• COVID-19
• 2014-2023close
• Open Access close
• ES close
• Diposit Digital de Documents de la UAB close
• COVID-19 close

Altres ajuts: Fundacio "la Caixa" (LCF/PR/SR20/52550004)

The communication industry in Colombia has promoted over the last decade a process of transformation and design of new proposals in both traditional media and digital natives, a range of operational strategies to distribute textual, sound, and visual formats through the social networks, adapting the content to the particularities and attributes of each one of them. The irruption of the implementation of the peace accords, the pandemic and citizen nonconformity taken to the streets have served to verify the real dimension of this reconfiguration, as well as its effectiveness in terms of credibility and scope in the face of an unprecedented scenario that has transformed the social and cultural interaction of citizens through technology. This research focuses on the response of Colombian journalistic agents to the demand for information during the period 2019, 2020 and 2021, from a mixed quantitative-descriptive methodology that allows identifying, quantifying, and assessing the relationship between newspapers, radio stations and television channels with the new platforms. The corpus of the study is made up of the publications on social networks of the Colombian media with the greatest circulation according to the Colombian Association for Media Research: two newspapers (El tiempo and El espectador), five radio stations (Caracol radio, W radio, Blu radio, RCN radio and La FM) and the news from the two television networks with the highest audience (Noticias Caracol and Noticias RCN). The results of the study show a reinforcement of the brand of the journalistic company as a reference for information and credibility, however, the current situation has not served to legitimize the role of journalists in social networks and has underlined the fragility of a media ecosystem highly exposed to polarization, manipulation, and mistrust. Resumen La industria de la comunicación en Colombia ha impulsado a lo largo de la última década un proceso de transformación y diseño de nuevas propuestas tanto en medios tradicionales como en nativos digitales, gama de estrategias operativas para distribuir formatos textuales, sonoros y visuales a través de las redes sociales, adaptando los contenidos a las particularidades y atributos de cada una de ellas. La irrupción de la implementación de los acuerdos de paz, la pandemia y el inconformismo ciudadano llevado a las calles han servido para constatar la dimensión real de esa reconfiguración, así como su efectividad en términos de credibilidad y alcance ante un escenario inédito que ha transformado la interacción social y cultural de los ciudadanos a través de la tecnología. Esta investigación centra su atención en la respuesta de los agentes periodísticos colombianos a la demanda de información durante el periodo 2019, 2020 y 2021, desde una metodología mixta cuantitativo-descriptiva que permite identificar, cuantificar y valorar la relación entre periódicos, emisoras de radio y canales de televisión con las nuevas plataformas. El corpus del estudio está compuesto por las publicaciones en redes sociales de los medios colombianos con mayor difusión según la Asociación Colombiana de Investigación de Medios: dos periódicos (El tiempo y El espectador), cinco cadenas de radio (Caracol radio, W radio, Blu radio, RCN radio y La FM) y los informativos de las dos cadenas televisivas de mayor audiencia (Noticias Caracol y Noticias RCN). Los resultados del estudio evidencian un refuerzo de la marca de la empresa periodística como referente de información y credibilidad, no obstante, la coyuntura del momento no ha servido para legitimar el papel de los periodistas en las redes sociales, y ha subrayado la fragilidad de un ecosistema mediático muy expuesto a la polarización, la manipulación y la desconfianza.

