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description Publicationkeyboard_double_arrow_right Report 2022 EnglishPublisher:Zenodo Funded by:NIH | A National Center for Dig..., NIH | OTA-21-015A Post-Acute Se...NIH| A National Center for Digital Health Informatics Innovation ,NIH| OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreAuthors: Johanna Loomba; Suchetha Sharma;Johanna Loomba; Suchetha Sharma;The goals of this electronic health record (EHR) query are to investigate: Amongst known COVID-19 patients, who is experiencing new Economic Instability? Amongst COVID-19 patients with documented Long COVID, who is experiencing new Economic Instability? The data source is the National COVID Cohort Collaborative (N3C) which hosts nearly 20 billion rows of medical record data, providing a rich resource for big data analysis.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7469476&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 146visibility views 146 download downloads 103 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7469476&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 EnglishPublisher:Zenodo Funded by:NIH | A National Center for Dig...NIH| A National Center for Digital Health Informatics InnovationAuthors: Melissa A Haendel; Chris Chute; N3C Consortium (See attached document);Melissa A Haendel; Chris Chute; N3C Consortium (See attached document);Objective COVID-19 poses societal challenges that require expeditious data and knowledge sharing. Though organizational clinical data are abundant, these are largely inaccessible to outside researchers. Statistical, machine learning, and causal analyses are most successful with large-scale data beyond what is available in any given organization. Here, we introduce the National COVID Cohort Collaborative (N3C), an open science community focused on analyzing patient-level data from many centers. Methods The Clinical and Translational Science Award (CTSA) Program and scientific community created N3C to overcome technical, regulatory, policy, and governance barriers to sharing and harmonizing individual-level clinical data. We developed solutions to extract, aggregate, and harmonize data across organizations and data models, and created a secure data enclave to enable efficient, transparent, and reproducible collaborative analytics. Organized in inclusive workstreams, in two months we created: legal agreements and governance for organizations and researchers; data extraction scripts to identify and ingest positive, negative, and possible COVID-19 cases; a data quality assurance and harmonization pipeline to create a single harmonized dataset; population of the secure data enclave with data, machine learning, and statistical analytics tools; dissemination mechanisms; and a synthetic data pilot to democratize data access. Discussion The N3C has demonstrated that a multi-site collaborative learning health network can overcome barriers to rapidly build a scalable infrastructure incorporating multi-organizational clinical data for COVID-19 analytics. We expect this effort to save lives by enabling rapid collaboration among clinicians, researchers, and data scientists to identify treatments and specialized care and thereby reduce the immediate and long-term impacts of COVID-19. LAY SUMMARY COVID-19 poses societal challenges that require expeditious data and knowledge sharing. Though medical records are abundant, they are largely inaccessible to outside researchers. Statistical, machine learning, and causal research are most successful with large datasets beyond what is available in any given organization. Here, we introduce the National COVID Cohort Collaborative (N3C), an open science community focused on analyzing patient-level data from many clinical centers to reveal patterns in COVID-19 patients. To create N3C, the community had to overcome technical, regulatory, policy, and governance barriers to sharing patient-level clinical data. In less than 2 months, we developed solutions to acquire and harmonize data across organizations and created a secure data environment to enable transparent and reproducible collaborative research. We expect the N3C to help save lives by enabling collaboration among clinicians, researchers, and data scientists to identify treatments and specialized care needs and thereby reduce the immediate and long-term impacts of COVID-19.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.3979623&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 446visibility views 446 download downloads 379 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.3979623&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 EnglishPublisher:Oxford University Press (OUP) Funded by:NIH | Emergency COVID-19 supple..., NIH | IMPROVEMENTS IN CLEVELAND..., NIH | Support of Yerkes Nationa... +3 projectsNIH| Emergency COVID-19 supplement for Atlanta Center for Microsystems Engineered Point-of-Care Technoloites (ACME POCT) ,NIH| IMPROVEMENTS IN CLEVELAND CLINIC FOUNDATION ANIMAL CARE ,NIH| Support of Yerkes National Primate Research Center ,NIH| IMMUNOLOGICAL MEMORY TO VACCINATION ,NIH| Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity ,NIH| Georgia Clinical & Translational Science Alliance (GaCTSA)Sexton, Mary Elizabeth; Waggoner, Jesse J; Carmola, Ludy R; Nguyen, Phuong-Vi; Wang, Ethan; Khosravi, Dara; Taz, Azmain; Arthur, Robert; Patel, Mit; Edara, Venkata-Viswanadh; Foster, Stephanie L; Moore, Kathryn M; Gagne, Matthew; Roberts-Torres, Jesmine; Henry, Amy R; Godbole, Sucheta; Douek, Daniel C; Rouphael, Nadine; Suthar, Mehul S; Piantadosi, Anne;pmc: PMC8807227
