy, Denis; Atlani-Duault, Laetitia; Benamouzig, Daniel; Druais, Pierre-Louis; Yazdanpanah, Yazdan; Delfraissy, Jean-François; Lina, Bruno;Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. International audience
HAL-ENS-LYON; Mémoir... arrow_drop_down AgritropArticle . 2023Full-Text: http://agritrop.cirad.fr/603033/7/603033.pdfData sources: Agritropadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0140-6736(22)01840-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert HAL-ENS-LYON; Mémoir... arrow_drop_down AgritropArticle . 2023Full-Text: http://agritrop.cirad.fr/603033/7/603033.pdfData sources: Agritropadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0140-6736(22)01840-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 FrancePublisher:Research Square Platform LLC Authors: Alexandre J. Vivanti; Christelle Vauloup-Fellous; Sophie Prevot; Veronique Zupan; +4 AuthorsAlexandre J. Vivanti; Christelle Vauloup-Fellous; Sophie Prevot; Veronique Zupan; Cecile Suffee; Jeremy Do Cao; Alexandra Benachi; Daniele De Luca;SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients. Congenital infection of SARS-CoV-2 has been described, but the transmission routes remain unclear. Here, the authors report evidence of transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise.
Nature Communication... arrow_drop_down Europe PubMed CentralArticle . 2020 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC7360599Data sources: PubMed CentralHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-28884/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 815 citations 815 popularity Top 0.01% influence Top 1% impulse Top 0.01% Powered by BIP!more_vert Nature Communication... arrow_drop_down Europe PubMed CentralArticle . 2020 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC7360599Data sources: PubMed CentralHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-28884/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 FrancePublisher:Cold Spring Harbor Laboratory Yang, Fan; Pahlavan, Amir A.; Mendez, Simon; Abkarian, Manouk; Stone, Howard A.;It is now recognized that aerosol transport contributes to the transmission of the SARS-CoV-2 virus. Here we improve existing social distancing guidelines for airborne pathogens, which are typically given in terms of distance with vague statements (if any) about contact times. Also, estimates of inhalation of virus in a contaminated space usually assume a well-mixed environment, which is realistic for some, but not all, situations. In particular, we consider a local casual interaction of an infected individual and a susceptible individual, both maskless, account for the air flow and aerosol transport characteristics of speaking and breathing, and propose social distancing guidelines that involve both space and contact time, based on a conservative model of the interactions.
Physical Review Flui... arrow_drop_down Physical Review FluidsArticle . 2020 . Peer-reviewedLicense: APS Licenses for Journal Article Re-useadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.08.31.20185439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 40 citations 40 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Physical Review Flui... arrow_drop_down Physical Review FluidsArticle . 2020 . Peer-reviewedLicense: APS Licenses for Journal Article Re-useadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.08.31.20185439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 France, France, ItalyPublisher:Center for Open Science Federica Somma; Paolo Bartolomeo; Federica Vallone; Federica Vallone; Antonietta Argiuolo; Antonio Cerrato; Orazio Miglino; Orazio Miglino; Laura Mandolesi; Maria Clelia Zurlo; Onofrio Gigliotta;BackgroundThe measures taken to contain the coronavirus disease 2019 (COVID-19) pandemic, such as the lockdown in Italy, do impact psychological health; yet, less is known about their effect on cognitive functioning. The transactional theory of stress predicts reciprocal influences between perceived stress and cognitive performance. However, the effects of a period of stress due to social isolation on spatial cognition and exploration have been little examined. The aim of the present study was to investigate the possible effects and impact of the COVID-19 pandemic on spatial cognition tasks, particularly those concerning spatial exploration, and the physiological leftward bias known as pseudoneglect. A right-hemisphere asymmetry for spatial attention processes crucially contributes to pseudoneglect. Other evidence indicates a predominantly right-hemisphere activity in stressful situations. We also analyzed the effects of lockdown on coping strategies, which typically show an opposite pattern of hemispheric asymmetry, favoring the left hemisphere. If so, then pseudoneglect should increase during the lockdown and be negatively correlated with the efficacy of coping strategies.MethodsOne week before the start of the lockdown due to COVID-19 in Italy (T1), we had collected data from a battery of behavioral tests including tasks of peri-personal spatial cognition. During the quarantine period, from late April to early May 2020 (T2), we repeated the testing sessions with a subgroup of the same participants (47 right-handed students, mean age = 20, SD = 1.33). At both testing sessions, participants performed digitized neuropsychological tests, including a Cancellation task, Radial Arm Maze task, and Raven’s Advanced Progressive Matrices. Participants also completed a newly developed COVID-19 Student Stress Scale, based on transactional models of stress, and the Coping Orientation to Problems Experienced—New Italian Version (COPE-NIV) to assess coping orientation.ResultsThe tendency to start cancelation from a left-sided item, to explore first a left-sided arm of the maze, and to choose erroneous response items on the left side of the page on Raven’s matrices increased from T1 to T2. The degree of pseudoneglect increment positively correlated with perceived stress and negatively correlated with Positive Attitude and Problem-Solving COPE-NIV subscales.ConclusionLockdown-related stress may have contributed to increase leftward bias during quarantine through a greater activation of the right hemisphere. On the other hand, pseudoneglect was decreased for better coping participants, perhaps as a consequence of a more balanced hemispheric activity in these individuals.
Frontiers in Psychol... arrow_drop_down Frontiers in Psychology; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2021 . Peer-reviewedLicense: CC BYFrontiers in PsychologyArticle . 2021Full-Text: http://europepmc.org/articles/PMC7977289Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.31234/osf.io/xb954&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 23 citations 23 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Frontiers in Psychol... arrow_drop_down Frontiers in Psychology; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2021 . Peer-reviewedLicense: CC BYFrontiers in PsychologyArticle . 2021Full-Text: http://europepmc.org/articles/PMC7977289Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020Publisher:Elsevier BV Miyakawa, Lina; Rothman, Adam; Sheth, Vishad; Patrawalla, Paru; Steiger, David; Li, Nan; Zatakia, Jigna; Mathew, Joseph; Lee, Young Im;pmc: PMC7548593
CHEST Journal arrow_drop_down CHEST JournalArticle . 2020Full-Text: http://europepmc.org/articles/PMC7548593Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.chest.2020.09.036&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert CHEST Journal arrow_drop_down CHEST JournalArticle . 2020Full-Text: http://europepmc.org/articles/PMC7548593Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.chest.2020.09.036&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 FrancePublisher:Springer Science and Business Media LLC Izza Nasrullah; Azeem Mehmood Butt; Shifa Tahir; Muhammad Idrees; Yigang Tong;Abstract Background The Marburg virus (MARV) has a negative-sense single-stranded RNA genome, belongs to the family Filoviridae, and is responsible for several outbreaks of highly fatal hemorrhagic fever. Codon usage patterns of viruses reflect a series of evolutionary changes that enable viruses to shape their survival rates and fitness toward the external environment and, most importantly, their hosts. To understand the evolution of MARV at the codon level, we report a comprehensive analysis of synonymous codon usage patterns in MARV genomes. Multiple codon analysis approaches and statistical methods were performed to determine overall codon usage patterns, biases in codon usage, and influence of various factors, including mutation pressure, natural selection, and its two hosts, Homo sapiens and Rousettus aegyptiacus. Results Nucleotide composition and relative synonymous codon usage (RSCU) analysis revealed that MARV shows mutation bias and prefers U- and A-ended codons to code amino acids. Effective number of codons analysis indicated that overall codon usage among MARV genomes is slightly biased. The Parity Rule 2 plot analysis showed that GC and AU nucleotides were not used proportionally which accounts for the presence of natural selection. Codon usage patterns of MARV were also found to be influenced by its hosts. This indicates that MARV have evolved codon usage patterns that are specific to both of its hosts. Moreover, selection pressure from R. aegyptiacus on the MARV RSCU patterns was found to be dominant compared with that from H. sapiens. Overall, mutation pressure was found to be the most important and dominant force that shapes codon usage patterns in MARV. Conclusions To our knowledge, this is the first detailed codon usage analysis of MARV and extends our understanding of the mechanisms that contribute to codon usage and evolution of MARV.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4550055Data sources: PubMed CentralMémoires en Sciences de l'Information et de la CommunicationArticle . 2015Full-Text: https://hal.science/hal-01353258/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12862-015-0456-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 93 citations 93 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4550055Data sources: PubMed CentralMémoires en Sciences de l'Information et de la CommunicationArticle . 