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532 Research products

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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Kirby, Leslie D.; Qian, Weiqiang; Adiguzel, Zafer; Afshar Jahanshahi, Asghar; +16 Authors

    COVID-19 has had a devastating impact on people worldwide. We conducted an international survey (n = 3646) examining the degree to which people's appraisals and coping activities around the pandemic predicted their health and well-being. We obtained subsamples from 12 countries-Bangladesh, Bulgaria, China, Colombia, India, Israel, the Netherlands, Norway, Peru, Portugal, Turkey and the United States. For each, we assessed appraisals and coping strategies as well as indicators of physical and mental health and well-being. Results indicated that, despite mean-level societal differences in outcomes, the pattern of appraisals and coping strategies predicting health and well-being was consistent across countries. Use of disengagement coping (particularly behavioural disengagement and self-isolation) was associated with relatively negative outcomes. In contrast, optimistic appraisals (particularly of high accommodation-focused coping potential and the ability to meet one's physical needs), use of problem-focused coping strategies (especially problem-solving) and accommodative coping strategies (especially positive reappraisal and self-encouragement) were associated with relatively positive outcomes. Our study highlights the critical importance of considering accommodative coping in stress and coping research. It also provides important information on how people have been dealing with the pandemic, the predictors of well-being under pandemic conditions and the generality of such relations.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao HBO Kennisbankarrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    HBO Kennisbank
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao HBO Kennisbankarrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      HBO Kennisbank
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      Data sources: HBO Kennisbank
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Cristina Valenti;

    Attività del Coordinamento Teatro Carcere Emilia Romagna nel corso dell'annualità 2020 in sette Istituti penitenziari della Regione: laboratori, spettacoli in presenza e in streaming, attività con le scuole. Con il sostegno di Regione Emilia Romagna, Ministero della Giustizia, Chiesa Valdese. Con il patrocinio di PRAP - Provveditorato Regionale dell'Emilia Romagna e Marche, Dipartimento delle Arti - Unibo. Un progetto di: Con...tatto associazione di volontariato (Forlì), Lady Godiva Teatro associazione (Ravenna), Le mani parlanti coop. sociale (Parma), Teatro dei Venti APS (Modena), Teatro del Pratello coop. sociale (Bologna), Teatro Nucleo coop. (Ferrara). CONSULENZA SCIENTIFICA: CRISTINA VALENTI. PRESENTAZIONE di Cristina Valenti (consulente scientifico) : STANZE DI TEATRO IN CARCERE AL TEMPO DEL CORONAVIRUS. Dopo l’immediata e pressoché totale sospensione delle attività, in seguito al DPCM dell’8 marzo 2020, che ha introdotto le misure per il contrasto al Covid-19, i registi del Coordinamento Teatro Carcere Emilia Romagna si sono impegnati a dare continuità al progetto “Padri e figli”, inaugurato nel 2018, sperimentando modalità di lavoro del tutto anomale. Incontri in remoto, videolezioni, epistolari teatrali, prove a distanza supportate da collegamenti via tablet e anche da radio locali hanno sostituito, laddove possibile, i laboratori in presenza, a dimostrazione dell’importanza che il lavoro teatrale in carcere ha assunto non solo per gli artisti, ma anche per gli attori detenuti e per l’istituzione, consapevole del valore del progetto e delle sue ricadute. A Castelfranco Emilia e a Modena il regista Stefano Tè ha continuato a sviluppare la drammaturgia dello spettacolo Padri e Figli lavorando sul confronto con due testi guida, Le avventure di Pinocchio e i Vangeli, attraverso sessioni di prove che sono riprese in aprile da remoto (con l’ausilio di collegamenti video via tablet) e in agosto in presenza, per arrivare a proporre il lavoro in ottobre a Gombola, nell’Appennino modenese, al termine di un periodo in residenza. A Ferrara i registi Horacio Czertok e Marco Luciano hanno ripreso a lavorare a distanza in marzo, con il laboratorio in forma epistolare Esercizi di libertà, per ricominciare ad agosto l’attività in presenza con le prove dello spettacolo Album di famiglia, ispirato alla tragedia di Amleto e alle sue riscritture novecentesche. A Bologna il lavoro del regista Paolo Billi con le attrici della sezione femminile si è sviluppato a partire da marzo in un Epistolario teatrale a distanza. Una fitta corrispondenza via mail che ha prodotto un’ampia raccolta di materiali drammaturgici e azioni fisiche lavorando sul copione Figlie di Lear. Da aprile la simulazione virtuale delle sedute di prove ha dato vita alla rubrica Prove a distanza, in onda settimanalmente su Radio Fujico, e a dicembre l’esperienza è stata ospitata nella trasmissione Natale liberi dentro, sulle stesse frequenze e sul canale di Teletricolore. A Forlì la regista Sabina Spazzoli ha inaugurato un’attività di videolezioni portando avanti, a partire da aprile, il lavoro sulla Tempesta di Shakespeare, interrotto a febbraio e ripreso in presenza a giugno. Si è invece fermata l’attività di Eugenio Sideri a Ravenna, dove il gruppo che ha lavorato con il regista fino all’inverno 2019 ha subito avvicendamenti e trasferimenti, ancor prima di incontrare l’emergenza Coronavirus che ha causato la sospensione degli incontri. Le attività sono riprese a settembre 2020 con un nuovo gruppo, per poi essere nuovamente sospese a novembre per l’aggravarsi della situazione sanitaria. Allo stesso modo durante tutto il 2020 l’attività di Corrado Vecchi a Parma non si è potuta svolgere neppure a distanza, in quanto nelle settimane antecedenti al lockdown il gruppo degli attori era in fase di formazione. Assai limitate sono state le attività in presenza, circoscritte ai primissimi mesi dell’anno e, in alcuni casi, all’autunno. Fra di esse, i laboratori con i minori e i giovani adulti dei Servizi di Giustizia Minorile, che hanno dato luogo allo spettacolo Le orme dei figli, presentato a Bologna, nel cortile dell’IPM, fra agosto e settembre. Molti gli eventi annullati, di cui abbiamo voluto comunque conservare traccia nel calendario contenuto in questa brochure. Nonostante l’emergenza sanitaria, le Stanze di Teatro in Carcere, giunte alla decima edizione, hanno proseguito e approfondito il rapporto teatro-carcere-scuola con il progetto Il Teatro Carcere incontra gli istituti superiori dell’Emilia Romagna, un percorso online realizzato su piattaforma Zoom nei mesi di aprile e maggio per riflettere sulla condizione della detenzione e sul valore della cultura e del teatro come fattori di trasformazione e di crescita.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Gugole, Federica; Coffeng, Luc; Edeling, Wouter; Sanderse, Benjamin; +2 Authors

