Quick search
Advanced search in
Research outcomes
Field to searchTerm
Add rule
Filters (3)
The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
Download Results
7 research outcomes, page 1 of 1
  • publication . Article . 2016
    Open Access English
    Authors:
    Mauthe, Mario; Langereis, Martijn; Jung, Jennifer; Zhou, Xingdong; Jones, Alex; Omta, Wienand; Tooze, Sharon A.; Stork, Björn; Paludan, Søren Riis; Ahola, Tero; ...
    Project: EC | XABA (282333), AKA | Mechanisms in the formati... (265997), WT , NWO | The role of autophagy in ... (2300175628), NWO | Viral strategies to evade... (2300180032), NWO | A three-dimensional look ... (2300175771), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy-related (ATG) proteins regulate autophagy, but recent work indicates that some also have autophagy-independent roles. Here, Mauthe et al. perform an unbiased siRNA screen to examine the effects of ATG protein depletion on viral replication and demonstrate auto...

    Add to ORCIDorcid
  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

  • publication . Article . 2017
    Open Access English
    Authors:
    Melia, Charlotte E.; van der Schaar, Hilde M.; Lyoo, Heyrhyoung; Limpens, Ronald W.A.L.; Feng, Qian; Wahedi, Maryam; Overheul, Gijs J.; van Rij, Ronald P.; Snijder, Eric J.; Koster, Abraham J.; ...
    Project: NWO | The +RNA virus replicatio... (2300150213), EC | EUVIRNA (264286), NWO | SysVirDrug: Translating S... (2300189186), NWO | Viral redesign of the cel... (2300174141), EC | VIVARNASILENCING (615680), EC | ANTIVIRALS (642434)

    Summary Enteroviruses reorganize cellular endomembranes into replication organelles (ROs) for genome replication. Although enterovirus replication depends on phosphatidylinositol 4-kinase type IIIβ (PI4KB), its role, and that of its product, phosphatidylinositol 4-phosp...

    Add to ORCIDorcid
  • publication . Article . 2015
    Open Access English
    Authors:
    Cristina M. Dorobantu; Lucian Albulescu; Christian Harak; Qian Feng; Mirjam van Kampen; Jeroen R.P.M. Strating; Alexander E. Gorbalenya; Volker Lohmann; Hilde M. van der Schaar; Frank J. M. van Kuppeveld;
    Project: NWO | Viral redesign of the cel... (2300174141), EC | EUVIRNA (264286), NWO | Greasing the viral life-c... (2300174167)

    Author Summary All positive-sense RNA viruses [(+)RNA viruses] replicate their viral genomes in tight association with reorganized membranous structures. Viruses generate these unique structures, often termed “replication organelles” (ROs), by efficiently manipulating t...

    Add to ORCIDorcid
  • publication . Article . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Landi, Alessia; Mari, Muriel; Kleiser, Svenja; Wolf, Tobias; Gretzmeier, Christine; Wilhelm, Isabel; Kiritsi, Dimitra; Thünauer, Roland; Geiger, Roger; Nyström, Alexander; ...
    Publisher: Life Science Alliance, LLC
    Project: EC | LEC&LIP2INVADE (282105), EC | DRIVE (765912), NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660)

    Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aerugi...

    Add to ORCIDorcid
  • publication . Article . 2016
    Open Access English
    Authors:
    Flierman, Dennis; van der Heden van Noort, Gerbrand J.; Ekkebus, Reggy; Geurink, Paul P.; Mevissen, Tycho E.T.; Hospenthal, Manuela K.; Komander, David; Ovaa, Huib;
    Publisher: The Authors. Published by Elsevier Ltd.
    Project: NWO | Covalent Enzyme Capture (2300182105), NWO | Targeting poly-ubiquitin;... (2300185720), EC | UBSPECIFIC (309756), EC | UBICODE (281699)

    Deubiquitylating enzymes (DUBs) use multiple ubiquitin-binding pockets to disassemble polyubiquitin chains. Most tools probing DUB specificity target pockets adjacent to the active site. The protease-resistant diUb probes described here monitor linkage specificity of an...

    Add to ORCIDorcid
  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Yingying Cong; Pauline Verlhac; Fulvio Reggiori;
    Publisher: MDPI AG
    Project: NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

    Add to ORCIDorcid
7 research outcomes, page 1 of 1