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description Publicationkeyboard_double_arrow_right Other literature type , Article 2023 FrancePublisher:Elsevier BV Funded by:ARC | Discovery Projects - Gran..., ARC | Discovery Projects - Gran..., NHMRC | Repurposing and re-optimi...ARC| Discovery Projects - Grant ID: DP210100235 ,ARC| Discovery Projects - Grant ID: DP210100233 ,NHMRC| Repurposing and re-optimising drugs that disrupt glycoprotein folding to treat COVID-19Thimali Arumapperuma; Jinling Li; Bastian Hornung; Niccolay Madiedo Soler; Ethan D. Goddard-Borger; Nicolas Terrapon; Spencer J. Williams;International audience; The Carbohydrate-Active Enzyme classification groups enzymes that breakdown, assemble, or decorate glycans into protein families based on sequence similarity. The glycoside hydrolases (GH) are arranged into over 170 enzyme families, with some being very large and exhibiting distinct activities/specificities towards diverse substrates. Family GH31 is a large family that contains more than 20,000 sequences with a wide taxonomic diversity. Less than 1% of GH31 members are biochemically characterized and exhibit many different activities that include glycosidases, lyases, and transglycosidases. This diversity of activities limits our ability to predict the activities and roles of GH31 family members in their host organism and our ability to exploit these enzymes for practical purposes. Here, we established a subfamily classification using sequence similarity networks that was further validated by a structural analysis. While sequence similarity networks provide a sequence-based separation, we obtained good segregation between activities among the subfamilies. Our subclassification consists of 20 subfamilies with sixteen subfamilies containing at least one characterized member and eleven subfamilies that are monofunctional based on the available data. We also report the biochemical characterization of a member of the large subfamily 2 (GH31_2) that lacked any characterized members: RaGH31 from Rhodoferax aquaticus is an α-glucosidase with activity on a range of disaccharides including sucrose, trehalose, maltose, and nigerose. Our subclassification provides improved predictive power for the vast majority of uncharacterized proteins in family GH31 and highlights the remaining sequence space that remains to be functionally explored.
Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United Kingdom, France, FrancePublisher:American Association for the Advancement of Science (AAAS) Funded by:UKRI | Making Habitable Worlds: ..., UKRI | A pinch of salt: Earth's ..., UKRI | STFC Glasgow Earth 2019 D... +11 projectsUKRI| Making Habitable Worlds: The Formation and Evolution of Moons and Planets ,UKRI| A pinch of salt: Earth's halogen distribution and the habitability potential of planets ,UKRI| STFC Glasgow Earth 2019 DTP ,UKRI| A journey from the solar nebula to planetary bodies: cycling of heat, water and organics ,UKRI| Building Habitable Worlds ,UKRI| Planetary Science at Bristol ,UKRI| Planetary Science at Kent 2019 - 2022 ,ARC| Discovery Projects - Grant ID: DP200102073 ,UKRI| Origin and processing of water in the early Solar System ,UKRI| Planetary Science at The University of Manchester ,UKRI| The cosmic carbon observatory ,EC| ParisRegionFP ,UKRI| Planetary Origins and Evolution at Imperial (2019-2022) ,UKRI| UK leadership in extraterrestrial sample returnKing, Ashley J; Daly, Luke; Rowe, James; Joy, Katherine H; Greenwood, Richard C; Devillepoix, Hadrien AR; Suttle, Martin D; Chan, Queenie HS; Russell, Sara S; Bates, Helena C; Bryson, James FJ; Clay, Patricia L; Vida, Denis; Lee, Martin R; O'Brien, Áine; Hallis, Lydia J; Stephen, Natasha R; Tartèse, Romain; Sansom, Eleanor K; Towner, Martin C; Cupak, Martin; Shober, Patrick