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17 research outcomes, page 1 of 2
  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Viktoriya Borisevich; Benhur Lee; Andrew C. Hickey; Blair L. DeBuysscher; Christopher C. Broder; Heinz Feldmann; Barry Rockx;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: NIH | Nipah Virus and Hendra Vi... (5R01AI054715-03)

    textabstractHenipaviruses are zoonotic viruses that can cause severe and acute respiratory diseases and encephalitis in humans. To date, no vaccine or treatments are approved for human use. The presence of neutralizing antibodies is a strong correlate of protection agai...

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  • publication . Other literature type . Article . 2012
    Open Access English
    Authors:
    Sander Herfst; Albert D. M. E. Osterhaus; Ron A. M. Fouchier;
    Persistent Identifiers
    Publisher: Oxford University Press

    Recently, we and others obtained experimental evidence that highly pathogenic avian influenza virus subtype H5 can acquire the ability to transmit via aerosols between ferrets. Upon submission of manuscripts describing the results of these studies, the US National Scien...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Eelke Brandsma; Han J.M.P. Verhagen; Thijs J.W. van de Laar; Eric C. J. Claas; Marion Cornelissen; Emile van den Akker;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Abstract Background Recent advances in CRISPR-based diagnostics suggest that DETECTR, a combination of reverse-transcriptase loop-mediated isothermal amplification (RT-LAMP) and subsequent Cas12 bystander nuclease activation by amplicon-targeting ribonucleoprotein comp...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Falsey, Ann; McElhaney, Janet; Beran, Jiri; van Essen, Gerrit; Duval, Xavier; Esen, Meral; Galtier, Florence; Gervais, Pierre; Hwang, Shinn-Jang; Kremsner, Peter; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: CIHR

    International audience; Background. Few studies have prospectively assessed viral etiologies of acute respiratory infections in community-based elderly individuals. We assessed viral respiratory pathogens in individuals ≥65 years with influenza-like illness (ILI).Method...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Rimoin, Anne W; Lu, Kai; Bramble, Matthew S; Steffen, Imke; Doshi, Reena H; Hoff, Nicole A; Mukadi, Patrick; Nicholson, Bradly P; Alfonso, Vivian H; Olinger, Gerrard; ...
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: NIH | University of California ... (5D43TW009343-07), NIH | Serological prevalence of... (5R21AI107420-02)

    Duration of immunity against Ebola virus among survivors remains unclear. We assessed serological immune profiles and retention of Ebola virus neutralizing antibodies in 14 survivors of the 1976 Yambuku outbreak 40 years postinfection, providing the longest documentatio...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Reina S. Sikkema; Elmoubasher Farag; Sayed Himatt; Adel K Ibrahim; Hamad Al-Romaihi; Salih A. Al-Marri; Mohamed Al-Thani; Ahmed M. El-Sayed; Mohammed Al-Hajri; Bart L. Haagmans; ...
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: EC | PREPARE (602525), EC | COMPARE (643476)

    Abstract The transmission routes and risk factors for zoonotic Middle East respiratory syndrome coronavirus (MERS-CoV) infections are still unknown. We used the World Health Organization questionnaire for MERS-CoV case-control studies to assess risk factors for human ME...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Kiyuka, Patience K.; Agoti, Charles N.; Munywoki, Patrick K.; Njeru, Regina; Bett, Anne; Otieno, James R.; Otieno, Grieven P.; Kamau, Everlyn; Clark, Taane G.; van der Hoek, Lia; ...
    Persistent Identifiers
    Project: UKRI | Understanding the transmi... (MR/N010469/1), UKRI | The interactions between ... (MR/K000551/1), UKRI | Zika: Zika virus surveill... (MC_PC_15103), UKRI | Geographic genetic profil... (MR/M01360X/1), WT | Defining pathways of resp... (102975)

    Infections with human coronavirus NL63 are common and reinfections occur repeatedly throughout life. A subset of repeat infections show enhanced virus replication with no evidence of genotype switching, indicating that initial exposure is insufficient to elicit a protec...

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  • publication . Article . 2020
    Open Access English
    Authors:
    de Nooijer, Aline H; Grondman, Inge; Janssen, Nico A F; Netea, Mihai G; Willems, Loek; van de Veerdonk, Frank L; Giamarellos-Bourboulis, Evangelos J; Toonen, Erik J M; Joosten, Leo A B; Jaeger, Martin; ...
    Persistent Identifiers
    Project: EC | TRAIN-OLD (833247)

    Abstract Background Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications, and mortality rate. The complement system is an important component of innate immunity and can stimulate i...

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  • publication . Article . 2021
    Open Access
    Authors:
    Nico A. F. Janssen; Inge Grondman; Aline H. de Nooijer; Collins K Boahen; Valerie A C M Koeken; Vasiliki Matzaraki; Vinod Kumar; Xuehui He; Matthijs Kox; Hans J. P. M. Koenen; ...
    Project: EC | TRAIN-OLD (833247)

    Abstract The clinical spectrum of COVID-19 varies and the differences in host response characterizing this variation have not been fully elucidated. COVID-19 disease severity correlates with an excessive proinflammatory immune response and profound lymphopenia. Inflamma...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Werner J. D. Ouwendijk; Matthijs P. Raadsen; Jeroen J. A. van Kampen; Robert M. Verdijk; Jan H. von der Thüsen; Lihui Guo; Rogier A.S. Hoek; Johannes P.C. van den Akker; Henrik Endeman; Thomas Langerak; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    SARS-CoV-2 induced lower respiratory tract (LRT) disease can deteriorate to acute respiratory distress syndrome (ARDS). Because the release of neutrophil extracellular traps (NETs) is implicated in ARDS pathogenesis, we investigated the presence of NETs and correlates o...

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17 research outcomes, page 1 of 2