2015Full-Text: https://hal.science/hal-01353258/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Springer Science and Business Media LLC Funded by:NIH | HARVARD-MIT-NEMC RESEARCH..., NIH | UCLA Clinical Translation..., EC | PERISCOPE +17 projectsNIH| HARVARD-MIT-NEMC RESEARCH TRAINING IN HEALTH INFORMATICS ,NIH| UCLA Clinical Translational Science Institute ,EC| PERISCOPE ,NIH| The role of angiotensin-(1-7) in hypertension and hypertension-induced heart and kidney damage ,NIH| Modeling the Incompleteness and Biases of Health Data ,NIH| A framework to stratify patient cohorts for clinical management ,NIH| Frontiers: University of Kansas Clinical and Translational Science Institute ,NIH| Kentucky Center for Clinical and Translational Science ,NIH| Wake forest Clinical and Translational Science Award ,NIH| Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) ,NIH| Integrating EHR and Genomics to Predict Multiple Sclerosis Drug Response ,NIH| The Harvard Clinical and Translational Science Center ,NIH| University of Michigan Proteogenomics Data Analysis Center ,NIH| Michigan Institute for Clinical and Health Research (MICHR) ,NIH| University of Pittsburgh Clinical and Translational Science Institute ,NIH| University of Pittsburgh Clinical and Translational Science Institute ,NIH| The LungMAP Data Coordination Center for Next Gen Systems Biology of Respiration ,NIH| Biases introduced by filtering electronic health records for patients with "complete data" ,NIH| Developing i2b2 into a Health Innovation Platform for Clinical Decision Support in the Genomics Era ,NIH| eMERGE Phase IV Clinical Center at Partners HealthCareHarrison G. Zhang; Arianna Dagliati; Zahra Shakeri Hossein Abad; Xin Xiong; Clara-Lea Bonzel; Zongqi Xia; Bryce W. Q. Tan; Paul Avillach; Gabriel A. Brat; Chuan Hong; Michele Morris; Shyam Visweswaran; Lav P. Patel; Alba Gutiérrez-Sacristán; David A. Hanauer; John H. Holmes; Malarkodi Jebathilagam Samayamuthu; Florence T. Bourgeois; Sehi L’Yi; Sarah E. Maidlow; Bertrand Moal; Shawn N. Murphy; Zachary H. Strasser; Antoine Neuraz; Kee Yuan Ngiam; Ne Hooi Will Loh; Gilbert S. Omenn; Andrea Prunotto; Lauren A. Dalvin; Jeffrey G. Klann; Petra Schubert; Fernando J. Sanz Vidorreta; Vincent Benoit; Guillaume Verdy; Ramakanth Kavuluru; Hossein Estiri; Yuan Luo; Alberto Malovini; Valentina Tibollo; Riccardo Bellazzi; Kelly Cho; Yuk-Lam Ho; Amelia L. M. Tan; Byorn W. L. Tan; Nils Gehlenborg; Sara Lozano-Zahonero; Vianney Jouhet; Luca Chiovato; Bruce J. Aronow; Emma M. S. Toh; Wei Gen Scott Wong; Sara Pizzimenti; Kavishwar B. Wagholikar; Mauro Bucalo; The Consortium for Clinical Characterization of COVID-19 by EHR (4CE); Tianxi Cai; Andrew M. South; Isaac S. Kohane; Griffin M. Weber;AbstractThe risk profiles of post-acute sequelae of COVID-19 (PASC) have not been well characterized in multi-national settings with appropriate controls. We leveraged electronic health record (EHR) data from 277 international hospitals representing 414,602 patients with COVID-19, 2.3 million control patients without COVID-19 in the inpatient and outpatient settings, and over 221 million diagnosis codes to systematically identify new-onset conditions enriched among patients with COVID-19 during the post-acute period. Compared to inpatient controls, inpatient COVID-19 cases were at significant risk for angina pectoris (RR 1.30, 95% CI 1.09–1.55), heart failure (RR 1.22, 95% CI 1.10–1.35), cognitive dysfunctions (RR 1.18, 95% CI 1.07–1.31), and fatigue (RR 1.18, 95% CI 1.07–1.30). Relative to outpatient controls, outpatient COVID-19 cases were at risk for pulmonary embolism (RR 2.10, 95% CI 1.58–2.76), venous embolism (RR 1.34, 95% CI 1.17–1.54), atrial fibrillation (RR 1.30, 95% CI 1.13–1.50), type 2 diabetes (RR 1.26, 95% CI 1.16–1.36) and vitamin D deficiency (RR 1.19, 95% CI 1.09–1.30). Outpatient COVID-19 cases were also at risk for loss of smell and taste (RR 2.42, 95% CI 1.90–3.06), inflammatory neuropathy (RR 1.66, 95% CI 1.21–2.27), and cognitive dysfunction (RR 1.18, 95% CI 1.04–1.33). The incidence of post-acute cardiovascular and pulmonary conditions decreased across time among inpatient cases while the incidence of cardiovascular, digestive, and metabolic conditions increased among outpatient cases. Our study, based on a federated international network, systematically identified robust conditions associated with PASC compared to control groups, underscoring the multifaceted cardiovascular and neurological phenotype profiles of PASC.
