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194 research outcomes, page 1 of 20
  • publication . Article . 2017
    Open Access
    Authors:
    Reina S. Sikkema; Elmoubasher Farag; Sayed Himatt; Adel K Ibrahim; Hamad Al-Romaihi; Salih A. Al-Marri; Mohamed H. Al-Thani; Ahmed M. El-Sayed; Mohammed Al-Hajri; Bart L. Haagmans; ...
    Persistent Identifiers
    Country: Netherlands
    Project: EC | PREPARE (602525), EC | COMPARE (643476)

    Abstract The transmission routes and risk factors for zoonotic Middle East respiratory syndrome coronavirus (MERS-CoV) infections are still unknown. We used the World Health Organization questionnaire for MERS-CoV case-control studies to assess risk factors for human ME...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Schuster, Susan; Miesen, Pascal; van Rij, Ronald P.;
    Persistent Identifiers
    Publisher: MDPI AG
    Country: Netherlands
    Project: EC | VIVARNASILENCING (615680)

    The RNA interference (RNAi) pathway is a potent antiviral defense mechanism in plants and invertebrates, in response to which viruses evolved suppressors of RNAi. In mammals, the first line of defense is mediated by the type I interferon system (IFN); however, the degre...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Bezemer, Daniela; Cori, Anne; Ratmann, Oliver; van Sighem, Ard; Hermanides, Hillegonda S; Dutilh, Bas E; Gras, Luuk; Rodrigues Faria, Nuno; van den Hengel, Rob; Duits, Ashley J; ...
    Countries: Netherlands, Netherlands, United Kingdom
    Project: NIH | LOC: HIV Prevention Trial... (5UM1AI068619-09), EC | BEEHIVE (339251), WT | Unraveling the dynamics o... (092311)

    Editors' Summary Background Since the first recorded case of AIDS in 1981, the number of people infected with HIV, the virus that causes AIDS, has risen steadily. Now, three and a half decades later, about 35 million people (more than half of whom are women) are infecte...

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  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Puck B. van Kasteren; Ben A. Bailey-Elkin; Terrence W. James; Dennis K. Ninaber; Corrine Beugeling; Mazdak Khajehpour; Eric J. Snijder; Brian L. Mark; Marjolein Kikkert;
    Persistent Identifiers
    Country: Netherlands
    Project: CIHR , EC | SILVER (260644), NSERC , NWO | Nidovirus deubiquitinatin... (2300160060)

    Protein ubiquitination regulates important innate immune responses. The discovery of viruses encoding deubiquitinating enzymes (DUBs) suggests they remove ubiquitin to evade ubiquitin-dependent antiviral responses; however, this has never been conclusively demonstrated ...

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  • publication . Article . 2019
    Open Access English
    Authors:
    van Houten, Chantal B.; Cohen, Asi; Engelhard, Dan; Hays, John P.; Karlsson, Roger; Moore, Edward; Fernández, David; Kreisberg, Racheli; Collins, Laurence V.; de Waal, Wouter; ...
    Country: Netherlands
    Project: EC | TAILORED-TREATMENT (602860)

    Respiratory tract infections (RTI) are more commonly caused by viral pathogens in children than in adults. Surprisingly, little is known about antibiotic use in children as compared to adults with RTI. This prospective study aimed to determine antibiotic misuse in child...

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  • publication . Article . 2016
    Open Access
    Authors:
    de Vries, Rory; Rimmelzwaan, Guus;
    Publisher: Informa UK Limited
    Country: Netherlands
    Project: EC | FLUNIVAC (602604), EC | FLUPLAN (250136)

    ABSTRACT Antigenic drift of seasonal influenza viruses and the occasional introduction of influenza viruses of novel subtypes into the human population complicate the timely production of effective vaccines that antigenically match the virus strains that cause epidemic ...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Corman, Victor M.; Jores, Joerg; Meyer, Benjamin; Younan, Mario; Liljander, Anne; Said, Mohammed Y.; Gluecks, Ilona; Lattwein, Erik; Bosch, Berend Jan; Drexler, Jan Felix; ...
    Persistent Identifiers
    Country: Netherlands
    Project: EC | ANTIGONE (278976), EC | EMPERIE (223498)

    Dromedary camels are a putative source for human infections with Middle East respiratory syndrome coronavirus. We showed that camels sampled in different regions in Kenya during 1992–2013 have antibodies against this virus. High densities of camel populations correlated...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Melanie Eck; Margarita García Durán; Meret E. Ricklin; Samira Locher; Javier Sarraseca; María José Morillo Rodríguez; Kenneth C. McCullough; Artur Summerfield; Gert Zimmer; Nicolas Ruggli;
    Persistent Identifiers
    Publisher: BioMed Central
    Countries: Switzerland, France
    Project: EC | PORRSCON (245141)

    International audience; AbstractPorcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of one of the most devastating and economically significant viral disease of pigs worldwide. The vaccines currently available on the market elicit only lim...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Melia, C E; van der Schaar, H M; de Jong, A W M; Lyoo, H R; Snijder, Eric J; Koster, A J; van Kuppeveld, F J M; Bárcena, Montserrat; dI&I I&I-1; LS Virologie; ...
    Publisher: American Society for Microbiology
    Country: Netherlands
    Project: EC | ANTIVIRALS (642434), NWO | Activating the VE-cadheri... (2300161085), EC | EUVIRNA (264286), NWO | Viral redesign of the cel... (2300174141), NWO | SysVirDrug: Translating S... (2300189186)

    ABSTRACT Picornaviruses induce dramatic rearrangements of endomembranes in the cells that they infect to produce dedicated platforms for viral replication. These structures, termed replication organelles (ROs), have been well characterized for the Enterovirus genus of t...

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  • publication . Article . 2018
    Open Access
    Authors:
    García-Nicolás, Obdulio; V'kovski, Philip; Vielle, Nathalie J.; Ebert, Nadine; Züst, Roland; Portmann, Jasmine; Stalder, Hanspeter; Gaschen, Véronique; Vieyres, Gabrielle; Stoffel, Michael; ...
    Persistent Identifiers
    Country: Germany
    Project: SNSF | Host innate immune respon... (310030_173085), SNSF | Zoonotic transmission of ... (320030E-165076), EC | COV RESTRIC (748627), EC | PREDEMICS (278433), EC | ZIKAlliance (734548)

    ABSTRACT The virus family Flaviviridae encompasses several viruses, including (re)emerging viruses which cause widespread morbidity and mortality throughout the world. Members of this virus family are positive-strand RNA viruses and replicate their genome in close assoc...

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194 research outcomes, page 1 of 20