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831 Research products, page 1 of 84

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  • Scientia, Dipòsit d’Informació Digital del Departament de Salut

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  • Open Access Catalan; Valencian
    Publisher: Regió Sanitària Alt Pirineu i Aran

    Sistema sanitari públic; Activitat assistencial; Memòria Sistema sanitario público; Actividad asistencial; Memoria Public health system; Assistance activity; Memory La memòria d’activitat de la Regió Sanitària Alt Pirineu i Aran relativa al 2021, un any en què el sistema sanitari ha iniciat un procés de transformació i enfortiment per encarar nous reptes i, alhora, començar a recuperar l’activitat endarrerida a causa de la pandèmia. Un any, també, en què tots plegats hem hagut d’aprendre a conviure amb la COVID-19, amb les dificultats que això ha comportat.

  • Open Access
    Authors: 
    Comissió Assessora per al Tractament Farmacològic de la Infecció per SARS-CoV-2;
    Publisher: Servei Català de la Salut
    Country: Spain

    Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Evidència científica; Tractament farmacològic Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Evidencia científica; Tratamiento farmacológico Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Scientific evidence; Pharmacological treatment L’objectiu d’aquest document és recollir i resumir les evidències científiques i clíniques actuals i les noves que es vagin generant sobre el tractament farmacològic de la infecció per SARSCoV-2.

  • Open Access English
    Authors: 
    Arévalos, Victor; Ortega Paz, Luis; Fernandez Rodríguez, Diego; Jiménez Díaz, Víctor Alfonso; Bañeras Rius, Jordi; Campo, Gianluca; Rodríguez Santamarta, Miguel; Pérez de Prado, Armando; Gómez Menchero, Antonio; Díaz Fernández, José Francisco; +13 more
    Publisher: Public Library of Science (PLoS)
    Country: Spain

    Background Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events, including death from cardiovascular causes. The long-term cardiovascular outcomes of these patients are entirely unknown. We aim to perform a registry of patients who have undergone a diagnostic nasopharyngeal swab for SARS-CoV-2 and to determine their long-term cardiovascular outcomes. Study and design This is a multicenter, observational, retrospective registry to be conducted at 17 centers in Spain and Italy (ClinicalTrials.gov number: NCT04359927). Consecutive patients older than 18 years, who underwent a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV2 in the participating institutions, will be included since March 2020, to August 2020. Patients will be classified into two groups, according to the results of the RT-PCR: COVID-19 positive or negative. The primary outcome will be cardiovascular mortality at 1 year. The secondary outcomes will be acute myocardial infarction, stroke, heart failure hospitalization, pulmonary embolism, and serious cardiac arrhythmias, at 1 year. Outcomes will be compared between the two groups. Events will be adjudicated by an independent clinical event committee. Conclusion The results of this registry will contribute to a better understanding of the long-term cardiovascular implications of the COVID19.

  • Open Access
    Authors: 
    Aida Perramon; Antoni Soriano-Arandes; David Pino; Uxue Lazcano; Cristina Andrés; Martí Català; Martí Català; Anna Gatell; Mireia Carulla; Dolors Canadell; +13 more
    Publisher: Frontiers Media SA
    Country: Spain

    COVID-19; Niño; Escuelas COVID-19; Nen; Escoles COVID-19; Child; Schools Objective: We describe and analyze the childhood (<18 years) COVID-19 incidence in Catalonia, Spain, during the first 36 weeks of the 2020-2021 school-year and to compare it with the incidence in adults. Methods: Data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests were obtained from the Catalan Agency for Quality and Health Assessment. Overall, 7,203,663 SARS-CoV-2 tests were performed, of which 491,819 were positive (6.8%). We collected epidemiological data including age-group incidence, diagnostic effort, and positivity rate per 100,000 population to analyze the relative results for these epidemiological characteristics. Results: Despite a great diagnostic effort among children, with a difference of 1,154 tests per 100,000 population in relation to adults, the relative incidence of SARS-CoV-2 for <18 years was slightly lower than for the general population, and it increased with the age of the children. Additionally, positivity of SARS-CoV-2 in children (5.7%) was lower than in adults (7.2%), especially outside vacation periods, when children were attending school (4.9%). Conclusions: A great diagnostic effort, including mass screening and systematic whole-group contact tracing when a positive was detected in the class group, was associated with childhood SARS-CoV-2 incidence and lower positivity rate in the 2020-2021 school year. Schools have been a key tool in epidemiological surveillance rather than being drivers of SARS-CoV-2 incidence in Catalonia, Spain. This study was partially supported by the Direcció General de Recerca i Innovació en Salut (DGRIS), Catalan Health Ministry, Generalitat de Catalunya through Vall d'Hebron Research Institute (VHIR).

