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description Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Wiley Authors: Zamponi, Hernan P.; Juarez-Aguayso, Leonardo; Kukoc, Gabriela; Domínguez, María Eugenia; +13 AuthorsZamponi, Hernan P.; Juarez-Aguayso, Leonardo; Kukoc, Gabriela; Domínguez, María Eugenia; Pini, Belén; Padilla, Eduardo G.; Calvó, María; Molina-Rangeon, Silvia Beatriz; Guerrero, Gonzalo; Figueredo-Aguiar, Mariana; Fumagalli, Emiliano; Yécora, Agustín; Brugha, Traolach S.; Seshadri, Sudha; Snyder, Heather M.; Erausquin, Gabriel A. de; Gonzalez-Aleman, Gabriela;doi: 10.1002/alz.057897
Fil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; Argentina Fil: Juarez-Aguayso, Leonardo. Ministerio de Salud de Jujuy; Argentina Fil: Kukoc, Gabriela. Ministerio de Salud de Jujuy; Argentina Fil: Domínguez, María Eugenia. Ministerio de Salud de Jujuy; Argentina Fil: Pini, Belén. Ministerio de Salud de Jujuy; Argentina Fil: Padilla, Eduardo G. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Calvó, María. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Molina-Rangeon, Silvia Beatriz. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Guerrero, Gonzalo. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Figueredo-Aguiar, Mariana. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Fumagalli, Emiliano. Universidad Nacional de Jujuy; Argentina Fil: Yécora, Agustín. Ministerio de Salud de Jujuy; Argentina Fil: Brugha, Traolach S. University of Leicester; Reino Unido Fil: Seshadri, Sudha. University of Texas Health Science Center at San Antonio; Estados Unidos Fil: Seshadri, Sudha. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos Fil: Snyder, Heather M. Alzheimer’s Association; Argentina Fil: Erausquin, Gabriel A. de. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos Fil: Erausquin, Gabriel A. de. University of Texas Health Science Center at San Antonio; Estados Unidos Fil: Gonzalez-Aleman, Gabriela. Pontificia Universidad Católica Argentina; Argentina Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia.
Repositorio Instituc... arrow_drop_down Alzheimer s & DementiaArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/alz.057897&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Repositorio Instituc... arrow_drop_down Alzheimer s & DementiaArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/alz.057897&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Frontiers Media SA Authors: Vargas Rubilar, Natalia; Oros, Laura Beatriz;Vargas Rubilar, Natalia; Oros, Laura Beatriz;Fil: Vargas Rubilar, Natalia. Universidad del Aconcagua. Instituto de Educación Superior N° 9-027; Argentina Fil: Oros, Laura Beatriz. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigación en Psicología y Psicopedagogía; Argentina Fil: Oros, Laura Beatriz. Consejo Nacional de Investigaciónes Científicas y Técnicas; Argentina Fil: Oros, Laura Beatriz. Universidad Adventista del Plata; Argentina Resumen: In Argentina, once mandatory isolation was declared due to the COVID-19 pandemic, teachers of all educational levels and modalities had to substantially modify their way of working. The aim of this study was to identify the work situations that education professionals perceived as threats under the modality of non-face-to-face teaching, and to describe the level of perceived stress and its possible effect on psychophysical symptoms. Likewise, it sought to examine possible differences in the manifestations of burnout depending on the level of perceived stress and associated symptoms. An empirical study with a cross-sectional design was developed, in which 9,058 Argentine teachers, who had to complete self-report measures, participated. The sampling method was non-random, using an online procedure of reclusion of volunteers. Descriptive techniques and non-parametric tests were used for data analysis. More than 60% of the educators reported high and moderately high levels of stress. The predominant stressors were uncertainty about the consequences of the pandemic, work overload and inadequate working environment. The more stress they perceived, the higher the manifestation of unwanted psychophysical symptoms. Professional burnout was higher for teachers with a higher load of stress and with more psychophysical indicators of discomfort. These results reveal the psychological impact of the COVID19 pandemic on the education staff, and encourage the development of intervention measures to preserve the health of professionals.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8660691Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fpsyg.2021.756007&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 44 citations 44 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8660691Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fpsyg.2021.756007&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:SAGE Publications Authors: Cyr, Jennifer; Bianchi, Matías Federico; Gonzalez, Lucas Isaac; Perini, Antonella;Cyr, Jennifer; Bianchi, Matías Federico; Gonzalez, Lucas Isaac; Perini, Antonella;handle: 11336/147127
Fil Cyr, Jennifer. Universidad Torcuato Di Tella; Argentina Fil: Bianchi, Matías. University of Arizona; Estados Unidos Fil: Bianchi, Matías. Asuntos del Sur; Argentina Fil: González, Lucas Isaac. Universidad Nacional de San Martín; Argentina Fil: Perini, Antonella. University of Oxford; Reino Unido Fil: Perini, Antonella. Asuntos del Sur; Argentina Abstract: How do governments address complex, cross-sectoral problems, like the COVID-19 pandemic? Why were some Latin American countries more successful at containing the pandemic’s most devastating health outcomes? We argue that national governments that were more collaborative in their response to COVID-19 were more successful in reducing death rates. Our original dataset offers a novel attempt to operationalise collaborative governance (CG). We undertake simple statistical tests to measure the relationship between CG and COVID-19-related mortality rates in Latin America. We then choose three case studies to assess whether collaboration was meaningful in practice. Initial evidence suggests governments that pursued CG were more effective at containing mortality rates early on in the pandemic. The collaboration helped to foster cooperation over resources; buy time to prepare for a potential case surge; and produce a unified message regarding what citizens should do to prevent viral spread. Resumen: ¿Cómo los gobiernos dan cuenta de problemas complejos y multidimensionales como la pandemia COVID-19? ¿Por qué algunos países de América Latina han sido más exitosos al contener los efectos sanitarios más devastadores? En este trabajo se argumenta que los gobiernos nacionales que fueron más colaborativos en su respuesta al COVID-19 han sido más exitosos al reducir las tasas de mortalidad. Se propone una base de datos original que ofrece un intento de operacionalizar la gobernanza colaborativa (GC). Se realizan testeos estadísticos simples que miden la relación entre GC y la tasa de mortalidad relacionada a COVID-19 en América Latina. Luego se hacen tres estudios de caso para observar si la colaboración ha sido sustantiva en la práctica. La evidencia inicial sugiere que los gobiernos que impulsaron la GC han sido más efectivos en contener las tasas de mortalidad al comienzo de la pandemia. La colaboración ayudó a: impulsar cooperación sobre los recursos; ganar tiempo para prepararse para un potencial crecimiento de casos; y producir un mensaje unificado para la ciudadanía sobre comportamientos para evitar la expansión viral.
