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218 Research products, page 1 of 22

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  • Closed Access English
    Authors: 
    Tartari, Morena;
    Country: Belgium
  • Other research product . Other ORP type
    Closed Access English
    Authors: 
    Moslinger, Emily;
    Country: Canada

    Background: Viral respiratory infections represent a significant burden of illness with high morbidity and mortality, which has been further magnified in recent years by the emergence of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Viruses including SARS-CoV-2, Influenza A Virus (Flu-A), and Respiratory Syncytial Virus (RSV) utilize the nasopharynx for viral entry, replication and infection. The nasopharynx epithelial cell mucous membrane harbors a diverse community of bacteria, called the nasal microbiota (NM). Flu-A can modulate changes in the NM community and lead to pathobiont enrichment. Therefore, here we aim to investigate the NM of individuals with SARS-CoV-2, Flu-A and RSV infection, and identify correlates between the NM community and viral load (VL) and SARS-CoV-2 variants of concern (VOC). Methods: Nasopharyngeal (NP) swabs were collected and tested for SARS-CoV-2, Flu-A, and RSV by validated real-time PCR (RT-PCR) assays. RNA extraction was performed using a Maxwell automatic nucleic acid extractor followed by 16S rRNA Illumina Next Generation Sequencing (NGS) library sample preparation for NGS on a MiSeq Sequencer. QIIME II, Microbiome Analyst and PRISM 9.0.0 were used for data analysis. Results: NP swabs from 118 SARS-CoV-2, 40 Flu-A, 26 RSV positive and 45 negative controls (NC) were included. An increase in alpha and beta bacterial diversity (p<0.001) was observed in the NM of SARS-CoV-2 patients and an enrichment in Streptococcus and Staphylococcus species and depletion of Bifidobacterium and Moraxella species compared to NC’s (p<0.001). Compared to Flu-A and RSV patients, SARS-CoV-2 positives showed enrichment in Streptococcus, and depletion in Haemophilus species (p<0.002). 73/118 SARS-CoV-2 specimens were further sequenced to identify VOC lineage and stratified by VL. No significance in bacterial richness, diversity, or abundance correlated to VL. Only a significant difference in beta diversity was observed between the alpha/delta and omicron cohorts (p<0.001). Conclusions: This study demonstrates that the NM community is different in individuals with respiratory illness and distinct between SARS-CoV-2, Flu-A and RSV infected individuals. This study also demonstrated that NM beta diversity was different between individuals with different SARS-CoV-2 lineages, suggesting virus-NM interplay that may be important in explaining differences in transmission potentials and pathogenesis between SARS-CoV-2 VOCs.

  • Closed Access Croatian
    Authors: 
    Tomić, Petra;
    Country: Croatia

    Tema ovog rada je upravljanje rizikom odnosno krizama koji su obilježile 2020. godinu. Rad se sastoji od četiri dijela, a cilj je prikazati kako svijet, Europska unija, Republika Hrvatska i Grad Zagreb odgovaraju na predstojeće rizike te tijek događaja odnosno tijek njihovih radnji u suzbijanju rizika. U prvom dijelu polazi se od opće definicije rizika te objašnjavanje što rizik znači u suvremenom društvu. U drugom dijelu polazi se na konkretan rizik koji je pogodio cijeli svijet, a to je pandemija COVID – 19 te razmatra se i objašnjava pogled, radnja, politika i tijek događaja svijeta i Europske unije. Fokus ovog rada je u zadnjim dijelovima zbog specifičnosti Republike Hrvatske te Grada Zagreba i okolice jer osim COVID – 19, Grad Zagreb i okolica su pretrpjeli novi rizik, a to je prirodna katastrofa zvana potres te u ovom dijelu objašnjavaju se radnje u suzbijanju pandemije te usporedba akcija učinjene u svrhu suzbijanja pandemije COVID – 19 i u svrhu potresa.