  • Open Access English
    Authors: 
    Grau, Santiago; Hernandez, Sergi; Echeverría-Esnal, Daniel; Almendral, Alexander; Ferrer, Ricard; Limón, Enrique; Horcajada Gallego, Juan Pablo; Antimicrobial Stewardship Program;
    Publisher: MDPI
    Country: Spain

    COVID-19; Consumo de antimicrobianos; Dosis diarias definidas COVID-19; Consum d'antimicrobians; Dosis diàries definides COVID-19; Antimicrobial consumption; Defined daily doses Background: Antimicrobials have been widely used during the COVID-19 pandemic. This study aimed to analyze the impact of the COVID-19 pandemic on the antimicrobial consumption of 66 hospitals in Catalonia. Methods: Adult antibacterial and antimycotic consumption was calculated as defined daily doses (DDD)/100 bed-days and DDD/100 discharges. Firstly, overall and ICU consumption in 2019 and 2020 were compared. Secondly, observed ICU 2020 consumptions were compared with non-COVID-19 2020 estimated consumptions (based on the trend from 2008–2019). Results: Overall, antibacterial consumption increased by 2.31% and 4.15% DDD/100 bed-days and DDD/100 discharges, respectively. Azithromycin (105.4% and 109.08% DDD/100 bed-days and DDD/100 discharges, respectively) and ceftriaxone (25.72% and 27.97% DDD/100 bed-days and DDD/100 discharges, respectively) mainly accounted for this finding. Likewise, antifungal consumption increased by 10.25% DDD/100 bed-days and 12.22% DDD/100 discharges, mainly due to echinocandins or amphotericin B. ICU antibacterial and antimycotic consumption decreased by 1.28% and 4.35% DDD/100 bed-days, respectively. On the contrary, antibacterial and antifungal use, expressed in DDD/100 discharges, increased by 23.42% and 19.58%. Azithromycin (275.09%), ceftriaxone (55.11%), cefepime (106.35%), vancomycin (29.81%), linezolid (31.28%), amphotericin B (87.98%), and voriconazole (96.17%) use changed the most. Observed consumption of amphotericin B, azithromycin, caspofungin, ceftriaxone, vancomycin, and voriconazole were higher than estimated values. Conclusions: The consumption indicators for most antimicrobials deviated from the expected trend pattern. A worrisome increase in antibacterial and antifungal consumption was observed in ICUs in Catalonia. The present study was carried out as part of our routine work. The VINCat program is supported by public funding from the Catalan Health Service, Department of Health, Generalitat de Catalunya.

  • Open Access
    Authors: 
    Adrià Marco-Ahulló; Lluïsa Montesinos-Magraner; Luis-Millán González; José F. Morales; Jose Antonio Bernabéu-García; Xavier García-Massó;
    Publisher: Informa UK Limited

    Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Activitat física; Lesió medul·lar Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Actividad física; Lesión de la médula espinal Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Physical activity; Spinal cord injury Context The emergence of COVID-19 caused a new public health crisis, leading to major changes in daily life routines, often including physical activity (PA) levels. The main goal of this study was to analyze the differences in self-reported physical activity of people with complete spinal cord injuries between the time prior to the COVID-19 lockdown and the lockdown period itself. Methods A sample of 20 participants with complete thoracic spinal cord injuries completed the Physical Activity Scale for Individuals with Physical Disabilities before and during the COVID-19 lockdown. Results The results showed differences between the pre-lockdown and lockdown measurements in total self-reported PA (z=−3.92; P<0.001; d=1.28), recreational PA (z=−3.92; P<0.001; d=1.18) and occupational PA (z=−2.03; P=0.042; d=0.55). Nevertheless, no differences were found in housework PA between the two time periods. Furthermore, the results showed differences in total minutes (z=−3.92; P<0.001; d=1.75), minutes spent on recreational activities (z=−3.82; P<0.001; d=1.56) and minutes spent on occupational activities (z=−2.032; P=0.042; d=0.55) of moderate/vigorous intensity. Conclusions Individuals with thoracic spinal cord injuries who were full-time manual wheelchair users displayed lower levels of PA during the pandemic than in the pre-pandemic period. The results suggest that the prohibition and restrictions on carrying out recreational and/or occupational activities are the main reasons for this inactivity. Physical activity promotion strategies should be implemented within this population to lessen the effects of this physical inactivity stemming from the COVID-19 pandemic. This work was supported by the Fundació la Marató de la TV3 under [grant number 201720-10].

  • Open Access English
    Authors: 
    Ferran Tarrés-Freixas; Benjamin Trinité; Anna Pons-Grífols; Miguel Romero-Durana; Eva Riveira-Muñoz; Carlos Ávila-Nieto; Mónica Pérez; Edurne Garcia-Vidal; Daniel Perez-Zsolt; Jordana Muñoz-Basagoiti; +17 more
    Publisher: Frontiers Media SA
    Country: Spain

    The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced transmissibility, more severity and/or immune evasion; however, the pathogenesis of these new VOCs in experimental SARS-CoV-2 models or the potential infection of other animal species is not completely understood. Here we infected K18-hACE2 transgenic mice with B.1, B.1.351/Beta, B.1.617.2/Delta and BA.1.1/Omicron isolates and demonstrated heterogeneous infectivity and pathogenesis. B.1.351/Beta variant was the most pathogenic, while BA.1.1/Omicron led to lower viral RNA in the absence of major visible clinical signs. In parallel, we infected wildtype (WT) mice and confirmed that, contrary to B.1 and B.1.617.2/Delta, B.1.351/Beta and BA.1.1/Omicron can infect them. Infection in WT mice coursed without major clinical signs and viral RNA was transient and undetectable in the lungs by day 7 post-infection. In silico modeling supported these findings by predicting B.1.351/Beta receptor binding domain (RBD) mutations result in an increased affinity for both human and murine ACE2 receptors, while BA.1/Omicron RBD mutations only show increased affinity for murine ACE2. The research of CBIG consortium (constituted by IRTA-CReSA, BSC & IrsiCaixa) is supported by Grifols. We thank Foundation Dormeur for financial support for the acquisition of the QuantStudio-5 real time PCR system. CÁ-N has a grant by Secretaria d’Universitats i Recerca de la Generalitat de Catalunya and Fons Social Europeu. EG-V is a research fellow from PERIS (SLT017/20/000090). This work was partially funded by grant PID2020-117145RB-I00 from the Spanish Ministry of Science and Innovation (NI-U) the Departament de Salut of the Generalitat de Catalunya (grant SLD016 to JB and Grant SLD015 to JC), the Spanish Health Institute Carlos III (Grant PI17/01518. PI20/00093 to JB and PI18/01332 to JC), Fundació La Marató de TV3 (Project202126-30-21), CERCA Programme/Generalitat de Catalunya 2017 SGR 252, and the crowdfunding initiatives #joemcorono (https://www.yomecorono.com), BonPreu/Esclat and Correos. Funded in part by Fundació Glòria Soler (JB). The funders had no role in study design, data collection and analysis, the decision to publish, or the preparation of the manuscript. Peer Reviewed "Article signat per 27 autors/es: Ferran Tarrés-Freixas, Benjamin Trinité, Anna Pons-Grífols, Miguel Romero-Durana, Eva Riveira-Muñoz, Carlos Ávila-Nieto, Mónica Pérez, Edurne Garcia-Vidal, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Dàlia Raïch-Regué, Nuria Izquierdo-Useros, Cristina Andrés, Andrés Antón, Tomàs Pumarola, Ignacio Blanco, Marc Noguera-Julián, Victor Guallar, Rosalba Lepore, Alfonso Valencia, Victor Urrea, Júlia Vergara-Alert, Bonaventura Clotet, Ester Ballana, Jorge Carrillo, Joaquim Segalés and Julià Blanco"

