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description Publicationkeyboard_double_arrow_right Article , Preprint 2021Embargo end date: 15 Dec 2021 United Kingdom, FrancePublisher:Apollo - University of Cambridge Repository Funded by:EC | RECoVER, ANR | INCEPTION, EC | VEOEC| RECoVER ,ANR| INCEPTION ,EC| VEOTran Kiem, Cécile; Bosetti, Paolo; Paireau, Juliette; Crépey, Pascal; Salje, Henrik; Lefrancq, Noémie; Fontanet, Arnaud; Benamouzig, Daniel; Boëlle, Pierre-Yves; Desenclos, Jean-Claude; Opatowski, Lulla; Cauchemez, Simon;The shielding of older individuals has been proposed to limit COVID-19 hospitalizations while relaxing general social distancing in the absence of vaccines. Evaluating such approaches requires a deep understanding of transmission dynamics across ages. Here, we use detailed age-specific case and hospitalization data to model the rebound in the French epidemic in summer 2020, characterize age-specific transmission dynamics and critically evaluate different age-targeted intervention measures in the absence of vaccines. We find that while the rebound started in young adults, it reached individuals aged ���80 y.o. after 4 weeks, despite substantial contact reductions, indicating substantial transmission flows across ages. We derive the contribution of each age group to transmission. While shielding older individuals reduces mortality, it is insufficient to allow major relaxations of social distancing. When the epidemic remains manageable (R close to 1), targeting those most contributing to transmission is better than shielding at-risk individuals. Pandemic control requires an effort from all age groups. Funder: We acknowledge financial support from the Investissement d'Avenir program, the Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases program (grant ANR-10-LABX-62-IBEID), Sant�� Publique France, the INCEPTION project (PIA/ANR-16-COV-0005), the European Union���s Horizon 2020 research and innovation program under grant 101003589 (RECOVER) and 874735 (VEO), AXA and Groupama. Funder: AXA Research Fund (Le Fonds AXA pour la Recherche); doi: https://doi.org/10.13039/501100001961
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8617041Data sources: PubMed CentralHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BYFull-Text: https://hal.science/hal-03468461/documentHAL Descartes; HAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-PasteurArticle . 2021License: CC BYFull-Text: https://hal.science/hal-03468461v3/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.78875&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8617041Data sources: PubMed CentralHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BYFull-Text: https://hal.science/hal-03468461/documentHAL Descartes; HAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-PasteurArticle . 2021License: CC BYFull-Text: https://hal.science/hal-03468461v3/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.78875&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Italy, FrancePublisher:Elsevier BV Funded by:EC | RECoVER, EC | VEO, ANR | INCEPTIONEC| RECoVER ,EC| VEO ,ANR| INCEPTIONCécile Tran Kiem; Clément Massonnaud; Daniel Lévy-Bruhl; Chiara Poletto; Vittoria Colizza; Paolo Bosetti; Arnaud Fontanet; Amélie Gabet; Valérie Olié; Laura Zanetti; Pierre-Yves Boëlle; Pascal Crépey; Simon Cauchemez;Background: The roll-out of COVID-19 vaccines is a multi-faceted challenge whose performance depends on pace of vaccination, vaccine characteristics and heterogeneities in individual risks. Methods: We developed a mathematical model accounting for the risk of severe disease by age and comorbidity, and transmission dynamics. We compared vaccine prioritisation strategies in the early roll-out stage and quantified the extent to which measures could be relaxed as a function of the vaccine coverage achieved in France. Findings: Prioritizing at-risk individuals reduces morbi-mortality the most if vaccines only reduce severity, but is of less importance if vaccines also substantially reduce infectivity or susceptibility. Age is the most important factor to consider for prioritization; additionally accounting for comorbidities increases the performance of the campaign in a context of scarce resources. Vaccinating 90% of 65 y.o. and 70% of 18À64 y.o. before autumn 2021 with a vaccine that reduces severity by 90% and susceptibility by 80%, we find that control measures reducing transmission rates by 15À27% should be maintained to remain below 1000 daily hospital admissions in France with a highly transmissible variant (basic reproduction number R 0 = 4). Assuming 90% of 65 y.o. are vaccinated, full relaxation of control measures might be achieved with a vaccine coverage of 89À100% in 18À64 y.o or 60À69% of 0À64 y.o. Interpretation: Age and comorbidity-based vaccine prioritization strategies could reduce the burden of the disease. Very high vaccination coverage may be required to completely relax control measures. Vaccination of children, if possible, could lower coverage targets necessary to achieve this objective. International audience
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8278244Data sources: PubMed CentralArchivio istituzionale della ricerca - Università di Padova; EClinicalMedicineOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotArticle . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.eclinm.2021.101001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 44 citations 44 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8278244Data sources: PubMed CentralArchivio istituzionale della ricerca - Università di Padova; EClinicalMedicineOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotArticle . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.eclinm.2021.101001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2020 France EnglishPublisher:HAL CCSD Funded by:EC | VEO, EC | RECoVER, EC | ARBODYNAMIC +1 projectsEC| VEO ,EC| RECoVER ,EC| ARBODYNAMIC ,ANR| INCEPTIONLefrancq, Noémie; Paireau, Juliette; Hozé, Nathanaël; Courtejoie, Noémie; Yazdanpanah, Yazdan; Bouadma, Lila; Boëlle, Pierre-Yves; Chereau, Fanny; Salje, Henrik; Cauchemez, Simon;As SARS-CoV-2 continues to spread, a thorough characterization of healthcare needs and patient outcomes is essential to inform planning; however, these analyses are complicated by ongoing changes in patient profiles. Here we develop age and sex adjusted models to analyze detailed patient trajectories from 91,304 hospitalizations in France during the first 4 months of the epidemic. Only 25% of hospital deaths occurred in patients that were admitted into ICU. The probability of entering ICU fell by 50% and the probability of death by 52% over the study period. Had the age and sex profile not changed over time, these reductions would have been 59% and 56%, respectively. These findings suggest substantial improvements in patient outcomes since the start of the pandemic.
Hal-Diderot arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Preprint . 2020License: CC BY NC NDFull-Text: https://hal.science/hal-02946545/documentAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______2100::13443ebd8b99e14572c6e9ab0691bac2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Hal-Diderot arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Preprint . 2020License: CC BY NC NDFull-Text: https://hal.science/hal-02946545/documentAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______2100::13443ebd8b99e14572c6e9ab0691bac2&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Preprint 2021Embargo end date: 15 Dec 2021 United Kingdom, FrancePublisher:Apollo - University of Cambridge Repository Funded by:EC | RECoVER, ANR | INCEPTION, EC | VEOEC| RECoVER ,ANR| INCEPTION ,EC| VEOTran Kiem, Cécile; Bosetti, Paolo; Paireau, Juliette; Crépey, Pascal; Salje, Henrik; Lefrancq, Noémie; Fontanet, Arnaud; Benamouzig, Daniel; Boëlle, Pierre-Yves; Desenclos, Jean-Claude; Opatowski, Lulla; Cauchemez, Simon;The shielding of older individuals has been proposed to limit COVID-19 hospitalizations while relaxing general social distancing in the absence of vaccines. Evaluating such approaches requires a deep understanding of transmission dynamics across ages. Here, we use detailed age-specific case and hospitalization data to model the rebound in the French epidemic in summer 2020, characterize age-specific transmission dynamics and critically evaluate different age-targeted intervention measures in the absence of vaccines. We find that while the rebound started in young adults, it reached individuals aged ���80 y.o. after 4 weeks, despite substantial contact reductions, indicating substantial transmission flows across ages. We derive the contribution of each age group to transmission. While shielding older individuals reduces mortality, it is insufficient to allow major relaxations of social distancing. When the epidemic remains manageable (R close to 1), targeting those most contributing to transmission is better than shielding at-risk individuals. Pandemic control requires an effort from all age groups. Funder: We acknowledge financial support from the Investissement d'Avenir program, the Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases program (grant ANR-10-LABX-62-IBEID), Sant�� Publique France, the INCEPTION project (PIA/ANR-16-COV-0005), the European Union���s Horizon 2020 research and innovation program under grant 101003589 (RECOVER) and 874735 (VEO), AXA and Groupama. Funder: AXA Research Fund (Le Fonds AXA pour la Recherche); doi: https://doi.org/10.13039/501100001961
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8617041Data sources: PubMed CentralHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BYFull-Text: https://hal.science/hal-03468461/documentHAL Descartes; HAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-PasteurArticle . 2021License: CC BYFull-Text: https://hal.science/hal-03468461v3/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.78875&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8617041Data sources: PubMed CentralHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BYFull-Text: https://hal.science/hal-03468461/documentHAL Descartes; HAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-PasteurArticle . 2021License: CC BYFull-Text: https://hal.science/hal-03468461v3/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.78875&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Italy, FrancePublisher:Elsevier BV Funded by:EC | RECoVER, EC | VEO, ANR | INCEPTIONEC| RECoVER ,EC| VEO ,ANR| INCEPTIONCécile Tran Kiem; Clément Massonnaud; Daniel Lévy-Bruhl; Chiara Poletto; Vittoria Colizza; Paolo Bosetti; Arnaud Fontanet; Amélie Gabet; Valérie Olié; Laura Zanetti; Pierre-Yves Boëlle; Pascal Crépey; Simon Cauchemez;Background: The roll-out of COVID-19 vaccines is a multi-faceted challenge whose performance depends on pace of vaccination, vaccine characteristics and heterogeneities in individual risks. Methods: We developed a mathematical model accounting for the risk of severe disease by age and comorbidity, and transmission dynamics. We compared vaccine prioritisation strategies in the early roll-out stage and quantified the extent to which measures could be relaxed as a function of the vaccine coverage achieved in France. Findings: Prioritizing at-risk individuals reduces morbi-mortality the most if vaccines only reduce severity, but is of less importance if vaccines also substantially reduce infectivity or susceptibility. Age is the most important factor to consider for prioritization; additionally accounting for comorbidities increases the performance of the campaign in a context of scarce resources. Vaccinating 90% of 65 y.o. and 70% of 18À64 y.o. before autumn 2021 with a vaccine that reduces severity by 90% and susceptibility by 80%, we find that control measures reducing transmission rates by 15À27% should be maintained to remain below 1000 daily hospital admissions in France with a highly transmissible variant (basic reproduction number R 0 = 4). Assuming 90% of 65 y.o. are vaccinated, full relaxation of control measures might be achieved with a vaccine coverage of 89À100% in 18À64 y.o or 60À69% of 0À64 y.o. Interpretation: Age and comorbidity-based vaccine prioritization strategies could reduce the burden of the disease. Very high vaccination coverage may be required to completely relax control measures. Vaccination of children, if possible, could lower coverage targets necessary to achieve this objective. International audience
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8278244Data sources: PubMed CentralArchivio istituzionale della ricerca - Università di Padova; EClinicalMedicineOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotArticle . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.eclinm.2021.101001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 44 citations 44 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8278244Data sources: PubMed CentralArchivio istituzionale della ricerca - Università di Padova; EClinicalMedicineOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMHAL Descartes; HAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotArticle . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.eclinm.2021.101001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2020 France EnglishPublisher:HAL CCSD Funded by:EC | VEO, EC | RECoVER, EC | ARBODYNAMIC +1 projectsEC| VEO ,EC| RECoVER ,EC| ARBODYNAMIC ,ANR| INCEPTIONLefrancq, Noémie; Paireau, Juliette; Hozé, Nathanaël; Courtejoie, Noémie; Yazdanpanah, Yazdan; Bouadma, Lila; Boëlle, Pierre-Yves; Chereau, Fanny; Salje, Henrik; Cauchemez, Simon;As SARS-CoV-2 continues to spread, a thorough characterization of healthcare needs and patient outcomes is essential to inform planning; however, these analyses are complicated by ongoing changes in patient profiles. Here we develop age and sex adjusted models to analyze detailed patient trajectories from 91,304 hospitalizations in France during the first 4 months of the epidemic. Only 25% of hospital deaths occurred in patients that were admitted into ICU. The probability of entering ICU fell by 50% and the probability of death by 52% over the study period. Had the age and sex profile not changed over time, these reductions would have been 59% and 56%, respectively. These findings suggest substantial improvements in patient outcomes since the start of the pandemic.
Hal-Diderot arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Preprint . 2020License: CC BY NC NDFull-Text: https://hal.science/hal-02946545/documentAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______2100::13443ebd8b99e14572c6e9ab0691bac2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Hal-Diderot arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Preprint . 2020License: CC BY NC NDFull-Text: https://hal.science/hal-02946545/documentAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______2100::13443ebd8b99e14572c6e9ab0691bac2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu