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Existe una clara relacion entre la infeccion por el nuevo coronavirus 2 y el diagnostico de enfermedad tromboembolica venosa, como consecuencia del desarrollo de un sindrome de respuesta inflamatoria sistemica debido a la activacion de la cascada de la coagulacion. Se presenta en el 90% de los pacientes con formas graves de la infeccion, lo que revela la presencia de microtrombosis y macrotrombosis intravascular pulmonar. Esto sugiere un posible beneficio clinico de la aplicacion de una tromboprofilaxis adecuada al riesgo clinico de cada paciente. Asimismo, la sospecha de enfermedad tromboembolica venosa en el contexto de esta pandemia representa un reto diagnostico debido a la existencia de similitudes entre ambas alteraciones en varios aspectos. Debe tenerse en cuenta que el diagnostico de tromboembolismo pulmonar agudo no excluye la posibilidad de infeccion viral. La valoracion de pacientes con sospecha de tromboembolismo pulmonar agudo en el contexto de la pandemia debe ser eficaz para establecer un diagnostico y tratamiento con rapidez, a fin de reducir la morbilidad y mortalidad adjuntas, sin que ello eleve el riesgo de infeccion para los profesionales de la salud y otros pacientes.

Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 activity with reduced toxicity. In this report, we demonstrate that the block of HIV-1 replication by GPS491 is accompanied by a drastic inhibition of viral gene expression (IC50 ~ 0.25 µM), and alterations in the production of unspliced, singly spliced, and multiply spliced HIV-1 RNAs. GPS491 also inhibited the replication of adenovirus and multiple coronaviruses. Low µM doses of GPS491 reduced adenovirus infectious yield ~1000 fold, altered virus early gene expression/viral E1A RNA processing, blocked viral DNA amplification, and inhibited late (hexon) gene expression. Loss of replication of multiple coronaviruses (229E, OC43, SARS-CoV2) upon GPS491 addition was associated with the inhibition of viral structural protein expression and the formation of virus particles. Consistent with the observed changes in viral RNA processing, GPS491 treatment induced selective alterations in the accumulation/phosphorylation/function of splicing regulatory SR proteins. Our study establishes that a compound that impacts the activity of cellular factors involved in RNA processing can prevent the replication of several viruses with minimal effect on cell viability.

Background. COVID-19 research has relied heavily on convenience-based samples, which—though often necessary—are susceptible to important sampling biases. We begin with a theoretical overview and introduction to the dynamics that underlie sampling bias. We then empirically examine sampling bias in online COVID-19 surveys and evaluate the degree to which common statistical adjustments for demographic covariates successfully attenuate such bias. Methods. We analysed responses to identical questions from three convenience and three largely representative samples (total N = 13,731) collected online in Canada within the International COVID-19 Awareness and Responses Evaluation Study (www.icarestudy.com). We compared samples on 11 behavioural and psychological outcomes (e.g., adherence to COVID-19 prevention measures, vaccine intentions) across three time points and employed multiverse-style analyses to examine how 512 combinations of demographic covariates (e.g., sex, age, education, income, ethnicity) impacted sampling discrepancies on these outcomes.Results. Significant discrepancies emerged between samples on 73% of outcomes. Participants in the convenience samples held more positive thoughts towards and engaged in more COVID-19 prevention behaviours. Covariates attenuated sampling differences in only 55% of cases and increased differences in 45%. No covariate performed reliably well. Conclusion. Our results suggest that online convenience samples may display more positive dispositions towards COVID-19 prevention behaviours being studied than would samples drawn using more representative means. Adjusting results for demographic covariates frequently increased rather than decreased bias, suggesting that researchers should be cautious when interpreting adjusted findings. Using multiverse-style analyses as extended sensitivity analyses is recommended.

Education for sustainable development (ESD) is considered vital to the success of the United Nations¿ sustainable development goals. Systems thinking has been identified as a core competency that must be included in ESD. However, systems thinking-orientated ESD learning tools, established methods of the assessment of sustainability skills, and formal trials to demonstrate the effectiveness of such learning tools are all lacking. This research presents a randomised controlled trial (n = 106) to investigate whether an innovative online sustainability learning tool that incorporates two factors, systems thinking and system dynamics simulation, increases the understanding of a specific sustainability problem. A further aim was to investigate whether these factors also support the transfer of knowledge to a second problem with a similar systemic structure. The effects of the two factors were tested separately and in combination using a two-by-two factorial study design. ANOVA and related inferential statistical techniques were used to analyse the effect of the factors on sustainability understanding. Cohen¿s d effect sizes were also calculated. Simulation alone was found to increase ESD learning outcomes significantly, and also to support the transfer of skills, although less significantly. Qualitative feedback was also gathered from participants, most of whom reported finding systems thinking and simulation very helpful. This research was undertaken for the PhD studies of the corresponding author at the National University of Ireland Galway (NUIG) and was supported by funding from ResponSEAble (EU Horizon 2020 project number 652643), Ireland’s Higher Education Authority and Department of Further and Higher Education, Research, Innovation and Science (through the IT Investment Fund and ComputerDISC, and the COVID-19 Costed Extension), and the NUIG PhD Write-Up Bursary. peer-reviewed