M; Bland, Phil A; Findlay, Ross; Franchi, Ian A; Verchovsky, Alexander B; Abernethy, Feargus AJ; Grady, Monica M; Floyd, Cameron J; Van Ginneken, Matthias; Bridges, John; Hicks, Leon J; Jones, Rhian H; Mitchell, Jennifer T; Genge, Matthew J; Jenkins, Laura; Martin, Pierre-Etienne; Sephton, Mark A; Watson, Jonathan S; Salge, Tobias; Shirley, Katherine A; Curtis, Rowan J; Warren, Tristram J; Bowles, Neil E; Stuart, Finlay M; Di Nicola, Luigia; Györe, Domokos; Boyce, Adrian J; Shaw, Kathryn MM; Elliott, Tim; Steele, Robert CJ; Povinec, Pavel; Laubenstein, Matthias; Sanderson, David; Cresswell, Alan; Jull, Anthony JT; Sýkora, Ivan; Sridhar, Sanjana; Harrison, Richard J; Willcocks, Francesca M; Harrison, Catherine S; Hallatt, Daniel; Wozniakiewicz, Penny J; Burchell, Mark J; Alesbrook, Luke S; Dignam, Aishling; Almeida, Natasha V; Smith, Caroline L; Clark, Brett; Humphreys-Williams, Emma R; Schofield, Paul F; Cornwell, Luke T; Spathis, Vassilia; Morgan, Geraint H; Perkins, Mark J; Kacerek, Richard; Campbell-Burns, Peter; Colas, Francois; Zanda, Brigitte; Vernazza, Pierre; Bouley, Sylvain; Jeanne, Simon; Hankey, Mike; Collins, Gareth S; Young, John S; Shaw, Clive; Horak, Jana; Jones, Dave; James, Nick; Bosley, Steve; Shuttleworth, Alan; Dickinson, Paul; McMullan, Ian; Robson, Derek; Smedley, Andrew RD; Stanley, Ben; Bassom, Richard; McIntyre, Mark; Suttle, Adam A; Fleet, Richard; Bastiaens, Luc; Ihász, Míra B; McMullan, Sarah; Boazman, Sarah J; Dickeson, Zach I; Grindrod, Peter M; Pickersgill, Annemarie E; Weir, Colin J; Suttle, Fiona M; Farrelly, Sarah; Spencer, Ieun; Naqvi, Sheeraz; Mayne, Ben; Skilton, Dan; Kirk, Dan; Mounsey, Ann; Mounsey, Sally E; Mounsey, Sarah; Godfrey, Pamela; Bond, Lachlan; Bond, Victoria; Wilcock, Cathryn; Wilcock, Hannah; Wilcock, Rob;Direct links between carbonaceous chondrites and their parent bodies in the solar system are rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite fall. Its pre-atmospheric orbit and cosmic-ray exposure age confirm that it arrived on Earth shortly after ejection from a primitive asteroid. Recovered only hours after falling, the composition of the Winchcombe meteorite is largely unmodified by the terrestrial environment. It contains abundant hydrated silicates formed during fluid-rock reactions, and carbon- and nitrogen-bearing organic matter including soluble protein amino acids. The near-pristine hydrogen isotopic composition of the Winchcombe meteorite is comparable to the terrestrial hydrosphere, providing further evidence that volatile-rich carbonaceous asteroids played an important role in the origin of Earth’s water. 8;46
Oxford University Re... arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BY NCData sources: Oxford University Research ArchiveSpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositorySt Andrews Research RepositoryArticle . 2022 . Peer-reviewedData sources: St Andrews Research RepositoryThe University of Manchester - Institutional Repository; Science AdvancesArticle . 2022 . Peer-reviewedHAL AMU; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-04259418/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/sciadv.abq3925&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 20 citations 20 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 143visibility views 143 download downloads 172 Powered bymore_vert Oxford University Re... arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BY NCData sources: Oxford University Research ArchiveSpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositorySt Andrews Research RepositoryArticle . 2022 . Peer-reviewedData sources: St Andrews Research RepositoryThe University of Manchester - Institutional Repository; Science AdvancesArticle . 