  • Closed Access English
    Authors: 
    Baud, David; Pomar, Léo;
    Country: Switzerland

    Viruses that emerged in the past decades, such as arboviruses and SARS-coronaviruses, are increasingly recognized as potential risk factors for adverse pregnancy outcomes. On the fetal side, arboviruses have proved their ability to cross the placental barrier, at different stages of pregnancy, and have been associated with fetal losses, fetal malformations (Zika, West Nile, and Venezuelan equine encephalitis viruses) and adverse neonatal outcomes (Dengue and Chikungunya viruses). The SARS-COV-2 has also be associated with rare maternal-fetal transmission and placental affection leading to fetal losses. More common viruses, like cytomegalovirus, are also well-known causes of fetal and childhood sequelae, and recent research on its prognosis factors and in-utero treatment may be welcome. On the maternal side, SARS-COV-2 might compromise maternal health, as well as Dengue viruses have been associated with high risks of adverse obstetrical outcomes, including maternal death, pre-eclampsia or post-partum hemorrhage. Thus, research on the maternal physiopathology would also be welcome. In this Special Issue of Viruses, we aim for original researchs, reviews and commentaries that contribute to an improved understanding of viral infection of placenta and fetal cells, or that report on the maternal and fetal outcomes after an emerging viral infection during pregnancy.

  • Closed Access Italian
    Authors: 
    Cristina Valenti;
    Country: Italy

    Attività del Coordinamento Teatro Carcere Emilia Romagna nel corso dell'annualità 2020 in sette Istituti penitenziari della Regione: laboratori, spettacoli in presenza e in streaming, attività con le scuole. Con il sostegno di Regione Emilia Romagna, Ministero della Giustizia, Chiesa Valdese. Con il patrocinio di PRAP - Provveditorato Regionale dell'Emilia Romagna e Marche, Dipartimento delle Arti - Unibo. Un progetto di: Con...tatto associazione di volontariato (Forlì), Lady Godiva Teatro associazione (Ravenna), Le mani parlanti coop. sociale (Parma), Teatro dei Venti APS (Modena), Teatro del Pratello coop. sociale (Bologna), Teatro Nucleo coop. (Ferrara). CONSULENZA SCIENTIFICA: CRISTINA VALENTI. PRESENTAZIONE di Cristina Valenti (consulente scientifico) : STANZE DI TEATRO IN CARCERE AL TEMPO DEL CORONAVIRUS. Dopo l’immediata e pressoché totale sospensione delle attività, in seguito al DPCM dell’8 marzo 2020, che ha introdotto le misure per il contrasto al Covid-19, i registi del Coordinamento Teatro Carcere Emilia Romagna si sono impegnati a dare continuità al progetto “Padri e figli”, inaugurato nel 2018, sperimentando modalità di lavoro del tutto anomale. Incontri in remoto, videolezioni, epistolari teatrali, prove a distanza supportate da collegamenti via tablet e anche da radio locali hanno sostituito, laddove possibile, i laboratori in presenza, a dimostrazione dell’importanza che il lavoro teatrale in carcere ha assunto non solo per gli artisti, ma anche per gli attori detenuti e per l’istituzione, consapevole del valore del progetto e delle sue ricadute. A Castelfranco Emilia e a Modena il regista Stefano Tè ha continuato a sviluppare la drammaturgia dello spettacolo Padri e Figli lavorando sul confronto con due testi guida, Le avventure di Pinocchio e i Vangeli, attraverso sessioni di prove che sono riprese in aprile da remoto (con l’ausilio di collegamenti video via tablet) e in agosto in presenza, per arrivare a proporre il lavoro in ottobre a Gombola, nell’Appennino modenese, al termine di un periodo in residenza. A Ferrara i registi Horacio Czertok e Marco Luciano hanno ripreso a lavorare a distanza in marzo, con il laboratorio in forma epistolare Esercizi di libertà, per ricominciare ad agosto l’attività in presenza con le prove dello spettacolo Album di famiglia, ispirato alla tragedia di Amleto e alle sue riscritture novecentesche. A Bologna il lavoro del regista Paolo Billi con le attrici della sezione femminile si è sviluppato a partire da marzo in un Epistolario teatrale a distanza. Una fitta corrispondenza via mail che ha prodotto un’ampia raccolta di materiali drammaturgici e azioni fisiche lavorando sul copione Figlie di Lear. Da aprile la simulazione virtuale delle sedute di prove ha dato vita alla rubrica Prove a distanza, in onda settimanalmente su Radio Fujico, e a dicembre l’esperienza è stata ospitata nella trasmissione Natale liberi dentro, sulle stesse frequenze e sul canale di Teletricolore. A Forlì la regista Sabina Spazzoli ha inaugurato un’attività di videolezioni portando avanti, a partire da aprile, il lavoro sulla Tempesta di Shakespeare, interrotto a febbraio e ripreso in presenza a giugno. Si è invece fermata l’attività di Eugenio Sideri a Ravenna, dove il gruppo che ha lavorato con il regista fino all’inverno 2019 ha subito avvicendamenti e trasferimenti, ancor prima di incontrare l’emergenza Coronavirus che ha causato la sospensione degli incontri. Le attività sono riprese a settembre 2020 con un nuovo gruppo, per poi essere nuovamente sospese a novembre per l’aggravarsi della situazione sanitaria. Allo stesso modo durante tutto il 2020 l’attività di Corrado Vecchi a Parma non si è potuta svolgere neppure a distanza, in quanto nelle settimane antecedenti al lockdown il gruppo degli attori era in fase di formazione. Assai limitate sono state le attività in presenza, circoscritte ai primissimi mesi dell’anno e, in alcuni casi, all’autunno. Fra di esse, i laboratori con i minori e i giovani adulti dei Servizi di Giustizia Minorile, che hanno dato luogo allo spettacolo Le orme dei figli, presentato a Bologna, nel cortile dell’IPM, fra agosto e settembre. Molti gli eventi annullati, di cui abbiamo voluto comunque conservare traccia nel calendario contenuto in questa brochure. Nonostante l’emergenza sanitaria, le Stanze di Teatro in Carcere, giunte alla decima edizione, hanno proseguito e approfondito il rapporto teatro-carcere-scuola con il progetto Il Teatro Carcere incontra gli istituti superiori dell’Emilia Romagna, un percorso online realizzato su piattaforma Zoom nei mesi di aprile e maggio per riflettere sulla condizione della detenzione e sul valore della cultura e del teatro come fattori di trasformazione e di crescita.

