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This study used a mixed method approach comprising of an online survey with public contributors involved in health and social care research; an online survey with public involvement professionals, those who are employed by organisations; and qualitative interviews with public contributors. We had 244 respondents to the public contributor survey and 65 for the public involvement professionals (PIPs) survey and conducted 22 qualitative interviews.This study has been prompted by the shift to non-face-to-face - remote - forms of working in patient public involvement and engagement (PPIE) brought on by Covid-19 prevention measures (such as social distancing). Working remotely includes using digital technologies such as: online conferencing software (Zoom, Microsoft Teams), emails, telephone calls and social media (WhatsApp, Facebook). Due to measures such as shielding and social distancing the usual ways of involving the public in research that included face-to-face meetings and events are not possible, and even with the eventual easing of lockdown, remote working is likely to continue. This creates particular challenges for ensuring access and engagement from all parts of society in health and social care research. There is a well-documented digital divide between those who use or have access to digital technologies and those who do not. This digital divide reflects the existing socio-economic inequalities, and PPIE that takes place remotely has the potential to further exclude already disadvantaged groups. This project aims to facilitate and improve ways of doing PPIE remotely and increase the diversity of public contributors involved in health and social care research. Our objectives are to: 1. Understand the barriers and facilitators to remote working, by: a. Exploring public contributors and PPIE professionals' experiences of remote PPIE. b. Exploring public contributors' preferences for different types of remote working. 2. Develop mechanisms for implementing improvements in remote working and ways to increase diversity in PPIE by: a. Conducting a rapid review of research and 'how to guides'. b. Develop training packages. We will recruit public contributors involved in research projects across the UK: the NIHR, charities, universities and other research organisations and people involved professionally with PPIE. This is a mixed-methods study with: surveys, qualitative interviews, and a discrete choice experiment. We will produce an analysis of how remote working in PPIE is affected by socio-economic and health inequalities, make recommendations for improving practice and develop training packages. The public contributor survey was comprised of tick box questions, Likert scale questions and open-ended questions where participants could enter free text responses. The survey asked general questions about role and PPIE experience, digital literacy and different aspects of remote working. We collected demographic information to enable us to draw conclusions from the data on how age, ethnicity, living arrangements and socio-economic status impact on participants use of remote communication tools. The survey ran from September to November 2020. For the survey for PPIE professionals, those who work in PPIE, organising PPIE activities, we developed the survey with input from our public contributors and PPIE professionals from the ARC NWC and the NIHR Research Design Service. Again, the development of this survey drew on our own experiences. We piloted the survey with members of the ARC team and public contributor (NT) to check for sense, consistency and readability. Like the PPIE contributor survey, the professional version was comprised of tick box questions, Likert scale questions, and open-ended questions for additional response. We asked what support and training they offered their public contributors; and any suggestions they had for improving remote working in PPIE. After the survey conducted with public contributors had closed, we purposively sample informants from key communities and conducted 22 semi-structured qualitative interviews with public contributors from across the UK. The topic guide was co-developed with the research team and public contributor (NT) from a preliminary analysis of the survey results and was designed to probe and explore the issues raised by the survey. The interviews were conducted via Zoom and audio reordered with the participant’s consent. The interviews were transcribed and then checked for accuracy and anonymised. The interviews last on average 60 minutes.

Fonds audiovisuel de l'Inalco, France, © 2021; En août 2016, le meurtre d'un couturier chinois à Aubervilliers provoquait des manifestations massives de la communauté asiatique de France. Ce drame avait mis en lumière les agressions physiques, mais aussi le racisme du quotidien subi par une population jugée "discrète, travailleuse et communautariste".Cette mobilisation, faisant écho à celle de 2010, a permis de donner une visibilité associative, médiatique et politique, à une communauté parfois oubliée des luttes anti-racistes des dernières décennies.Quatre ans plus tard, la pandémie du Covid-19 est venue replacer le racisme anti-asiatique dans le débat public. Aux titres de journaux racoleurs, se sont ajoutés des vexations du quotidien mais aussi des appels à "frapper chaque Chinois" sur les réseaux sociaux.Cette conférence aura pour but d'analyser les spécificités du racisme anti-asiatique en France et de cerner ses racines historiques, politiques et sociales. Nos intervenants, jeunes associatifs, journalistes et chercheurs, débattront également des moyens d'action pour faire avancer la lutte contre le racisme et les préjugés anti-asiatiques.

Im Rahmen des Forschungsprojekts LehrstellenPuls bietet dieses Informationsblatt einen Überblick über die Auswirkungen der COVID-19-Pandemie auf die berufliche Grundbildung in der Schweiz im Februar 2021 und vergleicht diese Ergebnisse mit der Situation in den Vormonaten von April 2020 bis Januar 2021.

What is the future of technocracy, after COVID-19, asks Jonathan White (LSE)? Current crisis management only blurs ever more the boundary between politics and technical expertise, he argues.

Mucins play an essential role in protecting the respiratory tract against microbial infections. The heavily O-glycosylated gel-forming mucins MUC5AC and MUC5B eliminate pathogens by mucociliary clearance while transmembrane mucins MUC1, MUC4, and MUC16 restrict microbial invasion at the apical surface of the epithelium. In this study, we determined the impact of host mucins and mucin glycans on SARS-CoV-2 spike-mediated epithelial entry. Human lung epithelial Calu-3 cells have endogenous expression of the SARS-CoV-2 entry receptor ACE2 and express high levels of glycosylated MUC1 on the surface but not MUC4 and MUC16. Removal of the MUC1 extracellular domain (ED) using the O-glycan-specific mucinase StcE greatly enhanced spike binding and viral infection. By contrast, removal of mucin glycans sialic acid and fucose did not impact viral invasion. This study implicates the glycosylated ED of MUC1 as an important component of the host defense that restricts the severity of SARS-CoV-2 infection.