npj Digital Medicine arrow_drop_down HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03722096/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41746-022-00623-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 17 citations 17 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert npj Digital Medicine arrow_drop_down HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03722096/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41746-022-00623-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:Elsevier BV Thayyil Jayakrishnan; Thejus; Haag; Aaron; Mealy; Shane; Minich; Corbyn; Attah; Abraham; Turk; Michael; Alrifai; Nada; Alhuneafat; Laith; Khoury; Fadi; Nasrullah; Adeel; Wedgeworth; Patrick; Mosley; Melissa; Vashistha; Kirtivardhan; bakalov; veli; Chaturvedi; Abhishek; Manzi; Susan; Kapetanos; Anastasios; Sangli; Swathi;pmc: PMC8503153
CHEST Journal arrow_drop_down CHEST JournalArticle . 2021Full-Text: http://europepmc.org/articles/PMC8503153Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.chest.2021.07.963&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert CHEST Journal arrow_drop_down CHEST JournalArticle . 2021Full-Text: http://europepmc.org/articles/PMC8503153Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.chest.2021.07.963&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France EnglishPublisher:HAL CCSD Authors: Dequin, Pierre-François; Heming, Nicholas; Meziani, Ferhat; Plantefève, Gaëtan; +18 AuthorsDequin, Pierre-François; Heming, Nicholas; Meziani, Ferhat; Plantefève, Gaëtan; Voiriot, Guillaume; Badié, Julio; François, Bruno; Aubron, Cécile; Ricard, Jean-Damien; Ehrmann, Stephan; Jouan, Youenn; Guillon, Antoine; Leclerc, Marie; Coffre, Carine; Bourgoin, Hélène; Lengellé, Céline; Caille-Fénérol, Caroline; Tavernier, Elsa; Zohar, Sarah; Giraudeau, Bruno; Annane, Djillali; Le Gouge, Amélie;International audience; Importance: Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.Objective: To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute respiratory failure.Design, setting, and participants: Multicenter randomized double-blind sequential trial conducted in France, with interim analyses planned every 50 patients. Patients admitted to the intensive care unit (ICU) for COVID-19-related acute respiratory failure were enrolled from March 7 to June 1, 2020, with last follow-up on June 29, 2020. The study intended to enroll 290 patients but was stopped early following the recommendation of the data and safety monitoring board.Interventions: Patients were randomized to receive low-dose hydrocortisone (n = 76) or placebo (n = 73).Main outcomes and measures: The primary outcome, treatment failure on day 21, was defined as death or persistent dependency on mechanical ventilation or high-flow oxygen therapy. Prespecified secondary outcomes included the need for tracheal intubation (among patients not intubated at baseline); cumulative incidences (until day 21) of prone position sessions, extracorporeal membrane oxygenation, and inhaled nitric oxide; Pao2:Fio2 ratio measured daily from day 1 to day 7, then on days 14 and 21; and the proportion of patients with secondary infections during their ICU stay.Results: The study was stopped after 149 patients (mean age, 62.2 years; 30.2% women; 81.2% mechanically ventilated) were enrolled. One hundred forty-eight patients (99.3%) completed the study, and there were 69 treatment failure events, including 11 deaths in the hydrocortisone group and 20 deaths in the placebo group. The primary outcome, treatment failure on day 21, occurred in 32 of 76 patients (42.1%) in the hydrocortisone group compared with 37 of 73 (50.7%) in the placebo group (difference of proportions, -8.6% [95.48% CI, -24.9% to 7.7%]; P = .29). Of the 4 prespecified secondary outcomes, none showed a significant difference. No serious adverse events were related to the study treatment.Conclusions and relevance: In this study of critically ill patients with COVID-19 and acute respiratory failure, low-dose hydrocortisone, compared with placebo, did not significantly reduce treatment failure (defined as death or persistent respiratory support) at day 21. However, the study was stopped early and likely was underpowered to find a statistically and clinically important difference in the primary outcome.Trial registration: ClinicalTrials.gov Identifier: NCT02517489.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______4254::eb2d60aac3130eb0bee645edc27e8b03&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______4254::eb2d60aac3130eb0bee645edc27e8b03&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Wiley Philippe Colson; Philippe Gautret; Jeremy Delerce; Hervé Chaudet; Pierre Pontarotti; Patrick Forterre; Raphael Tola; Marielle Bedotto; Léa Delorme; Wahiba Bader; Anthony Levasseur; Jean‐Christophe Lagier; Matthieu Million; Nouara Yahi; Jacques Fantini; Bernard La Scola; Pierre‐Edouard Fournier; Didier Raoult;The nature and dynamics of mutations associated with the emergence, spread, and vanishing of SARS-CoV-2 variants causing successive waves are complex. We determined the kinetics of the most common French variant (“Marseille-4”) for 10 months since its onset in July 2020. Here, we analyzed and classified into subvariants and lineages 7453 genomes obtained by next-generation sequencing. We identified two subvariants, Marseille-4A, which contains 22 different lineages of at least 50 genomes, and Marseille-4B. Their average lifetime was 4.1 ± 1.4 months, during which 4.1 ± 2.6 mutations accumulated. Growth rate was 0.079 ± 0.045, varying from 0.010 to 0.173. Most of the lineages exhibited a bell-shaped distribution. Several beneficial mutations at unpredicted sites initiated a new outbreak, while the accumulation of other mutations resulted in more viral heterogenicity, increased diversity and vanishing of the lineages. Marseille-4B emerged when the other Marseille-4 lineages vanished. Its ORF8 gene was knocked out by a stop codon, as reported in SARS-CoV-2 of mink and in the Alpha variant. This subvariant was associated with increased hospitalization and death rates, suggesting that ORF8 is a nonvirulence gene. We speculate that the observed heterogenicity of a lineage may predict the end of the outbreak. International audience
Journal of Medical V... arrow_drop_down Journal of Medical VirologyArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-CEA; HAL-IRDArticle . 2022License: CC BY NC NDFull-Text: https://hal.science/hal-03805866/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/jmv.28102&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of Medical V... arrow_drop_down Journal of Medical VirologyArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-CEA; HAL-IRDArticle . 2022License: CC BY NC NDFull-Text: https://hal.science/hal-03805866/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/jmv.28102&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Elsevier BV Lefrançois, Thierry; Malvy, Denis; Atlani-Duault, Laetitia; Benamouzig, Daniel; Druais, Pierre-Louis; Yazdanpanah, Yazdan; Delfraissy, Jean-François; Lina, Bruno;Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. International audience
HAL-ENS-LYON; Mémoir... arrow_drop_down AgritropArticle . 2023Full-Text: http://agritrop.cirad.fr/603033/7/603033.pdfData sources: Agritropadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0140-6736(22)01840-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert HAL-ENS-LYON; Mémoir... arrow_drop_down AgritropArticle . 2023Full-Text: http://agritrop.cirad.fr/603033/7/603033.pdfData sources: Agritropadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0140-6736(22)01840-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 FrancePublisher:Research Square Platform LLC Authors: Alexandre J. Vivanti; Christelle Vauloup-Fellous; Sophie Prevot; Veronique Zupan; +4 AuthorsAlexandre J. Vivanti; Christelle Vauloup-Fellous; Sophie Prevot; Veronique Zupan; Cecile Suffee; Jeremy Do Cao; Alexandra Benachi; Daniele De Luca;SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients. Congenital infection of SARS-CoV-2 has been described, but the transmission routes remain unclear. Here, the authors report evidence of transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise.
