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Existe una clara relacion entre la infeccion por el nuevo coronavirus 2 y el diagnostico de enfermedad tromboembolica venosa, como consecuencia del desarrollo de un sindrome de respuesta inflamatoria sistemica debido a la activacion de la cascada de la coagulacion. Se presenta en el 90% de los pacientes con formas graves de la infeccion, lo que revela la presencia de microtrombosis y macrotrombosis intravascular pulmonar. Esto sugiere un posible beneficio clinico de la aplicacion de una tromboprofilaxis adecuada al riesgo clinico de cada paciente. Asimismo, la sospecha de enfermedad tromboembolica venosa en el contexto de esta pandemia representa un reto diagnostico debido a la existencia de similitudes entre ambas alteraciones en varios aspectos. Debe tenerse en cuenta que el diagnostico de tromboembolismo pulmonar agudo no excluye la posibilidad de infeccion viral. La valoracion de pacientes con sospecha de tromboembolismo pulmonar agudo en el contexto de la pandemia debe ser eficaz para establecer un diagnostico y tratamiento con rapidez, a fin de reducir la morbilidad y mortalidad adjuntas, sin que ello eleve el riesgo de infeccion para los profesionales de la salud y otros pacientes.

Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 activity with reduced toxicity. In this report, we demonstrate that the block of HIV-1 replication by GPS491 is accompanied by a drastic inhibition of viral gene expression (IC50 ~ 0.25 µM), and alterations in the production of unspliced, singly spliced, and multiply spliced HIV-1 RNAs. GPS491 also inhibited the replication of adenovirus and multiple coronaviruses. Low µM doses of GPS491 reduced adenovirus infectious yield ~1000 fold, altered virus early gene expression/viral E1A RNA processing, blocked viral DNA amplification, and inhibited late (hexon) gene expression. Loss of replication of multiple coronaviruses (229E, OC43, SARS-CoV2) upon GPS491 addition was associated with the inhibition of viral structural protein expression and the formation of virus particles. Consistent with the observed changes in viral RNA processing, GPS491 treatment induced selective alterations in the accumulation/phosphorylation/function of splicing regulatory SR proteins. Our study establishes that a compound that impacts the activity of cellular factors involved in RNA processing can prevent the replication of several viruses with minimal effect on cell viability.

Education for sustainable development (ESD) is considered vital to the success of the United Nations¿ sustainable development goals. Systems thinking has been identified as a core competency that must be included in ESD. However, systems thinking-orientated ESD learning tools, established methods of the assessment of sustainability skills, and formal trials to demonstrate the effectiveness of such learning tools are all lacking. This research presents a randomised controlled trial (n = 106) to investigate whether an innovative online sustainability learning tool that incorporates two factors, systems thinking and system dynamics simulation, increases the understanding of a specific sustainability problem. A further aim was to investigate whether these factors also support the transfer of knowledge to a second problem with a similar systemic structure. The effects of the two factors were tested separately and in combination using a two-by-two factorial study design. ANOVA and related inferential statistical techniques were used to analyse the effect of the factors on sustainability understanding. Cohen¿s d effect sizes were also calculated. Simulation alone was found to increase ESD learning outcomes significantly, and also to support the transfer of skills, although less significantly. Qualitative feedback was also gathered from participants, most of whom reported finding systems thinking and simulation very helpful. This research was undertaken for the PhD studies of the corresponding author at the National University of Ireland Galway (NUIG) and was supported by funding from ResponSEAble (EU Horizon 2020 project number 652643), Ireland’s Higher Education Authority and Department of Further and Higher Education, Research, Innovation and Science (through the IT Investment Fund and ComputerDISC, and the COVID-19 Costed Extension), and the NUIG PhD Write-Up Bursary. peer-reviewed

This chapter reflects on how youth, through the medium of youth-led research, can seek to influence public policy by bringing a more democratic and informed youth perspective into the policy-making arena. The chapter details the Youth as Researchers Programme Model. It outlines how the programme has supported youth, in Ireland and internationally, to undertake social research projects with their peers on issues of concern, to collectively inform policy dialogue. The chapter documents the development of the programme, including a case study of one of the early youth-led research projects set up in Ireland in response to Ireland¿s National Child and Family Agency seeking to better understand how young people facing adversity can be heard and helped. It traces the programme¿s development from its inception to the present day, when the programme is now central to UNESCO¿s global response to inform policy on supporting youth during COVID-19. Not peer reviewed 2023-06-24

