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Silvicultural herbicides are used in Integrated Vegetation Management (IVM) to suppress vegetation that competes with trees for growing space, light, nutrients, water, and other resources in managed forests. While the toxicity and environmental impacts of silvicultural herbicides have been widely studied, far less is known about their effects on culturally significant plants important to Indigenous Peoples in the Canadian Boreal Forest Region. The main objective of this thesis is to assess the silvicultural use of herbicides on ethnobotanical species in the Canadian boreal. I identified 914 ethnobotanical plants in the Canadian boreal, including plants used as food, medicines, tools, art and culture, and for spiritual purposes. Most of these plants are not considered threatened globally or in Canada but are vulnerable to decline or elimination following herbicide spraying in managed forests. The results of my thesis support restricting herbicide spraying as an IVM practice in areas important to Indigenous Peoples. Professor Robin Roth for providing funding for my thesis, through the Conservation through Reconciliation Partnership (CRP), Graduate Coordinators in the Department of Geography, Geomatics and Environment - Drs. Noella Gray and Aaron Berg for funding support that I received from the department and additional financial support from the University of Guelph’s College of Social and Applied Human Sciences (CSAHS) COVID-19 Delay Assistance Program

Objective: To determine the relative risk of drug-induced Long QT Syndrome (LQTS) associated with SARS-CoV-2 (COVID-19) proposed repurposed drugs compared to well-known torsadogenic compounds. Setting: Computer calculations and simulations were performed using primary pharmacokinetic and pharmacodynamic data for each proposed drug. Seven different LQTS indices were calculated and compared. The U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database was queried with specific key words relating to arrhythmogenic events. Interventions: A thorough literature search was performed to gather information on the pharmacological properties of six drugs (azithromycin, chloroquine, favipiravir, hydroxychloroquine, lopinavir/ritonavir, and remdesivir) repurposed to treat COVID-19. Researchers emphasized the affinity of these drugs to block the rapid component of the delayed rectifier cardiac potassium current (IKr) encoded by the human ether-a-go-go gene (hERG), their propensity to prolong cardiac repolarization (QT interval), and cause torsade de pointes (TdP). The risk of drug-induced LQTS for these drugs was quantified by comparing six indices that assess such risk. Primary and secondary outcome measures: Level of risk estimated for the six COVID-19 drugs being proposed compared to 23 torsadogenic drugs. Number of proarrhythmic adverse events identified for these drugs in the FAERS. Results: Estimators of LQTS risk levels indicated a very high or high risk for all COVID-19 repurposed drugs with the exception for azithromycin, although cases of TdP have been reported with this drug. There was excellent agreement among the various indices used to assess risk of drug-induced LQTS for the six repurposed drugs and 23 torsadogenic compounds. Conclusion: The risk-benefit assessment for the use of repurposed drugs to treat COVID-19 is complicated since benefits are currently anticipated, not proven. Mandatory monitoring of the QT interval shall be performed, as such monitoring is possible for hospitalized patients or with the use of biodevices for outpatients prescribed these drugs.

Background: Voluntary self-exclusion is a well-known harm reduction intervention in problem gambling, although primarily in operator-specific or venue-based systems. A nationwide overall self-exclusion system (“Spelpaus”) for all licensed gambling was introduced in Sweden in 2019. However, gambling in overseas companies despite national exclusion may be a concern in online gamblers. The present web survey study aimed to study self-reported self-exclusion and gambling despite exclusion in a nationwide multi-operator land-based/online exclusion system.Methods: Web survey in web panel members of a market survey company, carried out in May, 2020 (co-occurring with the COVID-19 pandemic). Past-year online gamblers (n = 997) answered questions about gambling patterns, gambling problems, psychological distress, self-exclusion since “Spelpaus” introduction, and gambling despite self-exclusion.Results: Seven percent reported ever self-excluded at Spelpaus, and this was associated with younger age, female gender, gambling problems, and chance-based games and online poker. In logistic regression, Spelpaus remained strongly associated with past-year online casino gambling, gambling problems, and absence of past-year sports betting. Among those having self-excluded, 38 percent reported gambling despite self-exclusion, most commonly online casino.Conclusions: In online gamblers in a setting with a nationwide self-exclusion system, using this was associated with past-year online casino gambling and gambling problems. Gambling despite self-exclusion appears to be common, and more commonly involves online casino. Stakeholders should aim to increase rates of self-exclusion in high-risk online gamblers, both during and beyond the COVID-19 situation in which the study was carried out. Also, policy makers should use gambling regulation in order to decrease the risk of breaching self-exclusion online, such as through the prohibition of non-registered gambling operators. Further research should focus on in-depth analysis of the reasons for gamblers to enroll or not enroll in multi-operator self-exclusion.

This paper introduces the ‘Independence’ themed special issue which includes research presented at the 22nd annual Association of Internet Researchers (AoIR) conference (2021). ‘Independence’ as a special issue theme could hardly be timelier, both in geopolitical and internet research terms. The call for the 2021 AoIR annual conference asked us to reflect on the ambivalence of the term, to look back on historical struggles for independence, the long waves of history, and prompted us to ask who benefits from independence (and who does not). Hosted online for a second year, this time by universities in Philadelphia (USA), the conference was bounded by the Black Lives Matter movement, the insurrectionist storming of Washington, D.C.’s Capitol Hill, and global struggles to control the COVID-19 pandemic. This special issue includes nine papers that showcase new research exploring the affordances offered by digital media platforms to people, users, and workers, while also identifying tendencies towards new forms of control and surveillance facilitated by platforms. Topics include geopolitical and biopolitical digital sovereignty, facial recognition technologies, data divides, new methods approaches and innovative data sourcing, mobile and social media, examinations of embodied local knowledge as well as patriarchal, racist, and gendered social structures, and a broad range of field sites from Asia, Africa, and South America.

COVID-19, due to its accelerated spread has brought in the need to use assistive tools for faster diagnosis in addition to typical lab swab testing. Chest X-Rays for COVID cases tend to show changes in the lungs such as ground glass opacities and peripheral consolidations which can be detected by deep neural networks. However, traditional convolutional networks use point estimate for predictions, lacking in capture of uncertainty, which makes them less reliable for adoption. There have been several works so far in predicting COVID positive cases with chest X-Rays. However, not much has been explored on quantifying the uncertainty of these predictions, interpreting uncertainty, and decomposing this to model or data uncertainty. To address these needs, we develop a visualization framework to address interpretability of uncertainty and its components, with uncertainty in predictions computed with a Bayesian Convolutional Neural Network. This framework aims to understand the contribution of individual features in the Chest-X-Ray images to predictive uncertainty. Providing this as an assistive tool can help the radiologist understand why the model came up with a prediction and whether the regions of interest captured by the model for the specific prediction are of significance in diagnosis. We demonstrate the usefulness of the tool in chest x-ray interpretation through several test cases from a benchmark dataset. Comment: Submitted to ISBI 2021

Introduction: Healthcare organizations around the world have embraced simulation to prepare healthcare professionals to the COVID-19 pandemic. However, this pandemic implies additional educational challenges in rapidly designing simulation activities, while remaining compliant with health and safety measures to prevent the spread of the virus. The effect of simulation-based education in this context remains to be evaluated. Objective: The purpose of this systematic review was to describe the features and evaluate the effect of simulation activities on the preparedness of healthcare professionals and students to safely deliver care during the COVID-19 pandemic. Methods: Databases were searched up to November 2020 using index terms and keywords related to healthcare professions, simulation, and COVID-19. All learning outcomes were considered according to the Kirkpatrick model adapted by Barr et al. (2020). Reference selection, data extraction, and quality assessment were performed in pairs and independently. Results were synthesized using meta-analytical methods and narrative summaries. Results: 22 studies were included, 21 of which were single-group studies and 14 of those included pretest/posttest assessments. Simulation activities were mostly implemented in clinical settings using manikins for training on the use of personal protective equipment, hand hygiene, identification and management of COVID-19 patients, and work processes and patient flow. Large improvements in learning outcomes after simulation activities were reported in all studies. Discussion and conclusion: Results should be interpreted cautiously due to significant threats to the internal validity of studies and the absence of control groups. However, these findings are coherent with the overall evidence on the positive effect of simulation-based education. Future studies should include control groups if feasible. Introduction : Les organisations de santé ont adopté la simulation pour préparer les professionnels à la pandémie de COVID-19. La conception en accéléré de simulations tout en respectant les mesures de prévention de la propagation du virus amène des défis. Dans ces conditions, l’efficacité de la simulation reste à être évaluée. Objectif : Décrire les caractéristiques et évaluer l’effet de simulations sur la préparation des professionnels de la santé et des étudiants pour fournir des soins sécuritaires pendant cette pandémie. Méthodes : Les bases de données ont été consultées jusqu’en novembre 2020 en utilisant des descripteurs et des mots-clés relatifs aux professions de la santé, à la simulation et à la COVID-19. Tous les résultats d’apprentissage ont été considérés. La sélection des articles, l’extraction des données et l’évaluation de la qualité ont été effectuées par paires. Les résultats ont été synthétisés par des méthodes méta-analytiques et des résumés narratifs. Résultats : 22 études ont été incluses ; 21 à groupe unique et, parmi ces 21, 14 évaluations pré-posttest. Les simulations ont principalement été déployées en milieux cliniques avec des mannequins pour la formation à l’utilisation d’équipements de protection individuelle, au lavage de mains, à l’identification et la prise en charge de patients atteints de la COVID-19 et à l’implantation de procédés organisationnels. Toutes les études rapportent des apprentissages importants après les simulations. Discussion et conclusion : Malgré les limites de validité interne et l’absence de groupes de contrôle, ces résultats sont cohérents avec l’état des connaissances sur les effets positifs de la simulation. De futures études devraient inclure des groupes de contrôle si possible.

Recent guidelines by WHO recommend delaying non-essential oral health care amid COVID-19 pandemic and call for research on aerosol generated during dental procedures. Thus, this study aims to assess the mechanisms of dental aerosol dispersion in dental offices and to provide recommendations based on a quantitative study to minimize infection transmission in dental offices. The spread and removal of aerosol particles generated from dental procedures in a dental office are measured near the source and at the corner of the office. We studied the effects of air purification (on/off), door condition (open/close), and particle sizes on the temporal concentration distribution of particles. The results show that in the worst-scenario scenario it takes 95 min for 0.5 um particles to settle, and that it takes a shorter time for the larger particles. The indoor air purifier tested expedited the removal time at least 6.3 times faster than the scenario air purifier off. Airborne particles may be transported from the source to the rest of the room, even when the particle concentrations in the generation zone return to the background level. These results are expected to be valuable to related policy making and technology development for infection disease control in dental offices and similar built environments. Comment: 9 figures 4 tables

My thesis explores older adult lifelong learners’ experiences in transitioning their continued education participation to an online model. This research acknowledges and situates itself in the geragogy contexts of older adult learners, drawing on their experiences of the pandemic and lifelong learning, in addition to their opinions on education for older adults. As such, a case study methodology was employed so that this case could be studied within boundaries created by the pandemic. In my study, 25 older adult learners participated in individual interviews and provided their opinions and perceptions about their experiences with the pandemic and its effect on their learning ambitions. The COVID-19 pandemic has impacted these individuals differently based on their motivations and previous experiences with technology. Four distinct dialogue groups emerged based on the motivations that older adults have to participate in lifelong learning, which are social or instrumental, and also the opinions they have about technology, which are either positive or negative. The four dialogues are distinct in that they each hold alternate opinions about the two issues raised (motivators and opinions on technology) but there were no major identifiers within the groups that could characteristically distinguish one from another. The results indicate that not all discourses of lifelong learners are reducible to identities or recent experiences. My findings suggest that potential refinement in program delivery based on specific user needs could improve the experiences that older adults have in the virtual classroom, and that it is crucial to the administration of lifelong learning that older adults' unique needs are addressed in a collaborative manner. Thesis Master of Arts (MA) This study investigated how older adults, who pursue lifelong learning in-person, have interpreted their transition to online learning because of COVID-19 pandemic meeting restrictions. Lifelong learners have had to transition from in-person learning to virtual formats, which has encouraged new older adults to become lifelong learners, and also for some lifelong learners to drop out of the practice entirely. The key goal of the study was to describe the Transitioners, New learners, and Dropout learners' experience with lifelong learning with respect to COVID-19’s impacts on their participation. Interviews were conducted with individuals who fell into these three categories and, through their responses, distinct dialogues emerged to describe their motivation to participate in lifelong learning, and their opinions on using technology as a means to access it. Confirming the motives to participate and how technology is appreciated by lifelong learners enables us to better develop and implement lifelong learning.

Two years after the onset of the COVID-19 pandemic, many nations and communities continue to grapple with waves of infection and social fallout from pandemic fatigue and frustration. While we are still years away from realizing the full impacts of COVID-19, reflecting on our collective responses has offered some insights into the impact that various public health policies and decisions had on nations’ abilities to weather the multifaceted impacts of the pandemic. Widely believed to have the potential to be devastated by COVID-19, many Indigenous communities in Canada were extremely successful in managing outbreaks. This paper outlines one such example, Wapekeka First Nation, and the community’s formidable response to the pandemic with a specific focus on food mobilization efforts. Built on over a decade of community-based participatory action research and informed by six interviews with key pandemic leaders in the community, this paper, co-led by two community hunters and band council members, emphasizes the various decisions and initiatives that led to Wapekeka’s successful pandemic response. Proactive leadership, along with strong traditional harvesting and processing efforts, helped to take care of the community while they remained strictly isolated from virus exposure.

The COVID-19 pandemic has presented community sport organizations with many complex challenges, but also unique opportunities to reflect and rethink their practices (Fullagar, 2020). This study presents an autoethnography of my experiences working as a Technical Leader for a community sport organization (CSO) throughout the COVID-19 pandemic. The research questions were: 1) What were the features of organizational capacity that were most important to the CSO’s effectiveness, survival and resilience during the pandemic? and 2) What were the capacity features that were most impactful to my own ability to carry out my role effectively within the club? Through the autoethnographic process, I observed leader dedication, redundancy, dedicated staff, shared values and open communication to be essential features of organizational capacity and resilience during the pandemic. I also observed environmental instability, failures to retain staff and conflict to limit the club’s ability to be effective during return to play, and my own effectiveness within my role. Through sharing my experiences, community sport organizations may gain a greater understanding of the capacity features and necessary steps for efficient functioning and survival. Leaders and managers of CSOs may also gain valuable insight into how to effectively manage an organization through environmental uncertainty.