  • Other research product . Other ORP type . 2020
    Closed Access

    Ein kurzer Praxisbericht von heute und morgen Forscherinnen und Forscher sind eigenverantwortlich für die Einhaltung der guten wissenschaftlichen Praxis. Die Universitätsbibliothek Hildesheim begegnet ihnen im Forschungsdatenmanagement. Für die fortlaufende Unterstützung und Information zum Forschungsdatenmanagement (FDM) sind seit Beginn der Covid-19 Pandemie einfach vorhandene Formate für den digitalen Raum neu geformt worden. Der Support zum Datenmanagement wird vom Homeoffice aus geleistet. Es findet ständig Kontakt und Austausch mit den Forschenden statt, online mehr als früher vor Ort. Die Services sind geprägt durch Unterstützung bei der Erstellung von Datenmanagementplänen (RDMO). Forschungsnahe Services beschäftigen sich mit der Datenvielfalt, mit Karten, Texten, audiovisuellen Materialien, Fotosammlungen und Forschungssoftware, um nur einige Beispiele zu nennen. Hinzugekommen sind Beratungen im Bereich der Metadaten und fachspezifischen Metadatenschemata. Fragen sind immer auch, ob es rechtliche und ethische Hindernisse gibt, um Forschungsdaten zugänglich zu machen. Wie ist definiert, welche Daten aufbewahrt werden sollten und welche nicht.

  • Closed Access English
    Authors: 
    C. Sacerdoti Coen, I. Salvo;
    Publisher: Sun SITE Central Europe
    Country: Italy

    The Italian Conference on Theoretical Computer Science (ICTCS) is the annual conference of the Italian Chapter of the European Association for Theoretical Computer Science (IC-EATCS), The purpose of the meeting is to foster the cross-fertilization of ideas stemming from different areas of theoretical computer science. In particular, ICTCS provides an ideal environment where junior researchers and PhD students can meet senior researchers. The topics of interest include, but are not limited to, the following: agents, algorithms, argumentation, automata theory, complexity theory, computational logic, computational social choice, concurrency theory, cryptography, discrete mathematics, distributed computing, dynamical systems, formal methods, game theory, graph theory, knowledge representation, languages, model checking, process algebras, quantum computing, rewriting systems, security and trust, semantics, specification and verification, systems biology, theorem proving, type theory. The 22nd Italian Conference on Theoretical Computer Science (ICTCS 2021) has been hosted by the University of Bologna. Due to the worldwide evolution of COVID-19, it was held online on September 13–15, 2021. ICTCS 2021 received 38 submissions (25 regular papers and 13 communications), of which 28 were accepted for presentation at the conference and then published on http://ceurws.org/ (18 regular papers and 10 communications). Each submission was assessed by at least 3 reviewers, for a total of 69 reviewers (23 program committee members plus 46 additional reviewers) producing 114 reviews overall. The authors of the accepted contributions mostly came from Italy (16). Foreign contributions came from USA (2), India (2), Japan (1), Germany (1), Switzerland (1), and Algeria (1). 4 contributions are joint work between italian and foreign authors. ICTCS 2021 was attended by 68 people.

  • Closed Access English
    Authors: 
    Evans, Paul C.; Davidson, Sean M.; Wojta, Johann; Bäck, Magnus; Bollini, Sveva; Brittan, Mairi; Catapano, Alberico L.; Chaudhry, Bill; Cluitmans, Matthijs; Gnecchi, Massimiliano; +13 more

    Here, we review the highlights of cardiovascular basic science published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell 'omics are providing new insights into cardiovascular development, inflammation, and disease. We also review recent discoveries on the biology of extracellular vesicles in driving either protective or pathogenic responses. The Nobel Prize in Physiology or Medicine 2021 recognized the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. We also summarize discoveries in the field of atherosclerosis including the role of clonal haematopoiesis of indeterminate potential, and new mechanisms of crosstalk between hyperglycaemia, lipid mediators, and inflammation. The past 12 months also witnessed major advances in the field of cardiac arrhythmia including new mechanisms of fibrillation. We also focus on inducible pluripotent stem cell technology which has demonstrated disease causality for several genetic polymorphisms in long-QT syndrome and aortic valve disease, paving the way for personalized medicine approaches. Finally, the cardiovascular community has continued to better understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system.

  • Closed Access Turkish
    Authors: 
    Köksal, Yağmur Öznur;
    Publisher: Hitit Üniversitesi
    Country: Turkey

    YÖK ID: 685768 Giriş ve Amaç: Sağlık okuryazarlığı; kişilerin sağlıkla ilgili bilgileri ve teknolojileri anlamalarına ve kullanmalarına izin veren, sağlıkla ilgili konularda sağlık çalışanları ile problemsiz iletişim kurabilmelerini sağlayan ve ayrıca edindikleri tüm bu bilgileri eleştirebilmeye de olanak tanıyan bilgi ve becerilere sahip olmak anlamına gelmektedir. COVID-19'un hızla pandemiye dönüşümü, insanları bu yeni durum hakkında bilgi edinmeye, bu bilgileri uygulamaya ve davranışlarını da bu bilgilere göre değiştirmeye zorlamıştır. Sağlık verilerini anlayamamak paniğe neden olabilir, gerçek bilginin ve doğru bilgi kaynaklarının etkisini azaltabilir. Bu nedenle yüksek seviyedeki sağlık okuryazarlığının, kriz durumları için gerekli olduğu düşünülmektedir. Bu çalışmada sağlık okuryazarlığının; pandemi ortamında COVİD-19 korku düzeyi üzerine etkisini araştırmayı amaçladık. Gereç ve Yöntem: Çalışma 2021 yılının Nisan ayında, hastanemize başvuran 268 yetişkinle yapıldı. Bireylere; Sosyodemografik Veri Toplama Aracıyla beraber TSOY-32 Ölçeği ve COVİD-19 Korkusu Ölçeği uygulandı. Bulgular: Analiz sonuçlarına göre TSOY-32 ölçek puanının 1 birim artmasının COVID-19 Korkusu Ölçek puanında 0,28 birim azalmaya sebep olduğu belirlendi. (P<0.05) TSOY-32 düzeyi yetersiz olan katılımcıların COVID-19 Korkusu Ölçek puanları, TSOY-32 düzeyi sorunlu–sınırlı, yeterli ve mükemmel düzeyde olan katılımcılara göre anlamlı daha yüksektir. (P=0.047, P=0.001, P<0.001). Katılımcılardan COVID-19 hastalığı geçirenlerin sağlık okuryazarlığı düzeyleri istatistiksel olarak anlamlı düşük bulunmuştur (P=0.034). Tartışma-Sonuç: Çalışmamızda TSOY-32 ölçek puanı, ülkemizde pandemi öncesi yapılmış çalışmalara nazaran daha yüksektir. Bu da pandeminin sağlık okuryazarlığı üzerine etkisi olarak düşünülebilir. Sağlık okuryazarlığının, insanların ruh sağlığını korumaya ve yaşam kalitesini artırmaya yardımcı olabileceği düşünülmektedir. Çalışmamızda COVİD-19 hastalığı geçiren kişilerin sağlık okuryazarlığı, geçirmeyen kişilere göre anlamlı olarak düşük çıkmıştır bu da yukarıdaki açıklamayı desteklemektedir. Bu nedenle insanların sağlık okuryazarlığını yükseltmek, korkularını azaltmak ve sağlıklarını arttırmak için stratejik bir yaklaşım olabilir. Ayrıca sağlık okuryazarlığının, mevcut pandemiyi ve gelecekteki potansiyel pandemileri azaltmak ve kontrol altına almak için sosyal sorumluluğun temel bir unsuru olarak görülmesi gereklidir. Introduction and Aim: Health literacy means having the knowledge and skills which allow people to understand and use the health-related information and technologies, enable them to communicate with health workers on health-related issues without any problems, also enable them to criticize all this information they have acquired. The rapid transformation of COVID-19 into a pandemic has forced people to learn about this new situation, apply this information, and change their behavior according to the information they receive. Failure to understand the health data can cause panic and reduce the impact of real information and accurate sources of information. Therefore, we think that a high level of health literacy is necessary for crisis situations. In this study we aimed to investigate the effects of health literacy on the level of fear of COVID-19 in the current pandemic environment. Materials and Methods: The study was conducted with 268 adults who had been admitted to our hospital in April 2021. The TSOY-32 Scale and the COVID-19 Fear Scale were applied to the individuals along with the socio-demographic questionnaire form. Results: According to the results of the analysis, it was determined that 1 unit increase in the TSOY-32 scale score, led to 0.28 unit decrease in the COVID-19 Fear scale score. (P<0.05) The COVID-19 Fear scale scores of the participants with insufficient TSOY-32 level were significantly higher than the participants whose TSOY-32 level was problematic – limited, adequate and excellent. (P=0.047, P=0.001, P<0.001). The health literacy levels of the participants who had COVID-19 disease were found to be statistically significantly lower (P=0.034). Discussion- Conclusion: In our study, the scale score of TSOY-32 was higher than the studies conducted before the pandemic started in our country. This can be considered as the impact of the pandemic on health literacy. It is thought that health literacy can help protect people's mental health and improve their quality of life. In our study, the health literacy of people who had COVID-19 disease was found to be significantly lower than those who did not, which supports the explanation above. Therefore, it can be a strategic approach to increase health literacy, reduce fear, and improve their health. In addition to that, health literacy needs to be seen as an essential element of social responsibility to reduce and contain the current pandemic and potential future pandemics.

  • Closed Access English
    Authors: 
    Costa, Elga; Ferreira, Fernanda A.; Ribeiro, Joaquim; Meneses, Daniela;
    Publisher: International Business Information Management Association (IBIMA)
    Country: Portugal

    The investigation focuses on the identification of actions and strategies that hoteliers apply on their websites, to capture direct bookings versus their dependence on the OTA, to evaluate the importance and function of the websites of the 4- and 5-star hotels in Porto and Northern Portugal. Online distribution is a necessity for a hotel, either to reach the largest number of customers or to give visibility to the brand. Hotel websites, however, allow greater proximity and communication with the customer, potentiating hotels’ possibility to increase direct bookings. It is therefore necessary to understand which actions and strategies hoteliers must consider for capturing direct bookings. Thus, the main objective of the study is to identify the hoteliers’ dependence on the OTA and the consequent actions and strategies they apply on their websites to capture direct bookings. In the present investigation, the quantitative methodology was chosen, and the data collection instrument was a questionnaire survey, applied in a total universe of 150 hotels, 4- and 5-star hotels in the Region of Porto and Northern Portugal, where 55 responses were obtained. The data obtained were treated and analysed using the SPSS software. The results obtained confirm the existence of actions and strategies in hotels to capture direct reservations; hotels consider these strategies as an essential condition for increasing direct bookings. Limitations have arisen in the collection of questionnaires due to the Covid-19 pandemic. Most hotels closed due to lack of customers and consequently, the sample for the present study is limited in the diversity of the typology of respondents. It is intended with this work to understand what actions and strategies hotels apply on the website, as well as to understand if hotels follow the new technological trends, in what the contact and communication with the client concerns.