    This repository contains the Python and R codes used for the paper titled: Uncertainty quantification and sensitivity analysis of COVID-19 exit strategies in an individual-based transmission model.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao NARCISarrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    NARCIS
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao NARCISarrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      NARCIS
      Other ORP type . 2020
      Data sources: NARCIS
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Tomić, Petra;

    Tema ovog rada je upravljanje rizikom odnosno krizama koji su obilježile 2020. godinu. Rad se sastoji od četiri dijela, a cilj je prikazati kako svijet, Europska unija, Republika Hrvatska i Grad Zagreb odgovaraju na predstojeće rizike te tijek događaja odnosno tijek njihovih radnji u suzbijanju rizika. U prvom dijelu polazi se od opće definicije rizika te objašnjavanje što rizik znači u suvremenom društvu. U drugom dijelu polazi se na konkretan rizik koji je pogodio cijeli svijet, a to je pandemija COVID – 19 te razmatra se i objašnjava pogled, radnja, politika i tijek događaja svijeta i Europske unije. Fokus ovog rada je u zadnjim dijelovima zbog specifičnosti Republike Hrvatske te Grada Zagreba i okolice jer osim COVID – 19, Grad Zagreb i okolica su pretrpjeli novi rizik, a to je prirodna katastrofa zvana potres te u ovom dijelu objašnjavaju se radnje u suzbijanju pandemije te usporedba akcija učinjene u svrhu suzbijanja pandemije COVID – 19 i u svrhu potresa.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Repository Faculty o...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Repository Faculty o...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: GORDON, A.L.; SPILSBURY, K.; Achterberg, W.P.; ADAMS, R.; +2 Authors