Journal of Politics ... arrow_drop_down Journal of Politics in Latin AmericaArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefRepositorio Institucional (UCA) - Pontificia Universidad Católica ArgentinaArticle . 2021License: CC BY NC SARepositorio Institucional UCAArticle . 2021License: CC BY NC SAData sources: Repositorio Institucional UCAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/1866802x211049250&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Journal of Politics ... arrow_drop_down Journal of Politics in Latin AmericaArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefRepositorio Institucional (UCA) - Pontificia Universidad Católica ArgentinaArticle . 2021License: CC BY NC SARepositorio Institucional UCAArticle . 2021License: CC BY NC SAData sources: Repositorio Institucional UCAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/1866802x211049250&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Fundacion Universidad Catolica Argentina Authors: Alejandro Danón; Andrés S. Mena; Andrés Ramasco;Alejandro Danón; Andrés S. Mena; Andrés Ramasco;Fil: Danón, Alejandro. Universidad Nacional de Tucumán; Argentina Fil: Danón, Alejandro. Banco de Inversión y Comercio Exterior; Argentina Fil: Mena, Andrés S. Universidad Nacional de Tucumán; Argentina Fil: Mena, Andrés S. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ramasco, Andrés. Universidad Nacional de Tucumán; Argentina Resumen: Este trabajo presenta un modelo capaz de describir y proyectar la evolución del COVID-19 a nivel local. Para ello, diseñamos, programamos, y calibramos un modelo epidemiológico “SEIR plus” que además de los cuatro estados principales del modelo SEIR clásico, describe la trayectoria de enfermos severos y críticos, estados esenciales para la planificación del sistema de salud. Además, sumamos particularidades locales, como ser la curva etaria de la población y medidas de mitigación que impacten en el factor reproductivo. Asimismo, nuestro modelo es estocástico debido a la incorporación de incertidumbre en variables claves asociadas al virus y de difícil proyección para el hacedor de políticas. El modelo muestra un buen ajuste adentro y afuera de la muestra en su aplicación a Ciudad de Buenos Aires y Tucumán, Argentina. Finalmente, mostramos su aplicación para Tucumán, proyectando un escenario epidemiológico factible, y las demandas del sistema sanitario. Abstract: This article presents a model able to describe and forecast the evolution of Covid-19 at the local level. This involves the design, programming and calibration of an epidemiological model that, in addition to the four states of a SEIR model, describes the path of severe and critical patients, fundamental states in order to plan the health system. Our model embeds local characteristics, such as the age composition of the population and the effect of mitigation measures on the reproductive factor. Likewise, our model is stochastic due to the incorporation of uncertainty in key variables associated with the virus and of difficult projection for the policy maker. Besides, we show the goodness of fit inside and outside the sample for Tucumán and Ciudad de Buenos Aires, Argentina. Finally, we show its application at the local level, forecasting a likely epidemiological scenario, and demands to the health system for Tucumán, Argentina.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.46553/ensayos.3.3.2021.p1-24&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.46553/ensayos.3.3.2021.p1-24&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:ST Bio-life Authors: Reiter, Russel J.; Cardinali, Daniel Pedro; Neel, Richard L.; Domínguez Rodriguez, Alberto; +2 AuthorsReiter, Russel J.; Cardinali, Daniel Pedro; Neel, Richard L.; Domínguez Rodriguez, Alberto; Brown, Gregory M.; Tesarik, Jan;doi: 10.32794/mr112500107
Fil: Reiter, Russel J. University of Texas Health Science Center at San Antonio. Department of Cell Systems and Anatomy; Estados Unidos Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Medicas; Argentina Fil: Neel, Richard L. Family Doctor; Estados Unidos Fil: Dominguez Rodriguez, Alberto. University Hospital of Canary Islands San Cristóbal de La Laguna. Department of Cardiology; España Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry; Canada Fil: Tesarik, Jan. MAR & Gen Clinic Granada; España Abstract: Melatonin was shown to prevent or mitigate a number of different respiratory and nonrespiratory viral diseases. Given its non-specific anti-viral action, it is likely to be effective against the delta variant of SARS-CoV-2 as well as any eventual future variants of the virus.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.32794/mr112500107&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.32794/mr112500107&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:MDPI AG Authors: Gregory M. Brown; Seithikurippu R. Pandi-Perumal; Harold Pupko; James L. Kennedy; +1 AuthorsGregory M. Brown; Seithikurippu R. Pandi-Perumal; Harold Pupko; James L. Kennedy; Daniel P. Cardinali;Fil: Brown, Gregory M. Univeridad de Toronto. Centro para la Adicción y la Salud Mental. Ciencias Moleculares del Cerebro; Canadá Fil: Pandi Perumal, Seithikurippu R. Universidad Saveetha. Instituto Saveetha de Medicina y Ciencias Médicas. Hospital Universitario Saveetha; India Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc.; Canadá Fil: Pupko, Harold. Investigador independiente; Canadá Fil: Kennedy, James L. Univeridad de Toronto. Centro para la Adicción y la Salud Mental. Ciencias Moleculares del Cerebro; Canadá Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina Abstract: This brief review was written to provide a perspective on the flurry of reports suggesting that melatonin can be an important add-on therapy for COVID-19. Despite the passage of more than 60 years since its discovery and much evidence representing the contrary, there has been great reluctance to conceive melatonin as anything other