El reforç dels equips de neteja farà que s’incorporin entre el 66 i el 75% de treballadors i treballadores i es produeix d’acord al major ús de l’espai públic amb la relaxació de les mesures preventives de la COVID-19. Imatges de l’11-5-2020.

The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into the epidemiology of COVID-19, important questions remain about the clinical complexities and underlying mechanisms of disease phenotypes. Severe COVID-19 most commonly involves respiratory manifestations, although other systems are also affected, and acute disease is often followed by protracted complications. Such complex manifestations suggest that SARS-CoV-2 dysregulates the host response, triggering wide-ranging immuno-inflammatory, thrombotic, and parenchymal derangements. We review the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels. Some similarities exist between COVID-19 and respiratory failure of other origins, but evidence for many distinctive mechanistic features indicates that COVID-19 constitutes a new disease entity, with emerging data suggesting involvement of an endotheliopathy-centred pathophysiology. Further research, combining basic and clinical studies, is needed to advance understanding of pathophysiological mechanisms and to characterise immuno-inflammatory derangements across the range of phenotypes to enable optimum care for patients with COVID-19.

Background: International travel is a major driver of the introduction and spread of SARS-CoV-2. Aim: To investigate SARS-CoV-2 genetic diversity in the region of a major transport hub in Germany, we characterized the viral sequence diversity of the SARS-CoV-2 variants circulating in Frankfurt am Main, the city with the largest airport in Germany, from the end of October to the end of December 2020. Methods: In total, we recovered 136 SARS-CoV-2 genomes from nasopharyngeal swab samples. We isolated 104 isolates that were grown in cell culture and RNA from the recovered viruses and subjected them to full-genome sequence analysis. In addition, 32 nasopharyngeal swab samples were directly sequenced. Results and conclusion: We found 28 different lineages of SARS-CoV-2 circulating during the study period, including the variant of concern B.1.1.7 (Δ69/70, N501Y). Six of the lineages had not previously been observed in Germany. We detected the spike protein (S) deletion Δ69/Δ70 in 15% of all sequences, a four base pair (bp) deletion (in 2.9% of sequences) and a single bp deletion (in 0.7% of sequences) in ORF3a, leading to ORF3a truncations. In four sequences (2.9%), an amino acid deletion at position 210 in S was identified. In a single sample (0.7%), both a 9 bp deletion in ORF1ab and a 7 bp deletion in ORF7a were identified. One sequence in lineage B.1.1.70 had an N501Y substitution while lacking the Δ69/70 in S. The high diversity of sequences observed over two months in Frankfurt am Main highlights the persisting need for continuous SARS-CoV-2 surveillance using full-genome sequencing, particularly in cities with international airport connections.

[ES] Es evidente que existe un antes y un después de la pandemia de la Covid-19 por lo que se refiere a las interacciones sociales, el funcionamiento de la economía y la protección de la salud (física y mental) de las personas. Aunque los resultados han sido en muchos aspectos catastróficos, también ha habido detalles que han aportado ciertas dosis de esperanza para el futuro inmediato del mundo. Por ejemplo, durante los meses de confinamiento la naturaleza volvió a tomar el protagonismo incluso en las grandes urbes y quedó demostrado que existen alternativas reales para hacer frente al cambio climático. Por este motivo, la Sociedad Española de Psicoanálisis ha decidido titular su acto inaugural que tendrá lugar el próximo 17 de septiembre “Emergencia Climática: vaivén entre mundo interno y mundo externo”. Uno de los ponentes destacados será Josep Lluís Pelegrí, oceanógrafo, profesor de investigación y director del Instituto de Ciencias del Mar, CSIC. Hemos conversado con él para conocer más detalles sobre su apasionante carrera profesional y los retos que está afrontando la ciencia para hacer frente a los importantes cambios que acontecen en nuestro planeta. Porque la ciencia medioambiental y el psicoanálisis están más relacionadas de lo que imaginamos [CAT] És evident que existeix un abans i un després de la pandèmia del Covid-19 pel que fa a les interaccions socials, el funcionament de l’economia i la protecció de la salut (física i mental) de les persones. Encara que els resultats han estat en molts aspectes catastròfics, també hi ha hagut detalls que han aportat certes dosis d’esperança per al futur immediat del món. Per exemple, durant els mesos de confinament la naturalesa va tornar a prendre el protagonisme fins i tot en les grans ciutats i va quedar demostrat que existeixen alternatives reals per a fer front al canvi climàtic. Per aquest motiu, la Societat Espanyola de Psicoanàlisi ha decidit titular el seu acte inaugural,que tindrà lloc el pròxim 17 de setembre, “Emergència Climàtica: vaivé entre món intern i món extern”. Un dels ponents destacats serà Josep Lluís Pelegrí, oceanògraf, professor de recerca i director de l’Institut de Ciències de la Mar, CSIC. Hem conversat amb ell per conèixer més detalls sobre la seva apassionant carrera professional i els reptes que està afrontant la ciència per a fer front als importants canvis que tenen lloc al nostre planeta. Perquè la ciència mediambiental i la psicoanàlisi estan més relacionades del que imaginem Peer reviewed

Problems of this severity and scope can only be solved through global cooperation, write Muhammad Shahbaz and Muhammad Ali Nasir