    Long-term care homes play an essential role within health and social care. Successful measures to support older people at home for longer have led to increased prevalence of disability, frailty and cognitive impairment in those who live in care homes over the last two decades. The need for care home places is projected to increase for the next two decades. Modern care homes provide care for people who are predominantly over 80, have multiple long-term conditions, take multiple medicines, are physically dependent and live with cognitive impairment. Residents do better when services recognise the contributions of staff and care home providers rather than treating residents as individual patients living in a communal setting. There is a strong case given residents' frailty, multimorbidity and disability, that care should be structured around Comprehensive Geriatric Assessment (CGA). Care should be designed to allow opportunities for multiprofessional teams to come together for CGA, particularly if healthcare professionals are based outside care homes. Good data about care homes and residents are central to efforts to deliver high quality care-in some countries, these data are collected but not collated. Collating such data is a priority. Care home staff are under-recognised and underpaid-parity of pay and opportunity with NHS staff is the bare minimum to ensure that the best are recruited and retained in the sector. During the COVID-19 pandemic, residents and relatives have frequently been left out of decisions about policies that affect them, and better consultation is needed to deliver high quality care.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao NARCISarrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    NARCIS
    Other ORP type . 2022
    Data sources: NARCIS
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao NARCISarrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      NARCIS
      Other ORP type . 2022
      Data sources: NARCIS
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      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Baud, David; Pomar, Léo;

    Viruses that emerged in the past decades, such as arboviruses and SARS-coronaviruses, are increasingly recognized as potential risk factors for adverse pregnancy outcomes. On the fetal side, arboviruses have proved their ability to cross the placental barrier, at different stages of pregnancy, and have been associated with fetal losses, fetal malformations (Zika, West Nile, and Venezuelan equine encephalitis viruses) and adverse neonatal outcomes (Dengue and Chikungunya viruses). The SARS-COV-2 has also be associated with rare maternal-fetal transmission and placental affection leading to fetal losses. More common viruses, like cytomegalovirus, are also well-known causes of fetal and childhood sequelae, and recent research on its prognosis factors and in-utero treatment may be welcome. On the maternal side, SARS-COV-2 might compromise maternal health, as well as Dengue viruses have been associated with high risks of adverse obstetrical outcomes, including maternal death, pre-eclampsia or post-partum hemorrhage. Thus, research on the maternal physiopathology would also be welcome. In this Special Issue of Viruses, we aim for original researchs, reviews and commentaries that contribute to an improved understanding of viral infection of placenta and fetal cells, or that report on the maternal and fetal outcomes after an emerging viral infection during pregnancy.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Hes-so: ArODES Open ...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Hes-so: ArODES Open ...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Wolfensberger, Marca; Vroom, Marte;

    The coronavirus created a new reality: a digital revolution has transformed education at universities around the world within a couple of weeks. In most European countries, the governments obliged universities to cancel face-to-face education because of the high health risks involved. This shift was needed because of the risk of infection with COVID-19. Arguments that were given to cancel face-to-face education were the age of the students, the international body of students and a large amount of traffic involved. Before the COVID-19 pandemic, most honors educators would agree that honors education thrives on face-to-face encounters. Creating a committed community is one of the main pillars of honors teaching (Wolfensberger, 2012). In this article, we describe how the honors program of the Human Geography and Spatial Planning department of Utrecht University, a research university in the Netherlands, has adapted to the current pandemic to meet the needs of the honors students. The aim of this article is to explain how the digitalization of education, due to the coronavirus, has led to an adapted honors course with a focus on wellbeing and creating community.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao HBO Kennisbankarrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    HBO Kennisbank
    Other ORP type . 2020
    Data sources: HBO Kennisbank
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao HBO Kennisbankarrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      HBO Kennisbank
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      Data sources: HBO Kennisbank
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Ramazzotti, Daniele; Angaroni, Fabrizio; Maspero, Davide; Gambacorti-Passerini, Carlo; +3 Authors

