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Biochemical analysis of similarities between human and SARS-CoV-2 proteins

This dataset contains the results of the electrochemical impedance spectroscopy (EIS) measurements of the boron-doped diamond (BDD) electrode functionalization with IgG2B receptor. The functionalized electrode was then used for the electrochemical detection of the SARS-CoV-2 virus S1 protein. All electrochemical measurements were carried out in a three-electrode system using a potentiostat SP-300 (Biologic) / PalmSens4. The electrolyte was 1 mM K3[Fe(CN)6] and 1 mM K4[Fe(CN)6] in PBS (pH 7.4), deoxidized by passing through a stream of argon prior to measurement. The electrolyte volume was 1 mL. A platinum wire was used as the counter electrode. The reference electrode was a silver chloride electrode with an Ag|AgCl|3M KCl. The working electrode was the functionalised BDD with an electrolyte-exposed surface area of 0.196 cm2. Cyclic voltammetry (CV) measurements were performed from -0.5 to +0.75 V vs. Ag|AgCl|3MKCl with a polarisation rate of 50 mV/s over three cycles. Electrochemical impedance spectroscopy (EIS) measurement was performed for the sample polarised for 30 s to the potential E0’ before the measurement. The measurement was performed in the frequency range from 10 kHz to 0.1 Hz at 11 points per decade. The amplitude of the excitation signal was 10 mV. The procedure details are placed in the metadata.txt file. The dataset is a part of the results published in the Sensors and Actuators B journal: DOI: 10.1016/j.snb.2022.132427

This dataset contains the data collected for the assessment of the quality attributes of a new online educational platform. The questionnaire used for data collection the Kano methodology and was designed as a hybrid Kano-importance questionnaire. The purpose of this data collection consists of the analysis of the students’ expectations regarding the features proposed for a new online educational platform. This analysis facilitates the identification of student needs during times of COVID-19 pandemic and post-pandemic times, while a transition to an online educational system was used throughout the world. The corresponding Google form has been attached as a .pdf file. The form and the collected data contain information in Romanian and English. The dataset contains the translation into English of the data collected in Romanian.

AusAEM-WA, Murchison Airborne Electromagnetic Survey Blocks: SkyTEM�� airborne electromagnetic data and GALEI inversion conductivity estimates The accompanying data package, titled ���AusAEM���WA, Murchison Airborne Electromagnetic Survey Blocks: SkyTEM�� airborne electromagnetic data and GALEI inversion conductivity estimates���, was released on March 2022 by Geoscience Australia (GA) in collaboration with the Geological Survey of Western Australia. The data represents the first second of the AusAEM2020 (WA) survey flown with a with a rotary aircraft contracted to Geoscience Australia, using the SkyTEM�� airborne electromagnetic system. The survey was flown at a 20-kilometre nominal line spacing over the most over the Murchison area and across to the west coast of Western Australia. The area encompasses over 17,600 line kilometres of newly acquired airborne electromagnetic geophysical data. This package contains (~17,600 kms) of the total of survey data which have been quality-controlled, processed, modelled and inverted both by the contractor and by GA. The survey was divided in four blocks, flown east-west. All four block���s projected grid coordinates have been supplied in GDA2020 MGA Zone 50 datum, and contain the geodetic latitude and longitude coordinate fields. Geoscience Australia and Western Australia (Department of Mines, Industry Regulation and Safety) commissioned the AusAEM 2020 survey as part of the national airborne electromagnetic acquisition program, to complete 20km line separation AEM coverage over WA. The program is designed to deliver freely available pre-competitive geophysical data to assist in the investigation and discovery of potential mineral, energy and groundwater resources within Australia. Funding for the survey came from the Western Australian government���s Exploration Incentive Scheme and additional support from the State���s COVID-19 recovery plan. Geoscience Australia managed the survey data acquisition, processing, contracts, quality control of the survey and generated the inversion products included in the data package. The data release package contains 1. A data release package summary PDF document. 2. The survey logistics and processing report. 3. KML and Shapefiles for the regional flight lines. 4. Final processed point located line data in ASEG-GDF2 format. 5. Conductivity estimates generated by SkyTEM���s Workbench. 6. Conductivity estimates and products (suitable for various 3D packages) generated by Geoscience Australia's Layered Earth Inversion algorithm.

Project Tycho datasets contain case counts for reported disease conditions for countries around the world. The Project Tycho data curation team extracts these case counts from various reputable sources, typically from national or international health authorities, such as the US Centers for Disease Control or the World Health Organization. These original data sources include both open- and restricted-access sources. For restricted-access sources, the Project Tycho team has obtained permission for redistribution from data contributors. All datasets contain case count data that are identical to counts published in the original source and no counts have been modified in any way by the Project Tycho team, except for aggregation of individual case count data into daily counts when that was the best data available for a disease and location. The Project Tycho team has pre-processed datasets by adding new variables, such as standard disease and location identifiers, that improve data interpretability. We also formatted the data into a standard data format. All geographic locations at the country and admin1 level have been represented at the same geographic level as in the data source, provided an ISO code or codes could be identified, unless the data source specifies that the location is listed at an inaccurate geographical level. For more information about decisions made by the curation team, recommended data processing steps, and the data sources used, please see the README that is included in the dataset download ZIP file.