pmid: 35037030
We describe rapid detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant using targeted spike single-nucleotide polymorphism polymerase chain reaction and viral genome sequencing. This case occurred in a fully vaccinated and boosted returning traveler with mild symptoms who was identified through community surveillance rather than clinical care.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8807227Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC8807227&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8807227Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC8807227&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Report 2021 EnglishPublisher:Hindawi Funded by:NIH | NRSA Training CoreNIH| NRSA Training CoreAuthors: Motelow, Joshua E.; Kahn, Stacie; Wilson, Patrick T.;Motelow, Joshua E.; Kahn, Stacie; Wilson, Patrick T.;As the pandemic continues to evolve, more cases of COVID-19 in pediatric patients are being detected. A 12-year-old boy with HbSC disease alpha-thalassemia trait presented to a pediatric emergency room with fever and weakness. His vital signs were notable for fever, tachypnea, and tachycardia. His physical exam was concerning for increased work of breathing. He tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by PCR although his hemoglobin level remained near his baseline. His chest radiograph showed a retrocardiac opacity concerning for evolving acute chest syndrome. He decompensated quickly requiring invasive mechanical ventilation and exchange transfusion. He received hydroxychloroquine, broad-spectrum antibiotics, and enoxaparin for DVT prophylaxis. Despite showing clinical signs of improvement, he became acutely hypoxemic and suffered a cardiac arrest. We believe this to be an unusual case of a pediatric patient with HbSC disease and COVID-19. We outline clearly the course of illness and treatments trialed, which can prove beneficial to providers facing similar challenges as this virus continues to strike areas around the world. Although children have significantly better outcomes than adults, providers must remain vigilant while treating any patient with a hemoglobinopathy in the setting of severe COVID-19.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=hindawi_publ::7b87dae42ec4debd546e73993d778f1c&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=hindawi_publ::7b87dae42ec4debd546e73993d778f1c&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2022 EnglishPublisher:Multidisciplinary Digital Publishing Institute Funded by:NIH | Connecting our Neighborho..., NIH | CTSA Admin Supp QAQC - UL...NIH| Connecting our Neighborhoods Need for Enhanced and Coordinated Testing to Achieve Equity: CoNNECT to Achieve Equality ,NIH| CTSA Admin Supp QAQC - UL1 - RevisionAuthors: Warmack, Pearl A. McElfish; Don E. Willis; Sumit K. Shah; Sharon Reece; Jennifer A. Andersen; Mario Schootman; Gloria Richard-Davis; James P. Selig; T. Scott;Warmack, Pearl A. McElfish; Don E. Willis; Sumit K. Shah; Sharon Reece; Jennifer A. Andersen; Mario Schootman; Gloria Richard-Davis; James P. Selig; T. Scott;A cross-sectional survey design was used to assess Arkansas parents’/guardians’ intentions to vaccinate their child against COVID-19. Parents/guardians whose oldest child was age 0–11 years (n = 171) or 12–17 years (n = 198) were recruited between 12 July and 30 July 2021 through random digit dialing. Among parents/guardians with an age-eligible child, age 12–17, 19% reported their child had been vaccinated, and 34% reported they would have their child vaccinated right away. Among parents/guardians with a child aged 0–11, 33% of parents/guardians reported they would have their child vaccinated right away. Twenty-eight percent (28%) of parents/guardians whose oldest child was 12–17 and 26% of parents/guardians whose oldest child was 0–11 reported they would only have their child vaccinated if their school required it; otherwise, they would definitely not vaccinate them. For both groups, parents’/guardians’ education, COVID-19 vaccination status, and COVID-19 vaccine hesitancy were significantly associated with intentions to vaccinate their child. More than a third of parents/guardians whose child was eligible for vaccination at the time of the survey reported they intended to have them vaccinated right away; however, they had not vaccinated their child more than two months after approval. This finding raises questions about the remaining barriers constraining some parents/guardians from vaccinating their child.