2022 . Peer-reviewedHAL AMU; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-04259418/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Book , Preprint 2022 France, Italy, France, United KingdomPublisher:The Royal Society Funded by:UKRI | Investigating SARS-CoV-2 ..., WT | Immunity dynamics and epi...UKRI| Investigating SARS-CoV-2 Transmission in UK Jewish Communities ,WT| Immunity dynamics and epidemiology of cross-reactive pathogensW. Waites; M. Cavaliere; V. Danos; R. Datta; R. M. Eggo; T. B. Hallett; D. Manheim; J. Panovska-Griffiths; T. W. Russell; V. I. Zarnitsyna;Transmission models for infectious diseases are typically formulated in terms of dynamics between individuals or groups with processes such as disease progression or recovery for each individual captured phenomenologically, without reference to underlying biological processes. Furthermore, the construction of these models is often monolithic: they do not allow one to readily modify the processes involved or include the new ones, or to combine models at different scales. We show how to construct a simple model of immune response to a respiratory virus and a model of transmission using an easily modifiable set of rules allowing further refining and merging the two models together. The immune response model reproduces the expected response curve of PCR testing for COVID-19 and implies a long-tailed distribution of infectiousness reflective of individual heterogeneity. This immune response model, when combined with a transmission model, reproduces the previously reported shift in the population distribution of viral loads along an epidemic trajectory. This article is part of the theme issue ‘Technical challenges of modelling real-life epidemics and examples of overcoming these’. International audience
CORE (RIOXX-UK Aggre... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2021Data sources: arXiv.org e-Print ArchiveSpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositoryPhilosophical Transactions of the Royal Society A Mathematical Physical and Engineering SciencesArticle . 2022 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2021License: arXiv Non-Exclusive DistributionData sources: DataciteHyper Article en Ligne; Hal-DiderotOther literature type . Preprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rsta.2021.0307&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 70visibility views 70 download downloads 64 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2021Data sources: arXiv.org e-Print ArchiveSpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositoryPhilosophical Transactions of the Royal Society A Mathematical Physical and Engineering SciencesArticle . 2022 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2021License: arXiv Non-Exclusive DistributionData sources: DataciteHyper Article en Ligne; Hal-DiderotOther literature type . Preprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rsta.2021.0307&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 Spain, Netherlands, Italy, FrancePublisher:Wiley Funded by:EC | ARCHEC| ARCHAuthors: Pitsillidou, Christina; Alonso-Rubido, Sandra; Ávila-Ávila, Andrea; Romero-Mulero, Mari Carmen; +14 AuthorsPitsillidou, Christina; Alonso-Rubido, Sandra; Ávila-Ávila, Andrea; Romero-Mulero, Mari Carmen; Labedz, Agata; Oikonomou, Athanasios; Proietti, Ludovica; Psychoyiou, Maria Eleni; Tellez-Quijorna, Clara; Hillary, Maniriho; Fasouli, Eirini Sofia; Fernández-Rodríguez, Guillermo; Giner-Laguarda, Natalia; Skinder, Natalia; Taroni, Chiara; Strouboulis, John; Katsantoni, Eleni; Ronchi, Antonella Ellena;pmid: 35928544
pmc: PMC9345638
This project has received funding from the European Union’s Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie grant agreement no. 813091 (ARCH, age-related changes in hematopoiesis). Peer reviewed 3 p.-1 fig.
HemaSphere arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICOther literature type . 2023 . 2022 . Peer-reviewedBOA - Bicocca Open Archive; HemaSphereOther literature type . Article . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/hs9.0000000000000763&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 13visibility views 13 download downloads 15 Powered bymore_vert HemaSphere arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICOther literature type . 2023 . 2022 . Peer-reviewedBOA - Bicocca Open Archive; HemaSphereOther literature type . Article . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/hs9.0000000000000763&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, United Kingdom, United States, FrancePublisher:Springer Science and Business Media LLC Funded by:WT | Thailand Africa and Asia ..., WT, NIH | Malaria Epidemiology in S... +1 projectsWT| Thailand Africa and Asia Programme - GBP Core ,WT ,NIH| Malaria Epidemiology in Southeast Asia: Intra- and Inter-Country Dynamics ,NHMRC| Optimising treatment and prevention strategies to accelerate malaria eliminationRae, JD; Nosten, S; Kajeechiwa, L; Wiladphaingern, J; Parker, DM; Landier, J; Thu, AM; Dah, H; Be, A; Cho, WC; Paw, KN; Paw, ES; Shee, PB; Poe, C; Nu, C; Nyaw, B; Simpson, JA; Devine, A; Maude, RJ; Moo, KL; Min, MC; Thwin, MM; Tun, SW; Nosten, FH;Background: The collection and utilization of surveillance data is essential in monitoring progress towards achieving malaria elimination, in the timely response to increases in malaria case numbers and in the assessment of programme functioning. This paper describes the surveillance activities used by the malaria elimination task force (METF) programme which operates in eastern Myanmar, and provides an analysis of data collected from weekly surveillance, case investigations, and monitoring and evaluation of programme performance.Methods: This retrospective analysis was conducted using data collected from a network of 1250 malaria posts operational between 2014 and 2021. To investigate changes in data completeness, malaria post performance, malaria case numbers, and the demographic details of malaria cases, summary statistics were used to compare data collected over space and time.Results: In the first 3 years of the METF programme, improvements in data transmission routes resulted in a 18.9% reduction in late reporting, allowing for near real-time analysis of data collected at the malaria posts. In 2020, travel restrictions were in place across Karen State in response to COVID-19, and from February 2021 the military coup in Myanmar resulted in widescale population displacement. However, over that period there has been no decline in malaria post attendance, and the majority of consultations continue to occur within 48 h of fever onset. Case investigations found that 43.8% of cases travelled away from their resident village in the 3 weeks prior to diagnosis and 36.3% reported never using a bed net whilst sleeping in their resident village, which increased to 72.2% when sleeping away from their resident village. Malaria post assessments performed in 82.3% of the METF malaria posts found malaria posts generally performed to a high standard.Conclusions: Surveillance data collected by the METF programme demonstrate that despite significant changes in the context in which the programme operates, malaria posts have remained accessible and continue to provide early diagnosis and treatment contributing to an 89.3% decrease in Plasmodium falciparum incidence between 2014 and 2021. International audience
Mémoires en Sciences... arrow_drop_down Oxford University Research Archive; Malaria JournalArticle . 2022 . 2023 . Peer-reviewedLicense: CC BYeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12936-022-04175-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!visibility 1visibility views 1 download downloads 6 Powered bymore_vert Mémoires en Sciences... arrow_drop_down Oxford University Research Archive; Malaria JournalArticle . 2022 . 2023 . Peer-reviewedLicense: CC BYeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12936-022-04175-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, Belgium, Italy, Former Yugoslav Republic of Macedonia, Brazil, France, France, Netherlands, Switzerland, Turkey, Spain, Turkey, France, France, Denmark, Italy, France, BelgiumPublisher:Proceedings of the National Academy of Sciences Funded by:EC | ATAC, ANR | AABIFNCOV, EC | EASI-Genomics +12 projectsEC| ATAC ,ANR| AABIFNCOV ,EC| EASI-Genomics ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,ANR| CNSVIRGEN ,NIH| Yale Center for Mendelian Genomics ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| Characterization of host immune responses to SARS-CoV-2 ,NIH| NHGRI Genome Sequencing Program Coordinating Center ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,NIH| Host factors contributing to susceptibility to COVID-19 disease ,EC| MORE2ADA2 ,NIH| Type I interferon-stimulated genes and the antiviral immune response ,NIH| Modulation of Human Dendritic Cell Development by Adjuvants and Vaccines ,NIH| High Performance Computing Instrumentation for the Yale Center for Genome AnalysiJérémy Manry; Paul Bastard; Adrian Gervais; Tom Le Voyer; Jérémie Rosain; Quentin Philippot; Eleftherios Michailidis; Hans-Heinrich Hoffmann; Shohei Eto; Marina Garcia-Prat; Lucy Bizien; Alba Parra-Martínez; Rui Yang; Liis Haljasmägi; Mélanie Migaud; Karita Särekannu; Julia Maslovskaja; Nicolas de Prost; Yacine Tandjaoui-Lambiotte; Charles-Edouard Luyt; Blanca Amador-Borrero; Alexandre Gaudet; Julien Poissy; Pascal Morel; Pascale Richard; Fabrice Cognasse; Jesús Troya; Sophie Trouillet-Assant; Alexandre Belot; Kahina Saker; Pierre Garçon; Jacques G. Rivière; Jean-Christophe Lagier; Stéphanie Gentile; Lindsey B. Rosen; Elana Shaw; Tomohiro Morio; Junko Tanaka; David Dalmau; Pierre-Louis Tharaux; Damien Sene; Alain Stepanian; Bruno Mégarbane; Vasiliki Triantafyllia; Arnaud Fekkar; James R. Heath; José Luis Franco; Juan-Manuel Anaya; Jordi Solé-Violán; Luisa Imberti; Andrea Biondi; Paolo Bonfanti; Riccardo Castagnoli; Ottavia M. Delmonte; Yu Zhang; Andrew L. Snow; Steven M. Holland; Catherine M. Biggs; Marcela Moncada-Vélez; Andrés Augusto Arias; Lazaro Lorenzo; Soraya Boucherit; Dany Anglicheau; Anna M. Planas; Filomeen Haerynck; Sotirija Duvlis; Tayfun Ozcelik; Sevgi Keles; Ahmed A. Bousfiha; Jalila El Bakkouri; Carolina Ramirez-Santana; Stéphane Paul; Qiang Pan-Hammarström; Lennart Hammarström; Annabelle Dupont; Alina Kurolap; Christine N. Metz; Alessandro Aiuti; Giorgio Casari; Vito Lampasona; Fabio Ciceri; Lucila A. Barreiros; Elena Dominguez-Garrido; Mateus Vidigal; Mayana Zatz; Diederik van de Beek; Sabina Sahanic; Ivan Tancevski; Yurii Stepanovskyy; Oksana Boyarchuk; Yoko Nukui; Miyuki Tsumura; Loreto Vidaur; Stuart G. Tangye; Sonia Burrel; Darragh Duffy; Lluis Quintana-Murci; Adam Klocperk; Nelli Y. Kann; Anna Shcherbina; Yu-Lung Lau; Daniel Leung; Matthieu Coulongeat; Julien Marlet; Rutger Koning; Luis Felipe Reyes; Angélique Chauvineau-Grenier; Fabienne Venet; Guillaume Monneret; Michel C. Nussenzweig; Romain Arrestier; Idris Boudhabhay; Hagit Baris-Feldman; David Hagin; Joost Wauters; Isabelle Meyts; Adam H. Dyer; Sean P. Kennelly; Nollaig M. Bourke; Rabih Halwani; Fatemeh Saheb Sharif-Askari; Karim Dorgham; Jérôme Sallette; Souad Mehlal Sedkaoui; Suzan AlKhater; Raúl Rigo-Bonnin; Francisco Morandeira; Lucie Roussel; Donald C. Vinh; Christian Erikstrup; Antonio Condino-Neto; Carolina Prando; Anastasiia Bondarenko; András N. Spaan; Laurent Gilardin; Jacques Fellay; Stanislas Lyonnet; Kaya Bilguvar; Richard P. Lifton; Shrikant Mane; Mark S. Anderson; Bertrand Boisson; Vivien Béziat; Shen-Ying Zhang; Evangelos Andreakos; Olivier Hermine; Aurora Pujol; Pärt Peterson; Trine H. Mogensen; Lee Rowen; James Mond; Stéphanie Debette; Xavier de Lamballerie; Charles Burdet; Lila Bouadma; Marie Zins; Pere Soler-Palacin; Roger Colobran; Guy Gorochov; Xavier Solanich; Sophie Susen; Javier Martinez-Picado; Didier Raoult; Marc Vasse; Peter K. Gregersen; Lorenzo Piemonti; Carlos Rodríguez-Gallego; Luigi D. Notarangelo; Helen C. Su; Kai Kisand; Satoshi Okada; Anne Puel; Emmanuelle Jouanguy; Charles M. Rice; Pierre Tiberghien; Qian Zhang; Jean-Laurent Casanova; Laurent Abel; Aurélie Cobat; Peng Zhang; Yoann Seeleuthner; Estelle Talouarn; Astrid Marchal; Daniela Matuozzo; Aliénor de la Chapelle; Jie Chen; Maya Chrabieh; Dana Liu; Yelena Nemirowskaya; Inés Marín Cruz; Marie Materna; Sophie Pelet; Chloé Thibault; Zhiyong Liu; Jorge Abad; Giulia Accordino; Cristian Achille; Sergio Aguilera-Albesa; Aina Aguiló-Cucurull; Alessandro Aiuti; Teresa Auguet; Mateus V. Castro; Cyril Cyrus; Olov Ekwall; Jan Gunst; Mikko Seppänen; Ali Sobh; Guillaume Voiriot; Virginia Quaresima; Olivier Terrier; Laurent Renia;pmid: 36179016
pmc: PMC9173764
handle: 10261/279776 , 20.500.11768/129015 , 11693/111766 , 1854/LU-8767983 , 11443/2890 , 10281/376820
pmid: 36179016
pmc: PMC9173764
handle: 10261/279776 , 20.500.11768/129015 , 11693/111766 , 1854/LU-8767983 , 11443/2890 , 10281/376820
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged 4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death. ispartof: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol:119 issue:21 ispartof: location:United States status: published
UGD Academic Reposit... arrow_drop_down Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTABilkent University Institutional RepositoryArticle . 2022Data sources: Bilkent University Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsHAL Descartes; HAL-PasteurArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03856619/documentAcibadem University Open Access RepositoryArticle . 2022Data sources: Acibadem University Open Access Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu98 citations 98 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert UGD Academic Reposit... arrow_drop_down Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTABilkent University Institutional RepositoryArticle . 2022Data sources: Bilkent University Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsHAL Descartes; HAL-PasteurArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03856619/documentAcibadem University Open Access RepositoryArticle . 2022Data sources: Acibadem University Open Access Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 United Kingdom, FrancePublisher:Informa UK Limited Funded by:EC | JITSUVAXEC| JITSUVAXVerger, Pierre; Fressard, Lisa; Soveri, Anna; Dauby, Nicolas; Fasce, Angelo; Karlsson, Linda; Lewandowsky, Stephan; Schmid, Philipp; Dubé, Eve; Gagneur, Arnaud;pmid: 35238274
OBJECTIVES The lack of validated instruments assessing vaccine hesitancy/confidence among health care professionals (HCPs) for themselves, and their patients led us to develop and validate the Pro-VC-Be instrument to measure vaccine confidence and other psychosocial determinants of HCPs’ vaccination behavior among diverse HCPs in different countries.METHODS Cross-sectional survey in October-November 2020 among 1,249 GPs in France, 432 GPs in French-speaking parts of Belgium, and 1,055 nurses in Quebec (Canada), all participating in general population immunization. Exploratory and confirmatory factor analyses evaluated the instrument’s construct validity. We used HCPs’ self-reported vaccine recommendations to patients, general immunization activity, self-vaccination, and future COVID-19 vaccine acceptance to test criterion validity.RESULTS The final results indicated a 6-factor structure with good fit: vaccine confidence (combining complacency, perceived vaccine risks, perceived benefit-risk balance, perceived collective responsibility), trust in authorities, perceived constraints, proactive efficacy (combining commitment to vaccination and self-efficacy), reluctant trust, and openness to patients. The instrument showed good convergent and criterion validity and adequate discriminant validity.CONCLUSIONS This study found that the Pro-VC-Be is a valid instrument for measuring psychosocial determinants of HCPs’ vaccination behaviors in different settings. Its validation is currently underway in Europe among various HCPs in different languages.
Expert Review of Vac... arrow_drop_down HAL Descartes; HAL AMU; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2022License: CC BY NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Expert Review of Vac... arrow_drop_down HAL Descartes; HAL AMU; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2022License: CC BY NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, Norway, Denmark, Spain, United KingdomPublisher:Elsevier BV Funded by:ANR | AMSE (EUR), EC | DECISIONS, UKRI | PhysioWizard®- Covid-...ANR| AMSE (EUR) ,EC| DECISIONS ,UKRI| PhysioWizard®- Covid-19Hess, S; Lancsar, E; Mariel, P; Meyerhoff, J; Song, F; van den Broek-Altenburg, E; Alaba, OA; Amaris, G; Arellana, J; Basso, LJ; Benson, J; Bravo-Moncayo, L; Chanel, O; Choi, S; Crastes dit Sourd, R; Cybis, HB; Dorner, Z; Falco, P; Garzón-Pérez, L; Glass, K; Guzman, LA; Huang, Z; Huynh, E; Kim, B; Konstantinus, A; Konstantinus, I; Larranaga, AM; Longo, A; Loo, BPY; Oehlmann, M; O'Neill, V; de Dios Ortúzar, J; Sanz, MJ; Sarmiento, OL; Moyo, HT; Tucker, S; Wang, Y; Wang, Y; Webb, EJD; Zhang, J; Zuidgeest, MHP;Despite unprecedented progress in developing COVID-19 vaccines, global vaccination levels needed to reach herd immunity remain a distant target, while new variants keep emerging. Obtaining near universal vaccine uptake relies on understanding and addressing vaccine resistance. Simple questions about vaccine acceptance however ignore that the vaccines being offered vary across countries and even population subgroups, and differ in terms of efficacy and side effects. By using advanced discrete choice models estimated on stated choice data collected in 18 countries/territories across six continents, we show a substantial influence of vaccine characteristics. Uptake increases if more efficacious vaccines (95% vs 60%) are offered (mean across study areas = 3.9%, range of 0.6%–8.1%) or if vaccines offer at least 12 months of protection (mean across study areas = 2.4%, range of 0.2%–5.8%), while an increase in severe side effects (from 0.001% to 0.01%) leads to reduced uptake (mean = −1.3%, range of −0.2% to −3.9%). Additionally, a large share of individuals (mean = 55.2%, range of 28%–75.8%) would delay vaccination by 3 months to obtain a more efficacious (95% vs 60%) vaccine, where this increases further if the low efficacy vaccine has a higher risk (0.01% instead of 0.001%) of severe side effects (mean = 65.9%, range of 41.4%–86.5%). Our work highlights that careful consideration of which vaccines to offer can be beneficial. In support of this, we provide an interactive tool to predict uptake in a country as a function of the vaccines being deployed, and also depending on the levels of infectiousness and severity of circulating variants of COVID-19. International audience
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2022License: CC BY NC NDData sources: CORE (RIOXX-UK Aggregator)Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; ARCHIVO DIGITAL PARA LA DOCENCIA Y LA INVESTIGACIONArticle . 2022License: CC BY NC NDHAL Descartes; Mémoires en Sciences de l'Information et de la Communication; HAL AMUArticle . 2022License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 23visibility views 23 download downloads 15 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2022License: CC BY NC NDData sources: CORE (RIOXX-UK Aggregator)Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; ARCHIVO DIGITAL PARA LA DOCENCIA Y LA INVESTIGACIONArticle . 2022License: CC BY NC NDHAL Descartes; Mémoires en Sciences de l'Information et de la Communication; HAL AMUArticle . 2022License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Netherlands, France, United KingdomPublisher:Elsevier BV Prashant Nasa; Elie Azoulay; Arunaloke Chakrabarti; Jigeeshu V Divatia; Ravi Jain; Camilla Rodrigues; Victor D. Rosenthal; Waleed Alhazzani; Yaseen M. Arabi; Jan Bakker; Matteo Bassetti; Jan J. De Waele; George Dimopoulos; Bin Du; Sharon Einav; Laura Evans; Simon Finfer; Claude Guérin; Naomi E Hammond; Samir Jaber; Ruth M. Kleinpell; Younsuck Koh; Marin H. Kollef; Mitchell M. Levy; Flávia Ribeiro Machado; Jordi Mancebo; Ignacio Martin-Loeches; Mervyn Mer; Michael S. Niederman; Paolo Pelosi; Anders Perner; John Victor Peter; Jason Phua; Lise Piquilloud; Mathias W. Pletz; Andrew Rhodes; Marcus J. Schultz; Mervyn Singer; Jean-François Timsit; Balasubramanian Venkatesh; Jean Louis Vincent; Tobias Welte; Sheila Nainan Myatra;During the current COVID-19 pandemic, health-care workers and uninfected patients in intensive care units (ICUs) are at risk of being infected with SARS-CoV-2 as a result of transmission from infected patients and health-care workers. In the absence of high-quality evidence on the transmission of SARS-CoV-2, clinical practice of infection control and prevention in ICUs varies widely. Using a Delphi process, international experts in intensive care, infectious diseases, and infection control developed consensus statements on infection control for SARS-CoV-2 in an ICU. Consensus was achieved for 31 (94%) of 33 statements, from which 25 clinical practice statements were issued. These statements include guidance on ICU design and engineering, health-care worker safety, visiting policy, personal protective equipment, patients and procedures, disinfection, and sterilisation. Consensus was not reached on optimal return to work criteria for health-care workers who were infected with SARS-CoV-2 or the acceptable disinfection strategy for heat-sensitive instruments used for airway management of patients with SARS-CoV-2 infection. Well designed studies are needed to assess the effects of these practice statements and address the remaining uncertainties.
The Lancet Infectiou... arrow_drop_down The Lancet Infectious DiseasesArticle . 2021Full-Text: http://europepmc.org/articles/PMC8580499Data sources: PubMed CentralThe Lancet Infectious DiseasesOther literature type . Article . 2022 . Peer-reviewedLicense: Elsevier TDMMémoires en Sciences de l'Information et de la CommunicationArticle . 2021Full-Text: https://hal.science/hal-03430305/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert The Lancet Infectiou... arrow_drop_down The Lancet Infectious DiseasesArticle . 2021Full-Text: http://europepmc.org/articles/PMC8580499Data sources: PubMed CentralThe Lancet Infectious DiseasesOther literature type . Article . 2022 . Peer-reviewedLicense: Elsevier TDMMémoires en Sciences de l'Information et de la CommunicationArticle . 2021Full-Text: https://hal.science/hal-03430305/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s1473-3099(21)00626-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:MDPI AG Feng Zhu; Veasna Duong; Xiao Fang Lim; Vibol Hul; Tanu Chawla; Lucy Keatts; Tracey Goldstein; Alexandre Hassanin; Vuong Tan Tu; Philippe Buchy; October M. Sessions; Lin-Fa Wang; Philippe Dussart; Danielle E. Anderson;Bats have been recognized as an exceptional viral reservoir, especially for coronaviruses. At least three bat zoonotic coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) have been shown to cause severe diseases in humans and it is expected more will emerge. One of the major features of CoVs is that they are all highly prone to recombination. An extreme example is the insertion of the P10 gene from reoviruses in the bat CoV GCCDC1, first discovered in Rousettus leschenaultii bats in China. