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21 Research products, page 1 of 3

  • COVID-19
  • Other research products
  • 2022-2022
  • Closed Access
  • Other ORP type
  • English
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  • COVID-19

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  • Closed Access English
    Authors: 
    GORDON, A.L.; SPILSBURY, K.; Achterberg, W.P.; ADAMS, R.; JONES, L.; GOODMAN, C.;
    Country: Netherlands

    Long-term care homes play an essential role within health and social care. Successful measures to support older people at home for longer have led to increased prevalence of disability, frailty and cognitive impairment in those who live in care homes over the last two decades. The need for care home places is projected to increase for the next two decades. Modern care homes provide care for people who are predominantly over 80, have multiple long-term conditions, take multiple medicines, are physically dependent and live with cognitive impairment. Residents do better when services recognise the contributions of staff and care home providers rather than treating residents as individual patients living in a communal setting. There is a strong case given residents' frailty, multimorbidity and disability, that care should be structured around Comprehensive Geriatric Assessment (CGA). Care should be designed to allow opportunities for multiprofessional teams to come together for CGA, particularly if healthcare professionals are based outside care homes. Good data about care homes and residents are central to efforts to deliver high quality care-in some countries, these data are collected but not collated. Collating such data is a priority. Care home staff are under-recognised and underpaid-parity of pay and opportunity with NHS staff is the bare minimum to ensure that the best are recruited and retained in the sector. During the COVID-19 pandemic, residents and relatives have frequently been left out of decisions about policies that affect them, and better consultation is needed to deliver high quality care.

  • Closed Access English
    Authors: 
    Huang, Futao; Craciun, Daniela; de Wit, Hans;
    Country: Netherlands
  • Other research product . Other ORP type . 2022
    Closed Access English
    Authors: 
    Mugabushaka, A.-M.; Eck, N.J.P. van; Waltman, L.R,;
    Country: Netherlands
  • Other research product . Other ORP type . 2022
    Closed Access English
    Country: Netherlands

    After two years of COVID-19 we all know that communicating through a flat screen is exhausting. Since long before that, professor Pablo Cesar has been focussing his research on highly realistic volumetric video conferencing which will allow smooth, natural, communication and collaboration – making remoteness a thing of the past.

  • Closed Access English
    Authors: 
    Orchard, Christa; Smith, Peter M; Kromhout, Hans; IRAS OH Epidemiology Chemical Agents; dIRAS RA-2;
    Country: Netherlands

    OBJECTIVE: To explore whether the COVID-19 pandemic has impacted productivity of female academics in the field of occupational and environmental health, by examining trends in male and female authorship of submissions during and prior to the COVID-19 pandemic in Occupational and Environmental Medicine. METHODS: Administrative data on submissions between January 2017 and November 2021 were obtained through databases held at BMJ journals. Author gender was identified using an existing algorithm based on matching names to social media accounts. The number and proportion of female and male primary (first) and senior (last) authors were examined for each quarter, and the average change in share of monthly submissions from male authors in the months since the pandemic compared with corresponding months prior to the pandemic were identified using regression models estimating least squares means. RESULTS: Among 2286 (64.7%) and 2335 (66.1%) manuscripts for which first and last author gender were identified, respectively, 49.3% of prepandemic submissions were from male first authors, increasing to 55.4% in the first year of the pandemic (difference of 6.1%, 95% CI 1.3% to 10.7%), before dropping to 46.6% from April 2021 onwards. Quarterly counts identified a large increase in submissions from male authors during the first year after the onset of the pandemic, and a smaller increase from female authors. The proportion of male last authors did not change significantly during the pandemic. CONCLUSIONS: These findings suggest that there has been an increase in male productivity during the COVID-19 pandemic within the field of occupational and environmental health research that is present to a lesser extent among women.

  • Other research product . Other ORP type . 2022
    Closed Access English
    Authors: 
    Bauer, Lisa; Laksono, Brigitta M.; de Vrij, Femke M.S.; Kushner, Steven A.; Harschnitz, Oliver; van Riel, Debby;
    Country: Netherlands

    Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with a diverse spectrum of neurological complications during the acute and postacute stages. The pathogenesis of these complications is complex and dependent on many factors. For accurate and consistent interpretation of experimental data in this fast-growing field of research, it is essential to use terminology consistently. In this article, we outline the distinctions between neuroinvasiveness, neurotropism, and neurovirulence. Additionally, we discuss current knowledge of these distinct features underlying the pathogenesis of SARS-CoV-2-associated neurological complications. Lastly, we briefly discuss the advantages and limitations of different experimental models, and how these approaches can further be leveraged to advance the field.

  • Closed Access English
    Authors: 
    Tomris, Ilhan; Unione, Luca; Nguyen, Linh; Zaree, Pouya; Bouwman, Kim M; Liu, Lin; Li, Zeshi; Fok, Jelle A; Ríos Carrasco, María; van der Woude, Roosmarijn; +15 more
    Publisher: bioRxiv
    Country: Netherlands

    SARS-CoV-2 viruses engage ACE2 as a functional receptor with their spike protein. The S1 domain of the spike protein contains a C-terminal receptor-binding domain (RBD) and an N-terminal domain (NTD). The NTD of other coronaviruses includes a glycan-binding cleft. However, for the SARS-CoV-2 NTD protein-glycan binding was only observed weakly for sialic acids with highly sensitive methods. Amino acid changes in the NTD of Variants of Concern (VoC) shows antigenic pressure, which can be an indication of NTD-mediated receptor binding. Trimeric NTD proteins of SARS-CoV-2, Alpha, Beta, Delta, and Omicron did not reveal a receptor binding capability. Unexpectedly, the SARS-CoV-2 Beta subvariant strain (501Y.V2-1) NTD binding to Vero E6 cells was sensitive to sialidase pretreatment. Glycan microarray analyses identified a putative 9- O -acetylated sialic acid as a ligand, which was confirmed by catch-and-release ESI-MS, STD-NMR analyses, and a graphene-based electrochemical sensor. The Beta (501Y.V2-1) variant attained an enhanced glycan binding modality in the NTD with specificity towards 9- O -acetylated structures, suggesting a dual-receptor functionality of the SARS-CoV-2 S1 domain, which was quickly selected against. These results indicate that SARS-CoV-2 can probe additional evolutionary space, allowing binding to glycan receptors on the surface of target cells. Graphical abstract: Synopsis: Coronaviruses utilize their N-terminal domain (NTD) for initial reversible low-affinity interaction to (sialylated) glycans. This initial low-affinity/high-avidity engagement enables viral surfing on the target membrane, potentially followed by a stronger secondary receptor interaction. Several coronaviruses, such as HKU1 and OC43, possess a hemagglutinin-esterase for viral release after sialic acid interaction, thus allowing viral dissemination. Other coronaviruses, such as MERS-CoV, do not possess a hemagglutinin-esterase, but interact reversibly to sialic acids allowing for viral surfing and dissemination. The early 501Y.V2-1 subvariant of the Beta SARS-CoV-2 Variant of Concern has attained a receptor-binding functionality towards 9- O -acetylated sialic acid using its NTD. This binding functionality was selected against rapidly, most likely due to poor dissemination. Ablation of sialic acid binding in more recent SARS-CoV-2 Variants of Concern suggests a fine balance of sialic acid interaction of SARS-CoV-2 is required for infection and/or transmission.

  • Closed Access English
    Authors: 
    Gordon, A.L.; Achterberg, W.P.; Delden, J.J.M. van;
    Country: Netherlands

    The COVID-19 pandemic has particularly adversely affected older people with frailty and functional dependency. Essential regular contact with care staff has been evidenced as an important source of infection for this group. Vaccinating care staff can reduce the incidence, duration and severity of infection, preventing onward transmission to older people and minimising the harm associated with discontinuity caused by staff absence. Voluntary vaccination programmes for staff are more likely to be effective when associated with information and education, community engagement and financial incentives, but programmes using all of these approaches have failed to establish consistently high vaccination rates among care staff during the pandemic. Mandatory vaccination, proposed as a solution in some countries, can increase vaccination rates. It is only ethical if a vaccine is effective and cost-effective, the risk associated with vaccinating care workers is proportionate to the risk reduction achieved through vaccination, and where all efforts to encourage voluntary vaccination have been exhausted. Even when these conditions have been met, careful attention is required to ensure that the penalties associated with conscientious objection are proportionate and to ensure that implementation is equitable in a way that does not disadvantage particular groups of staff.

  • Closed Access English
    Authors: 
    Gravesteijn, B.; Krijkamp, E.; Alphen, A. van; Busschbach, J.; Geleijnse, G.; Helmrich, I.R.; Bruinsma, S.; Lint, C. van; Veen, E. van; Steyerberg, E.; +4 more
    Country: Netherlands
  • Other research product . Other ORP type . 2022
    Closed Access English
    Authors: 
    Pottegård, Anton; Klungel, Olaf H; Afd Pharmacoepi & Clinical Pharmacology; Pharmacoepidemiology and Clinical Pharmacology;
    Country: Netherlands
Advanced search in Research products
Research products
arrow_drop_down
Searching FieldsTerms
Any field
arrow_drop_down
includes
arrow_drop_down
Include:
The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
21 Research products, page 1 of 3
  • Closed Access English
    Authors: 
    GORDON, A.L.; SPILSBURY, K.; Achterberg, W.P.; ADAMS, R.; JONES, L.; GOODMAN, C.;
    Country: Netherlands

    Long-term care homes play an essential role within health and social care. Successful measures to support older people at home for longer have led to increased prevalence of disability, frailty and cognitive impairment in those who live in care homes over the last two decades. The need for care home places is projected to increase for the next two decades. Modern care homes provide care for people who are predominantly over 80, have multiple long-term conditions, take multiple medicines, are physically dependent and live with cognitive impairment. Residents do better when services recognise the contributions of staff and care home providers rather than treating residents as individual patients living in a communal setting. There is a strong case given residents' frailty, multimorbidity and disability, that care should be structured around Comprehensive Geriatric Assessment (CGA). Care should be designed to allow opportunities for multiprofessional teams to come together for CGA, particularly if healthcare professionals are based outside care homes. Good data about care homes and residents are central to efforts to deliver high quality care-in some countries, these data are collected but not collated. Collating such data is a priority. Care home staff are under-recognised and underpaid-parity of pay and opportunity with NHS staff is the bare minimum to ensure that the best are recruited and retained in the sector. During the COVID-19 pandemic, residents and relatives have frequently been left out of decisions about policies that affect them, and better consultation is needed to deliver high quality care.

  • Closed Access English
    Authors: 
    Huang, Futao; Craciun, Daniela; de Wit, Hans;
    Country: Netherlands
  • Other research product . Other ORP type . 2022
    Closed Access English
    Authors: 
    Mugabushaka, A.-M.; Eck, N.J.P. van; Waltman, L.R,;
    Country: Netherlands
  • Other research product . Other ORP type . 2022
    Closed Access English
    Country: Netherlands

    After two years of COVID-19 we all know that communicating through a flat screen is exhausting. Since long before that, professor Pablo Cesar has been focussing his research on highly realistic volumetric video conferencing which will allow smooth, natural, communication and collaboration – making remoteness a thing of the past.

  • Closed Access English
    Authors: 
    Orchard, Christa; Smith, Peter M; Kromhout, Hans; IRAS OH Epidemiology Chemical Agents; dIRAS RA-2;
    Country: Netherlands

    OBJECTIVE: To explore whether the COVID-19 pandemic has impacted productivity of female academics in the field of occupational and environmental health, by examining trends in male and female authorship of submissions during and prior to the COVID-19 pandemic in Occupational and Environmental Medicine. METHODS: Administrative data on submissions between January 2017 and November 2021 were obtained through databases held at BMJ journals. Author gender was identified using an existing algorithm based on matching names to social media accounts. The number and proportion of female and male primary (first) and senior (last) authors were examined for each quarter, and the average change in share of monthly submissions from male authors in the months since the pandemic compared with corresponding months prior to the pandemic were identified using regression models estimating least squares means. RESULTS: Among 2286 (64.7%) and 2335 (66.1%) manuscripts for which first and last author gender were identified, respectively, 49.3% of prepandemic submissions were from male first authors, increasing to 55.4% in the first year of the pandemic (difference of 6.1%, 95% CI 1.3% to 10.7%), before dropping to 46.6% from April 2021 onwards. Quarterly counts identified a large increase in submissions from male authors during the first year after the onset of the pandemic, and a smaller increase from female authors. The proportion of male last authors did not change significantly during the pandemic. CONCLUSIONS: These findings suggest that there has been an increase in male productivity during the COVID-19 pandemic within the field of occupational and environmental health research that is present to a lesser extent among women.

  • Other research product . Other ORP type . 2022
    Closed Access English
    Authors: 
    Bauer, Lisa; Laksono, Brigitta M.; de Vrij, Femke M.S.; Kushner, Steven A.; Harschnitz, Oliver; van Riel, Debby;
    Country: Netherlands

    Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with a diverse spectrum of neurological complications during the acute and postacute stages. The pathogenesis of these complications is complex and dependent on many factors. For accurate and consistent interpretation of experimental data in this fast-growing field of research, it is essential to use terminology consistently. In this article, we outline the distinctions between neuroinvasiveness, neurotropism, and neurovirulence. Additionally, we discuss current knowledge of these distinct features underlying the pathogenesis of SARS-CoV-2-associated neurological complications. Lastly, we briefly discuss the advantages and limitations of different experimental models, and how these approaches can further be leveraged to advance the field.

