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COVID-19 European Commission ZAPI NL

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COVID-19 European Commission ZAPI NL

The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
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12 research outcomes, page 1 of 2
  • publication . Conference object . Article . 2019
    Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
    Open Access
    Authors:
    Widjaja, Ivy; Wang, Chunyan; van Haperen, Rien; Gutiérrez-Álvarez, Javier; van Dieren, Brenda; Okba, Nisreen M.A.; Raj, V. Stalin; Li, Wentao; Fernandez-Delgado, Raul; Grosveld, Frank; ...
    Persistent Identifiers

    doi: 10.1080/22221751.2019.1597644

    handle: 1765/116248 , 10261/204537 , 10261/204200 , 1874/396130

    pmc: PMC6455120

    pmid: 30938227

    Countries: Spain, Netherlands
    Project: EC | ZAPI (115760)

    The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have mainly focused on neutralizing antibodies that target the receptor binding ...

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  • publication . Article . 2020
    A human monoclonal antibody blocking SARS-CoV-2 infection
    Open Access English
    Authors:
    Wang, Chunyan; Li, Wentao; Drabek, Dubravka; Okba, Nisreen M A; van Haperen, Rien; Osterhaus, Albert D M E; van Kuppeveld, Frank J M; Haagmans, Bart L; Grosveld, Frank; Bosch, Berend-Jan; ...
    Persistent Identifiers

    doi: 10.1101/2020.03.11.987958 , 10.1038/s41467-020-16256-y

    pmc: PMC7198537

    pmid: 32366817

    handle: 1874/396265

    Country: Netherlands
    Project: EC | ZAPI (115760)

    The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody ...

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  • publication . Article . 2017
    Factors determining human-to-human transmissibility of zoonotic pathogens via contact
    Open Access English
    Authors:
    Mathilde Richard; Sascha Knauf; Philip Lawrence; Alison E. Mather; Vincent J. Munster; Marcel A. Müller; Derek J. Smith; Thijs Kuiken;
    Persistent Identifiers

    doi: 10.17863/cam.53831 , 10.1016/j.coviro.2016.11.004

    handle: 1765/108125

    Countries: United Kingdom, Germany, Netherlands, France, United Kingdom, France
    Project: UKRI | The devil we know? Using ... (BB/M014088/1), EC | ZAPI (115760), EC | ANTIGONE (278976)

    The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their hu...

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  • publication . Article . 2019
    Sensitive and Specific Detection of Low-Level Antibody Responses in Mild Middle East Respiratory Syndrome Coronavirus Infections
    Open Access English
    Authors:
    Okba, Nisreen M.A.; Raj, V. Stalin; Widjaja, Ivy; GeurtsvanKessel, Corine H.; de Bruin, Erwin; Chandler, Felicity D.; Park, Wan Beom; Kim, Nam-Joong; Farag, Elmoubasher A.B.A.; Al-Hajri, Mohammed; ...
    Persistent Identifiers

    doi: 10.3201/eid2510.190051

    handle: 1765/120478

    pmc: PMC6759241

    pmid: 31423970

    Publisher: Centers for Disease Control and Prevention
    Country: Netherlands
    Project: EC | ZAPI (115760)

    Middle East respiratory syndrome coronavirus (MERS-CoV) infections in humans can cause asymptomatic to fatal lower respiratory lung disease. Despite posing a probable risk for virus transmission, asymptomatic to mild infections can go unnoticed; a lack of seroconversion...

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  • publication . Article . 2017
    Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches
    Open Access
    Authors:
    Nisreen M.A. Okba; V. Stalin Raj; Bart L. Haagmans;
    Persistent Identifiers

    doi: 10.1016/j.coviro.2017.03.007

    pmc: PMC7102752

    pmid: 28412285

    handle: 1765/99255

    Country: Netherlands
    Project: EC | ZAPI (115760)

    Middle East respiratory syndrome coronavirus (MERS-CoV) is a cause of severe respiratory infection in humans, specifically the elderly and people with comorbidities. The re-emergence of lethal coronaviruses calls for international collaboration to produce coronavirus va...

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  • publication . Preprint . 2020
    SARS-CoV-2 specific antibody responses in COVID-19 patients
    Open Access
    Authors:
    OKBA, NISREEN M.A.; Muller, Marcel A; Li, Wentao; Wang, Chunyan; GeurtsvanKessel, Corine H.; Corman, Victor M.; Lamers, Mart M.; Sikkema, Reina S.; de Bruin, Erwin; Chandler, Felicity D.; ...
    Persistent Identifiers

    doi: 10.1101/2020.03.18.20038059

    Publisher: medRxiv
    Project: EC | ZAPI (115760)

    AbstractA new coronavirus, SARS-CoV-2, has recently emerged to cause a human pandemic. Whereas molecular diagnostic tests were rapidly developed, serologic assays are still lacking, yet urgently needed. Validated serologic assays are important for contact tracing, ident...

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  • publication . Article . Other literature type . 2016
    Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels
    Open Access
    Authors:
    Widagdo, W; Raj, V Stalin; Schipper, Debby; Kolijn, Kimberley; van Leenders, Geert J L H; Bosch, Berend J; Bensaid, Albert; Segalés, Joaquim; Baumgärtner, Wolfgang; Osterhaus, Albert D M E; ...
    Persistent Identifiers

    doi: 10.1128/jvi.02994-15

    handle: 1765/90296 , 1874/345913

    pmc: PMC4836314

    pmid: 26889022

    Country: Netherlands
    Project: EC | ZAPI (115760)

    ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor—dipeptidyl peptidase 4 (DPP4)—is expressed in the upper respiratory ...

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  • publication . Article . 2019
    Detection of MERS-CoV antigen on formalin-fixed paraffin-embedded nasal tissue of alpacas by immunohistochemistry using human monoclonal antibodies directed against different epitopes of the spike protein
    Open Access
    Authors:
    Haverkamp, Ann-Kathrin; Bosch, Berend J; Spitzbarth, Ingo; Lehmbecker, Annika; Te, Nigeer; Bensaid, Albert; Segalés, Joaquim; Baumgärtner, Wolfgang; dI&I I&I-1; LS Virologie;
    Persistent Identifiers

    doi: 10.1016/j.vetimm.2019.109939

    handle: 1874/396134 , 20.500.12327/700

    pmc: PMC7112921

    pmid: 31526954

    Countries: Netherlands, Spain
    Project: EC | VetBioNet (731014), EC | ZAPI (115760)

    Middle East respiratory syndrome (MERS) represents an important respiratory disease accompanied by lethal outcome in one third of human patients. In recent years, several investigators developed protective antibodies which could be used as prophylaxis in prospective hum...

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  • publication . Other literature type . Article . 2019
    Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein
    Open Access English
    Authors:
    Rodon, Jordi; Okba, Nisreen M.A.; Te, Nigeer; van Dieren, Brenda; Bosch, Berend Jan; Bensaid, Albert; Segalés, Joaquim; Haagmans, Bart L.; Vergara-Alert, Júlia; LS Virologie; ...
    Persistent Identifiers

    doi: 10.1080/22221751.2019.1685912 , 10.6084/m9.figshare.10289336.v1 , 10.6084/m9.figshare.10289336

    handle: 1874/396129 , 20.500.12327/692 , 1765/121493

    pmc: PMC6853226

    pmid: 31711379

    Publisher: Taylor & Francis Open
    Countries: Netherlands, Spain
    Project: EC | VetBioNet (731014), EC | ZAPI (115760)

    The ongoing Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks pose a worldwide public health threat. Blocking MERS-CoV zoonotic transmission from dromedary camels, the animal reservoir, could potentially reduce the number of primary human cases. Here we ...

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  • publication . Article . 2018
    Co-localization of Middle East respiratory syndrome coronavirus (MERS-CoV) and dipeptidyl peptidase-4 in the respiratory tract and lymphoid tissues of pigs and llamas
    Open Access English
    Authors:
    Te, Nigeer; Vergara‐Alert, Júlia; Lehmbecker, Annika; Pérez, Mónica; Haagmans, Bart L.; Baumgärtner, Wolfgang; Bensaid, Albert; Segalés, Joaquim;
    Persistent Identifiers

    doi: 10.1111/tbed.13092

    handle: 20.500.12327/455

    pmc: PMC7027813

    pmid: 30520548

    Countries: Spain, Netherlands
    Project: EC | ZAPI (115760)

    This study investigated the co‐localization of the Middle East respiratory syndrome coronavirus (MERS‐CoV) and its receptor dipeptidyl peptidase‐4 (DPP4) by immunohistochemistry (IHC) across respiratory and lymphoid organs of experimentally MERS‐CoV infected pigs and ll...

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12 research outcomes, page 1 of 2