The current study investigates the mental health condition of Mainland Chinese in Canada and identifies the associated sociodemographic and COVID-19-related predictors. A sample of 471 Mainland Chinese aged 18 or older completed an online survey that collected information on demographics, experience, cognition, and behaviours related to the COVID-19 pandemic and mental health condition. Mental health condition was assessed with the Depression, Anxiety, and Stress Scale-21 (DASS-21) for the depression, anxiety, and stress levels of Mainland Chinese during the pandemic. Moderate to severe depression, anxiety, and stress levels were respectively reported by 11.30%, 10.83%, and 5.10% of respondents. Univariate analysis of variance models (ANOVAs) were conducted to assess mental health condition variance as stratified by independent sociodemographic- or COVID-19-related explanatory variables, to identify possible predictors to be entered into the subsequent regression models. The regression models identified age, income level, health status, and perceived discrimination as significant sociodemographic predictors (absolute value of βs = 1.19–7.11, ps βs = 1.33–3.45, ps < 0.05) for mental health outcomes. The results shed light on our understanding of the major factors associated with the mental health condition of Mainland Chinese in Canada during the COVID-19 pandemic.

Background There are concerns that vaccine hesitancy may impede COVID-19 vaccine rollout and prevent the achievement of herd immunity. Vaccine hesitancy is a delay in acceptance or refusal of vaccines despite their availability. Objective We aimed to identify which people are more and less likely to take a COVID-19 vaccine and factors associated with vaccine hesitancy to inform public health messaging. Methods A Canadian cross-sectional survey was conducted in Canada in October and November 2020, prior to the regulatory approval of the COVID-19 vaccines. Vaccine hesitancy was measured by respondents answering the question “what would you do if a COVID-19 vaccine were available to you?” Negative binomial regression was used to identify the factors associated with vaccine hesitancy. Cluster analysis was performed to identify distinct clusters based on intention to take a COVID-19 vaccine, beliefs about COVID-19 and COVID-19 vaccines, and adherence to nonpharmaceutical interventions. Results Of 4498 participants, 2876 (63.9%) reported COVID-19 vaccine hesitancy. Vaccine hesitancy was significantly associated with (1) younger age (18-39 years), (2) lower education, and (3) non-Liberal political leaning. Participants that reported vaccine hesitancy were less likely to believe that a COVID-19 vaccine would end the pandemic or that the benefits of a COVID-19 vaccine outweighed the risks. Individuals with vaccine hesitancy had higher prevalence of being concerned about vaccine side effects, lower prevalence of being influenced by peers or health care professionals, and lower prevalence of trust in government institutions. Conclusions These findings can be used to inform targeted public health messaging to combat vaccine hesitancy as COVID-19 vaccine administration continues. Messaging related to preventing COVID among friends and family, highlighting the benefits, emphasizing safety and efficacy of COVID-19 vaccination, and ensuring that health care workers are knowledgeable and supported in their vaccination counselling may be effective for vaccine-hesitant populations.

Cet article s’appuie sur mon lien avec les fils à coudre et explore comment le défi en ligne 2020 Massive Microscopic Sensemaking (MMS) a contribué à un enchevêtrement émergent de l’espace-temps lié à COVID-19, à l’enseignement et à la recherche sur l’apprentissage médical en obstétrique, et à la réflexion plus approfondie de mon doctorat . Il explore les processus affirmatifs mis en œuvre pendant les périodes d’anxiété, lorsque mes pensées se frayaient un chemin à travers des espaces intermédiaires avec des moments et des matériaux différents qui étaient génératifs et productifs. J’explique mes mouvements rhizomatiques qui saignent à travers les séparations conventionnelles et les hypothèses de délimitation. Je m’appuie sur le réalisme agential de Karen Barad pour théoriser l’émergence de relations créatives avec des artefacts astucieux mis en scène avec des étudiants de premier cycle en médecine, avec des participants au projet MMS et avec mon propre doctorat en période de tension. This article draws on my connection with sewing threads, and explores how the 2020 Massive Microscopic Sensemaking (MMS) online challenge contributed to an emergent entanglement of timespacemattering related to COVID-19, teaching and researching medical learning in obstetrics, and thinking further with my PhD. It explores affirmative processes enacted during times of anxiety, when my thoughts needled through in-between spaces with different times and materials that were generative and productive. I explain my rhizomatic movements that bleed through conventional separations and boundary-making assumptions. I draw on Karen Barad’s agential realism to theorize the emergence of creative relationalities with artful artifacts enacted with medical undergraduate students, with participants in the MMS project, and with my own PhD during times of tension.

Comment donner un sens à ce qui est à la fois global et granulaire ? Cet essai visuel explore la relation entre le macro et le micro à travers les pratiques quotidiennes de création, de recadrage et de partage d'images. Il pose la question de savoir si de nouveaux modes de connaissance émergent ou si des modèles de création de sens préexistent, un équivalent psychologique ou social des formes fractales dans la nature. Cela est particulièrement pertinent si l'on considère que c'est précisément dans les détails banals et les actions quotidiennes de création de sens que naissent les structures d'interprétation futures. Alors que l'on traverse une période traumatique à l'échelle du globe, l'essai s'interroge sur la façon dont ces micro-pratiques pourraient contribuer à renforcer ou à résister aux relations existantes entre les humains, les technologies et la planète. How do we make sense of the global and granular at the same time? This visual essay explores the relationship of the macro and micro through everyday practices of image making, cropping, and sharing. It asks whether new ways of knowing emerge or if perhaps patterns of sensemaking pre-exist, a psychological or social equivalent to fractals in nature. This becomes relevant when we consider that it is precisely within the mundane details of everyday actions of sensemaking that future structures are born. In wonders about how, in times of global trauma, might these micro practices reinforce or resist existing relations among humans, technologies, and the planet.

L’article explore l’écoute médiatisée du point de vue de l’intimité pendant les premières semaines de la pandémie de coronavirus. Le cadre théorique s’appuie sur la littérature, sur l’écoute et la présence dans des environnements médiatisés, l’engagement du public et l’intimité en tant que connexions significatives. Méthodologiquement, l’étude est une ethnographie connective, les données ont été collectées par autoethnographie collaborative. Nos données montrent que l’écoute était une stratégie de perception individuelle du monde extérieur et un moyen de former une connectivité. Le filetage entre différents écrans sur les plates-formes numériques a provoqué l’effondrement de contextes publics et privés et, à travers ces derniers, des types particuliers d’intimité sont apparus. Lorsque la position des mères universitaires est souvent celle d’une “connaisseuse”, la crise grave les oblige à rechercher de manières réceptives de savoir, comme une écoute attentive des autres. L’écoute est un moyen de former l’appartenance et la compréhension, mais à partir d’une position silencieuse. Cela suggère que nous devrions accorder plus d’attention aux présences silencieuses et aux publics, dans les environnements médiatisés contemporains. This article explores mediated listening from the perspective of intimacy during the first weeks of the coronavirus pandemic. The theoretical frame builds on the literature on listening and presence in mediated environments, audience engagement, and intimacy as meaningful connections. Methodologically, the study is connective ethnography, and the data was collected by collaborative autoethnography. Our data show that listening was an individual sensemaking strategy of the outside world and a means to form connectedness. Threading between different screens on digital platforms caused the collapse of public and private contexts, and through these, particular types of intimacy arose. When the position of academic mothers is often that of a ‘knower,’ the severe crisis compels them to look for receptive ways of knowing, such as careful listening of others. Listening is a means to form belonging and understanding, but from a silent position. We should pay more attention to the silent presences and audiences in contemporary mediated environments.

La pandémie COVID-19 a occasionné une cruelle pédagogie au sujet du néolibéralisme. Le néolibéralisme incarne un processus présentant de multiples facettes selon lesquelles après les années mi-1970, le compromis Fordiste post-1945 a été graduellement transformé en un ordre mondial qui privilégiait la rivalité ou concurrence dans le monde des affaires comme pratique quotidienne et philosophie de règle. Cet ordre d’affaire fut empêtré dans une crise organique depuis 2007-8. Ceci a révélé progressivement le statut problématique du néolibéralisme en lien non seulement avec la pratique démocratique mais surtout avec la survie de notre espèce. Cet article se centre surtout sur les manières dont la pandémie a mis en lumière non seulement les contradictions au coeur du néolibéralisme, mais elle présage également leur impact grandissant. La pandemia de Covid-19 acarrea una pedagogía cruel en relación al neoliberalismo. El neoliberalismo encarna un proceso multifacético en el que el compromiso Fordista pos-1945 fue gradualmente transformado después de mediados de los años de 1970 en un mundo que privilegia la competición de los negocios como práctica diaria y como filosofía dominante. Este orden ha sido enmarañado en una “crisis orgánica” desde 2007-8, la que ha revelado progresivamente el status problemático del neoliberalismo con respecto no solo a la práctica de la democracia sino a la sobrevivencia de la especie humana. Este artículo discute específicamente las maneras en que la pandemia ha iluminado no sólo las contradicciones centrales del neoliberalismo sino presagia su intensificación y amplio impacto. The Covid-19 pandemic entailed a cruel pedagogy with regard to neoliberalism. Neoliberalism embodies a multifaceted process whereby the post-1945 Fordist compromise was gradually transformed, after the mid-1970s, into a world order privileging business competition, both as a daily practice and a philosophy of rule. This order has been enmeshed in an “organic crisis” since 2007-08, which has progressively revealed neoliberalism’s problematic status in relation not only to the practice of democracy, but to the survival of the species. This article focuses specifically on the ways in which the pandemic has not only illuminated neoliberalism’s core contradictions, but portends their intensification and widening impact.