Autophagy is an intracellular catabolic process that controls infections both directly and indirectly via its multifaceted effects on the innate and adaptive immune responses. It has been reported that LPS stimulates this cellular process, whereas the effect of IL-36α on autophagy remains largely unknown. We, therefore, investigated how IL-36α modulates the endogenous and LPS-induced autophagy in THP-1 cells. The levels of LC3B-II and autophagic flux were determined by western blotting. The intracellular localization of LC3B was measured by immunofluorescence assay. The activation levels of signaling pathways implicated in autophagy regulation were evaluated by using a phosphokinase array. Our results showed that combined IL-36α and LPS treatment cooperatively increased the levels of LC3B-II and Beclin-1, stimulated the autophagic flux, facilitated intracellular redistribution of LC3B, and increased the average number of autophagosomes per cell. The IL36α/LPS combined treatment increased phosphorylation of STAT5a/b, had minimal effect on the Akt/PRAS40/mTOR pathway, and reduced the levels of phospho-Yes, phospho-FAK, and phospho-WNK1. Thus, this cytokine/PAMP combination triggers pro-autophagic biased signaling by several mechanisms and thus cooperatively stimulates the autophagic cascade. An increased autophagic activity of innate immune cells simultaneously exposed to IL-36α and LPS may play an important role in the pathogenesis of Gram-negative bacterial infections. SARS-CoV-2 can infect and replicate in esophageal cells and enterocytes, leading to direct damage to the intestinal epithelium. The infection decreases the level of angiotensin converting enzyme 2 receptors, thereby altering the composition of the gut microbiota. SARS-CoV-2 elicits a cytokine storm, which contributes to gastrointestinal inflammation. The direct cytopathic effects of SARS-CoV-2, gut dysbiosis, and aberrant immune response result in increased intestinal permeability, which may exacerbate existing symptoms and worsen the prognosis. By exploring the elements of pathogenesis, several therapeutic options have emerged for the treatment of COVID-19 patients, such as biologics and biotherapeutic agents. However, the presence of SARS-CoV-2 in the feces may facilitate the spread of COVID-19 through fecal-oral transmission and contaminate the environment. Thus, gastrointestinal SARS-CoV-2 infection has important epidemiological significance. The development of new therapeutic and preventive options is necessary to treat and restrict the spread of this severe and widespread infection more effectively.

Purpose – The COVID-19 has brought with it valuable opportunities for the retail sector. Notably, online channels have assumed a key role for businesses that can rely less on physical channels due to the pandemic’s restrictions. Within this context, the study aims to identify the main antecedents leading to the formation of the male and female customers’ continuance intention of using online food delivery services (OFDS) in the restaurant industry. Design/methodology/approach – A web-based self-completion survey and a subsequent structural equation modelling have been employed on a sample of 360 participants. Findings – Findings reveal that perceived healthiness, quarantine procedures, perceived hygiene, perceived ease of app use and attitude significantly influence continuance intention. Moreover, the moderator analysis corroborates that male consumers’ continuance intention is mainly influenced by perceived healthiness, quarantine procedures and perceived hygiene. Conversely, female customers’ continuance intention is predicated on perceived healthiness and attitude. Research limitations/implications – Although the adoption of a sample of young customers (18–29 years) guarantees good research internal validity, findings are not generalizable. Practical implications – The study provides valuable contributions for restaurants related to the (1) creation/management of their own OFDS platforms; (2) selection of the right third-party platforms. Originality/value – The paper is one of the first studies examining the predictors impacting on customers’ OFDS continuance intention in the COVID-19 context by also focusing on gender differences.

Ongoing developments, such as digitalization, increased the interference of the work and nonwork life domains, urging many to continuously manage engagement in respective domains. The COVID-19 pandemic and subsequent home-office regulations further boosted the need for employees to find a good work-nonwork balance, thereby optimizing their health and well-being. Consequently, proactive individual-level crafting strategies for balancing work with other relevant life domains were becoming increasingly important. However, these strategies received insufficient attention in previous research despite their potential relevance for satisfying psychological needs, such as psychological detachment. We addressed this research gap by introducing a new scale measuring crafting for a work-nonwork balance and examining its relevance in job-and life satisfaction, work engagement, subjective vitality, family role and job performance, boundary management and self-rated work-nonwork balance. The Work-Nonwork Balance Crafting Scale was validated in five countries (Austria, Finland, Germany, Japan, and Switzerland), encompassing data from a heterogeneous sample of more than 4,200 employees. In study 1, exploratory factor analysis revealed a two-factorial scale structure. Confirmatory factor analysis, test for measurement invariance, and convergent validity were provided in study 2. Replication of confirmatory factor analysis, incremental and criterion validity of the Work-Nonwork Balance Crafting Scale for job and life satisfaction were assessed in study 3. Study 4 displayed criterion validity, test–retest reliability, testing measurement invariance, and applicability of the scale across work cultures. Finally, study 5 delivered evidence for the Work-Nonwork Balance Crafting Scale in predicting work-nonwork balance. The novel Work-Nonwork Balance Crafting Scale captured crafting for the challenging balance between work and nonwork and performed well across several different working cultures in increasingly digitalized societies. Both researchers and practitioners may use this tool to assess crafting efforts to balance both life domains and to study relationships with outcomes relevant to employee health and well-being.

Dress code is standard in the Australian public sector, with smart business casual the norm. However, over the last two years, as many workers relocated to the home office, bedroom or kitchen table during the COVID-19 pandemic , work attire has taken on new meaning. A key but under-researched advantage of remote working has been the relaxing in many professions dress codes, with ‘COVID casual’ becoming the norm for many workers. This report highlights the role of dress codes, appearance, and aesthetics in the Australian public sector and the refashioning of professional attire in the age of remote work.