Vaccines arrow_drop_down VaccinesOther literature type . 2022License: CC BYFull-Text: http://www.mdpi.com/2076-393X/10/3/361/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=multidiscipl::eb907d44274535add608a34a9de998ea&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Vaccines arrow_drop_down VaccinesOther literature type . 2022License: CC BYFull-Text: http://www.mdpi.com/2076-393X/10/3/361/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=multidiscipl::eb907d44274535add608a34a9de998ea&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 EnglishPublisher:Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine. Funded by:NIH | The Harvard Clinical and ..., NIH | Harvard Clinical and Tran...NIH| The Harvard Clinical and Translational Science Center ,NIH| Harvard Clinical and Translational Science CenterDomar, Alice D.; Shah, Jaimin S.; Gompers, Annika; Meyers, Alison J.; Khodakhah, Darya R.; Hacker, Michele R.; Penzias, Alan S.; Sakkas, Denny; Toth, Thomas L.; Vaughan, Denis A.;pmc: PMC8786401
pmid: 35098174
Objective To compare the impact of the COVID-19 pandemic on the psychological health of infertility patients who have become pregnant to women who have not. Design Prospective cohort study from April to June 2020. Participants completed three questionnaires over this period. Setting A single large, university-affiliated infertility practice. Patient(s) 443 pregnant women and 1476 women still experiencing infertility who completed all three questionnaires. Intervention(s) None. Main Outcome Measure(s) Patient-reported primary stressor over three months of the first major COVID-19 surge. Further data on self-reported sadness, anxiety, loneliness and the use of personal use of coping strategies. Results Pregnant participants were significantly less likely to report taking an antidepressant (p<0.01) or anxiolytic medication (p<0.001), to have a prior diagnosis of depression (p<0.01), were more likely to cite COVID-19 as a top stressor (p<0.001) and overall were less likely to practice stress-relieving activities during the first surge. Conclusion Women pregnant following infertility treatment cited the pandemic as their top stressor and were more distressed about the pandemic than their non-pregnant counterparts but were less likely to be engaging in stress-relieving activities. Given the ongoing impact of the pandemic, infertility patients pregnant after treatment should be counseled and encouraged to practice specific stress-reduction strategies. Women pregnant after infertility treatment were more concerned about COVID-19 than patients continuing with infertility treatment but overall were less distressed.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8786401Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC8786401&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8786401Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC8786401&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United States EnglishPublisher:American Society for Clinical investigation Funded by:NIH | Mechanisms and Duration o..., NIH | Stanford Center for Clini...NIH| Mechanisms and Duration of Immunity to SARS-CoV-2 ,NIH| Stanford Center for Clinical & Translational Education and Research (Spectrum)Jia, Xiaolin; Cao, Shu; Lee, Alexandra S; Manohar, Monali; Sindher, Sayantani B; Ahuja, Neera; Artandi, Maja; Blish, Catherine A; Blomkalns, Andra L; Chang, Iris; Collins, William J; Desai, Manisha; Din, Hena Naz; Do, Evan; Fernandes, Andrea; Geng, Linda N; Rosenberg-Hasson, Yael; Mahoney, Megan Ruth; Glascock, Abigail L; Chan, Lienna Y; Fong, Sharon Y; Consortium, CLIAHUB; Biohub, Chan Zuckerberg; Phelps, Maira; Raeber, Olivia; Group, Stanford COVID-19 Biobank Study; Purington, Natasha; Röltgen, Katharina; Rogers, Angela J; Snow, Theo; Wang, Taia T; Solis, Daniel; Vaughan, Laura; Verghese, Michelle; Maecker, Holden; Wittman, Richard; Puri, Rajan; Kistler, Amy; Yang, Samuel; Boyd, Scott D; Pinsky, Benjamin A; Chinthrajah, Sharon; Nadeau, Kari C;BACKGROUND Prolonged symptoms after SARS-CoV-2 infection are well documented. However, which factors influence development of long-term symptoms, how symptoms vary across ethnic groups, and whether long-term symptoms correlate with biomarkers are points that remain elusive.METHODS Adult SARS-CoV-2 reverse transcription PCR–positive (RT-PCR–positive) patients were recruited at Stanford from March 2020 to February 2021. Study participants were seen for in-person visits at diagnosis and every 1–3 months for up to 1 year after diagnosis; they completed symptom surveys and underwent blood draws and nasal swab collections at each visit.RESULTS Our cohort (n = 617) ranged from asymptomatic to critical COVID-19 infections. In total, 40% of participants reported at least 1 symptom associated with COVID-19 six months after diagnosis. Median time from diagnosis to first resolution of all symptoms was 44 days; median time from diagnosis to sustained symptom resolution with no recurring symptoms for 1 month or longer was 214 days. Anti-nucleocapsid IgG level in the first week after positive RT-PCR test and history of lung disease were associated with time to sustained symptom resolution. COVID-19 disease severity, ethnicity, age, sex, and remdesivir use did not affect time to sustained symptom resolution.CONCLUSION We found that all disease severities had a similar risk of developing post–COVID-19 syndrome in an ethnically diverse population. Comorbid lung disease and lower levels of initial IgG response to SARS-CoV-2 nucleocapsid antigen were associated with longer symptom duration.TRIAL REGISTRATION ClinicalTrials.gov, NCT04373148.FUNDING NIH UL1TR003142 CTSA grant, NIH U54CA260517 grant, NIEHS R21 ES03304901, Sean N Parker Center for Allergy and Asthma Research at Stanford University, Chan Zuckerberg Biohub, Chan Zuckerberg Initiative, Sunshine Foundation, Crown Foundation, and Parker Foundation.
eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______325::ce4de024c04aec26a834887ad332e1f0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______325::ce4de024c04aec26a834887ad332e1f0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 English Funded by:NIH | Center for Clinical and T..., NIH | Training Program in Behav...NIH| Center for Clinical and Translational Research ,NIH| Training Program in Behavioral and Health Services Cancer Control ResearchAuthors: Adams, Elizabeth; Brickhouse, Tegwyn; Dugger, Roddrick; Bean, Melanie;Adams, Elizabeth; Brickhouse, Tegwyn; Dugger, Roddrick; Bean, Melanie;pmc: PMC9614666
pmid: 35500174
Temporary expansion of the Child Tax Credit (CTC) during the COVID-19 pandemic provided additional monthly income for US families, with no restrictions on use, from July through December 2021. This study examined food security and children's dietary intake after three months of expanded CTC payments. Parents completed online surveys before and after three months of CTC payments. Among parents participating in the expansion, food and beverage purchases were the most common use of expanded CTC funds (45.9 percent), particularly in households with very low food security (63.0 percent). From before to midway through the CTC expansion, very low food security decreased from 12.7 percent to 5.6 percent, and simultaneously, food security increased from 57.4 percent to 66.4 percent. The CTC expansion was also associated with decreases in children's consumption of added sugar, sugar-sweetened beverages, and sweetened fruit beverages. No changes were observed in children's intake of other dietary components. Our findings suggest that the expanded CTC payments may have helped lessen food insecurity and supported reductions in children's intake of added sugar in participating households.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC9614666&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC9614666&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 EnglishPublisher:Centers for Disease Control and Prevention (CDC) Funded by:NIH | NRSA Training CoreNIH| NRSA Training CoreStephen M. Bart; Eileen Flaherty; Tara Alpert; Sherry Carlson; Lisa Fasulo; Rebecca Earnest; Elizabeth B. White; Noel Dickens; Anderson F. Brito; Nathan D. Grubaugh; James L. Hadler; Lynn E. Sosa;In fall 2020, a coronavirus disease cluster comprising 16 cases occurred in Connecticut, USA. Epidemiologic and genomic evidence supported transmission among persons at a school and fitness center but not a workplace. The multiple transmission chains identified within this cluster highlight the necessity of a combined investigatory approach.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=doajarticles::3ae76d948e6a5a6e2dd96c4b806c35ae&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Former Yugoslav Republic of Macedonia English Funded by:ANR | AABIFNCOV, NIH | Developing, Demonstrating..., NIH | Monogenic basis of resist... +6 projectsANR| AABIFNCOV ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,NIH| CORE--BIOSTATISTICS FACILITY ,EC| CURE ,EC| ImmunAID ,NIH| IL-13/17-regulated airway epithelial miRNAs in asthma ,EC| EASI-GenomicsAuthors: Bastard, Paul; Vazquez, Sara; Liu, Jamin; Casanova, Jean-Laurent;Bastard, Paul; Vazquez, Sara; Liu, Jamin; Casanova, Jean-Laurent;Life-threatening 'breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, while two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.