    A global cross-discipline effort is ongoing to characterize the evolution of SARS-CoV-2 virus and generate reliable epidemiological models of its diffusion. To this end, phylogenomic approaches leverage accumulating genomic mutations as barcodes to track the evolutionary history of the virus and can benefit from the surge of sequences deposited in public databases. Yet, such methods typically rely on consensus sequences representing the dominant virus lineage, whereas a complex sublineage architecture is often observed within single hosts. Furthermore, most approaches do not account for variants accumulation processes and might produce inaccurate results in condition of limited sampling, as witnessed in most countries currently affected by the epidemics. We here introduce a new framework for the characterization of viral (sub)lineage evolution and transmission of SARS-CoV-2, which considers both clonal and intra-host minor variants and exploits the achievements of cancer evolution research to account for mutation accumulation and uncertainty in the data. The application of our approach to 18 SARS-CoV-2 samples for which raw sequencing data are available reveals a high-resolution phylogenomic model, which confirms and improves recent findings on viral types and highlights the existence of patterns of co-occurrence of minor variants, uncovering likely infection paths among hosts harboring the same viral lineage. Our findings confirm a significant increase of genomic diversity of SARS-CoV-2 in time, which is reflected in minor variants, and show that standard methods may struggle when handling datasets with important sampling limitations. Importantly, our framework allows to pinpoint minor variants that might be positively selected across distinct lineages and regions of the viral genome under purifying selection, thus driving the design of treatments and vaccines. In particular, minor variant g.29039A>U, detected in multiple viral lineages and validated on an independent dataset, shows that SARS-CoV-2 can lose its main Nucleocapsid immunogenic epitopes, raising concerns about the effectiveness of vaccines targeting the C-terminus of this protein. To conclude, we advocate the use of our framework in combination with data-driven epidemiological models, to deliver a high-precision platform for pathogen detection, surveillance and analysis.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao BOA - Bicocca Open A...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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    Authors: Reeskens, Tim; Muis, Quita; Sieben, Inge; Vandecasteele, Leen; +2 Authors
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao NARCISarrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Willems, Lucia D.; Dyzel, Vernandi; Sterkenburg, P.S.;

    Background: A worldwide vaccination program is the chosen strategy against the COVID-19 pandemic. Vaccine hesitancy however, forms a threat because vaccine uptake is voluntary in most countries. Care-professionals of people with intellectual disabilities are exposed to greater risks than other healthcare workers due to the vulnerable group they attend to and the assisted-living facilities in which they often work. Little is still known of the reasons for vaccine hesitancy in this specific group in contrast to those of other healthcare workers. Objective: To provide insight in the intentions and attitudes on COVID-vaccination of healthcare workers, including those who care for people with intellectual disabilities, by means of a scoping review. Methods: The databases that were searched for papers are CINAHL, APA PsycArticles, APA PsycInfo, Web of Science, Semantic Scolar, Prospero, Outbreak Science, Cochrane and Scopus. The search was broadened to healthcare workers in general because only two papers were found on those caring for people with intellectual disabilities. A total of 26 papers were identified concerning the vaccine intentions of 43,199 healthcare workers worldwide. Data were gathered both quantitively and qualitatively. The papers were analysed for all themes regarding vaccine willingness and vaccine hesitancy. Results: The themes that came to light included: percentages of vaccine willingness, predictors of willingness differentiated by 11 sub-themes (mainly profession, age, gender and past vaccine behaviour), attitudes of willingness and hesitancy differentiated by 19 sub-themes (perceived COVID treat and protecting others for willingness, concerns on vaccine safety and efficacy for hesitancy), sources of vaccination information, contextual factors and changes in COVID-19 vaccine acceptance over time and finally, future strategies for interventions. Conclusions: There was overlap in the percentages of vaccination, predictors of vaccine willingness and the attitudes of vaccine willingness and hesitancy between healthcare workers and those caring for people with intellectual disabilities. Vaccine safety and efficacy are the most prominent concerns with regard to vaccine hesitancy. Therefore, future strategies for interventions should address vaccine safety and efficacy. Furthermore, interventions are recommended to be interactive in order to facilitate exchange. Discussion groups that are able to address specific concerns and personal experiences, show to be effective in addressing vaccine hesitancy. Accurate information can also be made more accessible to target groups by promoting video’s on social media platforms. Hence, further research is necessary to specify more precisely the attitudes of healthcare workers caring for people with intellectual disabilities and in more countries worldwide.

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532 Research products
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Kirby, Leslie D.; Qian, Weiqiang; Adiguzel, Zafer; Afshar Jahanshahi, Asghar; +16 Authors

    COVID-19 has had a devastating impact on people worldwide. We conducted an international survey (n = 3646) examining the degree to which people's appraisals and coping activities around the pandemic predicted their health and well-being. We obtained subsamples from 12 countries-Bangladesh, Bulgaria, China, Colombia, India, Israel, the Netherlands, Norway, Peru, Portugal, Turkey and the United States. For each, we assessed appraisals and coping strategies as well as indicators of physical and mental health and well-being. Results indicated that, despite mean-level societal differences in outcomes, the pattern of appraisals and coping strategies predicting health and well-being was consistent across countries. Use of disengagement coping (particularly behavioural disengagement and self-isolation) was associated with relatively negative outcomes. In contrast, optimistic appraisals (particularly of high accommodation-focused coping potential and the ability to meet one's physical needs), use of problem-focused coping strategies (especially problem-solving) and accommodative coping strategies (especially positive reappraisal and self-encouragement) were associated with relatively positive outcomes. Our study highlights the critical importance of considering accommodative coping in stress and coping research. It also provides important information on how people have been dealing with the pandemic, the predictors of well-being under pandemic conditions and the generality of such relations.

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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Cristina Valenti;

    Attività del Coordinamento Teatro Carcere Emilia Romagna nel corso dell'annualità 2020 in sette Istituti penitenziari della Regione: laboratori, spettacoli in presenza e in streaming, attività con le scuole. Con il sostegno di Regione Emilia Romagna, Ministero della Giustizia, Chiesa Valdese. Con il patrocinio di PRAP - Provveditorato Regionale dell'Emilia Romagna e Marche, Dipartimento delle Arti - Unibo. Un progetto di: Con...tatto associazione di volontariato (Forlì), Lady Godiva Teatro associazione (Ravenna), Le mani parlanti coop. sociale (Parma), Teatro dei Venti APS (Modena), Teatro del Pratello coop. sociale (Bologna), Teatro Nucleo coop. (Ferrara). CONSULENZA SCIENTIFICA: CRISTINA VALENTI. PRESENTAZIONE di Cristina Valenti (consulente scientifico) : STANZE DI TEATRO IN CARCERE AL TEMPO DEL CORONAVIRUS. Dopo l’immediata e pressoché totale sospensione delle attività, in seguito al DPCM dell’8 marzo 2020, che ha introdotto le misure per il contrasto al Covid-19, i registi del Coordinamento Teatro Carcere Emilia Romagna si sono impegnati a dare continuità al progetto “Padri e figli”, inaugurato nel 2018, sperimentando modalità di lavoro del tutto anomale. Incontri in remoto, videolezioni, epistolari teatrali, prove a distanza supportate da collegamenti via tablet e anche da radio locali hanno sostituito, laddove possibile, i laboratori in presenza, a dimostrazione dell’importanza che il lavoro teatrale in carcere ha assunto non solo per gli artisti, ma anche per gli attori detenuti e per l’istituzione, consapevole del valore del progetto e delle sue ricadute. A Castelfranco Emilia e a Modena il regista Stefano Tè ha continuato a sviluppare la drammaturgia dello spettacolo Padri e Figli lavorando sul confronto con due testi guida, Le avventure di Pinocchio e i Vangeli, attraverso sessioni di prove che sono riprese in aprile da remoto (con l’ausilio di collegamenti video via tablet) e in agosto in presenza, per arrivare a proporre il lavoro in ottobre a Gombola, nell’Appennino modenese, al termine di un periodo in residenza. A Ferrara i registi Horacio Czertok e Marco Luciano hanno ripreso a lavorare a distanza in marzo, con il laboratorio in forma epistolare Esercizi di libertà, per ricominciare ad agosto l’attività in presenza con le prove dello spettacolo Album di famiglia, ispirato alla tragedia di Amleto e alle sue riscritture novecentesche. A Bologna il lavoro del regista Paolo Billi con le attrici della sezione femminile si è sviluppato a partire da marzo in un Epistolario teatrale a distanza. Una fitta corrispondenza via mail che ha prodotto un’ampia raccolta di materiali drammaturgici e azioni fisiche lavorando sul copione Figlie di Lear. Da aprile la simulazione virtuale delle sedute di prove ha dato vita alla rubrica Prove a distanza, in onda settimanalmente su Radio Fujico, e a dicembre l’esperienza è stata ospitata nella trasmissione Natale liberi dentro, sulle stesse frequenze e sul canale di Teletricolore. A Forlì la regista Sabina Spazzoli ha inaugurato un’attività di videolezioni portando avanti, a partire da aprile, il lavoro sulla Tempesta di Shakespeare, interrotto a febbraio e ripreso in presenza a giugno. Si è invece fermata l’attività di Eugenio Sideri a Ravenna, dove il gruppo che ha lavorato con il regista fino all’inverno 2019 ha subito avvicendamenti e trasferimenti, ancor prima di incontrare l’emergenza Coronavirus che ha causato la sospensione degli incontri. Le attività sono riprese a settembre 2020 con un nuovo gruppo, per poi essere nuovamente sospese a novembre per l’aggravarsi della situazione sanitaria. Allo stesso modo durante tutto il 2020 l’attività di Corrado Vecchi a Parma non si è potuta svolgere neppure a distanza, in quanto nelle settimane antecedenti al lockdown il gruppo degli attori era in fase di formazione. Assai limitate sono state le attività in presenza, circoscritte ai primissimi mesi dell’anno e, in alcuni casi, all’autunno. Fra di esse, i laboratori con i minori e i giovani adulti dei Servizi di Giustizia Minorile, che hanno dato luogo allo spettacolo Le orme dei figli, presentato a Bologna, nel cortile dell’IPM, fra agosto e settembre. Molti gli eventi annullati, di cui abbiamo voluto comunque conservare traccia nel calendario contenuto in questa brochure. Nonostante l’emergenza sanitaria, le Stanze di Teatro in Carcere, giunte alla decima edizione, hanno proseguito e approfondito il rapporto teatro-carcere-scuola con il progetto Il Teatro Carcere incontra gli istituti superiori dell’Emilia Romagna, un percorso online realizzato su piattaforma Zoom nei mesi di aprile e maggio per riflettere sulla condizione della detenzione e sul valore della cultura e del teatro come fattori di trasformazione e di crescita.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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    Authors: Gugole, Federica; Coffeng, Luc; Edeling, Wouter; Sanderse, Benjamin; +2 Authors