Nature Communication... arrow_drop_down Europe PubMed CentralArticle . 2020 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC7360599Data sources: PubMed CentralHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-28884/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 815 citations 815 popularity Top 0.01% influence Top 1% impulse Top 0.01% Powered by BIP!more_vert Nature Communication... arrow_drop_down Europe PubMed CentralArticle . 2020 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC7360599Data sources: PubMed CentralHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-28884/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 FrancePublisher:Cold Spring Harbor Laboratory Yang, Fan; Pahlavan, Amir A.; Mendez, Simon; Abkarian, Manouk; Stone, Howard A.;It is now recognized that aerosol transport contributes to the transmission of the SARS-CoV-2 virus. Here we improve existing social distancing guidelines for airborne pathogens, which are typically given in terms of distance with vague statements (if any) about contact times. Also, estimates of inhalation of virus in a contaminated space usually assume a well-mixed environment, which is realistic for some, but not all, situations. In particular, we consider a local casual interaction of an infected individual and a susceptible individual, both maskless, account for the air flow and aerosol transport characteristics of speaking and breathing, and propose social distancing guidelines that involve both space and contact time, based on a conservative model of the interactions.
Physical Review Flui... arrow_drop_down Physical Review FluidsArticle . 2020 . Peer-reviewedLicense: APS Licenses for Journal Article Re-useadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.08.31.20185439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 40 citations 40 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Physical Review Flui... arrow_drop_down Physical Review FluidsArticle . 2020 . Peer-reviewedLicense: APS Licenses for Journal Article Re-useadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.08.31.20185439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 France, France, ItalyPublisher:Center for Open Science Federica Somma; Paolo Bartolomeo; Federica Vallone; Federica Vallone; Antonietta Argiuolo; Antonio Cerrato; Orazio Miglino; Orazio Miglino; Laura Mandolesi; Maria Clelia Zurlo; Onofrio Gigliotta;BackgroundThe measures taken to contain the coronavirus disease 2019 (COVID-19) pandemic, such as the lockdown in Italy, do impact psychological health; yet, less is known about their effect on cognitive functioning. The transactional theory of stress predicts reciprocal influences between perceived stress and cognitive performance. However, the effects of a period of stress due to social isolation on spatial cognition and exploration have been little examined. The aim of the present study was to investigate the possible effects and impact of the COVID-19 pandemic on spatial cognition tasks, particularly those concerning spatial exploration, and the physiological leftward bias known as pseudoneglect. A right-hemisphere asymmetry for spatial attention processes crucially contributes to pseudoneglect. Other evidence indicates a predominantly right-hemisphere activity in stressful situations. We also analyzed the effects of lockdown on coping strategies, which typically show an opposite pattern of hemispheric asymmetry, favoring the left hemisphere. If so, then pseudoneglect should increase during the lockdown and be negatively correlated with the efficacy of coping strategies.MethodsOne week before the start of the lockdown due to COVID-19 in Italy (T1), we had collected data from a battery of behavioral tests including tasks of peri-personal spatial cognition. During the quarantine period, from late April to early May 2020 (T2), we repeated the testing sessions with a subgroup of the same participants (47 right-handed students, mean age = 20, SD = 1.33). At both testing sessions, participants performed digitized neuropsychological tests, including a Cancellation task, Radial Arm Maze task, and Raven’s Advanced Progressive Matrices. Participants also completed a newly developed COVID-19 Student Stress Scale, based on transactional models of stress, and the Coping Orientation to Problems Experienced—New Italian Version (COPE-NIV) to assess coping orientation.ResultsThe tendency to start cancelation from a left-sided item, to explore first a left-sided arm of the maze, and to choose erroneous response items on the left side of the page on Raven’s matrices increased from T1 to T2. The degree of pseudoneglect increment positively correlated with perceived stress and negatively correlated with Positive Attitude and Problem-Solving COPE-NIV subscales.ConclusionLockdown-related stress may have contributed to increase leftward bias during quarantine through a greater activation of the right hemisphere. On the other hand, pseudoneglect was decreased for better coping participants, perhaps as a consequence of a more balanced hemispheric activity in these individuals.