AG has received support by NordForsk Nordic Trial Alliance (NTA) grant, by Academy of Finland Fellow grant N. 323116 and the Academy of Finland for PREDICT consortium N. 340541. The Richards research group is supported by the Canadian Institutes of Health Research (CIHR) (365825 and 409511), the Lady Davis Institute of the Jewish General Hospital, the Canadian Foundation for Innovation (CFI), the NIH Foundation, Cancer Research UK, Genome Québec, the Public Health Agency of Canada, the McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé (FRQS). TN is supported by a research fellowship of the Japan Society for the Promotion of Science for Young Scientists. GBL is supported by a CIHR scholarship and a joint FRQS and Québec Ministry of Health and Social Services scholarship. JBR is supported by an FRQS Clinical Research Scholarship. Support from Calcul Québec and Compute Canada is acknowledged. TwinsUK is funded by the Welcome Trust, the Medical Research Council, the European Union, the National Institute for Health Research-funded BioResource and the Clinical Research Facility and Biomedical Research Centre based at Guy’s and St. Thomas’ NHS Foundation Trust in partnership with King’s College London. The Biobanque Québec COVID19 is funded by FRQS, Genome Québec and the Public Health Agency of Canada, the McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé. These funding agencies had no role in the design, implementation or interpretation of this study. The COVID19-Host(a)ge study received infrastructure support from the DFG Cluster of Excellence 2167 “Precision Medicine in Chronic Inflammation (PMI)” (DFG Grant: “EXC2167”). The COVID19-Host(a)ge study was supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the Computational Life Sciences funding concept (CompLS grant 031L0165). Genotyping in COVID19-Host(a)ge was supported by a philantropic donation from Stein Erik Hagen. The COVID GWAs, Premed COVID-19 study (COVID19-Host(a)ge_3) was supported by "Grupo de Trabajo en Medicina Personalizada contra el COVID-19 de Andalucia"and also by the Instituto de Salud Carlos III (CIBERehd and CIBERER). Funding comes from COVID-19-GWAS, COVID-PREMED initiatives. Both of them are supported by "Consejeria de Salud y Familias" of the Andalusian Government. DMM is currently funded by the the Andalussian government (Proyectos Estratégicos-Fondos Feder PE-0451-2018). The Columbia University Biobank was supported by Columbia University and the National Center for Advancing Translational Sciences, NIH, through Grant Number UL1TR001873. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or Columbia University. The SPGRX study was supported by the Consejería de Economía, Conocimiento, Empresas y Universidad #CV20-10150. The GEN-COVID study was funded by: the MIUR grant “Dipartimenti di Eccellenza 2018-2020” to the Department of Medical Biotechnologies University of Siena, Italy; the “Intesa San Paolo 2020 charity fund” dedicated to the project NB/2020/0119; and philanthropic donations to the Department of Medical Biotechnologies, University of Siena for the COVID-19 host genetics research project (D.L n.18 of March 17, 2020). Part of this research project is also funded by Tuscany Region “Bando Ricerca COVID-19 Toscana” grant to the Azienda Ospedaliero Universitaria Senese (CUP I49C20000280002). Authors are grateful to: the CINECA consortium for providing computational resources; the Network for Italian Genomes (NIG) (http://www.nig.cineca.it) for its support; the COVID-19 Host Genetics Initiative (https://www.covid19hg.org/); the Genetic Biobank of Siena, member of BBMRI-IT, Telethon Network of Genetic Biobanks (project no. GTB18001), EuroBioBank, and RD-Connect, for managing specimens. Genetics against coronavirus (GENIUS), Humanitas University (COVID19-Host(a)ge_4) was supported by Ricerca Corrente (Italian Ministry of Health), intramural funding (Fondazione Humanitas per la Ricerca). The generous contribution of Banca Intesa San Paolo and of the Dolce&Gabbana Fashion Firm is gratefully acknowledged. Data acquisition and sample processing was supported by COVID-19 Biobank, Fondazione IRCCS Cà Granda Milano; LV group was supported by MyFirst Grant AIRC n.16888, Ricerca Finalizzata Ministero della Salute RF-2016-02364358, Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, the European Union (EU) Programme Horizon 2020 (under grant agreement No. 777377) for the project LITMUS- “Liver Investigation: Testing Marker Utility in Steatohepatitis”, Programme “Photonics” under grant agreement “101016726” for the project “REVEAL: Neuronal microscopy for cell behavioural examination and manipulation”, Fondazione Patrimonio Ca’ Granda “Liver Bible” PR-0361. DP was supported by Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, CV PREVITAL “Strategie di prevenzione primaria nella popolazione Italiana” Ministero della Salute, and Associazione Italiana per la Prevenzione dell’Epatite Virale (COPEV). Genetic modifiers for COVID-19 related illness (BeLCovid_1) was supported by the "Fonds Erasme". The Host genetics and immune response in SARS-Cov-2 infection (BelCovid_2) study was supported by grants from Fondation Léon Fredericq and from Fonds de la Recherche Scientifique (FNRS). The INMUNGEN-CoV2 study was funded by the Consejo Superior de Investigaciones Científicas. KUL is supported by the German Research Foundation (LU 1944/3-1) SweCovid is funded by the SciLifeLab/KAW national COVID-19 research program project grant to Michael Hultström (KAW 2020.0182) and the Swedish Research Council to Robert Frithiof (2014-02569 and 2014-07606). HZ is supported by Jeansson Stiftelser, Magnus Bergvalls Stiftelse. The COMRI cohort is funded by Technical University of Munich, Munich, Germany. Genotyping for the COMRI cohort was performed and funded by the Genotyping Laboratory of Institute for Molecular Medicine Finland FIMM Technology Centre, University of Helsinki, Helsinki, Finland. These funding agencies had no role in the design, implementation or interpretation of this study. Background: There is considerable variability in COVID-19 outcomes amongst younger adults—and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium. Method: The major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by age and were independent from known clinical COVID-19 risk factors. Findings: We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (hazard ratio [HR] 1·4, 95% confidence interval [CI] 1·2–1·6) and COVID-19 related mortality (HR 1·5, 95%CI 1·3–1·8). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (odds ratio [OR] 2·0, 95%CI 1·6-2·6), venous thromboembolism (OR 1·7, 95%CI 1·2-2·4), and hepatic injury (OR 1·6, 95%CI 1·2-2·0). Risk allele carriers ≤ 60 years had higher odds of death or severe respiratory failure (OR 2·6, 95%CI 1·8-3·9) compared to those > 60 years OR 1·5 (95%CI 1·3-1·9, interaction p-value=0·04). Amongst individuals ≤ 60 years who died or experienced severe respiratory COVID-19 outcome, we found that 31·8% (95%CI 27·6-36·2) were risk variant carriers, compared to 13·9% (95%CI 12·6-15·2%) of those not experiencing these outcomes. Prediction of death or severe respiratory failure among those ≤ 60 years improved when including the risk allele (AUC 0·82 vs 0·84, p=0·016) and the prediction ability of rs10490770 risk allele was similar to, or better than, most established clinical risk factors. Interpretation: The major common COVID-19 risk locus on chromosome 3 is associated with increased risks of morbidity and mortality—and these are more pronounced amongst individuals ≤ 60 years. The effect on COVID-19 severity was similar to, or larger than most established risk factors, suggesting potential implications for clinical risk management. CV PREVITAL “Strategie di prevenzione primaria nella popolazione Italiana” Ministero della Salute, and Associazione Italiana per la Prevenzione dell’Epatite Virale (COPEV) Genotyping Laboratory of Institute for Molecular Medicine Finland FIMM Technology Centre, University of Helsinki, Helsinki, Finland Clinical Research Facility and Biomedical Research Centre based at Guy’s and St. Thomas’ NHS Foundation Trust McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé (FRQS) CIHR scholarship and a joint FRQS and Québec Ministry of Health and Social Services scholarship European Union (EU) Programme Horizon 2020 (under grant agreement No. 777377) "Grupo de Trabajo en Medicina Personalizada contra el COVID-19 de Andalucia" “Intesa San Paolo 2020 charity fund” dedicated to the project NB/2020/0119 Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico SciLifeLab/KAW national COVID-19 research program project (KAW 2020.0182) Andalusian government (Proyectos Estratégicos-Fondos Feder PE-0451-2018) Consejería de Economía, Conocimiento, Empresas y Universidad #CV20-10150 Canadian Institutes of Health Research (CIHR) (365825 and 409511) Japan Society for the Promotion of Science for Young Scientists "Consejeria de Salud y Familias" of the Andalusian Government McGill Interdisciplinary Initiative in Infection and Immunity Ricerca Finalizzata Ministero della Salute RF-2016-02364358 National Institute for Health Research-funded BioResource Fondazione Patrimonio Ca’ Granda “Liver Bible” PR-0361 Swedish Research Council (2014-02569 and 2014-07606) Instituto de Salud Carlos III (CIBERehd and CIBERER) National Center for Advancing Translational Sciences Academy of Finland for PREDICT consortium N. 340541. Lady Davis Institute of the Jewish General Hospital MIUR grant “Dipartimenti di Eccellenza 2018-2020” Technical University of Munich, Munich, Germany Jeansson Stiftelser, Magnus Bergvalls Stiftelse Tuscany Region “Bando Ricerca COVID-19 Toscana” Consejo Superior de Investigaciones Científicas Ricerca Corrente (Italian Ministry of Health) Academy of Finland Fellow grant N. 323116 Fonds de la Recherche Scientifique (FNRS) German Research Foundation (LU 1944/3-1) Canadian Foundation for Innovation (CFI) Fondazione Humanitas per la Ricerca FRQS Clinical Research Scholarship Fondazione IRCCS Cà Granda Milano Network for Italian Genomes (NIG) COVID-19 Host Genetics Initiative Fonds de Recherche Québec Santé Public Health Agency of Canada NIH Grant Number UL1TR001873 Dolce&Gabbana Fashion Firm MyFirst Grant AIRC n.16888 COVID-PREMED initiatives Genetic Biobank of Siena Fondation Léon Fredericq “Photonics” “101016726” (CompLS grant 031L0165) Banca Intesa San Paolo Medical Research Counc (DFG Grant: “EXC2167”) King’s College London Columbia University Cancer Research UK CINECA consortium COVID-19 Biobank Stein Erik Hagen Compute Canada "Fonds Erasme" NIH Foundation European Union Genome Québec COVID-19-GWAS Calcul Québec Welcome Trust EuroBioBank RD-Connect

Emerging and re-emerging pathogens represent a substantial threat to public health, as demonstrated with numerous outbreaks over the past years, including the 2013–2016 outbreak of Ebola virus in western Africa. Coronaviruses are also a threat for humans, as evidenced in 2002/2003 with infection by the severe acute respiratory syndrome coronavirus (SARS-CoV), which caused more than 8000 human infections with 10% fatality rate in 37 countries. Ten years later, a novel human coronavirus (Middle East respiratory syndrome coronavirus, MERS-CoV), associated with severe pneumonia, arose in the Kingdom of Saudi Arabia. Until December 2016, MERS has accounted for more than 1800 cases and 35% fatality rate. Finding an animal model of disease is key to develop vaccines or antivirals against such emerging pathogens and to understand its pathogenesis. Knowledge of the potential role of domestic livestock and other animal species in the transmission of pathogens is of importance to understand the epidemiology of the disease. Little is known about MERS-CoV animal host range. In this paper, experimental data on potential hosts for MERS-CoV is reviewed. Advantages and limitations of different animal models are evaluated in relation to viral pathogenesis and transmission studies. Finally, the relevance of potential new target species is discussed.

Adolescence is a critical period in the consolidation of healthy lifestyles that can last into adulthood. To analyze changes in food consumption and eating behaviors in high-school adolescents during the first confinement, a cross-sectional study was conducted at the end of confinement in Spain. Changes in the frequency or quantity of consumption of different types of food and food-related behaviors were analyzed. Socioeconomic and health-related variables were also considered. To determine whether dietary changes were related to socioeconomic position (SEP), Poisson regression models with robust variance were estimated. Overall, there were some changes towards a healthier diet such as an increase in fruit consumption (38.9%) and a decrease in the consumption of soft drinks (49.8%), sweets and pastries (39.3%), and convenience foods (49.2%). Some changes, however, were related to less healthy behaviors, such as a more irregular pattern of meal distribution (39.9%) or an increase in snacking between meals (56.4%). Changes towards less healthy eating were also related to students’ SEP. The risk of worsening the diet was found to be 21% higher in adolescents from a more disadvantaged SEP. Future public policies could be adapted to avoid increasing nutritional and health inequalities.

