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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
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14 research outcomes, page 1 of 2
  • publication . Article . 2021
    Open Access English
    Authors:
    Rick Oerlemans; Angel J Ruiz-Moreno; Yingying Cong; Nilima Dinesh Kumar; Marco A. Velasco-Velázquez; Constantinos G. Neochoritis; Jolanda Smith; Fulvio Reggiori; Matthew Groves; Alexander Dömling;
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), EC | DRIVE (765912)

    The rapid growth of COVID-19 cases is causing an increasing death toll and also paralyzing the world economy. De novo drug discovery takes years to move from idea and/or pre-clinic to market, and it is not a short-term solution for the current SARS-CoV-2 pandemic. Drug ...

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  • publication . Article . 2017
    Open Access
    Authors:
    Xingdong Zhou; Yingying Cong; Tineke Veenendaal; Judith Klumperman; Dongfang Shi; Muriel Mari; Fulvio Reggiori;
    Publisher: MDPI AG
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771)

    The porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) belonging to the alpha-CoV genus and it causes high mortality in infected sucking piglets, resulting in substantial losses in the farming industry. CoV trigger a drastic reorganization of host cell membra...

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  • publication . Article . 2020
    Open Access
    Authors:
    Ong, Catherine Wei Min; Migliori, Giovanni Battista; Raviglione, Mario; MacGregor-Skinner, Gavin; Sotgiu, Giovanni; Alffenaar, Jan-Willem; Tiberi, Simon; Adlhoch, Cornelia; Alonzi, Tonino; Archuleta, Sophia; ...
    Persistent Identifiers
    Project: EC | PRONKJEWAIL (713660)

    Major epidemics, including some that qualify as pandemics, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A (H1N1)pdm/09 and most recently COVID-19, affect the lung. Tuberculosis (TB) remains the top infectious ...

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  • publication . Article . 2021
    Open Access
    Authors:
    Zubaida Hassan; Nilima Dinesh Kumar; Fulvio Reggiori; Gulfaraz Khan;
    Publisher: MDPI AG
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660)

    Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular...

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  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

  • publication . Article . 2021
    Open Access
    Authors:
    Parej Nath; Nishant Ranjan Chauhan; Kautilya Kumar Jena; Ankita Datey; Nilima Dinesh Kumar; Subhash Mehto; Saikat De; Tapas Kumar Nayak; Swatismita Priyadarsini; Kshitish Rout; ...
    Publisher: EMBO
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660)

    Abstract The type I interferon (IFN) response is the major host arsenal against invading viruses. IRGM is a negative regulator of IFN responses under basal conditions. However, the role of human IRGM during viral infection has remained unclear. In this study, we show th...

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  • research data . 2018
    Open Access
    Authors:
    Mauthe, Mario; Idil Orhon; Rocchi, Cecilia; Xingdong Zhou; Luhr, Morten; Kerst-Jan Hijlkema; Coppes, Robert P.; Engedal, Nikolai; Mari, Muriel; Reggiori, Fulvio;
    Publisher: Taylor & Francis
    Project: SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), EC | PRONKJEWAIL (713660)

    Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and...

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  • publication . Preprint . Article . 2022
    Open Access English
    Authors:
    Nilima Dinesh Kumar; Bram M. ter Ellen; Ellen M Bouma; Berit Troost; Denise P. I. van de Pol; Heidi van der Ende-Metselaar; Djoke van Gosliga; Leonie Apperloo; Orestes A Carpaij; Maarten van den Berge; ...
    Publisher: American Society for Microbiology
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660)

    AbstractAntiviral therapies are urgently needed to treat and limit the development of severe COVID-19 disease. Ivermectin, a broad-spectrum anti-parasitic agent, has been shown to have anti-SARS-CoV-2 activity in Vero cells at a concentration of 5 µM. These in vitro res...

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  • publication . Article . Other literature type . Review . 2020
    Open Access English
    Authors:
    Bahaa Abu-Raya; Giovanni Battista Migliori; Miguel O'Ryan; Kathryn Edwards; Antoni Torres; Jan-Willem Alffenaar; Jan-Willem Alffenaar; Jan-Willem Alffenaar; Anne-Grete Märtson; Rosella Centis; ...
    Publisher: Frontiers Media S.A.
    Countries: Belgium, Netherlands
    Project: EC | PRONKJEWAIL (713660)

    Coronavirus disease 2019 (COVID-19) is a rapidly evolving, highly transmissible, and potentially lethal pandemic caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of June 11 2020, more than 7,000,000 COVID-19 cases have been...

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  • publication . Preprint . Article . 2019
    Open Access English
    Authors:
    Alessia Landi; Muriel Mari; Tobias Wolf; Svenja Kleiser; Christine Gretzmeier; Isabel Wilhelm; Dimitra Kiritsi; Roland Thuenauer; Roger Geiger; Alexander Nyström; ...
    Publisher: Life Science Alliance LLC
    Country: Netherlands
    Project: EC | LEC&LIP2INVADE (282105), NWO | A three-dimensional look ... (2300175771), EC | DRIVE (765912), EC | PRONKJEWAIL (713660)

    Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aerugi...

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14 research outcomes, page 1 of 2