The current study investigates the mental health condition of Mainland Chinese in Canada and identifies the associated sociodemographic and COVID-19-related predictors. A sample of 471 Mainland Chinese aged 18 or older completed an online survey that collected information on demographics, experience, cognition, and behaviours related to the COVID-19 pandemic and mental health condition. Mental health condition was assessed with the Depression, Anxiety, and Stress Scale-21 (DASS-21) for the depression, anxiety, and stress levels of Mainland Chinese during the pandemic. Moderate to severe depression, anxiety, and stress levels were respectively reported by 11.30%, 10.83%, and 5.10% of respondents. Univariate analysis of variance models (ANOVAs) were conducted to assess mental health condition variance as stratified by independent sociodemographic- or COVID-19-related explanatory variables, to identify possible predictors to be entered into the subsequent regression models. The regression models identified age, income level, health status, and perceived discrimination as significant sociodemographic predictors (absolute value of βs = 1.19–7.11, ps βs = 1.33–3.45, ps < 0.05) for mental health outcomes. The results shed light on our understanding of the major factors associated with the mental health condition of Mainland Chinese in Canada during the COVID-19 pandemic.

Background There are concerns that vaccine hesitancy may impede COVID-19 vaccine rollout and prevent the achievement of herd immunity. Vaccine hesitancy is a delay in acceptance or refusal of vaccines despite their availability. Objective We aimed to identify which people are more and less likely to take a COVID-19 vaccine and factors associated with vaccine hesitancy to inform public health messaging. Methods A Canadian cross-sectional survey was conducted in Canada in October and November 2020, prior to the regulatory approval of the COVID-19 vaccines. Vaccine hesitancy was measured by respondents answering the question “what would you do if a COVID-19 vaccine were available to you?” Negative binomial regression was used to identify the factors associated with vaccine hesitancy. Cluster analysis was performed to identify distinct clusters based on intention to take a COVID-19 vaccine, beliefs about COVID-19 and COVID-19 vaccines, and adherence to nonpharmaceutical interventions. Results Of 4498 participants, 2876 (63.9%) reported COVID-19 vaccine hesitancy. Vaccine hesitancy was significantly associated with (1) younger age (18-39 years), (2) lower education, and (3) non-Liberal political leaning. Participants that reported vaccine hesitancy were less likely to believe that a COVID-19 vaccine would end the pandemic or that the benefits of a COVID-19 vaccine outweighed the risks. Individuals with vaccine hesitancy had higher prevalence of being concerned about vaccine side effects, lower prevalence of being influenced by peers or health care professionals, and lower prevalence of trust in government institutions. Conclusions These findings can be used to inform targeted public health messaging to combat vaccine hesitancy as COVID-19 vaccine administration continues. Messaging related to preventing COVID among friends and family, highlighting the benefits, emphasizing safety and efficacy of COVID-19 vaccination, and ensuring that health care workers are knowledgeable and supported in their vaccination counselling may be effective for vaccine-hesitant populations.

Abstract The world is still struggling in controlling and containing the spread of the COVID-19 pandemic caused by the SARS-CoV-2 virus. The medical conditions associated with SARS-CoV-2 infections have resulted in a surge in the number of patients at clinics and hospitals, leading to a significantly increased strain on healthcare resources. As such, an important part of managing patients with SARS-CoV-2 infections within the clinical workflow is severity assessment, which is often conducted with the use of chest x-ray (CXR) images. In this work, we introduce COVID-Net CXR-S, a convolutional neural network for predicting the airspace severity of a SARS-CoV-2 positive patient based on a CXR image of the patient's chest. More specifically, we leveraged transfer learning to transfer representational knowledge gained from over 16,000 CXR images from a multinational cohort of over 15,000 patient cases into a custom network architecture for severity assessment. Experimental results with a multi-national patient cohort curated by the Radiological Society of North America (RSNA) RICORD initiative showed that the proposed COVID-Net CXR-S has potential to be a powerful tool for computer-aided severity assessment of CXR images of COVID-19 positive patients. Furthermore, radiologist validation on select cases by two board-certified radiologists with over 10 and 19 years of experience, respectively, showed consistency between radiologist interpretation and critical factors leveraged by COVID-Net CXR-S for severity assessment. While not a production-ready solution, the ultimate goal for the open source release of COVID-Net CXR-S is to act as a catalyst for clinical scientists, machine learning researchers, as well as citizen scientists to develop innovative new clinical decision support solutions for helping clinicians around the world manage the continuing pandemic.