Frontiers in Psychol... arrow_drop_down Frontiers in Psychology; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2021 . Peer-reviewedLicense: CC BYFrontiers in PsychologyArticle . 2021Full-Text: http://europepmc.org/articles/PMC7977289Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.31234/osf.io/xb954&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 23 citations 23 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Frontiers in Psychol... arrow_drop_down Frontiers in Psychology; Archivio della ricerca - Università degli studi di Napoli Federico IIArticle . 2021 . Peer-reviewedLicense: CC BYFrontiers in PsychologyArticle . 2021Full-Text: http://europepmc.org/articles/PMC7977289Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.31234/osf.io/xb954&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020Publisher:Elsevier BV Miyakawa, Lina; Rothman, Adam; Sheth, Vishad; Patrawalla, Paru; Steiger, David; Li, Nan; Zatakia, Jigna; Mathew, Joseph; Lee, Young Im;pmc: PMC7548593
CHEST Journal arrow_drop_down CHEST JournalArticle . 2020Full-Text: http://europepmc.org/articles/PMC7548593Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.chest.2020.09.036&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert CHEST Journal arrow_drop_down CHEST JournalArticle . 2020Full-Text: http://europepmc.org/articles/PMC7548593Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.chest.2020.09.036&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 FrancePublisher:Springer Science and Business Media LLC Izza Nasrullah; Azeem Mehmood Butt; Shifa Tahir; Muhammad Idrees; Yigang Tong;Abstract Background The Marburg virus (MARV) has a negative-sense single-stranded RNA genome, belongs to the family Filoviridae, and is responsible for several outbreaks of highly fatal hemorrhagic fever. Codon usage patterns of viruses reflect a series of evolutionary changes that enable viruses to shape their survival rates and fitness toward the external environment and, most importantly, their hosts. To understand the evolution of MARV at the codon level, we report a comprehensive analysis of synonymous codon usage patterns in MARV genomes. Multiple codon analysis approaches and statistical methods were performed to determine overall codon usage patterns, biases in codon usage, and influence of various factors, including mutation pressure, natural selection, and its two hosts, Homo sapiens and Rousettus aegyptiacus. Results Nucleotide composition and relative synonymous codon usage (RSCU) analysis revealed that MARV shows mutation bias and prefers U- and A-ended codons to code amino acids. Effective number of codons analysis indicated that overall codon usage among MARV genomes is slightly biased. The Parity Rule 2 plot analysis showed that GC and AU nucleotides were not used proportionally which accounts for the presence of natural selection. Codon usage patterns of MARV were also found to be influenced by its hosts. This indicates that MARV have evolved codon usage patterns that are specific to both of its hosts. Moreover, selection pressure from R. aegyptiacus on the MARV RSCU patterns was found to be dominant compared with that from H. sapiens. Overall, mutation pressure was found to be the most important and dominant force that shapes codon usage patterns in MARV. Conclusions To our knowledge, this is the first detailed codon usage analysis of MARV and extends our understanding of the mechanisms that contribute to codon usage and evolution of MARV.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4550055Data sources: PubMed CentralMémoires en Sciences de l'Information et de la CommunicationArticle . 2015Full-Text: https://hal.science/hal-01353258/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12862-015-0456-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 93 citations 93 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4550055Data sources: PubMed CentralMémoires en Sciences de l'Information et de la CommunicationArticle . 2015Full-Text: https://hal.science/hal-01353258/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12862-015-0456-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu