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description Publicationkeyboard_double_arrow_right Bachelor thesis 2023 Sweden EnglishPublisher:Stockholms universitet, Institutionen för ekonomisk historia och internationella relationer Funded by:EC | IWASAWAEC| IWASAWAAuthors: De Laval, Henrik;De Laval, Henrik;Semiconductors are essential in virtually all electronic devices, ranging from civilian to military applications. The semiconductor industry is therefore a critical, and arguably strategic and security-related, industrial sector. Highlighting the complexity of the industry, the semiconductor supply and value chain structure is global, containing various process steps going through actors spread across the world. However, in this there is also a high geographical concentration of actors dominating certain industrial segments. The importance of semiconductors was meanwhile highlighted during the COVID-19 pandemic, which triggered disruptions in the semiconductor supply chain and led to shortages of chips worldwide. Among state actors implementing policies aimed at addressing recent challenges, the European Commission presented its proposal for a European Chips Act in 2022. In this study, this new European semiconductor policy was analyzed using a multidimensional security approach aimed at addressing the strategic importance of the semiconductor industry and its links to security. In this, security was specifically conceptualized around the economic, technological and defense (military) dimensions of security. Employing a version of qualitative content analysis, the study finds that by focusing on descriptions of 1) the main industrial segments within the semiconductor industry, and 2) specific semiconductor end-user sectors in Europe, aspects derived primarily, but not exclusively, from the economic and technological security dimensions can be identified. Within the main industrial segments, examples of findings include the EU lacking economic competitiveness and economic independence, as well as access to competence and infrastructure. Within the European end-user sectors, examples of findings include issues surrounding security of supply, decreased economic competitiveness and access to critical technologies.
Publikationer från S... arrow_drop_down Publikationer från Stockholms universitetBachelor thesis . 2023Data sources: Publikationer från Stockholms universitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______263::afd1a74a92c0a6571faf18584845fd00&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från S... arrow_drop_down Publikationer från Stockholms universitetBachelor thesis . 2023Data sources: Publikationer från Stockholms universitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______263::afd1a74a92c0a6571faf18584845fd00&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Elsevier BV Funded by:EC | CAREEC| CARELévy, Yves; Wiedemann, Aurélie; Hejblum, Boris P.; Durand, Mélany; Lefebvre, Cécile; Surénaud, Mathieu; Lacabaratz, Christine; Perreau, Matthieu; Foucat, Emile; Déchenaud, Marie; Tisserand, Pascaline; Blengio, Fabiola; Hivert, Benjamin; Gauthier, Marine; Cervantes-Gonzalez, Minerva; Bachelet, Delphine; Laouénan, Cédric; Bouadma, Lila; Timsit, Jean-François; Yazdanpanah, Yazdan; Pantaleo, Giuseppe; Hocini, Hakim; Thiébaut, Rodolphe;The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care. Immunology; Virology Graphical abstract
iScience arrow_drop_down iScienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8189740Data sources: PubMed CentralINRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCHAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2022.105715&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert iScience arrow_drop_down iScienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8189740Data sources: PubMed CentralINRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCHAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2022.105715&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 FrancePublisher:Proceedings of the National Academy of Sciences Funded by:EC | RECoVER, EC | VEOEC| RECoVER ,EC| VEOJuliette Paireau; Alessio Andronico; Nathanaël Hozé; Maylis Layan; Pascal Crépey; Alix Roumagnac; Marc Lavielle; Pierre-Yves Boëlle; Simon Cauchemez;Significance The COVID-19 pandemic is inducing significant stress on health care structures, which can be quickly saturated with negative consequences for patients. As hospitalization comes late in the infection history of a patient, early predictors—such as the number of cases, mobility, climate, and vaccine coverage—could improve forecasts of health care demand. Predictive models taken individually have their pros and cons, and it is advantageous to combine the predictions in an ensemble model. Here, we design an ensemble that combines several models to anticipate French COVID-19 health care needs up to 14 days ahead. We retrospectively test this model, identify the best predictors of the growth rate of hospital admissions, and propose a promising approach to facilitate the planning of hospital activity. International audience
Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-Pasteur; INRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2103302119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 24 citations 24 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-Pasteur; INRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2103302119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2022 Italy, France, FrancePublisher:Oxford University Press (OUP) Funded by:EC | ACEPOL, UKRI | AI-SAFE - Autonomous Inte..., EC | GROWINPROEC| ACEPOL ,UKRI| AI-SAFE - Autonomous Intelligent System for Assuring Safe Working Environments ,EC| GROWINPROSeverin Reissl; Alessandro Caiani; Francesco Lamperti; Mattia Guerini; Fabio Vanni; Giorgio Fagiolo; Tommaso Ferraresi; Leonardo Ghezzi; Mauro Napoletano; Andrea Roventini;doi: 10.1093/icc/dtac003
handle: 11382/558392 , 11379/564800
We build a novel computational input-output model to estimate the economic impact of lockdowns in Italy. The key advantage of our framework is to integrate the regional and sectoral dimensions of economic production in a very parsimonious numerical simulation framework. Lockdowns are treated as shocks to available labor supply and they are calibrated on regional and sectoral employment data coupled with the prescriptions of government decrees. We show that when estimated on data from the first “hard” lockdown, our model closely reproduces the observed economic dynamics during spring 2020. In addition, we show that the model delivers a good out-of-sample forecasting performance. We also analyze the effects of the second “mild” lockdown in fall of 2020 which delivered a much more moderate negative impact on production compared to both the spring 2020 lockdown and to a hypothetical second “hard” lockdown.
HAL Descartes; Mémoi... arrow_drop_down Industrial and Corporate ChangeArticle . 2022 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: CrossrefMémoires en Sciences de l'Information et de la CommunicationPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/icc/dtac003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert HAL Descartes; Mémoi... arrow_drop_down Industrial and Corporate ChangeArticle . 2022 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: CrossrefMémoires en Sciences de l'Information et de la CommunicationPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/icc/dtac003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Funded by:EC | Spray-ImagingEC| Spray-ImagingMehdi Stiti; Guillaume Castanet; Andrew Corber; Marcus Aldén; Edouard Berrocal;To control the evolution of a pandemic such as COVID-19, knowing the conditions under which the pathogen is being transmitted represents a critical issue, especially when implementing protection strategies like social distancing and face masks wearing. For viruses and bacteria that spread via airborne and/or droplet pathways, this requires understanding how saliva droplets evolve over time after their expulsion by speaking or coughing. Within this context, the transition from saliva droplets to solid residues, due to water evaporation, is studied here both experimentally, considering the saliva from 5 men and 5 women, and via numerical modeling to accurately predict the dynamics of this process. The model assumes saliva to be a binary water/salt mixture and is validated against experimental results using saliva droplets that are suspended in an ultrasound levitator. We demonstrate that droplets with an initial diameter smaller than 21 μm will produce a solid residue that would be considered an aerosol of <5 μm diameter within less than 2 second (for any relative humidity less than 80% and/or any temperature greater than 20 °C). Finally, the model developed here accounts for the influence of the saliva composition, relative humidity and ambient temperature on droplet drying. Thus, the travel distance prior to becoming a solid residue can be deduced. We found that saliva droplets of initial size below 80 μm, which corresponds to the vast majority of speech and cough droplets, will become solid residues prior to touching the ground when expelled from a height of 160 cm.
Environmental Resear... arrow_drop_down Environmental ResearchArticle . 2021Full-Text: http://europepmc.org/articles/PMC8459388Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envres.2021.112072&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Environmental Resear... arrow_drop_down Environmental ResearchArticle . 2021Full-Text: http://europepmc.org/articles/PMC8459388Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envres.2021.112072&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, France, ItalyPublisher:Elsevier BV Funded by:EC | COVIRNAEC| COVIRNABeatrice Cardinali; Claudia Provenzano; Mariapaola Izzo; Christine Voellenkle; Jonathan Battistini; Georgios Strimpakos; Elisabetta Golini; Silvia Mandillo; Ferdinando Scavizzi; Marcello Raspa; Alessandra Perfetti; Denisa Baci; Dejan Lazarevic; Jose Manuel Garcia-Manteiga; Geneviève Gourdon; Fabio Martelli; Germana Falcone;CRISPR/Cas9-mediated therapeutic gene editing is a promising technology for durable treatment of incurable monogenic diseases such as myotonic dystrophies. Gene-editing approaches have been recently applied to in vitro and in vivo models of myotonic dystrophy type 1 (DM1) to delete the pathogenic CTG-repeat expansion located in the 3′ untranslated region of the DMPK gene. In DM1-patient-derived cells removal of the expanded repeats induced beneficial effects on major hallmarks of the disease with reduction in DMPK transcript-containing ribonuclear foci and reversal of aberrant splicing patterns. Here, we set out to excise the triplet expansion in a time-restricted and cell-specific fashion to minimize the potential occurrence of unintended events in off-target genomic loci and select for the target cell type. To this aim, we employed either a ubiquitous promoter-driven or a muscle-specific promoter-driven Cas9 nuclease and tetracycline repressor-based guide RNAs. A dual-vector approach was used to deliver the CRISPR/Cas9 components into DM1 patient-derived cells and in skeletal muscle of a DM1 mouse model. In this way, we obtained efficient and inducible gene editing both in proliferating cells and differentiated post-mitotic myocytes in vitro as well as in skeletal muscle tissue in vivo. This paper describes a gene-editing approach designed to remove the pathologic CTG expansion mutation that causes myotonic dystrophy type 1. By using muscle-specific and drug-inducible expression of the CRISPR/Cas9 complex, effective deletion of the CTG expansion was obtained in myogenic cells and in mouse skeletal muscle. Graphical abstract
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8693309Data sources: PubMed CentralArchivio della ricerca- Università di Roma La SapienzaArticle . 2022Data sources: Archivio della ricerca- Università di Roma La SapienzaMolecular Therapy: Nucleic Acids; Archivio della ricerca- Università di Roma La Sapienza; CNR ExploRAArticle . 2021 . 2022 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.omtn.2021.11.024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8693309Data sources: PubMed CentralArchivio della ricerca- Università di Roma La SapienzaArticle . 2022Data sources: Archivio della ricerca- Università di Roma La SapienzaMolecular Therapy: Nucleic Acids; Archivio della ricerca- Università di Roma La Sapienza; CNR ExploRAArticle . 2021 . 2022 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.omtn.2021.11.024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Funded by:EC | CHiPS, UKRI | EPSRC Centre for Mathemat..., EC | NoMADS +2 projectsEC| CHiPS ,UKRI| EPSRC Centre for Mathematical and Statistical Analysis of Multimodal Clinical Imaging ,EC| NoMADS ,UKRI| Robust and Efficient Analysis Approaches of Remote Imagery for Assessing Population and Forest Health in India ,UKRI| PET++: Improving Localisation, Diagnosis and Quantification in Clinical and Medical PET Imaging with Randomised OptimisationAuthors: Aviles-Rivero, Angelica I; Sellars, Philip; Sch��nlieb, Carola-Bibiane; Papadakis, Nicolas;Aviles-Rivero, Angelica I; Sellars, Philip; Sch��nlieb, Carola-Bibiane; Papadakis, Nicolas;Can one learn to diagnose COVID-19 under extreme minimal supervision? Since the outbreak of the novel COVID-19 there has been a rush for developing Artificial Intelligence techniques for expert-level disease identification on Chest X-ray data. In particular, the use of deep supervised learning has become the go-to paradigm. However, the performance of such models is heavily dependent on the availability of a large and representative labelled dataset. The creation of which is a heavily expensive and time consuming task, and especially imposes a great challenge for a novel disease. Semi-supervised learning has shown the ability to match the incredible performance of supervised models whilst requiring a small fraction of the labelled examples. This makes the semi-supervised paradigm an attractive option for identifying COVID-19. In this work, we introduce a graph based deep semi-supervised framework for classifying COVID-19 from chest X-rays. Our framework introduces an optimisation model for graph diffusion that reinforces the natural relation among the tiny labelled set and the vast unlabelled data. We then connect the diffusion prediction output as pseudo-labels that are used in an iterative scheme in a deep net. We demonstrate, through our experiments, that our model is able to outperform the current leading supervised model with a tiny fraction of the labelled examples. Finally, we provide attention maps to accommodate the radiologist's mental model, better fitting their perceptual and cognitive abilities. These visualisation aims to assist the radiologist in judging whether the diagnostic is correct or not, and in consequence to accelerate the decision. International audience
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8387569Data sources: PubMed CentralarXiv.org e-Print ArchiveOther literature type . Preprint . 2020Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.patcog.2021.108274&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 24 citations 24 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 10visibility views 10 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8387569Data sources: PubMed CentralarXiv.org e-Print ArchiveOther literature type . Preprint . 2020Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.patcog.2021.108274&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, Poland, DenmarkPublisher:Elsevier BV Funded by:EC | EOSCsecretariat.euEC| EOSCsecretariat.euHans, Flaatten; Bertrand, Guidet; Dylan W, de Lange; Michael, Beil; Susannah K, Leaver; Jesper, Fjølner; Peter Vernon, van Heerden; Sviri, Sigal; Wojciech, Szczeklik; Christian, Jung;There is a strong link between limiting life-sustaining treatments(LST) and short-term outcomes, as is illustrated in a recent publication in this journal from Germany [1]. Once a patient has been admitted to the intensive care unit (ICU), limitation of LST is frequently discussed and applied. In the current pandemic, such information is of particular importance given the ongoing discussions in many countries about triage of (elderly) COVID-19 patients [2]. In this short communication we present data on the impact of limitation of LST on the outcome of elderly COVID-19 patients in Europe.
Journal of Critical ... arrow_drop_down Journal of Critical CareArticle . 2021Full-Text: http://europepmc.org/articles/PMC8588784Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcrc.2021.10.024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 14 citations 14 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of Critical ... arrow_drop_down Journal of Critical CareArticle . 2021Full-Text: http://europepmc.org/articles/PMC8588784Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcrc.2021.10.024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Funded by:EC | Big MacEC| Big MacCario, Anaïs; Aubert, Guillaume; Alcaraz, Jean-Pierre; Borra, Jean-Pascal; Jidenko, Nicolas; barrault, mathieu; Bourrous, Soleiman; Mocho, Victor; Ouf, François Xavier; Marre, Samuel; Cinquin, Philippe; Aymonier, Cyril;International audience; Supercritical Carbon Dioxide treatment of clean and soiled Filtering Face-Piece respirators is shown to meet mandatory requirements for safe reuse of FFP2. Preliminary tests enabled us to select optimal conditions for Supercritical Carbon Dioxide treatment of FFP2, for one hour at 343 K under 7.5 MPa, with a biocide solution. FFP2s from Paul Boyé ® were then tested before and after Supercritical Carbon Dioxide treatment with a soiling solution and a biological indicator (i.e. spores of GeoBacillus stearothermophilus) with respect to three objectives: (i) washing of organic deposits, (ii) sterilization (i.e. spores inactivation) and (iii) preservation of the filtration performances. The proposed Supercritical Carbon Dioxide treatment fulfils these three criterions, with effective decontamination of spores and promising washing preserving FFP2 requirements for filtration efficiency of aerosol (> 94%) with acceptable pressure drop (< 240 Pa). As a simple and low-cost one-step recycling method, Supercritical Carbon Dioxide fits to economical and sustainable development standpoints but also allows one to come back to good practices of face protective equipment use, lowering eventual shortage and tensions for most countries importing these respirators.
The Journal of Super... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022Full-Text: https://hal.science/hal-03384956/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert The Journal of Super... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022Full-Text: https://hal.science/hal-03384956/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Belgium, Belgium, FrancePublisher:Elsevier BV Funded by:EC | EU-RESPONSEEC| EU-RESPONSEAuthors: Ader, Florence; Bouscambert-Duchamp, Maude; Hites, Maya; Peiffer-Smadja, Nathan; +177 AuthorsAder, Florence; Bouscambert-Duchamp, Maude; Hites, Maya; Peiffer-Smadja, Nathan; Poissy, Julien; Belhadi, Drifa; Diallo, Alpha; Lê, Minh-Patrick; Peytavin, Gilles; Staub, Thérèse; Greil, Richard; Guedj, Jérémie; Paiva, Jose-Artur; Costagliola, Dominique; Yazdanpanah, Yazdan; Burdet, Charles; Mentré, France; Egle, Alexander; Greil, Richard; Joannidis, Michael; Lamprecht, Bernd; Altdorfer, Antoine; Belkhir, Leila; Fraipont, Vincent; Hites, Maya; Verschelden, Gil; Aboab, Jérôme; Ader, Florence; Ait-Oufella, Hafid; Andrejak, Claire; Andreu, Pascal; Argaud, Laurent; Bani-Sadr, Firouzé; Benezit, François; Blot, Mathieu; Botelho-Nevers, Elisabeth; Bouadma, Lila; Bouchaud, Olivier; Bougon, David; Bouiller, Kevin; Bounes-Vardon, Fanny; Boutoille, David; Boyer, Alexandre; Bruel, Cédric; Cabié, André; Canet, Emmanuel; Cazanave, Charles; Chabartier, Cyrille; Chirouze, Catherine; Clere-Jehl, Raphaël; Courjon, Johan; Crockett, Flora; Danion, François; Delbove, Agathe; Dellamonica, Jean; Djossou, Félix; Dubost, Clément; Duvignaud, Alexandre; Epaulard, Olivier; Epelboin, Loïc; Fartoukh, Murielle; Faure, Karine; Faure, Emmanuel; Ferry, Tristan; Ficko, Cécile; Figueiredo, Samy; Gaborit, Benjamin; Gaci, Rostane; Gagneux-Brunon, Amandine; Gallien, Sébastien; Garot, Denis; Geri, Guillaume; Gibot, Sébastien; Goehringer, François; Gousseff, Marie; Gruson, Didier; Hansmann, Yves; Hinschberger, Olivier; Jaureguiberry, Stéphane; Jeanmichel, Vanessa; Kerneis, Solen; Kimmoun, Antoine; Klouche, Kada; Lachâtre, Marie; Lacombe, Karine; Laine, Fabrice; Lanoix, Jean-Philippe; Launay, Odile; Laviolle, Bruno; Le Moing, Vincent; Le Pavec, Jérôme; Le Tulzo, Yves; Le Turnier, Paul; Lebeaux, David; Lefevre, Benjamin; Leroy, Sylvie; Lescure, François-Xavier; Lessire, Henry; Leveau, Benjamin; Loubet, Paul; Makinson, Alain; Malvy, Denis; Marquette, Charles-Hugo; Martin-Blondel, Guillaume; Martinot, Martin; Mayaux, Julien; Mekontso-Dessap, Armand; Meziani, Ferhat; Mira, Jean-Paul; Molina, Jean-Michel; Monnet, Xavier; Mootien, Joy; Mourvillier, Bruno; Murris-Espin, Marlène; Navellou, Jean-Christophe; Nseir, Saad; Oulehri, Walid; Peiffer-Smadja, Nathan; Perpoint, Thomas; Pialoux, Gilles; Pilmis, Benoît; Piriou, Vincent; Piroth, Lionel; Poissy, Julien; Pourcher, Valérie; Quenot, Jean-Pierre; Raffi, François; Reignier, Jean; Revest, Matthieu; Richard, Jean-Christophe; Riu-Poulenc, Béatrice; Robert, Céline; Roger, Pierre-Alexandre; Roger, Claire; Rouveix-Nordon, Elisabeth; Ruch, Yvon; Saidani, Nadia; Sayre, Naomi; Senneville, Eric; Sotto, Albert; Stefan, Francois; Tacquard, Charles; Terzi, Nicolas; Textoris, Julien; Thiery, Guillaume; Timsit, Jean-François; Tolsma, Violaine; Turmel, Jean-Marie; Valour, Florent; Wallet, Florent; Wattecamps, Guilhem; Yazdanpanah, Yazdan; Zerbib, Yoann; Berna, Marc; Reuter, Jean; Staub, Thérèse; Braz, Sandra; Ferreira Ribeiro, Joao-Miguel; Paiva, José-Artur; Roncon-Albuquerque, Roberto; Bouscambert-Duchamp, Maude; Gaymard, Alexandre; Lê, Minh-Patrick; Lina, Bruno; Peytavin, Gilles; Tubiana, Sarah; Couffin-Cadièrgues, Sandrine; Esperou, Hélène; Belhadi, Drifa; Burdet, Charles; Costagliola, Dominique; Dechanet, Aline; Delmas, Christelle; Diallo, Alpha; Fougerou, Claire; Guedj, Jérémie; Mentré, France; Mercier, Noémie; Noret, Marion; Saillard, Juliette; Velou, Priyanka;pmc: PMC8439621
pmid: 34534511