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description Publicationkeyboard_double_arrow_right Report 2022 EnglishPublisher:Zenodo Funded by:NIH | A National Center for Dig..., NIH | OTA-21-015A Post-Acute Se...NIH| A National Center for Digital Health Informatics Innovation ,NIH| OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreAuthors: Johanna Loomba; Suchetha Sharma;Johanna Loomba; Suchetha Sharma;The goals of this electronic health record (EHR) query are to investigate: Amongst known COVID-19 patients, who is experiencing new Economic Instability? Amongst COVID-19 patients with documented Long COVID, who is experiencing new Economic Instability? The data source is the National COVID Cohort Collaborative (N3C) which hosts nearly 20 billion rows of medical record data, providing a rich resource for big data analysis.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 146visibility views 146 download downloads 103 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7469476&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 EnglishPublisher:Zenodo Funded by:NIH | A National Center for Dig...NIH| A National Center for Digital Health Informatics InnovationAuthors: Melissa A Haendel; Chris Chute; N3C Consortium (See attached document);Melissa A Haendel; Chris Chute; N3C Consortium (See attached document);Objective COVID-19 poses societal challenges that require expeditious data and knowledge sharing. Though organizational clinical data are abundant, these are largely inaccessible to outside researchers. Statistical, machine learning, and causal analyses are most successful with large-scale data beyond what is available in any given organization. Here, we introduce the National COVID Cohort Collaborative (N3C), an open science community focused on analyzing patient-level data from many centers. Methods The Clinical and Translational Science Award (CTSA) Program and scientific community created N3C to overcome technical, regulatory, policy, and governance barriers to sharing and harmonizing individual-level clinical data. We developed solutions to extract, aggregate, and harmonize data across organizations and data models, and created a secure data enclave to enable efficient, transparent, and reproducible collaborative analytics. Organized in inclusive workstreams, in two months we created: legal agreements and governance for organizations and researchers; data extraction scripts to identify and ingest positive, negative, and possible COVID-19 cases; a data quality assurance and harmonization pipeline to create a single harmonized dataset; population of the secure data enclave with data, machine learning, and statistical analytics tools; dissemination mechanisms; and a synthetic data pilot to democratize data access. Discussion The N3C has demonstrated that a multi-site collaborative learning health network can overcome barriers to rapidly build a scalable infrastructure incorporating multi-organizational clinical data for COVID-19 analytics. We expect this effort to save lives by enabling rapid collaboration among clinicians, researchers, and data scientists to identify treatments and specialized care and thereby reduce the immediate and long-term impacts of COVID-19. LAY SUMMARY COVID-19 poses societal challenges that require expeditious data and knowledge sharing. Though medical records are abundant, they are largely inaccessible to outside researchers. Statistical, machine learning, and causal research are most successful with large datasets beyond what is available in any given organization. Here, we introduce the National COVID Cohort Collaborative (N3C), an open science community focused on analyzing patient-level data from many clinical centers to reveal patterns in COVID-19 patients. To create N3C, the community had to overcome technical, regulatory, policy, and governance barriers to sharing patient-level clinical data. In less than 2 months, we developed solutions to acquire and harmonize data across organizations and created a secure data environment to enable transparent and reproducible collaborative research. We expect the N3C to help save lives by enabling collaboration among clinicians, researchers, and data scientists to identify treatments and specialized care needs and thereby reduce the immediate and long-term impacts of COVID-19.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.3979623&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 446visibility views 446 download downloads 379 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.3979623&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 EnglishPublisher:Oxford University Press (OUP) Funded by:NIH | Emergency COVID-19 supple..., NIH | IMPROVEMENTS IN CLEVELAND..., NIH | Support of Yerkes Nationa... +3 projectsNIH| Emergency COVID-19 supplement for Atlanta Center for Microsystems Engineered Point-of-Care Technoloites (ACME POCT) ,NIH| IMPROVEMENTS IN CLEVELAND CLINIC FOUNDATION ANIMAL CARE ,NIH| Support of Yerkes National Primate Research Center ,NIH| IMMUNOLOGICAL MEMORY TO VACCINATION ,NIH| Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity ,NIH| Georgia Clinical & Translational Science Alliance (GaCTSA)Sexton, Mary Elizabeth; Waggoner, Jesse J; Carmola, Ludy R; Nguyen, Phuong-Vi; Wang, Ethan; Khosravi, Dara; Taz, Azmain; Arthur, Robert; Patel, Mit; Edara, Venkata-Viswanadh; Foster, Stephanie L; Moore, Kathryn M; Gagne, Matthew; Roberts-Torres, Jesmine; Henry, Amy R; Godbole, Sucheta; Douek, Daniel C; Rouphael, Nadine; Suthar, Mehul S; Piantadosi, Anne;pmc: PMC8807227