    This repository contains the Python and R codes used for the paper titled: Uncertainty quantification and sensitivity analysis of COVID-19 exit strategies in an individual-based transmission model.

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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Tomić, Petra;

    Tema ovog rada je upravljanje rizikom odnosno krizama koji su obilježile 2020. godinu. Rad se sastoji od četiri dijela, a cilj je prikazati kako svijet, Europska unija, Republika Hrvatska i Grad Zagreb odgovaraju na predstojeće rizike te tijek događaja odnosno tijek njihovih radnji u suzbijanju rizika. U prvom dijelu polazi se od opće definicije rizika te objašnjavanje što rizik znači u suvremenom društvu. U drugom dijelu polazi se na konkretan rizik koji je pogodio cijeli svijet, a to je pandemija COVID – 19 te razmatra se i objašnjava pogled, radnja, politika i tijek događaja svijeta i Europske unije. Fokus ovog rada je u zadnjim dijelovima zbog specifičnosti Republike Hrvatske te Grada Zagreba i okolice jer osim COVID – 19, Grad Zagreb i okolica su pretrpjeli novi rizik, a to je prirodna katastrofa zvana potres te u ovom dijelu objašnjavaju se radnje u suzbijanju pandemije te usporedba akcija učinjene u svrhu suzbijanja pandemije COVID – 19 i u svrhu potresa.

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    Authors: GORDON, A.L.; SPILSBURY, K.; Achterberg, W.P.; ADAMS, R.; +2 Authors

    Long-term care homes play an essential role within health and social care. Successful measures to support older people at home for longer have led to increased prevalence of disability, frailty and cognitive impairment in those who live in care homes over the last two decades. The need for care home places is projected to increase for the next two decades. Modern care homes provide care for people who are predominantly over 80, have multiple long-term conditions, take multiple medicines, are physically dependent and live with cognitive impairment. Residents do better when services recognise the contributions of staff and care home providers rather than treating residents as individual patients living in a communal setting. There is a strong case given residents' frailty, multimorbidity and disability, that care should be structured around Comprehensive Geriatric Assessment (CGA). Care should be designed to allow opportunities for multiprofessional teams to come together for CGA, particularly if healthcare professionals are based outside care homes. Good data about care homes and residents are central to efforts to deliver high quality care-in some countries, these data are collected but not collated. Collating such data is a priority. Care home staff are under-recognised and underpaid-parity of pay and opportunity with NHS staff is the bare minimum to ensure that the best are recruited and retained in the sector. During the COVID-19 pandemic, residents and relatives have frequently been left out of decisions about policies that affect them, and better consultation is needed to deliver high quality care.

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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Baud, David; Pomar, Léo;

    Viruses that emerged in the past decades, such as arboviruses and SARS-coronaviruses, are increasingly recognized as potential risk factors for adverse pregnancy outcomes. On the fetal side, arboviruses have proved their ability to cross the placental barrier, at different stages of pregnancy, and have been associated with fetal losses, fetal malformations (Zika, West Nile, and Venezuelan equine encephalitis viruses) and adverse neonatal outcomes (Dengue and Chikungunya viruses). The SARS-COV-2 has also be associated with rare maternal-fetal transmission and placental affection leading to fetal losses. More common viruses, like cytomegalovirus, are also well-known causes of fetal and childhood sequelae, and recent research on its prognosis factors and in-utero treatment may be welcome. On the maternal side, SARS-COV-2 might compromise maternal health, as well as Dengue viruses have been associated with high risks of adverse obstetrical outcomes, including maternal death, pre-eclampsia or post-partum hemorrhage. Thus, research on the maternal physiopathology would also be welcome. In this Special Issue of Viruses, we aim for original researchs, reviews and commentaries that contribute to an improved understanding of viral infection of placenta and fetal cells, or that report on the maternal and fetal outcomes after an emerging viral infection during pregnancy.

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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Hes-so: ArODES Open ...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Wolfensberger, Marca; Vroom, Marte;

    The coronavirus created a new reality: a digital revolution has transformed education at universities around the world within a couple of weeks. In most European countries, the governments obliged universities to cancel face-to-face education because of the high health risks involved. This shift was needed because of the risk of infection with COVID-19. Arguments that were given to cancel face-to-face education were the age of the students, the international body of students and a large amount of traffic involved. Before the COVID-19 pandemic, most honors educators would agree that honors education thrives on face-to-face encounters. Creating a committed community is one of the main pillars of honors teaching (Wolfensberger, 2012). In this article, we describe how the honors program of the Human Geography and Spatial Planning department of Utrecht University, a research university in the Netherlands, has adapted to the current pandemic to meet the needs of the honors students. The aim of this article is to explain how the digitalization of education, due to the coronavirus, has led to an adapted honors course with a focus on wellbeing and creating community.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao HBO Kennisbankarrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    HBO Kennisbank
    Other ORP type . 2020
    Data sources: HBO Kennisbank
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao HBO Kennisbankarrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      HBO Kennisbank
      Other ORP type . 2020
      Data sources: HBO Kennisbank
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Ramazzotti, Daniele; Angaroni, Fabrizio; Maspero, Davide; Gambacorti-Passerini, Carlo; +3 Authors

    A global cross-discipline effort is ongoing to characterize the evolution of SARS-CoV-2 virus and generate reliable epidemiological models of its diffusion. To this end, phylogenomic approaches leverage accumulating genomic mutations as barcodes to track the evolutionary history of the virus and can benefit from the surge of sequences deposited in public databases. Yet, such methods typically rely on consensus sequences representing the dominant virus lineage, whereas a complex sublineage architecture is often observed within single hosts. Furthermore, most approaches do not account for variants accumulation processes and might produce inaccurate results in condition of limited sampling, as witnessed in most countries currently affected by the epidemics. We here introduce a new framework for the characterization of viral (sub)lineage evolution and transmission of SARS-CoV-2, which considers both clonal and intra-host minor variants and exploits the achievements of cancer evolution research to account for mutation accumulation and uncertainty in the data. The application of our approach to 18 SARS-CoV-2 samples for which raw sequencing data are available reveals a high-resolution phylogenomic model, which confirms and improves recent findings on viral types and highlights the existence of patterns of co-occurrence of minor variants, uncovering likely infection paths among hosts harboring the same viral lineage. Our findings confirm a significant increase of genomic diversity of SARS-CoV-2 in time, which is reflected in minor variants, and show that standard methods may struggle when handling datasets with important sampling limitations. Importantly, our framework allows to pinpoint minor variants that might be positively selected across distinct lineages and regions of the viral genome under purifying selection, thus driving the design of treatments and vaccines. In particular, minor variant g.29039A>U, detected in multiple viral lineages and validated on an independent dataset, shows that SARS-CoV-2 can lose its main Nucleocapsid immunogenic epitopes, raising concerns about the effectiveness of vaccines targeting the C-terminus of this protein. To conclude, we advocate the use of our framework in combination with data-driven epidemiological models, to deliver a high-precision platform for pathogen detection, surveillance and analysis.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao BOA - Bicocca Open A...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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