Within just a few weeks, COVID-19 has caused unprecedented lockdowns, the extensive use of emergency powers, shifts in how and who makes decisions, and unforeseen consequences for marginalized and newly marginalized individuals. Political leaders and journalists were quick to blame animals, such as bats and pangolins, as the ones "responsible" for this crisis. These accusations have led to animals being stigmatized globally; in some places, they were burned or otherwise killed by the hundreds. Framing animals as the scapegoats of the Corona crisis, however, is neither useful nor justified. Ultimately, it isn't animals themselves, but the way in which we treat them that is the true cause of the pandemic. For the first time in history, experts from diverse fields such as has epidemiology, biology, chemistry, physics, and public health have called for a fundamental change in our relationships with animals. However, they do not sufficiently address what this change and our relationships with animals should look like in the future. Drawing on the recent "political turn" in animal ethics, this paper argues that COVID-19 prompts us to begin working to establish a Zoopolis - a shared interspecies society between humans and domesticated animals, and the recognition of wild animals as sovereigns. In doing so, the paper discusses linkages between pandemics and factory farming, structural similarities between human and animal oppression, and opportunities to consider animals in determining the public good, and to work toward a shared interspecies society. En tan solo unas pocas semanas, el COVID-19 ha causado bloqueos sin precedentes, el uso extensivo de poderes de emergencia, cambios en cómo y quién toma decisiones y consecuencias imprevistas para las personas marginadas y recientemente marginadas. Los líderes políticos y periodistas se apresuraron a culpar a los animales, como murciélagos y pangolines, como los "responsables" de esta crisis. Estas acusaciones han llevado a que los animales sean estigmatizados a nivel mundial; en algunos lugares, fueron quemados o asesinados por cientos. Sin embargo, enmarcar a los animales como chivos expiatorios de la crisis del Corona no es útil ni está justificado. En última instancia, no son los animales en sí mismos, sino la forma en que los tratamos, la verdadera causa de la pandemia. Por primera vez en la historia, expertos de diversos campos como la epidemiología, la biología, la química, la física y la salud pública han pedido un cambio fundamental en nuestras relaciones con los animales. Sin embargo, no abordan suficientemente cómo deberían ser este cambio y nuestras relaciones con los animales en el futuro. Basándose en el reciente "giro político" en la ética animal, este documento sostiene que el COVID-19 nos impulsa a comenzar a trabajar para establecer una Zoopolis, una sociedad interespecie compartida entre humanos y animales domésticos, y el reconocimiento de los animales salvajes como soberanos. Al hacerlo, el documento analiza los vínculos entre las pandemias y la agricultura industrial, las similitudes estructurales entre la opresión humana y animal y las oportunidades para considerar a los animales de cara a determinar el bien público y trabajar hacia una sociedad interespecie compartida.