Background: The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial. We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with standard of care alone in patients admitted to hospital with COVID-19, with indication of oxygen or ventilator support. Methods: DisCoVeRy was a phase 3, open-label, adaptive, multicentre, randomised, controlled trial conducted in 48 sites in Europe (France, Belgium, Austria, Portugal, Luxembourg). Adult patients (aged ≥18 years) admitted to hospital with laboratory-confirmed SARS-CoV-2 infection and illness of any duration were eligible if they had clinical evidence of hypoxaemic pneumonia, or required oxygen supplementation. Exclusion criteria included elevated liver enzymes, severe chronic kidney disease, any contraindication to one of the studied treatments or their use in the 29 days before random assignment, or use of ribavirin, as well as pregnancy or breastfeeding. Participants were randomly assigned (1:1:1:1:1) to receive standard of care alone or in combination with remdesivir, lopinavir-ritonavir, lopinavir-ritonavir and interferon beta-1a, or hydroxychloroquine. Randomisation used computer-generated blocks of various sizes; it was stratified on severity of disease at inclusion and on European administrative region. Remdesivir was administered as 200 mg intravenous infusion on day 1, followed by once daily, 1-h infusions of 100 mg up to 9 days, for a total duration of 10 days. It could be stopped after 5 days if the participant was discharged. The primary outcome was the clinical status at day 15 measured by the WHO seven-point ordinal scale, assessed in the intention-to-treat population. Safety was assessed in the modified intention-to-treat population and was one of the secondary outcomes. This trial is registered with the European Clinical Trials Database, EudraCT2020-000936-23, and ClinicalTrials.gov, NCT04315948. Findings: Between March 22, 2020, and Jan 21, 2021, 857 participants were enrolled and randomly assigned to remdesivir plus standard of care (n=429) or standard of care only (n=428). 15 participants were excluded from analysis in the remdesivir group, and ten in the control group. At day 15, the distribution of the WHO ordinal scale was: (1) not hospitalised, no limitations on activities (61 [15%] of 414 in the remdesivir group vs 73 [17%] of 418 in the control group); (2) not hospitalised, limitation on activities (129 [31%] vs 132 [32%]); (3) hospitalised, not requiring supplemental oxygen (50 [12%] vs 29 [7%]); (4) hospitalised, requiring supplemental oxygen (76 [18%] vs 67 [16%]); (5) hospitalised, on non-invasive ventilation or high flow oxygen devices (15 [4%] vs 14 [3%]); (6) hospitalised, on invasive mechanical ventilation or extracorporeal membrane oxygenation (62 [15%] vs 79 [19%]); (7) death (21 [5%] vs 24 [6%]). The difference between treatment groups was not significant (odds ratio 0·98 [95% CI 0·77-1·25]; p=0·85). There was no significant difference in the occurrence of serious adverse events between treatment groups (remdesivir, 135 [33%] of 406 vs control, 130 [31%] of 418; p=0·48). Three deaths (acute respiratory distress syndrome, bacterial infection, and hepatorenal syndrome) were considered related to remdesivir by the investigators, but only one by the sponsor's safety team (hepatorenal syndrome). Interpretation: No clinical benefit was observed from the use of remdesivir in patients who were admitted to hospital for COVID-19, were symptomatic for more than 7 days, and required oxygen support. 22;2
HAL-Rennes 1; HAL-EN... arrow_drop_down The Lancet Infectious DiseasesArticle . 2021Full-Text: http://europepmc.org/articles/PMC8439621Data sources: PubMed CentralVrije Universiteit Brussel Research PortalArticle . 2022Data sources: Vrije Universiteit Brussel Research PortalThe Lancet Infectious DiseasesOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 131 citations 131 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert HAL-Rennes 1; HAL-EN... arrow_drop_down The Lancet Infectious DiseasesArticle . 2021Full-Text: http://europepmc.org/articles/PMC8439621Data sources: PubMed CentralVrije Universiteit Brussel Research PortalArticle . 2022Data sources: Vrije Universiteit Brussel Research PortalThe Lancet Infectious DiseasesOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Bachelor thesis 2023 Sweden EnglishPublisher:Stockholms universitet, Institutionen för ekonomisk historia och internationella relationer Funded by:EC | IWASAWAEC| IWASAWAAuthors: De Laval, Henrik;De Laval, Henrik;Semiconductors are essential in virtually all electronic devices, ranging from civilian to military applications. The semiconductor industry is therefore a critical, and arguably strategic and security-related, industrial sector. Highlighting the complexity of the industry, the semiconductor supply and value chain structure is global, containing various process steps going through actors spread across the world. However, in this there is also a high geographical concentration of actors dominating certain industrial segments. The importance of semiconductors was meanwhile highlighted during the COVID-19 pandemic, which triggered disruptions in the semiconductor supply chain and led to shortages of chips worldwide. Among state actors implementing policies aimed at addressing recent challenges, the European Commission presented its proposal for a European Chips Act in 2022. In this study, this new European semiconductor policy was analyzed using a multidimensional security approach aimed at addressing the strategic importance of the semiconductor industry and its links to security. In this, security was specifically conceptualized around the economic, technological and defense (military) dimensions of security. Employing a version of qualitative content analysis, the study finds that by focusing on descriptions of 1) the main industrial segments within the semiconductor industry, and 2) specific semiconductor end-user sectors in Europe, aspects derived primarily, but not exclusively, from the economic and technological security dimensions can be identified. Within the main industrial segments, examples of findings include the EU lacking economic competitiveness and economic independence, as well as access to competence and infrastructure. Within the European end-user sectors, examples of findings include issues surrounding security of supply, decreased economic competitiveness and access to critical technologies.
Publikationer från S... arrow_drop_down Publikationer från Stockholms universitetBachelor thesis . 2023Data sources: Publikationer från Stockholms universitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______263::afd1a74a92c0a6571faf18584845fd00&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från S... arrow_drop_down Publikationer från Stockholms universitetBachelor thesis . 2023Data sources: Publikationer från Stockholms universitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______263::afd1a74a92c0a6571faf18584845fd00&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Elsevier BV Funded by:EC | CAREEC| CARELévy, Yves; Wiedemann, Aurélie; Hejblum, Boris P.; Durand, Mélany; Lefebvre, Cécile; Surénaud, Mathieu; Lacabaratz, Christine; Perreau, Matthieu; Foucat, Emile; Déchenaud, Marie; Tisserand, Pascaline; Blengio, Fabiola; Hivert, Benjamin; Gauthier, Marine; Cervantes-Gonzalez, Minerva; Bachelet, Delphine; Laouénan, Cédric; Bouadma, Lila; Timsit, Jean-François; Yazdanpanah, Yazdan; Pantaleo, Giuseppe; Hocini, Hakim; Thiébaut, Rodolphe;The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care. Immunology; Virology Graphical abstract
iScience arrow_drop_down iScienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8189740Data sources: PubMed CentralINRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCHAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert iScience arrow_drop_down iScienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8189740Data sources: PubMed CentralINRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCHAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 FrancePublisher:Proceedings of the National Academy of Sciences Funded by:EC | RECoVER, EC | VEOEC| RECoVER ,EC| VEOJuliette Paireau; Alessio Andronico; Nathanaël Hozé; Maylis Layan; Pascal Crépey; Alix Roumagnac; Marc Lavielle; Pierre-Yves Boëlle; Simon Cauchemez;Significance The COVID-19 pandemic is inducing significant stress on health care structures, which can be quickly saturated with negative consequences for patients. As hospitalization comes late in the infection history of a patient, early predictors—such as the number of cases, mobility, climate, and vaccine coverage—could improve forecasts of health care demand. Predictive models taken individually have their pros and cons, and it is advantageous to combine the predictions in an ensemble model. Here, we design an ensemble that combines several models to anticipate French COVID-19 health care needs up to 14 days ahead. We retrospectively test this model, identify the best predictors of the growth rate of hospital admissions, and propose a promising approach to facilitate the planning of hospital activity. International audience
Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-Pasteur; INRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2103302119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 24 citations 24 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Rennes 1; HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotPreprint . 2021License: CC BY NC NDHAL Descartes; HAL-Rennes 1; HAL-Pasteur; INRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2022 Italy, France, FrancePublisher:Oxford University Press (OUP) Funded by:EC | ACEPOL, UKRI | AI-SAFE - Autonomous Inte..., EC | GROWINPROEC| ACEPOL ,UKRI| AI-SAFE - Autonomous Intelligent System for Assuring Safe Working Environments ,EC| GROWINPROSeverin Reissl; Alessandro Caiani; Francesco Lamperti; Mattia Guerini; Fabio Vanni; Giorgio Fagiolo; Tommaso Ferraresi; Leonardo Ghezzi; Mauro Napoletano; Andrea Roventini;doi: 10.1093/icc/dtac003
handle: 11382/558392 , 11379/564800
We build a novel computational input-output model to estimate the economic impact of lockdowns in Italy. The key advantage of our framework is to integrate the regional and sectoral dimensions of economic production in a very parsimonious numerical simulation framework. Lockdowns are treated as shocks to available labor supply and they are calibrated on regional and sectoral employment data coupled with the prescriptions of government decrees. We show that when estimated on data from the first “hard” lockdown, our model closely reproduces the observed economic dynamics during spring 2020. In addition, we show that the model delivers a good out-of-sample forecasting performance. We also analyze the effects of the second “mild” lockdown in fall of 2020 which delivered a much more moderate negative impact on production compared to both the spring 2020 lockdown and to a hypothetical second “hard” lockdown.
HAL Descartes; Mémoi... arrow_drop_down Industrial and Corporate ChangeArticle . 2022 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: CrossrefMémoires en Sciences de l'Information et de la CommunicationPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert HAL Descartes; Mémoi... arrow_drop_down Industrial and Corporate ChangeArticle . 2022 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: CrossrefMémoires en Sciences de l'Information et de la CommunicationPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/icc/dtac003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Funded by:EC | Spray-ImagingEC| Spray-ImagingMehdi Stiti; Guillaume Castanet; Andrew Corber; Marcus Aldén; Edouard Berrocal;To control the evolution of a pandemic such as COVID-19, knowing the conditions under which the pathogen is being transmitted represents a critical issue, especially when implementing protection strategies like social distancing and face masks wearing. For viruses and bacteria that spread via airborne and/or droplet pathways, this requires understanding how saliva droplets evolve over time after their expulsion by speaking or coughing. Within this context, the transition from saliva droplets to solid residues, due to water evaporation, is studied here both experimentally, considering the saliva from 5 men and 5 women, and via numerical modeling to accurately predict the dynamics of this process. The model assumes saliva to be a binary water/salt mixture and is validated against experimental results using saliva droplets that are suspended in an ultrasound levitator. We demonstrate that droplets with an initial diameter smaller than 21 μm will produce a solid residue that would be considered an aerosol of <5 μm diameter within less than 2 second (for any relative humidity less than 80% and/or any temperature greater than 20 °C). Finally, the model developed here accounts for the influence of the saliva composition, relative humidity and ambient temperature on droplet drying. Thus, the travel distance prior to becoming a solid residue can be deduced. We found that saliva droplets of initial size below 80 μm, which corresponds to the vast majority of speech and cough droplets, will become solid residues prior to touching the ground when expelled from a height of 160 cm.
Environmental Resear... arrow_drop_down Environmental ResearchArticle . 2021Full-Text: http://europepmc.org/articles/PMC8459388Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Environmental Resear... arrow_drop_down Environmental ResearchArticle . 2021Full-Text: http://europepmc.org/articles/PMC8459388Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, France, ItalyPublisher:Elsevier BV Funded by:EC | COVIRNAEC| COVIRNABeatrice Cardinali; Claudia Provenzano; Mariapaola Izzo; Christine Voellenkle; Jonathan Battistini; Georgios Strimpakos; Elisabetta Golini; Silvia Mandillo; Ferdinando Scavizzi; Marcello Raspa; Alessandra Perfetti; Denisa Baci; Dejan Lazarevic; Jose Manuel Garcia-Manteiga; Geneviève Gourdon; Fabio Martelli; Germana Falcone;CRISPR/Cas9-mediated therapeutic gene editing is a promising technology for durable treatment of incurable monogenic diseases such as myotonic dystrophies. Gene-editing approaches have been recently applied to in vitro and in vivo models of myotonic dystrophy type 1 (DM1) to delete the pathogenic CTG-repeat expansion located in the 3′ untranslated region of the DMPK gene. In DM1-patient-derived cells removal of the expanded repeats induced beneficial effects on major hallmarks of the disease with reduction in DMPK transcript-containing ribonuclear foci and reversal of aberrant splicing patterns. Here, we set out to excise the triplet expansion in a time-restricted and cell-specific fashion to minimize the potential occurrence of unintended events in off-target genomic loci and select for the target cell type. To this aim, we employed either a ubiquitous promoter-driven or a muscle-specific promoter-driven Cas9 nuclease and tetracycline repressor-based guide RNAs. A dual-vector approach was used to deliver the CRISPR/Cas9 components into DM1 patient-derived cells and in skeletal muscle of a DM1 mouse model. In this way, we obtained efficient and inducible gene editing both in proliferating cells and differentiated post-mitotic myocytes in vitro as well as in skeletal muscle tissue in vivo. This paper describes a gene-editing approach designed to remove the pathologic CTG expansion mutation that causes myotonic dystrophy type 1. By using muscle-specific and drug-inducible expression of the CRISPR/Cas9 complex, effective deletion of the CTG expansion was obtained in myogenic cells and in mouse skeletal muscle. Graphical abstract
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8693309Data sources: PubMed CentralArchivio della ricerca- Università di Roma La SapienzaArticle . 2022Data sources: Archivio della ricerca- Università di Roma La SapienzaMolecular Therapy: Nucleic Acids; Archivio della ricerca- Università di Roma La Sapienza; CNR ExploRAArticle . 2021 . 2022 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8693309Data sources: PubMed CentralArchivio della ricerca- Università di Roma La SapienzaArticle . 2022Data sources: Archivio della ricerca- Università di Roma La SapienzaMolecular Therapy: Nucleic Acids; Archivio della ricerca- Università di Roma La Sapienza; CNR ExploRAArticle . 2021 . 2022 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Funded by:EC | CHiPS, UKRI | EPSRC Centre for Mathemat..., EC | NoMADS +2 projectsEC| CHiPS ,UKRI| EPSRC Centre for Mathematical and Statistical Analysis of Multimodal Clinical Imaging ,EC| NoMADS ,UKRI| Robust and Efficient Analysis Approaches of Remote Imagery for Assessing Population and Forest Health in India ,UKRI| PET++: Improving Localisation, Diagnosis and Quantification in Clinical and Medical PET Imaging with Randomised OptimisationAuthors: Aviles-Rivero, Angelica I; Sellars, Philip; Sch��nlieb, Carola-Bibiane; Papadakis, Nicolas;Aviles-Rivero, Angelica I; Sellars, Philip; Sch��nlieb, Carola-Bibiane; Papadakis, Nicolas;Can one learn to diagnose COVID-19 under extreme minimal supervision? Since the outbreak of the novel COVID-19 there has been a rush for developing Artificial Intelligence techniques for expert-level disease identification on Chest X-ray data. In particular, the use of deep supervised learning has become the go-to paradigm. However, the performance of such models is heavily dependent on the availability of a large and representative labelled dataset. The creation of which is a heavily expensive and time consuming task, and especially imposes a great challenge for a novel disease. Semi-supervised learning has shown the ability to match the incredible performance of supervised models whilst requiring a small fraction of the labelled examples. This makes the semi-supervised paradigm an attractive option for identifying COVID-19. In this work, we introduce a graph based deep semi-supervised framework for classifying COVID-19 from chest X-rays. Our framework introduces an optimisation model for graph diffusion that reinforces the natural relation among the tiny labelled set and the vast unlabelled data. We then connect the diffusion prediction output as pseudo-labels that are used in an iterative scheme in a deep net. We demonstrate, through our experiments, that our model is able to outperform the current leading supervised model with a tiny fraction of the labelled examples. Finally, we provide attention maps to accommodate the radiologist's mental model, better fitting their perceptual and cognitive abilities. These visualisation aims to assist the radiologist in judging whether the diagnostic is correct or not, and in consequence to accelerate the decision. International audience
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8387569Data sources: PubMed CentralarXiv.org e-Print ArchiveOther literature type . Preprint . 2020Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 24 citations 24 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 10visibility views 10 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8387569Data sources: PubMed CentralarXiv.org e-Print ArchiveOther literature type . Preprint . 2020Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, Poland, DenmarkPublisher:Elsevier BV Funded by:EC | EOSCsecretariat.euEC| EOSCsecretariat.euHans, Flaatten; Bertrand, Guidet; Dylan W, de Lange; Michael, Beil; Susannah K, Leaver; Jesper, Fjølner; Peter Vernon, van Heerden; Sviri, Sigal; Wojciech, Szczeklik; Christian, Jung;There is a strong link between limiting life-sustaining treatments(LST) and short-term outcomes, as is illustrated in a recent publication in this journal from Germany [1]. Once a patient has been admitted to the intensive care unit (ICU), limitation of LST is frequently discussed and applied. In the current pandemic, such information is of particular importance given the ongoing discussions in many countries about triage of (elderly) COVID-19 patients [2]. In this short communication we present data on the impact of limitation of LST on the outcome of elderly COVID-19 patients in Europe.
Journal of Critical ... arrow_drop_down Journal of Critical CareArticle . 2021Full-Text: http://europepmc.org/articles/PMC8588784Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 14 citations 14 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of Critical ... arrow_drop_down Journal of Critical CareArticle . 2021Full-Text: http://europepmc.org/articles/PMC8588784Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcrc.2021.10.024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Funded by:EC | Big MacEC| Big MacCario, Anaïs; Aubert, Guillaume; Alcaraz, Jean-Pierre; Borra, Jean-Pascal; Jidenko, Nicolas; barrault, mathieu; Bourrous, Soleiman; Mocho, Victor; Ouf, François Xavier; Marre, Samuel; Cinquin, Philippe; Aymonier, Cyril;International audience; Supercritical Carbon Dioxide treatment of clean and soiled Filtering Face-Piece respirators is shown to meet mandatory requirements for safe reuse of FFP2. Preliminary tests enabled us to select optimal conditions for Supercritical Carbon Dioxide treatment of FFP2, for one hour at 343 K under 7.5 MPa, with a biocide solution. FFP2s from Paul Boyé ® were then tested before and after Supercritical Carbon Dioxide treatment with a soiling solution and a biological indicator (i.e. spores of GeoBacillus stearothermophilus) with respect to three objectives: (i) washing of organic deposits, (ii) sterilization (i.e. spores inactivation) and (iii) preservation of the filtration performances. The proposed Supercritical Carbon Dioxide treatment fulfils these three criterions, with effective decontamination of spores and promising washing preserving FFP2 requirements for filtration efficiency of aerosol (> 94%) with acceptable pressure drop (< 240 Pa). As a simple and low-cost one-step recycling method, Supercritical Carbon Dioxide fits to economical and sustainable development standpoints but also allows one to come back to good practices of face protective equipment use, lowering eventual shortage and tensions for most countries importing these respirators.
The Journal of Super... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022Full-Text: https://hal.science/hal-03384956/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert The Journal of Super... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022Full-Text: https://hal.science/hal-03384956/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Belgium, Belgium, FrancePublisher:Elsevier BV Funded by:EC | EU-RESPONSEEC| EU-RESPONSEAuthors: Ader, Florence; Bouscambert-Duchamp, Maude; Hites, Maya; Peiffer-Smadja, Nathan; +177 AuthorsAder, Florence; Bouscambert-Duchamp, Maude; Hites, Maya; Peiffer-Smadja, Nathan; Poissy, Julien; Belhadi, Drifa; Diallo, Alpha; Lê, Minh-Patrick; Peytavin, Gilles; Staub, Thérèse; Greil, Richard; Guedj, Jérémie; Paiva, Jose-Artur; Costagliola, Dominique; Yazdanpanah, Yazdan; Burdet, Charles; Mentré, France; Egle, Alexander; Greil, Richard; Joannidis, Michael; Lamprecht, Bernd; Altdorfer, Antoine; Belkhir, Leila; Fraipont, Vincent; Hites, Maya; Verschelden, Gil; Aboab, Jérôme; Ader, Florence; Ait-Oufella, Hafid; Andrejak, Claire; Andreu, Pascal; Argaud, Laurent; Bani-Sadr, Firouzé; Benezit, François; Blot, Mathieu; Botelho-Nevers, Elisabeth; Bouadma, Lila; Bouchaud, Olivier; Bougon, David; Bouiller, Kevin; Bounes-Vardon, Fanny; Boutoille, David; Boyer, Alexandre; Bruel, Cédric; Cabié, André; Canet, Emmanuel; Cazanave, Charles; Chabartier, Cyrille; Chirouze, Catherine; Clere-Jehl, Raphaël; Courjon, Johan; Crockett, Flora; Danion, François; Delbove, Agathe; Dellamonica, Jean; Djossou, Félix; Dubost, Clément; Duvignaud, Alexandre; Epaulard, Olivier; Epelboin, Loïc; Fartoukh, Murielle; Faure, Karine; Faure, Emmanuel; Ferry, Tristan; Ficko, Cécile; Figueiredo, Samy; Gaborit, Benjamin; Gaci, Rostane; Gagneux-Brunon, Amandine; Gallien, Sébastien; Garot, Denis; Geri, Guillaume; Gibot, Sébastien; Goehringer, François; Gousseff, Marie; Gruson, Didier; Hansmann, Yves; Hinschberger, Olivier; Jaureguiberry, Stéphane; Jeanmichel, Vanessa; Kerneis, Solen; Kimmoun, Antoine; Klouche, Kada; Lachâtre, Marie; Lacombe, Karine; Laine, Fabrice; Lanoix, Jean-Philippe; Launay, Odile; Laviolle, Bruno; Le Moing, Vincent; Le Pavec, Jérôme; Le Tulzo, Yves; Le Turnier, Paul; Lebeaux, David; Lefevre, Benjamin; Leroy, Sylvie; Lescure, François-Xavier; Lessire, Henry; Leveau, Benjamin; Loubet, Paul; Makinson, Alain; Malvy, Denis; Marquette, Charles-Hugo; Martin-Blondel, Guillaume; Martinot, Martin; Mayaux, Julien; Mekontso-Dessap, Armand; Meziani, Ferhat; Mira, Jean-Paul; Molina, Jean-Michel; Monnet, Xavier; Mootien, Joy; Mourvillier, Bruno; Murris-Espin, Marlène; Navellou, Jean-Christophe; Nseir, Saad; Oulehri, Walid; Peiffer-Smadja, Nathan; Perpoint, Thomas; Pialoux, Gilles; Pilmis, Benoît; Piriou, Vincent; Piroth, Lionel; Poissy, Julien; Pourcher, Valérie; Quenot, Jean-Pierre; Raffi, François; Reignier, Jean; Revest, Matthieu; Richard, Jean-Christophe; Riu-Poulenc, Béatrice; Robert, Céline; Roger, Pierre-Alexandre; Roger, Claire; Rouveix-Nordon, Elisabeth; Ruch, Yvon; Saidani, Nadia; Sayre, Naomi; Senneville, Eric; Sotto, Albert; Stefan, Francois; Tacquard, Charles; Terzi, Nicolas; Textoris, Julien; Thiery, Guillaume; Timsit, Jean-François; Tolsma, Violaine; Turmel, Jean-Marie; Valour, Florent; Wallet, Florent; Wattecamps, Guilhem; Yazdanpanah, Yazdan; Zerbib, Yoann; Berna, Marc; Reuter, Jean; Staub, Thérèse; Braz, Sandra; Ferreira Ribeiro, Joao-Miguel; Paiva, José-Artur; Roncon-Albuquerque, Roberto; Bouscambert-Duchamp, Maude; Gaymard, Alexandre; Lê, Minh-Patrick; Lina, Bruno; Peytavin, Gilles; Tubiana, Sarah; Couffin-Cadièrgues, Sandrine; Esperou, Hélène; Belhadi, Drifa; Burdet, Charles; Costagliola, Dominique; Dechanet, Aline; Delmas, Christelle; Diallo, Alpha; Fougerou, Claire; Guedj, Jérémie; Mentré, France; Mercier, Noémie; Noret, Marion; Saillard, Juliette; Velou, Priyanka;pmc: PMC8439621
pmid: 34534511
Background: The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial. We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with standard of care alone in patients admitted to hospital with COVID-19, with indication of oxygen or ventilator support. Methods: DisCoVeRy was a phase 3, open-label, adaptive, multicentre, randomised, controlled trial conducted in 48 sites in Europe (France, Belgium, Austria, Portugal, Luxembourg). Adult patients (aged ≥18 years) admitted to hospital with laboratory-confirmed SARS-CoV-2 infection and illness of any duration were eligible if they had clinical evidence of hypoxaemic pneumonia, or required oxygen supplementation. Exclusion criteria included elevated liver enzymes, severe chronic kidney disease, any contraindication to one of the studied treatments or their use in the 29 days before random assignment, or use of ribavirin, as well as pregnancy or breastfeeding. Participants were randomly assigned (1:1:1:1:1) to receive standard of care alone or in combination with remdesivir, lopinavir-ritonavir, lopinavir-ritonavir and interferon beta-1a, or hydroxychloroquine. Randomisation used computer-generated blocks of various sizes; it was stratified on severity of disease at inclusion and on European administrative region. Remdesivir was administered as 200 mg intravenous infusion on day 1, followed by once daily, 1-h infusions of 100 mg up to 9 days, for a total duration of 10 days. It could be stopped after 5 days if the participant was discharged. The primary outcome was the clinical status at day 15 measured by the WHO seven-point ordinal scale, assessed in the intention-to-treat population. Safety was assessed in the modified intention-to-treat population and was one of the secondary outcomes. This trial is registered with the European Clinical Trials Database, EudraCT2020-000936-23, and ClinicalTrials.gov, NCT04315948. Findings: Between March 22, 2020, and Jan 21, 2021, 857 participants were enrolled and randomly assigned to remdesivir plus standard of care (n=429) or standard of care only (n=428). 15 participants were excluded from analysis in the remdesivir group, and ten in the control group. At day 15, the distribution of the WHO ordinal scale was: (1) not hospitalised, no limitations on activities (61 [15%] of 414 in the remdesivir group vs 73 [17%] of 418 in the control group); (2) not hospitalised, limitation on activities (129 [31%] vs 132 [32%]); (3) hospitalised, not requiring supplemental oxygen (50 [12%] vs 29 [7%]); (4) hospitalised, requiring supplemental oxygen (76 [18%] vs 67 [16%]); (5) hospitalised, on non-invasive ventilation or high flow oxygen devices (15 [4%] vs 14 [3%]); (6) hospitalised, on invasive mechanical ventilation or extracorporeal membrane oxygenation (62 [15%] vs 79 [19%]); (7) death (21 [5%] vs 24 [6%]). The difference between treatment groups was not significant (odds ratio 0·98 [95% CI 0·77-1·25]; p=0·85). There was no significant difference in the occurrence of serious adverse events between treatment groups (remdesivir, 135 [33%] of 406 vs control, 130 [31%] of 418; p=0·48). Three deaths (acute respiratory distress syndrome, bacterial infection, and hepatorenal syndrome) were considered related to remdesivir by the investigators, but only one by the sponsor's safety team (hepatorenal syndrome). Interpretation: No clinical benefit was observed from the use of remdesivir in patients who were admitted to hospital for COVID-19, were symptomatic for more than 7 days, and required oxygen support. 22;2
HAL-Rennes 1; HAL-EN... arrow_drop_down The Lancet Infectious DiseasesArticle . 2021Full-Text: http://europepmc.org/articles/PMC8439621Data sources: PubMed CentralVrije Universiteit Brussel Research PortalArticle . 2022Data sources: Vrije Universiteit Brussel Research PortalThe Lancet Infectious DiseasesOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 131 citations 131 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert HAL-Rennes 1; HAL-EN... arrow_drop_down The Lancet Infectious DiseasesArticle . 2021Full-Text: http://europepmc.org/articles/PMC8439621Data sources: PubMed CentralVrije Universiteit Brussel Research PortalArticle . 2022Data sources: Vrije Universiteit Brussel Research PortalThe Lancet Infectious DiseasesOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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