pmid: 35037030
We describe rapid detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant using targeted spike single-nucleotide polymorphism polymerase chain reaction and viral genome sequencing. This case occurred in a fully vaccinated and boosted returning traveler with mild symptoms who was identified through community surveillance rather than clinical care.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8807227Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC8807227&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8807227Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC8807227&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Report 2021 EnglishPublisher:Hindawi Funded by:NIH | NRSA Training CoreNIH| NRSA Training CoreAuthors: Motelow, Joshua E.; Kahn, Stacie; Wilson, Patrick T.;Motelow, Joshua E.; Kahn, Stacie; Wilson, Patrick T.;As the pandemic continues to evolve, more cases of COVID-19 in pediatric patients are being detected. A 12-year-old boy with HbSC disease alpha-thalassemia trait presented to a pediatric emergency room with fever and weakness. His vital signs were notable for fever, tachypnea, and tachycardia. His physical exam was concerning for increased work of breathing. He tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by PCR although his hemoglobin level remained near his baseline. His chest radiograph showed a retrocardiac opacity concerning for evolving acute chest syndrome. He decompensated quickly requiring invasive mechanical ventilation and exchange transfusion. He received hydroxychloroquine, broad-spectrum antibiotics, and enoxaparin for DVT prophylaxis. Despite showing clinical signs of improvement, he became acutely hypoxemic and suffered a cardiac arrest. We believe this to be an unusual case of a pediatric patient with HbSC disease and COVID-19. We outline clearly the course of illness and treatments trialed, which can prove beneficial to providers facing similar challenges as this virus continues to strike areas around the world. Although children have significantly better outcomes than adults, providers must remain vigilant while treating any patient with a hemoglobinopathy in the setting of severe COVID-19.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=hindawi_publ::7b87dae42ec4debd546e73993d778f1c&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2022 EnglishPublisher:Multidisciplinary Digital Publishing Institute Funded by:NIH | Connecting our Neighborho..., NIH | CTSA Admin Supp QAQC - UL...NIH| Connecting our Neighborhoods Need for Enhanced and Coordinated Testing to Achieve Equity: CoNNECT to Achieve Equality ,NIH| CTSA Admin Supp QAQC - UL1 - RevisionAuthors: Warmack, Pearl A. McElfish; Don E. Willis; Sumit K. Shah; Sharon Reece; Jennifer A. Andersen; Mario Schootman; Gloria Richard-Davis; James P. Selig; T. Scott;Warmack, Pearl A. McElfish; Don E. Willis; Sumit K. Shah; Sharon Reece; Jennifer A. Andersen; Mario Schootman; Gloria Richard-Davis; James P. Selig; T. Scott;A cross-sectional survey design was used to assess Arkansas parents’/guardians’ intentions to vaccinate their child against COVID-19. Parents/guardians whose oldest child was age 0–11 years (n = 171) or 12–17 years (n = 198) were recruited between 12 July and 30 July 2021 through random digit dialing. Among parents/guardians with an age-eligible child, age 12–17, 19% reported their child had been vaccinated, and 34% reported they would have their child vaccinated right away. Among parents/guardians with a child aged 0–11, 33% of parents/guardians reported they would have their child vaccinated right away. Twenty-eight percent (28%) of parents/guardians whose oldest child was 12–17 and 26% of parents/guardians whose oldest child was 0–11 reported they would only have their child vaccinated if their school required it; otherwise, they would definitely not vaccinate them. For both groups, parents’/guardians’ education, COVID-19 vaccination status, and COVID-19 vaccine hesitancy were significantly associated with intentions to vaccinate their child. More than a third of parents/guardians whose child was eligible for vaccination at the time of the survey reported they intended to have them vaccinated right away; however, they had not vaccinated their child more than two months after approval. This finding raises questions about the remaining barriers constraining some parents/guardians from vaccinating their child.
Vaccines arrow_drop_down VaccinesOther literature type . 2022License: CC BYFull-Text: http://www.mdpi.com/2076-393X/10/3/361/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=multidiscipl::eb907d44274535add608a34a9de998ea&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Vaccines arrow_drop_down VaccinesOther literature type . 2022License: CC BYFull-Text: http://www.mdpi.com/2076-393X/10/3/361/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=multidiscipl::eb907d44274535add608a34a9de998ea&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 EnglishPublisher:Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine. Funded by:NIH | The Harvard Clinical and ..., NIH | Harvard Clinical and Tran...NIH| The Harvard Clinical and Translational Science Center ,NIH| Harvard Clinical and Translational Science CenterDomar, Alice D.; Shah, Jaimin S.; Gompers, Annika; Meyers, Alison J.; Khodakhah, Darya R.; Hacker, Michele R.; Penzias, Alan S.; Sakkas, Denny; Toth, Thomas L.; Vaughan, Denis A.;pmc: PMC8786401
pmid: 35098174
Objective To compare the impact of the COVID-19 pandemic on the psychological health of infertility patients who have become pregnant to women who have not. Design Prospective cohort study from April to June 2020. Participants completed three questionnaires over this period. Setting A single large, university-affiliated infertility practice. Patient(s) 443 pregnant women and 1476 women still experiencing infertility who completed all three questionnaires. Intervention(s) None. Main Outcome Measure(s) Patient-reported primary stressor over three months of the first major COVID-19 surge. Further data on self-reported sadness, anxiety, loneliness and the use of personal use of coping strategies. Results Pregnant participants were significantly less likely to report taking an antidepressant (p<0.01) or anxiolytic medication (p<0.001), to have a prior diagnosis of depression (p<0.01), were more likely to cite COVID-19 as a top stressor (p<0.001) and overall were less likely to practice stress-relieving activities during the first surge. Conclusion Women pregnant following infertility treatment cited the pandemic as their top stressor and were more distressed about the pandemic than their non-pregnant counterparts but were less likely to be engaging in stress-relieving activities. Given the ongoing impact of the pandemic, infertility patients pregnant after treatment should be counseled and encouraged to practice specific stress-reduction strategies. Women pregnant after infertility treatment were more concerned about COVID-19 than patients continuing with infertility treatment but overall were less distressed.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8786401Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8786401Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC8786401&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United States EnglishPublisher:American Society for Clinical investigation Funded by:NIH | Mechanisms and Duration o..., NIH | Stanford Center for Clini...NIH| Mechanisms and Duration of Immunity to SARS-CoV-2 ,NIH| Stanford Center for Clinical & Translational Education and Research (Spectrum)Jia, Xiaolin; Cao, Shu; Lee, Alexandra S; Manohar, Monali; Sindher, Sayantani B; Ahuja, Neera; Artandi, Maja; Blish, Catherine A; Blomkalns, Andra L; Chang, Iris; Collins, William J; Desai, Manisha; Din, Hena Naz; Do, Evan; Fernandes, Andrea; Geng, Linda N; Rosenberg-Hasson, Yael; Mahoney, Megan Ruth; Glascock, Abigail L; Chan, Lienna Y; Fong, Sharon Y; Consortium, CLIAHUB; Biohub, Chan Zuckerberg; Phelps, Maira; Raeber, Olivia; Group, Stanford COVID-19 Biobank Study; Purington, Natasha; Röltgen, Katharina; Rogers, Angela J; Snow, Theo; Wang, Taia T; Solis, Daniel; Vaughan, Laura; Verghese, Michelle; Maecker, Holden; Wittman, Richard; Puri, Rajan; Kistler, Amy; Yang, Samuel; Boyd, Scott D; Pinsky, Benjamin A; Chinthrajah, Sharon; Nadeau, Kari C;BACKGROUND Prolonged symptoms after SARS-CoV-2 infection are well documented. However, which factors influence development of long-term symptoms, how symptoms vary across ethnic groups, and whether long-term symptoms correlate with biomarkers are points that remain elusive.METHODS Adult SARS-CoV-2 reverse transcription PCR–positive (RT-PCR–positive) patients were recruited at Stanford from March 2020 to February 2021. Study participants were seen for in-person visits at diagnosis and every 1–3 months for up to 1 year after diagnosis; they completed symptom surveys and underwent blood draws and nasal swab collections at each visit.RESULTS Our cohort (n = 617) ranged from asymptomatic to critical COVID-19 infections. In total, 40% of participants reported at least 1 symptom associated with COVID-19 six months after diagnosis. Median time from diagnosis to first resolution of all symptoms was 44 days; median time from diagnosis to sustained symptom resolution with no recurring symptoms for 1 month or longer was 214 days. Anti-nucleocapsid IgG level in the first week after positive RT-PCR test and history of lung disease were associated with time to sustained symptom resolution. COVID-19 disease severity, ethnicity, age, sex, and remdesivir use did not affect time to sustained symptom resolution.CONCLUSION We found that all disease severities had a similar risk of developing post–COVID-19 syndrome in an ethnically diverse population. Comorbid lung disease and lower levels of initial IgG response to SARS-CoV-2 nucleocapsid antigen were associated with longer symptom duration.TRIAL REGISTRATION ClinicalTrials.gov, NCT04373148.FUNDING NIH UL1TR003142 CTSA grant, NIH U54CA260517 grant, NIEHS R21 ES03304901, Sean N Parker Center for Allergy and Asthma Research at Stanford University, Chan Zuckerberg Biohub, Chan Zuckerberg Initiative, Sunshine Foundation, Crown Foundation, and Parker Foundation.
eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______325::ce4de024c04aec26a834887ad332e1f0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______325::ce4de024c04aec26a834887ad332e1f0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 English Funded by:NIH | Center for Clinical and T..., NIH | Training Program in Behav...NIH| Center for Clinical and Translational Research ,NIH| Training Program in Behavioral and Health Services Cancer Control ResearchAuthors: Adams, Elizabeth; Brickhouse, Tegwyn; Dugger, Roddrick; Bean, Melanie;Adams, Elizabeth; Brickhouse, Tegwyn; Dugger, Roddrick; Bean, Melanie;pmc: PMC9614666
pmid: 35500174
Temporary expansion of the Child Tax Credit (CTC) during the COVID-19 pandemic provided additional monthly income for US families, with no restrictions on use, from July through December 2021. This study examined food security and children's dietary intake after three months of expanded CTC payments. Parents completed online surveys before and after three months of CTC payments. Among parents participating in the expansion, food and beverage purchases were the most common use of expanded CTC funds (45.9 percent), particularly in households with very low food security (63.0 percent). From before to midway through the CTC expansion, very low food security decreased from 12.7 percent to 5.6 percent, and simultaneously, food security increased from 57.4 percent to 66.4 percent. The CTC expansion was also associated with decreases in children's consumption of added sugar, sugar-sweetened beverages, and sweetened fruit beverages. No changes were observed in children's intake of other dietary components. Our findings suggest that the expanded CTC payments may have helped lessen food insecurity and supported reductions in children's intake of added sugar in participating households.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC9614666&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 EnglishPublisher:Centers for Disease Control and Prevention (CDC) Funded by:NIH | NRSA Training CoreNIH| NRSA Training CoreStephen M. Bart; Eileen Flaherty; Tara Alpert; Sherry Carlson; Lisa Fasulo; Rebecca Earnest; Elizabeth B. White; Noel Dickens; Anderson F. Brito; Nathan D. Grubaugh; James L. Hadler; Lynn E. Sosa;In fall 2020, a coronavirus disease cluster comprising 16 cases occurred in Connecticut, USA. Epidemiologic and genomic evidence supported transmission among persons at a school and fitness center but not a workplace. The multiple transmission chains identified within this cluster highlight the necessity of a combined investigatory approach.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=doajarticles::3ae76d948e6a5a6e2dd96c4b806c35ae&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Former Yugoslav Republic of Macedonia English Funded by:ANR | AABIFNCOV, NIH | Developing, Demonstrating..., NIH | Monogenic basis of resist... +6 projectsANR| AABIFNCOV ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,NIH| CORE--BIOSTATISTICS FACILITY ,EC| CURE ,EC| ImmunAID ,NIH| IL-13/17-regulated airway epithelial miRNAs in asthma ,EC| EASI-GenomicsAuthors: Bastard, Paul; Vazquez, Sara; Liu, Jamin; Casanova, Jean-Laurent;Bastard, Paul; Vazquez, Sara; Liu, Jamin; Casanova, Jean-Laurent;Life-threatening 'breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, while two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert UGD Academic Reposit... arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_002::8c4c1936029f79778d74c5df7611f805&type=result"></script>'); --> </script>
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