The COVID-19 pandemic has sharpened the inequalities in our societies. In Spain, we observed that the impact on schooling varied according to socioeconomic, gender and sociocultural variables. In this article, we present a case analysis illustrating the impact of the COVID-19 pandemic on schooling in early educational grades (ages 3–6), which leads us to focus on school-family relationship. First, we present some studies that show the inequalities in education during the lockdown period, the digital divide faced by both schools and families and how digital mediation impacts school-family relationships. Then we will introduce our study, which aims to explore the uses, potentials and limitations of an app intended to facilitate the relationship. Our study took place during September 2020-January 2021, when social restriction persisted. It took the form of a telematic ethnography in which we monitored the meetings of the Early Childhood Education teachers and their interaction with the families via an app-based communication tool. Results have allowed us to identify that most conversations are initiated by the school and their aim is to show families the classroom activities. We have also observed some advantages regarding the use of this app: communication can become more direct and immediate, and teachers have developed strategies to foster proximity in this relationship, as well as to respond inclusively to diversity. Regarding the challenges, we identified the lack of involvement of some families, the need to transform the roles played by families and children, and the difficulty to maintain personalized relationships This research was funded by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO), the Spanish State Research Agency (AEI), and the European Regional Development Funds (European Union), grant number EDU2017-83363-R

The ongoing Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks pose a worldwide public health threat. Blocking MERS-CoV zoonotic transmission from dromedary camels, the animal reservoir, could potentially reduce the number of primary human cases. Here we report MERS-CoV transmission from experimentally infected llamas to naïve animals. Directly inoculated llamas shed virus for at least 6 days and could infect all in-contact naïve animals 4-5 days after exposure. With the aim to block virus transmission, we examined the efficacy of a recombinant spike S1-protein vaccine. In contrast to naïve animals, in-contact vaccinated llamas did not shed infectious virus upon exposure to directly inoculated llamas, consistent with the induction of strong virus neutralizing antibody responses. Our data provide further evidence that vaccination of the reservoir host may impede MERS-CoV zoonotic transmission to humans. info:eu-repo/semantics/publishedVersion

Infiltration of immune cells in the central nervous system is a common hallmark in different neuroinflammatory conditions. Accumulating evidences indicate that resident glial cells can establish a cross-talk with infiltrated immune cells, including T-cells, regulating their recruitment, activation and function within the CNS. Although the healthy CNS has been though to be devoid of professional dendritic cells (DCs), numerous studies have been reported the presence of a population of DCs in specific locations such as the meninges, choroid plexuses and the perivascular space. Moreover, the infiltration of DC-precursors during neuroinflammatory situations has been proposed, suggesting a putative role of these cells in the regulation of lymphocyte activity within the CNS. On the other hand, under determined circumstances, microglial cells are able to acquire a phenotype of DC expressing a wide range of molecules that equipped these cells with all the necessary machinery for the communication with T-cells. In this review we summarize the current knowledge on the expression of molecules involved in the cross-talk with T-cells in both microglial cells and DCs and discuss the potential contribution of each of these cell populations on the control of lymphocyte function within the CNS.

The article compares the way COVID-19 has been managed in the East African Community and in the EU. How were the initial measures in each of the regions and what have been the consequences of the measures adopted, especially those related to confinement and vaccination. It discusses how the strength of European integration and the notable economic and technological development of its member states have provided a comparative advantage over the resources available to the East African Community. They conclude that, in addition to the undoubted importance of advancing in economic development, continuing to deepen regional cooperation in African territory would be an opportunity to better manage future threats. L'article compara la manera com s'ha gestionat la COVID-19 a la Comunitat d'Àfrica Oriental ia la UE. Com van ser les mesures inicials a cadascuna de les regions i quines han estat les conseqüències que han tingut les mesures adoptades, especialment les relacionades amb el confinament i la vacunació. Planteja com la solidesa de la integració europea i el notable desenvolupament econòmic i tecnològic dels seus Estats membres han suposat un avantatge comparatiu respecte als recursos amb què han comptat la Comunitat de l'Àfrica Oriental. Conclouen que, a més de la importància indubtable d'avançar en el desenvolupament econòmic, continuar aprofundint en la cooperació regional en territori africà suposaria una oportunitat per poder gestionar millor amenaces futures. El artículo compara la forma en que se ha gestionado la COVID-19 en la Comunidad de África Oriental y en la UE. Cómo fueron las medidas iniciales en cada una de las regiones y cuáles han sido las consecuencias que han tenido las medidas adoptadas, especialmente las relacionadas con el confinamiento y la vacunación. Plantea cómo la solidez de la integración europea y el notable desarrollo económico y tecnológico de sus Estados miembros han supuesto una ventaja comparativa, respecto a los recursos con los que han contado la Comunidad de África Oriental. Concluyen que, además de la indudable importancia de avanzar en el desarrollo económico, seguir profundizando en la cooperación regional en territorio africano supondría una oportunidad para poder gestionar mejor futuras amenazas.