than a hormone. Many other body chemicals are known to have multiple roles. Melatonin was first shown to be a hormone derived from the pineal gland, to be actively synthesized there only at night, and to act on targets directly or via the G-proteincoupled receptors (GPCRs) superfamily. It is of note that over 40 years ago, it was also established that melatonin is present, synthesized locally, and acts within the gastrointestinal tract. A wider distribution was then found, including the retina and multiple body tissues. In addition, melatonin is now known to have non-hormonal actions, acting as a free radical scavenger, an antioxidant, and as modulating immunity, dampening down innate tissue responses to invaders while boosting the production of antibodies against them. These actions make it a potentially excellent weapon against infection by the SARS-CoV-2 virus. Early published results support that thesis. Recently, a randomized controlled study reported that low doses of melatonin significantly improved symptoms in hospitalized COVID-19 patients, leading to more rapid discharge with no side effects, while significantly decreasing levels of CRP, proinflammatory cytokines, and modulating dysregulated genes governing cellular and humoral immunity. It is now critical that these trials be repeated, with dose-response studies conducted and safety proven. Numerous randomized controlled trials are ongoing, which should complete those objectives while also allowing for a more thorough evaluation of the mechanisms of action and possible applications to other severe diseases.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8482145Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/diseases9030064&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8482145Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/diseases9030064&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Elsevier BV Authors: Francisco J. Barrantes;Francisco J. Barrantes;Although our current knowledge of the pathophysiology of COVID-19 is still fragmentary, the information so far accrued on the tropism and life cycle of its etiological agent SARS-CoV-2, together with the emerging clinical data, suffice to indicate that the severe acute pulmonary syndrome is the main, but not the only manifestation of COVID-19. Necropsy studies are increasingly revealing underlying endothelial vasculopathies in the form of micro-haemorrhages and micro-thrombi. Intertwined with defective antiviral responses, dysregulated coagulation mechanisms, abnormal hyper-inflammatory reactions and responses, COVID-19 is disclosing a wide pathophysiological palette. An additional property in categorising the disease is the combination of tissue (e.g. neuro- and vasculo-tropism) with organ tropism, whereby the virus preferentially attacks certain organs with highly developed capillary beds, such as the lungs gastrointestinal tract, kidney and brain. These multiple clinical presentations confirm that the acute respiratory syndrome as described initially is increasingly unfolding as a more complex nosological entity, a multiorgan syndrome of systemic breadth. The neurological manifestations of COVID-19, the focus of this review, reflect this manifold nature of the disease. Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Brain, Behavior, &am... arrow_drop_down Brain, Behavior, & Immunity - HealthArticle . 2021Full-Text: http://europepmc.org/articles/PMC8019247Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC NDRepositorio Institucional (UCA) - Pontificia Universidad Católica Argentina; Repositorio Institucional UCA; Brain, Behavior, & Immunity - HealthArticle . 2021 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.bbih.2021.100251&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 20 citations 20 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Brain, Behavior, &am... arrow_drop_down Brain, Behavior, & Immunity - HealthArticle . 2021Full-Text: http://europepmc.org/articles/PMC8019247Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC NDRepositorio Institucional (UCA) - Pontificia Universidad Católica Argentina; Repositorio Institucional UCA; Brain, Behavior, & Immunity - HealthArticle . 2021 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Annual Reviews Authors: Barrantes, Francisco Jose;Barrantes, Francisco Jose;Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a hijacking mechanism perfected over the course of evolution. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has successfully adopted this strategy using its spike glycoprotein to dock on the membrane-bound metalloprotease angiotensin-converting enzyme 2 (ACE2). The crystal structures of several SARS-CoV-2 proteins alone or in complex with their receptors or other ligands were recently solved at an unprecedented pace. This accomplishment is partly due to the increasing availability of data on other coronaviruses and ACE2 over the past 18 years. Likewise, other key intervening actors and mechanisms of viral infection were elucidated with the aid of biophysical approaches. An understanding of the various structurally important motifs of the interacting partners provides key mechanistic information for the development of structure-based designer drugs able to inhibit various steps of the infective cycle, including neutralizing antibodies, small organic drugs, and vaccines. This review analyzes current progress and the outlook for future structural studies. Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Repositorio Instituc... arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; Annual Review of BiophysicsArticle . 2021 . Peer-reviewedLicense: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Repositorio Instituc... arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; Annual Review of BiophysicsArticle . 2021 . Peer-reviewedLicense: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Elsevier BV Gustavo Lopardo; Waldo H. Belloso; Esteban Nannini; Mariana Colonna; Santiago Sanguineti; Vanesa Zylberman; Luciana Muñoz; Martín Dobarro; Gabriel Lebersztein; Javier Farina; Gabriela Vidiella; Anselmo Bertetti; Favio Crudo; Maria Fernanda Alzogaray; Laura Barcelona; Ricardo Teijeiro; Sandra Lambert; Darío Scublinsky; Marisa Iacono; Vanina Stanek; Rubén Solari; Pablo Cruz; Marcelo Martín Casas; Lorena Abusamra; Héctor Lucas Luciardi; Alberto Cremona; Diego Caruso; Bernardo de Miguel; Santiago Perez Lloret; Susana Millán; Yael Kilstein; Ana Pereiro; Omar Sued; Pedro Cahn; Linus Spatz; Fernando Alberto Goldbaum;handle: 11336/139002
Fil: Lopardo, Gustavo. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Lopardo, Gustavo. Fundación del Centro de Estudios Infectológicos; Argentina Fil: Belloso, Waldo H. Hospital Italiano de Buenos Aires. Department of Research; Argentina Fil: Nannini, Esteban. Sanatorio Británico. Departamento de Enfermedades Infecciosas; Argentina Fil: Nannini, Esteban. Consejo Nacional de Investigaciones Científicas y Tecnicas; Argentina Fil: Colonna, Mariana. Inmunova S.A; Argentina Fil: Sanguineti, Santiago. Inmunova S.A; Argentina Fil: Zylberman, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zylberman, Vanesa. Inmunova S.A; Argentina Fil: Munoz, Luciana. Inmunova S.A; Argentina Fil: Dobarro, Martín. Sanatorio Sagrado Corazón; Argentina Fil: Lebersztein, Gabriel. Sanatorio Sagrado Corazón; Argentina Fil: Farina, Javier. Hospital de Alta Complejidad Cuenca Alta Néstor Kirchner; Argentina Fil: Vidiella, Gabriela. Sanatorio Agote; Argentina Fil: Bertetti, Anselmo. Sanatorio Güemes; Argentina Fil: Crudo, Favio. Hospital Municipal Emilio Zerboni; Argentina Fil: Crudo, Favio. Universidad Nacional de San Antonio de Areco; Argentina Fil: Alzogaray, María Fernanda. Instituto Medico Platense; Argentina Fil: Barcelona, Laura. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Teijeiro, Ricardo. Hospital General de Agudos Dr. Ignacio Pirovano; Argentina Fil: Lambert, Sandra. Hospital de Alta Complejidad El Cruce Néstor Kirchner; Argentina Fil: Scublinsky, Darío. Clínica Zabala; Argentina Fil: Iacono, Marisa. Hospital Provincial Neuquén Dr. Castro Rendón; Argentina Fil: Stanek, Vanina. Hospital Italiano de Buenos Aires. Servicio de Medicina Interna. Sección de Infectología; Argentina Fil: Solari, Ruben. Hospital de Infecciosas Francisco Javier Muñiz; Argentina Fil: Cruz, Pablo. Centro Gallego de Buenos Aires; Argentina Fil: Casas, Marcelo Martín. Clínica Adventista Belgrano; Argentina Fil: Abusamra, Lorena. Hospital Municipal Dr. Diego Thompson; Argentina Fil: Luciardi, Hector Lucas. Hospital Centro de Salud Zenón J. Santillán; Argentina Fil: Cremona, Alberto. Hospital Italiano La Plata; Argentina Fil: Caruso, Diego. Hospital Español; Argentina Fil: Miguel, Bernardo de. mAbxience; España Fil: Millan, Susana. mAbxience; España Fil: Kilstein, Yael. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Kilstein, Yael. Hospital Italiano de Buenos Aires. Department of Research; Argentina Fil: Pereiro, Ana. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Pereiro, Ana. Sanatorio Británico. Departamento de Enfermedades Infecciosas; Argentina Fil: Sued, Omar. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Sued, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cahn, Pedro. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Cahn, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Spatz, Linus. Inmunova S.A.; Argentina Fil: Goldbaum, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Goldbaum, Fernando. Inmunova S.A.; Argentina Fil: Goldbaum, Fernando. Fundación Instituto Leloir; Argentina Fil: Goldbaum, Fernando. Universidad Nacional de San Martín Campus Miguelete. Centro de Rediseño e Ingeniería en Proteínas; Argentina Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Tecnicas; Argentina Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina Fil: Pérez Lloret, Santiago. Universidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina Abstract: Background: passive immunotherapy is a therapeutic alternative for patients with COVID-19. Equine polyclonal antibodies (EpAbs) could represent a source of scalable neutralizing antibodies against SARS-CoV-2. Methods: we conducted a double-blind, randomized, placebo-controlled trial to assess efficacy and safety of EpAbs (INM005) in hospitalized adult patients with moderate and severe COVID-19 pneumonia in 19 hospitals of Argentina. Primary endpoint was improvement in at least two categories in WHO ordinal clinical scale at day 28 or hospital discharge (ClinicalTrials.gov number NCT04494984). Findings: between August 1st and October 26th, 2020, a total of 245 patients were enrolled. Enrolled patients were assigned to receive two blinded doses of INM005 (n = 118) or placebo (n = 123). Median age was 54 years old, 65 1% were male and 61% had moderate disease at baseline. Median time from symptoms onset to study treatment was 6 days (interquartile range 5 to 8). No statistically significant difference was noted between study groups on primary endpoint (risk difference [95% IC]: 5 28% [-3 95; 14 50]; p = 0 15). Rate of improvement in at least two categories was statistically significantly higher for INM005 at days 14 and 21 of follow-up. Time to improvement in two ordinal categories or hospital discharge was 14 2 (§ 0 7) days in the INM005 group and 16 3 (§ 0 7) days in the placebo group, hazard ratio 1 31 (95% CI 1 0 to 1 74). Subgroup analyses showed a beneficial effect of INM005 over severe patients and in those with negative baseline antibodies. Overall mortality was 6 9% the INM005 group and 11 4% in the placebo group (risk difference [95% IC]: 0 57 [0 24 to 1 37]). Adverse events of special interest were mild or moderate; no anaphylaxis was reported. Interpretation: Albeit not having reached the primary endpoint, we found clinical improvement of hospitalized patients with SARS-CoV-2 pneumonia, particularly those with severe disease.
EClinicalMedicine arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC SARepositorio Institucional (UCA) - Pontificia Universidad Católica Argentina; Repositorio Institucional UCA; EClinicalMedicineArticle . 2021 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 38 citations 38 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert EClinicalMedicine arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC SARepositorio Institucional (UCA) - Pontificia Universidad Católica Argentina; Repositorio Institucional UCA; EClinicalMedicineArticle . 2021 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:MedCrave Group, LLC Authors: Garófalo, Carolina Sofía; Petrikovich, Lucia; Garcia, Claudia Silvina;Garófalo, Carolina Sofía; Petrikovich, Lucia; Garcia, Claudia Silvina;Fil: Garófalo, Carolina Sofía. Pontificia Universidad Católica Argentina. Facultad de Filosofía y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina Fil: Petrikovich, Lucia. Pontificia Universidad Católica Argentina. Facultad de Filosofía y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina Fil: Garcia, Claudia Silvina. Universidad del Aconcagua. Facultad de Psicología; Argentina Abstract: the study of older adults has gained relevance in recent years. Although personality traits, coping strategies, and nonspecific psychological distress are related to mental health, they have not been studied in depth in this age group. The main purpose of this review was to address the interaction between these variables, considering adaptive and maladaptive aspects, and clarifying their specific characteristics in older adults. The current context of the COVID-19 pandemic represents a risk factor and a challenge for individuals in this age group, influencing both physical and mental health.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Wiley Authors: Zamponi, Hernan P.; Juarez-Aguayso, Leonardo; Kukoc, Gabriela; Domínguez, María Eugenia; +13 AuthorsZamponi, Hernan P.; Juarez-Aguayso, Leonardo; Kukoc, Gabriela; Domínguez, María Eugenia; Pini, Belén; Padilla, Eduardo G.; Calvó, María; Molina-Rangeon, Silvia Beatriz; Guerrero, Gonzalo; Figueredo-Aguiar, Mariana; Fumagalli, Emiliano; Yécora, Agustín; Brugha, Traolach S.; Seshadri, Sudha; Snyder, Heather M.; Erausquin, Gabriel A. de; Gonzalez-Aleman, Gabriela;doi: 10.1002/alz.057897
Fil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; Argentina Fil: Juarez-Aguayso, Leonardo. Ministerio de Salud de Jujuy; Argentina Fil: Kukoc, Gabriela. Ministerio de Salud de Jujuy; Argentina Fil: Domínguez, María Eugenia. Ministerio de Salud de Jujuy; Argentina Fil: Pini, Belén. Ministerio de Salud de Jujuy; Argentina Fil: Padilla, Eduardo G. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Calvó, María. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Molina-Rangeon, Silvia Beatriz. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Guerrero, Gonzalo. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Figueredo-Aguiar, Mariana. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Fumagalli, Emiliano. Universidad Nacional de Jujuy; Argentina Fil: Yécora, Agustín. Ministerio de Salud de Jujuy; Argentina Fil: Brugha, Traolach S. University of Leicester; Reino Unido Fil: Seshadri, Sudha. University of Texas Health Science Center at San Antonio; Estados Unidos Fil: Seshadri, Sudha. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos Fil: Snyder, Heather M. Alzheimer’s Association; Argentina Fil: Erausquin, Gabriel A. de. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos Fil: Erausquin, Gabriel A. de. University of Texas Health Science Center at San Antonio; Estados Unidos Fil: Gonzalez-Aleman, Gabriela. Pontificia Universidad Católica Argentina; Argentina Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia.
Repositorio Instituc... arrow_drop_down Alzheimer s & DementiaArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Repositorio Instituc... arrow_drop_down Alzheimer s & DementiaArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Frontiers Media SA Authors: Vargas Rubilar, Natalia; Oros, Laura Beatriz;Vargas Rubilar, Natalia; Oros, Laura Beatriz;Fil: Vargas Rubilar, Natalia. Universidad del Aconcagua. Instituto de Educación Superior N° 9-027; Argentina Fil: Oros, Laura Beatriz. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigación en Psicología y Psicopedagogía; Argentina Fil: Oros, Laura Beatriz. Consejo Nacional de Investigaciónes Científicas y Técnicas; Argentina Fil: Oros, Laura Beatriz. Universidad Adventista del Plata; Argentina Resumen: In Argentina, once mandatory isolation was declared due to the COVID-19 pandemic, teachers of all educational levels and modalities had to substantially modify their way of working. The aim of this study was to identify the work situations that education professionals perceived as threats under the modality of non-face-to-face teaching, and to describe the level of perceived stress and its possible effect on psychophysical symptoms. Likewise, it sought to examine possible differences in the manifestations of burnout depending on the level of perceived stress and associated symptoms. An empirical study with a cross-sectional design was developed, in which 9,058 Argentine teachers, who had to complete self-report measures, participated. The sampling method was non-random, using an online procedure of reclusion of volunteers. Descriptive techniques and non-parametric tests were used for data analysis. More than 60% of the educators reported high and moderately high levels of stress. The predominant stressors were uncertainty about the consequences of the pandemic, work overload and inadequate working environment. The more stress they perceived, the higher the manifestation of unwanted psychophysical symptoms. Professional burnout was higher for teachers with a higher load of stress and with more psychophysical indicators of discomfort. These results reveal the psychological impact of the COVID19 pandemic on the education staff, and encourage the development of intervention measures to preserve the health of professionals.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8660691Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 44 citations 44 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8660691Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:SAGE Publications Authors: Cyr, Jennifer; Bianchi, Matías Federico; Gonzalez, Lucas Isaac; Perini, Antonella;Cyr, Jennifer; Bianchi, Matías Federico; Gonzalez, Lucas Isaac; Perini, Antonella;handle: 11336/147127
Fil Cyr, Jennifer. Universidad Torcuato Di Tella; Argentina Fil: Bianchi, Matías. University of Arizona; Estados Unidos Fil: Bianchi, Matías. Asuntos del Sur; Argentina Fil: González, Lucas Isaac. Universidad Nacional de San Martín; Argentina Fil: Perini, Antonella. University of Oxford; Reino Unido Fil: Perini, Antonella. Asuntos del Sur; Argentina Abstract: How do governments address complex, cross-sectoral problems, like the COVID-19 pandemic? Why were some Latin American countries more successful at containing the pandemic’s most devastating health outcomes? We argue that national governments that were more collaborative in their response to COVID-19 were more successful in reducing death rates. Our original dataset offers a novel attempt to operationalise collaborative governance (CG). We undertake simple statistical tests to measure the relationship between CG and COVID-19-related mortality rates in Latin America. We then choose three case studies to assess whether collaboration was meaningful in practice. Initial evidence suggests governments that pursued CG were more effective at containing mortality rates early on in the pandemic. The collaboration helped to foster cooperation over resources; buy time to prepare for a potential case surge; and produce a unified message regarding what citizens should do to prevent viral spread. Resumen: ¿Cómo los gobiernos dan cuenta de problemas complejos y multidimensionales como la pandemia COVID-19? ¿Por qué algunos países de América Latina han sido más exitosos al contener los efectos sanitarios más devastadores? En este trabajo se argumenta que los gobiernos nacionales que fueron más colaborativos en su respuesta al COVID-19 han sido más exitosos al reducir las tasas de mortalidad. Se propone una base de datos original que ofrece un intento de operacionalizar la gobernanza colaborativa (GC). Se realizan testeos estadísticos simples que miden la relación entre GC y la tasa de mortalidad relacionada a COVID-19 en América Latina. Luego se hacen tres estudios de caso para observar si la colaboración ha sido sustantiva en la práctica. La evidencia inicial sugiere que los gobiernos que impulsaron la GC han sido más efectivos en contener las tasas de mortalidad al comienzo de la pandemia. La colaboración ayudó a: impulsar cooperación sobre los recursos; ganar tiempo para prepararse para un potencial crecimiento de casos; y producir un mensaje unificado para la ciudadanía sobre comportamientos para evitar la expansión viral.
Journal of Politics ... arrow_drop_down Journal of Politics in Latin AmericaArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefRepositorio Institucional (UCA) - Pontificia Universidad Católica ArgentinaArticle . 2021License: CC BY NC SARepositorio Institucional UCAArticle . 2021License: CC BY NC SAData sources: Repositorio Institucional UCAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Journal of Politics ... arrow_drop_down Journal of Politics in Latin AmericaArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefRepositorio Institucional (UCA) - Pontificia Universidad Católica ArgentinaArticle . 2021License: CC BY NC SARepositorio Institucional UCAArticle . 2021License: CC BY NC SAData sources: Repositorio Institucional UCAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/1866802x211049250&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Fundacion Universidad Catolica Argentina Authors: Alejandro Danón; Andrés S. Mena; Andrés Ramasco;Alejandro Danón; Andrés S. Mena; Andrés Ramasco;Fil: Danón, Alejandro. Universidad Nacional de Tucumán; Argentina Fil: Danón, Alejandro. Banco de Inversión y Comercio Exterior; Argentina Fil: Mena, Andrés S. Universidad Nacional de Tucumán; Argentina Fil: Mena, Andrés S. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ramasco, Andrés. Universidad Nacional de Tucumán; Argentina Resumen: Este trabajo presenta un modelo capaz de describir y proyectar la evolución del COVID-19 a nivel local. Para ello, diseñamos, programamos, y calibramos un modelo epidemiológico “SEIR plus” que además de los cuatro estados principales del modelo SEIR clásico, describe la trayectoria de enfermos severos y críticos, estados esenciales para la planificación del sistema de salud. Además, sumamos particularidades locales, como ser la curva etaria de la población y medidas de mitigación que impacten en el factor reproductivo. Asimismo, nuestro modelo es estocástico debido a la incorporación de incertidumbre en variables claves asociadas al virus y de difícil proyección para el hacedor de políticas. El modelo muestra un buen ajuste adentro y afuera de la muestra en su aplicación a Ciudad de Buenos Aires y Tucumán, Argentina. Finalmente, mostramos su aplicación para Tucumán, proyectando un escenario epidemiológico factible, y las demandas del sistema sanitario. Abstract: This article presents a model able to describe and forecast the evolution of Covid-19 at the local level. This involves the design, programming and calibration of an epidemiological model that, in addition to the four states of a SEIR model, describes the path of severe and critical patients, fundamental states in order to plan the health system. Our model embeds local characteristics, such as the age composition of the population and the effect of mitigation measures on the reproductive factor. Likewise, our model is stochastic due to the incorporation of uncertainty in key variables associated with the virus and of difficult projection for the policy maker. Besides, we show the goodness of fit inside and outside the sample for Tucumán and Ciudad de Buenos Aires, Argentina. Finally, we show its application at the local level, forecasting a likely epidemiological scenario, and demands to the health system for Tucumán, Argentina.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.46553/ensayos.3.3.2021.p1-24&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.46553/ensayos.3.3.2021.p1-24&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:ST Bio-life Authors: Reiter, Russel J.; Cardinali, Daniel Pedro; Neel, Richard L.; Domínguez Rodriguez, Alberto; +2 AuthorsReiter, Russel J.; Cardinali, Daniel Pedro; Neel, Richard L.; Domínguez Rodriguez, Alberto; Brown, Gregory M.; Tesarik, Jan;doi: 10.32794/mr112500107
Fil: Reiter, Russel J. University of Texas Health Science Center at San Antonio. Department of Cell Systems and Anatomy; Estados Unidos Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Medicas; Argentina Fil: Neel, Richard L. Family Doctor; Estados Unidos Fil: Dominguez Rodriguez, Alberto. University Hospital of Canary Islands San Cristóbal de La Laguna. Department of Cardiology; España Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry; Canada Fil: Tesarik, Jan. MAR & Gen Clinic Granada; España Abstract: Melatonin was shown to prevent or mitigate a number of different respiratory and nonrespiratory viral diseases. Given its non-specific anti-viral action, it is likely to be effective against the delta variant of SARS-CoV-2 as well as any eventual future variants of the virus.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.32794/mr112500107&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.32794/mr112500107&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:MDPI AG Authors: Gregory M. Brown; Seithikurippu R. Pandi-Perumal; Harold Pupko; James L. Kennedy; +1 AuthorsGregory M. Brown; Seithikurippu R. Pandi-Perumal; Harold Pupko; James L. Kennedy; Daniel P. Cardinali;Fil: Brown, Gregory M. Univeridad de Toronto. Centro para la Adicción y la Salud Mental. Ciencias Moleculares del Cerebro; Canadá Fil: Pandi Perumal, Seithikurippu R. Universidad Saveetha. Instituto Saveetha de Medicina y Ciencias Médicas. Hospital Universitario Saveetha; India Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc.; Canadá Fil: Pupko, Harold. Investigador independiente; Canadá Fil: Kennedy, James L. Univeridad de Toronto. Centro para la Adicción y la Salud Mental. Ciencias Moleculares del Cerebro; Canadá Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina Abstract: This brief review was written to provide a perspective on the flurry of reports suggesting that melatonin can be an important add-on therapy for COVID-19. Despite the passage of more than 60 years since its discovery and much evidence representing the contrary, there has been great reluctance to conceive melatonin as anything other than a hormone. Many other body chemicals are known to have multiple roles. Melatonin was first shown to be a hormone derived from the pineal gland, to be actively synthesized there only at night, and to act on targets directly or via the G-proteincoupled receptors (GPCRs) superfamily. It is of note that over 40 years ago, it was also established that melatonin is present, synthesized locally, and acts within the gastrointestinal tract. A wider distribution was then found, including the retina and multiple body tissues. In addition, melatonin is now known to have non-hormonal actions, acting as a free radical scavenger, an antioxidant, and as modulating immunity, dampening down innate tissue responses to invaders while boosting the production of antibodies against them. These actions make it a potentially excellent weapon against infection by the SARS-CoV-2 virus. Early published results support that thesis. Recently, a randomized controlled study reported that low doses of melatonin significantly improved symptoms in hospitalized COVID-19 patients, leading to more rapid discharge with no side effects, while significantly decreasing levels of CRP, proinflammatory cytokines, and modulating dysregulated genes governing cellular and humoral immunity. It is now critical that these trials be repeated, with dose-response studies conducted and safety proven. Numerous randomized controlled trials are ongoing, which should complete those objectives while also allowing for a more thorough evaluation of the mechanisms of action and possible applications to other severe diseases.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8482145Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/diseases9030064&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8482145Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/diseases9030064&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Elsevier BV Authors: Francisco J. Barrantes;Francisco J. Barrantes;Although our current knowledge of the pathophysiology of COVID-19 is still fragmentary, the information so far accrued on the tropism and life cycle of its etiological agent SARS-CoV-2, together with the emerging clinical data, suffice to indicate that the severe acute pulmonary syndrome is the main, but not the only manifestation of COVID-19. Necropsy studies are increasingly revealing underlying endothelial vasculopathies in the form of micro-haemorrhages and micro-thrombi. Intertwined with defective antiviral responses, dysregulated coagulation mechanisms, abnormal hyper-inflammatory reactions and responses, COVID-19 is disclosing a wide pathophysiological palette. An additional property in categorising the disease is the combination of tissue (e.g. neuro- and vasculo-tropism) with organ tropism, whereby the virus preferentially attacks certain organs with highly developed capillary beds, such as the lungs gastrointestinal tract, kidney and brain. These multiple clinical presentations confirm that the acute respiratory syndrome as described initially is increasingly unfolding as a more complex nosological entity, a multiorgan syndrome of systemic breadth. The neurological manifestations of COVID-19, the focus of this review, reflect this manifold nature of the disease. Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Brain, Behavior, &am... arrow_drop_down Brain, Behavior, & Immunity - HealthArticle . 2021Full-Text: http://europepmc.org/articles/PMC8019247Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC NDRepositorio Institucional (UCA) - Pontificia Universidad Católica Argentina; Repositorio Institucional UCA; Brain, Behavior, & Immunity - HealthArticle . 2021 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.bbih.2021.100251&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 20 citations 20 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Brain, Behavior, &am... arrow_drop_down Brain, Behavior, & Immunity - HealthArticle . 2021Full-Text: http://europepmc.org/articles/PMC8019247Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC NDRepositorio Institucional (UCA) - Pontificia Universidad Católica Argentina; Repositorio Institucional UCA; Brain, Behavior, & Immunity - HealthArticle . 2021 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.bbih.2021.100251&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Annual Reviews Authors: Barrantes, Francisco Jose;Barrantes, Francisco Jose;Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a hijacking mechanism perfected over the course of evolution. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has successfully adopted this strategy using its spike glycoprotein to dock on the membrane-bound metalloprotease angiotensin-converting enzyme 2 (ACE2). The crystal structures of several SARS-CoV-2 proteins alone or in complex with their receptors or other ligands were recently solved at an unprecedented pace. This accomplishment is partly due to the increasing availability of data on other coronaviruses and ACE2 over the past 18 years. Likewise, other key intervening actors and mechanisms of viral infection were elucidated with the aid of biophysical approaches. An understanding of the various structurally important motifs of the interacting partners provides key mechanistic information for the development of structure-based designer drugs able to inhibit various steps of the infective cycle, including neutralizing antibodies, small organic drugs, and vaccines. This review analyzes current progress and the outlook for future structural studies. Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Repositorio Instituc... arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; Annual Review of BiophysicsArticle . 2021 . Peer-reviewedLicense: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1146/annurev-biophys-102620-080956&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Repositorio Instituc... arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; Annual Review of BiophysicsArticle . 2021 . Peer-reviewedLicense: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1146/annurev-biophys-102620-080956&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:Elsevier BV Gustavo Lopardo; Waldo H. Belloso; Esteban Nannini; Mariana Colonna; Santiago Sanguineti; Vanesa Zylberman; Luciana Muñoz; Martín Dobarro; Gabriel Lebersztein; Javier Farina; Gabriela Vidiella; Anselmo Bertetti; Favio Crudo; Maria Fernanda Alzogaray; Laura Barcelona; Ricardo Teijeiro; Sandra Lambert; Darío Scublinsky; Marisa Iacono; Vanina Stanek; Rubén Solari; Pablo Cruz; Marcelo Martín Casas; Lorena Abusamra; Héctor Lucas Luciardi; Alberto Cremona; Diego Caruso; Bernardo de Miguel; Santiago Perez Lloret; Susana Millán; Yael Kilstein; Ana Pereiro; Omar Sued; Pedro Cahn; Linus Spatz; Fernando Alberto Goldbaum;handle: 11336/139002
Fil: Lopardo, Gustavo. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Lopardo, Gustavo. Fundación del Centro de Estudios Infectológicos; Argentina Fil: Belloso, Waldo H. Hospital Italiano de Buenos Aires. Department of Research; Argentina Fil: Nannini, Esteban. Sanatorio Británico. Departamento de Enfermedades Infecciosas; Argentina Fil: Nannini, Esteban. Consejo Nacional de Investigaciones Científicas y Tecnicas; Argentina Fil: Colonna, Mariana. Inmunova S.A; Argentina Fil: Sanguineti, Santiago. Inmunova S.A; Argentina Fil: Zylberman, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zylberman, Vanesa. Inmunova S.A; Argentina Fil: Munoz, Luciana. Inmunova S.A; Argentina Fil: Dobarro, Martín. Sanatorio Sagrado Corazón; Argentina Fil: Lebersztein, Gabriel. Sanatorio Sagrado Corazón; Argentina Fil: Farina, Javier. Hospital de Alta Complejidad Cuenca Alta Néstor Kirchner; Argentina Fil: Vidiella, Gabriela. Sanatorio Agote; Argentina Fil: Bertetti, Anselmo. Sanatorio Güemes; Argentina Fil: Crudo, Favio. Hospital Municipal Emilio Zerboni; Argentina Fil: Crudo, Favio. Universidad Nacional de San Antonio de Areco; Argentina Fil: Alzogaray, María Fernanda. Instituto Medico Platense; Argentina Fil: Barcelona, Laura. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Teijeiro, Ricardo. Hospital General de Agudos Dr. Ignacio Pirovano; Argentina Fil: Lambert, Sandra. Hospital de Alta Complejidad El Cruce Néstor Kirchner; Argentina Fil: Scublinsky, Darío. Clínica Zabala; Argentina Fil: Iacono, Marisa. Hospital Provincial Neuquén Dr. Castro Rendón; Argentina Fil: Stanek, Vanina. Hospital Italiano de Buenos Aires. Servicio de Medicina Interna. Sección de Infectología; Argentina Fil: Solari, Ruben. Hospital de Infecciosas Francisco Javier Muñiz; Argentina Fil: Cruz, Pablo. Centro Gallego de Buenos Aires; Argentina Fil: Casas, Marcelo Martín. Clínica Adventista Belgrano; Argentina Fil: Abusamra, Lorena. Hospital Municipal Dr. Diego Thompson; Argentina Fil: Luciardi, Hector Lucas. Hospital Centro de Salud Zenón J. Santillán; Argentina Fil: Cremona, Alberto. Hospital Italiano La Plata; Argentina Fil: Caruso, Diego. Hospital Español; Argentina Fil: Miguel, Bernardo de. mAbxience; España Fil: Millan, Susana. mAbxience; España Fil: Kilstein, Yael. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Kilstein, Yael. Hospital Italiano de Buenos Aires. Department of Research; Argentina Fil: Pereiro, Ana. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Pereiro, Ana. Sanatorio Británico. Departamento de Enfermedades Infecciosas; Argentina Fil: Sued, Omar. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Sued, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cahn, Pedro. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Cahn, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Spatz, Linus. Inmunova S.A.; Argentina Fil: Goldbaum, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Goldbaum, Fernando. Inmunova S.A.; Argentina Fil: Goldbaum, Fernando. Fundación Instituto Leloir; Argentina Fil: Goldbaum, Fernando. Universidad Nacional de San Martín Campus Miguelete. Centro de Rediseño e Ingeniería en Proteínas; Argentina Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Tecnicas; Argentina Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina Fil: Pérez Lloret, Santiago. Universidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina Abstract: Background: passive immunotherapy is a therapeutic alternative for patients with COVID-19. Equine polyclonal antibodies (EpAbs) could represent a source of scalable neutralizing antibodies against SARS-CoV-2. Methods: we conducted a double-blind, randomized, placebo-controlled trial to assess efficacy and safety of EpAbs (INM005) in hospitalized adult patients with moderate and severe COVID-19 pneumonia in 19 hospitals of Argentina. Primary endpoint was improvement in at least two categories in WHO ordinal clinical scale at day 28 or hospital discharge (ClinicalTrials.gov number NCT04494984). Findings: between August 1st and October 26th, 2020, a total of 245 patients were enrolled. Enrolled patients were assigned to receive two blinded doses of INM005 (n = 118) or placebo (n = 123). Median age was 54 years old, 65 1% were male and 61% had moderate disease at baseline. Median time from symptoms onset to study treatment was 6 days (interquartile range 5 to 8). No statistically significant difference was noted between study groups on primary endpoint (risk difference [95% IC]: 5 28% [-3 95; 14 50]; p = 0 15). Rate of improvement in at least two categories was statistically significantly higher for INM005 at days 14 and 21 of follow-up. Time to improvement in two ordinal categories or hospital discharge was 14 2 (§ 0 7) days in the INM005 group and 16 3 (§ 0 7) days in the placebo group, hazard ratio 1 31 (95% CI 1 0 to 1 74). Subgroup analyses showed a beneficial effect of INM005 over severe patients and in those with negative baseline antibodies. Overall mortality was 6 9% the INM005 group and 11 4% in the placebo group (risk difference [95% IC]: 0 57 [0 24 to 1 37]). Adverse events of special interest were mild or moderate; no anaphylaxis was reported. Interpretation: Albeit not having reached the primary endpoint, we found clinical improvement of hospitalized patients with SARS-CoV-2 pneumonia, particularly those with severe disease.
EClinicalMedicine arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC SARepositorio Institucional (UCA) - Pontificia Universidad Católica Argentina; Repositorio Institucional UCA; EClinicalMedicineArticle . 2021 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 38 citations 38 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert EClinicalMedicine arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2021License: CC BY NC SARepositorio Institucional (UCA) - Pontificia Universidad Católica Argentina; Repositorio Institucional UCA; EClinicalMedicineArticle . 2021 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 ArgentinaPublisher:MedCrave Group, LLC Authors: Garófalo, Carolina Sofía; Petrikovich, Lucia; Garcia, Claudia Silvina;Garófalo, Carolina Sofía; Petrikovich, Lucia; Garcia, Claudia Silvina;Fil: Garófalo, Carolina Sofía. Pontificia Universidad Católica Argentina. Facultad de Filosofía y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina Fil: Petrikovich, Lucia. Pontificia Universidad Católica Argentina. Facultad de Filosofía y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina Fil: Garcia, Claudia Silvina. Universidad del Aconcagua. Facultad de Psicología; Argentina Abstract: the study of older adults has gained relevance in recent years. Although personality traits, coping strategies, and nonspecific psychological distress are related to mental health, they have not been studied in depth in this age group. The main purpose of this review was to address the interaction between these variables, considering adaptive and maladaptive aspects, and clarifying their specific characteristics in older adults. The current context of the COVID-19 pandemic represents a risk factor and a challenge for individuals in this age group, influencing both physical and mental health.
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