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42 research outcomes, page 1 of 5
  • publication . Article . 2016
    Open Access English
    Authors:
    Nicole L. Kallewaard; Davide Corti; Patrick J. Collins; Ursula Neu; Josephine M. McAuliffe; Ebony Benjamin; Leslie Wachter-Rosati; Frances J. Palmer-Hill; Andy Q. Yuan; Philip A. Walker; ...
    Persistent Identifiers
    Publisher: The Authors. Published by Elsevier Inc.
    Project: EC | BROADimmune (670955), SNSF | Analytic vaccinology (310030B_160279), EC | INFLUENZA FUSION (629829)

    Highlights • Binding to all influenza A subtypes neutralizing seasonal and pandemic strains • Utilizes a rare VH (VH6-1) and carries a low level of somatic mutations • Highly conserved epitope encompassing fusion peptide and hydrophobic groove • Superior therapeutic win...

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  • publication . Article . Other literature type . 2014
    Open Access
    Authors:
    Mindaugas Juozapaitis; Étori Aguiar Moreira; Ignacio Mena; Sebastian Giese; David Riegger; Anne Pohlmann; Dirk Höper; Gert Zimmer; Martin Beer; Adolfo García-Sastre; ...
    Persistent Identifiers
    Project: EC | EMPERIE (223498), SNSF | RNA replicons addressing ... (310030_129669)

    In 2012, the complete genomic sequence of a new and potentially harmful influenza A-like virus from bats (H17N10) was identified. However, infectious influenza virus was neither isolated from infected bats nor reconstituted, impeding further characterization of this vir...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Emilia Mikola; Varpu Elenius; Maria Saarinen; Oscar Palomares; Matti Waris; Riitta Turunen; Tuomo Puhakka; Lotta E. Ivaska; Beate Rückert; Alar Aab; ...
    Publisher: Wiley
    Project: SNSF | T cell interaction with t... (320030_132899), AKA | Viral Inception of Asthma (114034), AKA | Viral Inception of Asthma... (132595), EC | PREDICTA (260895)

    Background: Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between patients with tonsillar hypertrophy or recurrent...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Volker Thiel;
    Publisher: Public Library of Science (PLoS)
    Project: SNSF | Viral Plasticity Underlyi... (CRSII3_160780), EC | HONOURs (721367)

    The scientific community, politicians, decision makers, and the lay public have to continue, and probably intensify, a discussion on benefits and risks of synthetic biology in a broader sense. The impact of synthetic biology goes far beyond the question of Dual Use Rese...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Anannya Bhattacharya; Ahmed N. Hegazy; Nikolaus Deigendesch; Lindsay Kosack; Jovana Cupovic; Richard K. Kandasamy; Andrea Hildebrandt; Doron Merkler; Anja A. Kühl; Bojan Vilagos; ...
    Persistent Identifiers
    Publisher: The Authors. Published by Elsevier Inc.
    Project: SNSF | Viral triggers and gray m... (PP00P3_152928), EC | I-FIVE (250179), EC | GUT TC PHENOTYPES (330621)

    Bergthaler and colleagues show that superoxide dismutase 1 protects the liver from type I interferon-driven oxidative damage in viral hepatitis. Liver damage was mediated by hepatocyte-intrinsic IFNAR1-STAT1 signaling.

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  • publication . Article . 2016
    Open Access English
    Authors:
    Mario Mauthe; Martijn A. Langereis; Jennifer Jung; Xingdong Zhou; Alex Jones; Wienand A. Omta; Sharon A. Tooze; Bjoern Stork; Søren R. Paludan; Tero Ahola; ...
    Project: NWO | A three-dimensional look ... (2300175771), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), EC | XABA (282333), WT , NWO | Viral strategies to evade... (2300180032), NWO | The role of autophagy in ... (2300175628), AKA | Mechanisms in the formati... (265997)

    Autophagy-related (ATG) proteins regulate autophagy, but recent work indicates that some also have autophagy-independent roles. Here, Mauthe et al. perform an unbiased siRNA screen to examine the effects of ATG protein depletion on viral replication and demonstrate auto...

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  • publication . Article . 2021
    Open Access
    Authors:
    Philip V’kovski; Mitra Gultom; Jenna N. Kelly; Silvio Steiner; Julie Russeil; Bastien Mangeat; Elisa Cora; Joern Pezoldt; Melle Holwerda; Annika Kratzel; ...
    Publisher: Public Library of Science
    Project: EC | HONOURs (721367), SNSF | Real-time pandemic functi... (31CA30_196644)

    Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major public health burden. Despite its close phylogenetic relationship to SARS-CoV, SARS-CoV-2 exhibits increased human-to-human transmis...

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  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

  • publication . Article . 2018
    Open Access
    Authors:
    Obdulio García-Nicolás; Philip V'kovski; Nathalie J. Vielle; Nadine Ebert; Roland Züst; Jasmine Portmann; Hanspeter Stalder; Véronique Gaschen; Gabrielle Vieyres; Michael Hubert Stoffel; ...
    Persistent Identifiers
    Publisher: American Society for Microbiology
    Project: SNSF | Host innate immune respon... (310030_173085), EC | PREDEMICS (278433), SNSF | Zoonotic transmission of ... (320030E-165076), EC | ZIKAlliance (734548), EC | COV RESTRIC (748627)

    The virus family Flaviviridae encompasses several viruses, including (re)emerging viruses which cause widespread morbidity and mortality throughout the world. Members of this virus family are positive-strand RNA viruses and replicate their genome in close association wi...

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  • publication . Article . Other literature type . 2010
    Open Access
    Authors:
    Federica Sallusto; Antonio Lanzavecchia; Koichi Araki; Rafi Ahmed;
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: EC | IMECS (201169), SNSF | The role of innate recept... (31003AB-126027)

    Vaccines work by eliciting an immune response and consequent immunological memory that mediates protection from infection or disease. Recently, new methods have been developed to dissect the immune response in experimental animals and humans, which have led to increased...

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42 research outcomes, page 1 of 5