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12 research outcomes, page 1 of 2
  • publication . Conference object . Article . 2019
    Open Access
    Authors:
    Widjaja, Ivy; Wang, Chunyan; van Haperen, Rien; Gutiérrez-Álvarez, Javier; van Dieren, Brenda; Okba, Nisreen M.A.; Raj, V. Stalin; Li, Wentao; Fernandez-Delgado, Raul; Grosveld, Frank; ...
    Countries: Spain, Netherlands
    Project: EC | ZAPI (115760)

    The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have mainly focused on neutralizing antibodies that target the receptor binding ...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Wang, Chunyan; Li, Wentao; Drabek, Dubravka; Okba, Nisreen M A; van Haperen, Rien; Osterhaus, Albert D M E; van Kuppeveld, Frank J M; Haagmans, Bart L; Grosveld, Frank; Bosch, Berend-Jan; ...
    Country: Netherlands
    Project: EC | ZAPI (115760)

    The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody ...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Mathilde Richard; Sascha Knauf; Philip Lawrence; Alison E. Mather; Vincent J. Munster; Marcel A. Müller; Derek J. Smith; Thijs Kuiken;
    Countries: United Kingdom, Germany, Netherlands, France, United Kingdom, France
    Project: UKRI | The devil we know? Using ... (BB/M014088/1), EC | ZAPI (115760), EC | ANTIGONE (278976)

    The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their hu...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Okba, Nisreen M.A.; Raj, V. Stalin; Widjaja, Ivy; GeurtsvanKessel, Corine H.; de Bruin, Erwin; Chandler, Felicity D.; Park, Wan Beom; Kim, Nam-Joong; Farag, Elmoubasher A.B.A.; Al-Hajri, Mohammed; ...
    Persistent Identifiers
    Publisher: Centers for Disease Control and Prevention
    Country: Netherlands
    Project: EC | ZAPI (115760)

    Middle East respiratory syndrome coronavirus (MERS-CoV) infections in humans can cause asymptomatic to fatal lower respiratory lung disease. Despite posing a probable risk for virus transmission, asymptomatic to mild infections can go unnoticed; a lack of seroconversion...

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  • publication . Article . 2017
    Open Access
    Authors:
    Nisreen M.A. Okba; V. Stalin Raj; Bart L. Haagmans;
    Country: Netherlands
    Project: EC | ZAPI (115760)

    Middle East respiratory syndrome coronavirus (MERS-CoV) is a cause of severe respiratory infection in humans, specifically the elderly and people with comorbidities. The re-emergence of lethal coronaviruses calls for international collaboration to produce coronavirus va...

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  • publication . Preprint . 2020
    Open Access
    Authors:
    OKBA, NISREEN M.A.; Muller, Marcel A; Li, Wentao; Wang, Chunyan; GeurtsvanKessel, Corine H.; Corman, Victor M.; Lamers, Mart M.; Sikkema, Reina S.; de Bruin, Erwin; Chandler, Felicity D.; ...
    Persistent Identifiers
    Publisher: medRxiv
    Project: EC | ZAPI (115760)

    AbstractA new coronavirus, SARS-CoV-2, has recently emerged to cause a human pandemic. Whereas molecular diagnostic tests were rapidly developed, serologic assays are still lacking, yet urgently needed. Validated serologic assays are important for contact tracing, ident...

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  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Widagdo, W; Raj, V Stalin; Schipper, Debby; Kolijn, Kimberley; van Leenders, Geert J L H; Bosch, Berend J; Bensaid, Albert; Segalés, Joaquim; Baumgärtner, Wolfgang; Osterhaus, Albert D M E; ...
    Country: Netherlands
    Project: EC | ZAPI (115760)

    ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor—dipeptidyl peptidase 4 (DPP4)—is expressed in the upper respiratory ...

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  • publication . Article . 2019
    Open Access
    Authors:
    Haverkamp, Ann-Kathrin; Bosch, Berend J; Spitzbarth, Ingo; Lehmbecker, Annika; Te, Nigeer; Bensaid, Albert; Segalés, Joaquim; Baumgärtner, Wolfgang; dI&I I&I-1; LS Virologie;
    Countries: Netherlands, Spain
    Project: EC | VetBioNet (731014), EC | ZAPI (115760)

    Middle East respiratory syndrome (MERS) represents an important respiratory disease accompanied by lethal outcome in one third of human patients. In recent years, several investigators developed protective antibodies which could be used as prophylaxis in prospective hum...

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  • publication . Other literature type . Article . 2019
    Open Access English
    Authors:
    Rodon, Jordi; Okba, Nisreen M.A.; Te, Nigeer; van Dieren, Brenda; Bosch, Berend Jan; Bensaid, Albert; Segalés, Joaquim; Haagmans, Bart L.; Vergara-Alert, Júlia; LS Virologie; ...
    Publisher: Taylor & Francis Open
    Countries: Netherlands, Spain
    Project: EC | VetBioNet (731014), EC | ZAPI (115760)

    The ongoing Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks pose a worldwide public health threat. Blocking MERS-CoV zoonotic transmission from dromedary camels, the animal reservoir, could potentially reduce the number of primary human cases. Here we ...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Te, Nigeer; Vergara‐Alert, Júlia; Lehmbecker, Annika; Pérez, Mónica; Haagmans, Bart L.; Baumgärtner, Wolfgang; Bensaid, Albert; Segalés, Joaquim;
    Persistent Identifiers
    Countries: Spain, Netherlands
    Project: EC | ZAPI (115760)

    This study investigated the co‐localization of the Middle East respiratory syndrome coronavirus (MERS‐CoV) and its receptor dipeptidyl peptidase‐4 (DPP4) by immunohistochemistry (IHC) across respiratory and lymphoid organs of experimentally MERS‐CoV infected pigs and ll...

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12 research outcomes, page 1 of 2