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14 research outcomes, page 1 of 2
  • publication . Other literature type . 2018
    Authors:
    Ederveen, Thomas; Ferwerda, Gerben; Ahout, Inge; Vissers, Marloes; Groot, Ronald De; Boekhorst, Jos; Timmerman, Harro; Huynen, Martijn; Hijum, Sacha Van; Jonge, Marien De;
    Publisher: figshare
    Project: EC | PoC-ID (634415), NWO | XCiDE: Crossing the Combu... (2300153186)

    Potential confounding characteristics of this study. Figure S2 RSV disease and viral load in healthy and RSV-infected individuals can be explained by nasopharyngeal microbial makeup (OTU-level). Figure S3 Species richness, but not diversity, is reduced in RSV-infected i...

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  • publication . Article . 2017
    Open Access
    Authors:
    Xingdong Zhou; Yingying Cong; Tineke Veenendaal; Judith Klumperman; Dongfang Shi; Muriel Mari; Fulvio Reggiori;
    Publisher: MDPI AG
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771)

    The porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) belonging to the alpha-CoV genus and it causes high mortality in infected sucking piglets, resulting in substantial losses in the farming industry. CoV trigger a drastic reorganization of host cell membra...

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  • publication . Article . 2018
    Open Access
    Authors:
    Ederveen, Thomas H. A.; Ferwerda, Gerben; Ahout, Inge M.; Vissers, Marloes; de Groot, Ronald; Boekhorst, Jos; Timmerman, Harro M.; Huynen, Martijn A.; van Hijum, Sacha A. F. T.; de Jonge, Marien I.;
    Country: Netherlands
    Project: NWO | XCiDE: Crossing the Combu... (2300153186), EC | PoC-ID (634415)

    Background While almost all infants are infected with respiratory syncytial virus (RSV) before the age of 2 years, only a small percentage develops severe disease. Previous studies suggest that the nasopharyngeal microbiome affects disease development. We therefore stud...

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  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), NWO | A three-dimensional look ... (2300175771)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

  • publication . Article . 2018
    Open Access English
    Authors:
    Melia, C E; van der Schaar, H M; de Jong, A W M; Lyoo, H R; Snijder, Eric J; Koster, A J; van Kuppeveld, F J M; Bárcena, Montserrat; dI&I I&I-1; LS Virologie; ...
    Publisher: American Society for Microbiology
    Country: Netherlands
    Project: EC | ANTIVIRALS (642434), NWO | SysVirDrug: Translating S... (2300189186), NWO | Activating the VE-cadheri... (2300161085), NWO | Viral redesign of the cel... (2300174141), EC | EUVIRNA (264286)

    ABSTRACT Picornaviruses induce dramatic rearrangements of endomembranes in the cells that they infect to produce dedicated platforms for viral replication. These structures, termed replication organelles (ROs), have been well characterized for the Enterovirus genus of t...

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  • publication . Article . 2017
    Open Access
    Authors:
    Melia, Charlotte E; van der Schaar, Hilde M; Lyoo, Heyrhyoung; Limpens, Ronald W A L; Feng, Qian; Wahedi, Maryam; Overheul, Gijs J; van Rij, Ronald P; Snijder, Eric J; Koster, Abraham J; ...
    Countries: Netherlands, Switzerland
    Project: NWO | Viral redesign of the cel... (2300174141), EC | EUVIRNA (264286), NWO | SysVirDrug: Translating S... (2300189186), EC | ANTIVIRALS (642434), EC | VIVARNASILENCING (615680), NWO | The +RNA virus replicatio... (2300150213)

    Summary Enteroviruses reorganize cellular endomembranes into replication organelles (ROs) for genome replication. Although enterovirus replication depends on phosphatidylinositol 4-kinase type IIIβ (PI4KB), its role, and that of its product, phosphatidylinositol 4-phosp...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Natacha S. Ogando; Francois Ferron; Francois Ferron; Etienne Decroly; Bruno Canard; Clara C. Posthuma; Eric J. Snijder;
    Publisher: Frontiers Media S.A.
    Countries: Netherlands, Netherlands, France
    Project: NWO | Viral RNA polymerases: th... (2300162767), EC | ANTIVIRALS (642434)

    International audience; Among RNA viruses, the order Nidovirales stands out for including viruses with the largest RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing machinery comprising a variety of non-structural proteins (nsps). One of the pos...

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Mart M. Lamers; Joep Beumer; Jelte van der Vaart; Kèvin Knoops; Jens Puschhof; Tim I Breugem; Raimond B. G. Ravelli; J. Paul van Schayck; Anna Z Mykytyn; Hans Duimel; ...
    Country: Netherlands
    Project: EC | Organoid (670133), EC | Q-SORT (766970), NWO | Erasmus Graduate Programm... (2300181109), NWO | Bio-MEMS for Structural B... (2300191194)

    Intestinal organoids as an infection model Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an influenza-like disease with a respiratory transmission route; however, patients often present with gastrointestinal symptoms such as diarrhea, vomiting, an...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Stewart, Hazel; Brown, Katherine; Dinan, Adam; Irigoyen, Nerea; Snijder, Eric J; Firth, Andrew;
    Publisher: American Society for Microbiology
    Countries: Netherlands, United Kingdom
    Project: EC | ERVE (646891), WT | Encyclopedia of RNA Virus... (106207), NWO | Protein-directed ribosoma... (2300184220)

    ABSTRACT The genus Torovirus (subfamily Torovirinae, family Coronaviridae, order Nidovirales) encompasses a range of species that infect domestic ungulates, including cattle, sheep, goats, pigs, and horses, causing an acute self-limiting gastroenteritis. Using the proto...

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  • publication . Article . 2015
    Open Access
    Authors:
    Saskia eSmits; Rogier eBodewes; Rogier eBodewes; Aritz eRuiz-Gonzalez; Aritz eRuiz-Gonzalez; Aritz eRuiz-Gonzalez; Wolfgang eBaumgärtner; Marion eKoopmans; Marion eKoopmans; Albertus DME eOsterhaus; ...
    Publisher: Frontiers Media SA
    Country: Netherlands
    Project: EC | VIROGENESIS (634650), NWO | VIRGO Subsidiebesluit 200... (2300162323), EC | COMPARE (643476)

    Infectious disease metagenomics is driven by the question: "what is causing the disease?" in contrast to classical metagenome studies which are guided by "what is out there?" In case of a novel virus, a first step to eventually establishing etiology can be to recover a ...

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14 research outcomes, page 1 of 2