  • Open Access Catalan; Valencian
    Authors: 
    Falguera-Puig, Gemma; Coll-Navarro, Engràcia; Martínez, Cristina; Escuriet-Peiró, Ramon; Suy Franch, Anna; Prats, Blanca; Porta-Roda, Oriol; Meler-Barrabés, Eva; Gómez-Roig, Maria D.; Gatell, Anna M.; +4 more
    Publisher: Sub-direcció General de Vigilància i Resposta a Emergències de Salut Pública

    Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Dones embarassades; Nadons Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Mujeres embarazadas; Bebés Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Pregnant women; Babies En aquest document s’estableixen les pautes a seguir en l’abordatge de l’atenció a les dones embarassades i puèrperes i dels nadons en la situació epidemiològica actual. S’estableixen els centres de referència per a l’atenció obstètrica a les dones amb infecció COVID-19 que requereixen un ingrés hospitalari durant l’embaràs, i també els centres de referència per a l’atenció al part a les dones amb infecció per COVID-19 amb simptomatologia lleu que no requereixen ingrés hospitalari.

  • Open Access
    Authors: 
    Rodríguez A; Ruiz-Botella M; Martín-Loeches I; Jimenez Herrera M; Solé-Violan J; Gómez J; Bodí M; Trefler S; Papiol E; Díaz E; +22 more
    Publisher: Springer Science and Business Media LLC
    Country: Spain

    Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Fenotips; Factors de risc; Infecció greu per SARS-CoV-2 Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Fenotipos; Factores de riesgo; Infección grave por SARS-CoV-2 Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Phenotypes; Risk factors; Severe SARS-CoV-2 infection Background The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to clinical decision-making that improves prognostic outcomes. Methods Prospective, multicenter, observational study of critically ill patients with confirmed COVID-19 disease and acute respiratory failure admitted from 63 ICUs in Spain. The objective was to utilize an unsupervised clustering analysis to derive clinical COVID-19 phenotypes and to analyze patient’s factors associated with mortality risk. Patient features including demographics and clinical data at ICU admission were analyzed. Generalized linear models were used to determine ICU morality risk factors. The prognostic models were validated and their performance was measured using accuracy test, sensitivity, specificity and ROC curves. Results The database included a total of 2022 patients (mean age 64 [IQR 5–71] years, 1423 (70.4%) male, median APACHE II score (13 [IQR 10–17]) and SOFA score (5 [IQR 3–7]) points. The ICU mortality rate was 32.6%. Of the 3 derived phenotypes, the A (mild) phenotype (537; 26.7%) included older age ( 65 years), high severity of illness and a higher likelihood of development shock. Crude ICU mortality was 20.3%, 25% and 45.4% for A, B and C phenotype respectively. The ICU mortality risk factors and model performance differed between whole population and phenotype classifications. Conclusion The presented machine learning model identified three clinical phenotypes that significantly correlated with host-response patterns and ICU mortality. Different risk factors across the whole population and clinical phenotypes were observed which may limit the application of a “one-size-fits-all” model in practice. This study was supported by the Spanish Intensive Care Society (SEMICYUC) and Ricardo Barri Casanovas Foundation. The study sponsors have no role in the study design, data collection, data analysis, data interpretation, or writing of the report.

  • Open Access Catalan; Valencian
    Authors: 
    Corbella-Cordomí, Irena;

    Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Mesures de prevenció Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Medidas de prevención Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Prevention measures