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24 research outcomes, page 2 of 3
  • publication . Article . 2014
    Open Access English
    Authors:
    Yanfeng Yao; Linlin Bao; Wei Deng; Lili Xu; Fengdi Li; Qi Lv; Pin Yu; Ting Chen; Yanfeng Xu; Hua Zhu; ...
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    Abstract In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus–Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of M...

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  • publication . Article . 2013
    Open Access
    Authors:
    Jie Zhou; Hin Chu; Cun Li; Bosco Ho-Yin Wong; Zhongshan Cheng; Vincent Kwok-Man Poon; Tianhao Sun; Candy Choi-Yi Lau; Kenneth Kak Yuen Wong; Jimmy Yu Wai Chan; ...
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    Publisher: Oxford University Press (OUP)

    Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) infection caused severe pneumonia and multiorgan dysfunction and had a higher crude fatality rate (around 50% vs 10%) than SARS coronavirus (SARS-CoV) infection. To understand the pathogenesis, we studied ...

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  • publication . Article . 2013
    Open Access
    Authors:
    Jasper F. W. Chan; Kwok-Hung Chan; Garnet K. Y. Choi; Kelvin K. W. To; Herman Tse; Jian-Piao Cai; Man Lung Yeung; Vincent C. C. Cheng; Honglin Chen; Xiao-Yan Che; ...
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    Publisher: Oxford University Press (OUP)

    Abstract The emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) was recently isolated from patients with severe pneumonia and renal failure and was associated with an unexplained high crude fatality rate of 56%. We performed a cell line susceptibility study wit...

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  • publication . Other literature type . Article . 2011
    Open Access English
    Authors:
    Dennis K. M. Ip; Martin Schutten; Vicky J. Fang; Rita O. P. Fung; Regina Dutkowski; Kwok-Hung Chan; Gabriel M. Leung; J. S. Malik Peiris; Benjamin J. Cowling;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: NIH | Peer-Driven Intervention ... (5R01AI070005-02), NIH | MIDAS Center for Communic... (1U54GM088558-01), NIH | A Controlled Trial of Mas... (5U01CI000439-02)

    Few studies have investigated the validity of self-collected nose and throat swabs for influenza confirmation in community settings. We followed outpatients with confirmed influenza with sequential measurement of viral loads and applied log-linear regression models to t...

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  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Man To Ling; Wenwei Tu; Yan Han; Huawei Mao; Wai Po Chong; Jing Guan; Ming Liu; Kwok Tai Lam; Helen K. W. Law; J. S. Malik Peiris; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: NIH | Development of novel immu... (1U01AI074503-01)

    Background. Mannose-binding lectin (MBL) is a pattern-recognition molecule, which functions as a first line of host defense. Pandemic H1N1 (pdmH1N1) influenza A virus caused massive infection in 2009 and currently circulates worldwide. Avian influenza A H9N2 (H9N2/G1) v...

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  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Dasheng Zheng; Jun Wan; Yong Gu Cho; Leyao Wang; Chuang Jiun Chiou; Shweta G. Pai; Crystal Woodard; Jian Zhu; Gangling Liao; Otoniel Martínez-Maza; ...
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    Publisher: Oxford University Press (OUP)
    Project: NIH | MANIPULATION OF KINASE AC... (1R21CA138163-01), NIH | Regulation of replication... (4R37CA042245-23), NIH | Generation and Evaluation... (1RC2CA148402-01), NIH | Regional Oncology Researc... (3P30CA006973-53S2), NIH | EBV Genome Expression:Loc... (5R01CA030356-27)

    Background. Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, and Kaposi’s sarcoma–associated herpesvirus (KSHV) has a restricted seroprevalence. Both viruses are associated with malignancies that have an increased frequency in individuals who are coinfected with hu...

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  • publication . Article . 2011
    Open Access
    Authors:
    Tohru Miyoshi-Akiyama; Isao Ishida; Masaya Fukushi; Keina Yamaguchi; Yusuke Matsuoka; Takashi Ishihara; Masayoshi Tsukahara; Seisuke Hatakeyama; Norikazu Itoh; Aki Morisawa; ...
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    Publisher: Oxford University Press (OUP)

    Abstract Background. There is still no effective method to prevent or treat severe acute respiratory syndrome (SARS), which is caused by SARS coronavirus (CoV). In the present study, we evaluated the efficacy of a fully human monoclonal antibody capable of neutralizing ...

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  • publication . Article . Other literature type . 2010
    Open Access
    Authors:
    Lincoln L. H. Lau; Benjamin J. Cowling; Vicky J. Fang; Kwok-Hung Chan; Eric H. Y. Lau; Marc Lipsitch; Calvin K. Y. Cheng; Peter M. Houck; Timothy M. Uyeki; J. S. Malik Peiris; ...
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    Publisher: Oxford University Press (OUP)
    Project: NIH | A Controlled Trial of Mas... (5U01CI000439-02), NIH | MIDAS Center for Communic... (1U54GM088558-01)

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  • publication . Article . 2006
    Open Access English
    Authors:
    Fabrizio Poccia; Chiara Agrati; Concetta Castilletti; Licia Bordi; Cristiana Gioia; Douglas Horejsh; Giuseppe Ippolito; Paul K.S. Chan; David S.C. Hui; Joseph J.Y. Sung; ...
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    Publisher: The University of Chicago Press
    Project: NIH | THERAPEUTIC VACCINATION F... (5R01AI048401-04)

    Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus (SARS-CoV) strain. Analyses of T cell repertoires in health care workers who survived SARS-CoV infection during the 2003 outbreak revealed that their effector memory V gamma 9V delta 2 T cell popu...

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  • publication . Article . 2005
    Open Access
    Authors:
    Patrick C. Y. Woo; Susanna K. P. Lau; Hoi Wah Tsoi; Yi Huang; Rosana W. S. Poon; Chung-Ming Chu; Rodney A. Lee; Wei-Kwang Luk; Gilman K. M. Wong; Beatrice H.L. Wong; ...
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    Publisher: Oxford University Press (OUP)

    Background Recently, we described the discovery of a novel group 2 coronavirus, coronavirus HKU1 (CoV-HKU1), from a patient with pneumonia. However, the clinical and molecular epidemiological features of CoV-HKU1-associated pneumonia are unknown. Methods Prospectively c...

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24 research outcomes, page 2 of 3