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57 research outcomes, page 1 of 6
  • publication . Other literature type . Article . 2020 . Embargo End Date: 07 Dec 2020
    Open Access English
    Authors:
    Eric A. Meyerowitz; Aaron Richterman; Isaac I. Bogoch; Nicola Low; Muge Cevik;
    Publisher: Elsevier
    Project: SNSF | Zika virus: causality, op... (320030_176233), CIHR , EC | EpiPose (101003688)

    People with persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection experience no symptoms throughout the course of infection, and pre-symptomatic individuals become infectious days before they report symptoms. Transmission of SA...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Kallewaard, Nicole L.; Corti, Davide; Collins, Patrick J.; Neu, Ursula; McAuliffe, Josephine M.; Benjamin, Ebony; Wachter-Rosati, Leslie; Palmer-Hill, Frances J.; Yuan, Andy Q.; Walker, Philip A.; ...
    Persistent Identifiers
    Project: EC | INFLUENZA FUSION (629829), EC | BROADimmune (670955), SNSF | Analytic vaccinology (310030B_160279)

    Highlights • Binding to all influenza A subtypes neutralizing seasonal and pandemic strains • Utilizes a rare VH (VH6-1) and carries a low level of somatic mutations • Highly conserved epitope encompassing fusion peptide and hydrophobic groove • Superior therapeutic win...

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  • publication . Article . Other literature type . 2014
    Open Access
    Authors:
    Mindaugas Juozapaitis; Étori Aguiar Moreira; Ignacio Mena; Sebastian Giese; David Riegger; Anne Pohlmann; Dirk Höper; Gert Zimmer; Martin Beer; Adolfo García-Sastre; ...
    Persistent Identifiers
    Project: EC | EMPERIE (223498), SNSF | RNA replicons addressing ... (310030_129669)

    In 2012, the complete genomic sequence of a new and potentially harmful influenza A-like virus from bats (H17N10) was identified. However, infectious influenza virus was neither isolated from infected bats nor reconstituted, impeding further characterization of this vir...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Emilia Mikola; Varpu Elenius; Maria Saarinen; Oscar Palomares; Matti Waris; Riitta Turunen; Tuomo Puhakka; Lotta E. Ivaska; Beate Rückert; Alar Aab; ...
    Publisher: Wiley
    Project: AKA | Viral Inception of Asthma... (132595), SNSF | T cell interaction with t... (320030_132899), EC | PREDICTA (260895), AKA | Viral Inception of Asthma (114034)

    Background: Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between patients with tonsillar hypertrophy or recurrent...

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  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Thiel, Volker;
    Project: EC | HONOURs (721367), SNSF | Viral Plasticity Underlyi... (CRSII3_160780)

    The scientific community, politicians, decision makers, and the lay public have to continue, and probably intensify, a discussion on benefits and risks of synthetic biology in a broader sense. The impact of synthetic biology goes far beyond the question of Dual Use Rese...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Bhattacharya, Anannya; Hegazy, Ahmed N.; Deigendesch, Nikolaus; Kosack, Lindsay; Cupovic, Jovana; Kandasamy, Richard K.; Hildebrandt, Andrea; Merkler, Doron; Kühl, Anja A.; Vilagos, Bojan; ...
    Persistent Identifiers
    Publisher: The Authors. Published by Elsevier Inc.
    Project: SNSF | Viral triggers and gray m... (PP00P3_152928), EC | I-FIVE (250179), EC | GUT TC PHENOTYPES (330621)

    Bergthaler and colleagues show that superoxide dismutase 1 protects the liver from type I interferon-driven oxidative damage in viral hepatitis. Liver damage was mediated by hepatocyte-intrinsic IFNAR1-STAT1 signaling.

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  • publication . Article . 2016
    Open Access English
    Authors:
    Mauthe, Mario; Langereis, Martijn; Jung, Jennifer; Zhou, Xingdong; Jones, Alex; Omta, Wienand; Tooze, Sharon A.; Stork, Björn; Paludan, Søren Riis; Ahola, Tero; ...
    Project: EC | XABA (282333), AKA | Mechanisms in the formati... (265997), WT , NWO | The role of autophagy in ... (2300175628), NWO | Viral strategies to evade... (2300180032), NWO | A three-dimensional look ... (2300175771), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy-related (ATG) proteins regulate autophagy, but recent work indicates that some also have autophagy-independent roles. Here, Mauthe et al. perform an unbiased siRNA screen to examine the effects of ATG protein depletion on viral replication and demonstrate auto...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Philip V’kovski; Mitra Gultom; Jenna N. Kelly; Silvio Steiner; Julie Russeil; Bastien Mangeat; Elisa Cora; Joern Pezoldt; Melle Holwerda; Annika Kratzel; ...
    Publisher: Public Library of Science (PLoS)
    Project: EC | HONOURs (721367), SNSF | Host innate immune respon... (310030_173085), SNSF | Viral Plasticity Underlyi... (CRSII3_160780), SNSF | Real-time pandemic functi... (31CA30_196644), SNSF | Molecular characterizatio... (310030_179260)

    Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major public health burden. Despite its close phylogenetic relationship to SARS-CoV, SARS-CoV-2 exhibits increased human-to-human transmis...

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  • other research product . Collection . 2020
    Authors:
    Warne, David J.; Ebert, Anthony; Drovandi, Christopher; Wenbiao Hu; Mira, Antonietta; Mengersen, Kerrie;
    Publisher: figshare
    Project: SNSF | Statistical Inference on ... (105218_163196), ARC | Discovery Projects - Gran... (DP200102101), EC | PERISCOPE (101016233)

    Abstract Background The global impact of COVID-19 and the country-specific responses to the pandemic provide an unparalleled opportunity to learn about different patterns of the outbreak and interventions. We model the global pattern of reported COVID-19 cases during th...

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  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

57 research outcomes, page 1 of 6