  • Closed Access English
    Authors: 
    Tomris, Ilhan; Unione, Luca; Nguyen, Linh; Zaree, Pouya; Bouwman, Kim M; Liu, Lin; Li, Zeshi; Fok, Jelle A; Ríos Carrasco, María; van der Woude, Roosmarijn; +15 more
    Publisher: bioRxiv
    Country: Netherlands

    SARS-CoV-2 viruses engage ACE2 as a functional receptor with their spike protein. The S1 domain of the spike protein contains a C-terminal receptor-binding domain (RBD) and an N-terminal domain (NTD). The NTD of other coronaviruses includes a glycan-binding cleft. However, for the SARS-CoV-2 NTD protein-glycan binding was only observed weakly for sialic acids with highly sensitive methods. Amino acid changes in the NTD of Variants of Concern (VoC) shows antigenic pressure, which can be an indication of NTD-mediated receptor binding. Trimeric NTD proteins of SARS-CoV-2, Alpha, Beta, Delta, and Omicron did not reveal a receptor binding capability. Unexpectedly, the SARS-CoV-2 Beta subvariant strain (501Y.V2-1) NTD binding to Vero E6 cells was sensitive to sialidase pretreatment. Glycan microarray analyses identified a putative 9- O -acetylated sialic acid as a ligand, which was confirmed by catch-and-release ESI-MS, STD-NMR analyses, and a graphene-based electrochemical sensor. The Beta (501Y.V2-1) variant attained an enhanced glycan binding modality in the NTD with specificity towards 9- O -acetylated structures, suggesting a dual-receptor functionality of the SARS-CoV-2 S1 domain, which was quickly selected against. These results indicate that SARS-CoV-2 can probe additional evolutionary space, allowing binding to glycan receptors on the surface of target cells. Graphical abstract: Synopsis: Coronaviruses utilize their N-terminal domain (NTD) for initial reversible low-affinity interaction to (sialylated) glycans. This initial low-affinity/high-avidity engagement enables viral surfing on the target membrane, potentially followed by a stronger secondary receptor interaction. Several coronaviruses, such as HKU1 and OC43, possess a hemagglutinin-esterase for viral release after sialic acid interaction, thus allowing viral dissemination. Other coronaviruses, such as MERS-CoV, do not possess a hemagglutinin-esterase, but interact reversibly to sialic acids allowing for viral surfing and dissemination. The early 501Y.V2-1 subvariant of the Beta SARS-CoV-2 Variant of Concern has attained a receptor-binding functionality towards 9- O -acetylated sialic acid using its NTD. This binding functionality was selected against rapidly, most likely due to poor dissemination. Ablation of sialic acid binding in more recent SARS-CoV-2 Variants of Concern suggests a fine balance of sialic acid interaction of SARS-CoV-2 is required for infection and/or transmission.

  • Closed Access English
    Authors: 
    Gordon, A.L.; Achterberg, W.P.; Delden, J.J.M. van;
    Country: Netherlands

    The COVID-19 pandemic has particularly adversely affected older people with frailty and functional dependency. Essential regular contact with care staff has been evidenced as an important source of infection for this group. Vaccinating care staff can reduce the incidence, duration and severity of infection, preventing onward transmission to older people and minimising the harm associated with discontinuity caused by staff absence. Voluntary vaccination programmes for staff are more likely to be effective when associated with information and education, community engagement and financial incentives, but programmes using all of these approaches have failed to establish consistently high vaccination rates among care staff during the pandemic. Mandatory vaccination, proposed as a solution in some countries, can increase vaccination rates. It is only ethical if a vaccine is effective and cost-effective, the risk associated with vaccinating care workers is proportionate to the risk reduction achieved through vaccination, and where all efforts to encourage voluntary vaccination have been exhausted. Even when these conditions have been met, careful attention is required to ensure that the penalties associated with conscientious objection are proportionate and to ensure that implementation is equitable in a way that does not disadvantage particular groups of staff.

  • Closed Access English
    Authors: 
    Gravesteijn, B.; Krijkamp, E.; Alphen, A. van; Busschbach, J.; Geleijnse, G.; Helmrich, I.R.; Bruinsma, S.; Lint, C. van; Veen, E. van; Steyerberg, E.; +4 more
    Country: Netherlands
  • Other research product . Other ORP type . 2022
    Closed Access English
    Authors: 
    Pottegård, Anton; Klungel, Olaf H; Afd Pharmacoepi & Clinical Pharmacology; Pharmacoepidemiology and Clinical Pharmacology;
    Country: Netherlands