Bien que la vie biologique et la complexité sociale humaine soient fondamentalement interdépendantes, les chercheurs en biologie et en sciences sociales continuent de se percevoir à travers les clivages du scepticisme théorique, méthodologique et institutionnel. Cet article considère le travail de frontière conversationnel entre les scientifiques qualitatifs et quantitatifs comme une performance rhétorique institutionnalisée qui limite leur coopération, même face à la pandémie de COVID-19 lorsque cela est le plus urgent. À titre d’exemple, j’examine la manière dont des conflits épistémologiques familiers ont émergé de la collaboration entre moi-même et un bioscientifique au printemps 2020, lorsque j’ai participé au Massive Microscopic Sensemaking Project, un projet internationale d’écriture auto-ethnographique de 21 jours. Although biological life and human social complexity are fundamentally interdependent, biological and social researchers continue to perceive each other from across divides of theoretical, methodological, and institutional skepticism. This paper considers conversational boundary work between qualitative and quantitative scientists as an institutionalized rhetorical performance which throttles their cooperation, even in the face of the COVID-19 pandemic when it is most urgently needed. As an example, I look at the way familiar epistemological conflicts emerged out of collaboration between myself and a bioscientist during the spring of 2020, when co-participating in the Massive Microscopic Sensemaking Project, a 21-day international auto-ethnographic writing experiment.

Cet article s’appuie sur mon lien avec les fils à coudre et explore comment le défi en ligne 2020 Massive Microscopic Sensemaking (MMS) a contribué à un enchevêtrement émergent de l’espace-temps lié à COVID-19, à l’enseignement et à la recherche sur l’apprentissage médical en obstétrique, et à la réflexion plus approfondie de mon doctorat . Il explore les processus affirmatifs mis en œuvre pendant les périodes d’anxiété, lorsque mes pensées se frayaient un chemin à travers des espaces intermédiaires avec des moments et des matériaux différents qui étaient génératifs et productifs. J’explique mes mouvements rhizomatiques qui saignent à travers les séparations conventionnelles et les hypothèses de délimitation. Je m’appuie sur le réalisme agential de Karen Barad pour théoriser l’émergence de relations créatives avec des artefacts astucieux mis en scène avec des étudiants de premier cycle en médecine, avec des participants au projet MMS et avec mon propre doctorat en période de tension. This article draws on my connection with sewing threads, and explores how the 2020 Massive Microscopic Sensemaking (MMS) online challenge contributed to an emergent entanglement of timespacemattering related to COVID-19, teaching and researching medical learning in obstetrics, and thinking further with my PhD. It explores affirmative processes enacted during times of anxiety, when my thoughts needled through in-between spaces with different times and materials that were generative and productive. I explain my rhizomatic movements that bleed through conventional separations and boundary-making assumptions. I draw on Karen Barad’s agential realism to theorize the emergence of creative relationalities with artful artifacts enacted with medical undergraduate students, with participants in the MMS project, and with my own PhD during times of tension.

Ce projet, qui a débuté avec Prompt #2 du Massive Micro Sensemaking (MMS) dirigé par Annette Markham et Anne Harris de mai à juin 2020, m’a aidé à faire face à l’anxiété causée par le confinement de la COVID-19. J’ai mis en place quatre représentations visuelles - une série de photographies qui, à travers un processus de déploiement, établissent des liens avec des questionnements plus larges au cours de mes recherches d’archives dans le contexte de la colonisation de Sydney, en Australie. Explorer l’expérience vécue à travers la photographie prévoit un objectif a/r/tographique créatif, axé sur la représentation des objets afin qu’ils prennent un aspect plus que représentatif, touchant la matérialité des objets en tant que données. Adapter la superposition des rendus va au-delà de l’aspect dimensionnel en tant que simple capture d’un phénomène observé. Cette première photographie a ici une couche d’ombre supplémentaire pour créer du volume et recréer des semblants du monde figuratif à travers le reflet. This project, starting with Prompt 2 from the Massive Micro Sensemaking (MMS) led by Annette Markham and Anne Harris in May through June 2020, assisted me to move through the anxiety of COVID-19 lockdown. I set up four visual renderings—a series of photographs that, through a process of unfolding, make links to broader issues in my archival research in the context of settler colonial Sydney, Australia. Exploring lived experience through photography anticipates a creative a/r/tographic lens, focusing on rendering objects so that they take on a more-than-representational aspect, touching the materiality of objects as data. Adaptively layering the renderings moves beyond one dimensionality as a strict capturing of an observed phenomena. Here, an initial photograph has a latent, additional layer of shadow to build volume and re-cast semblances of the representational world through reflection.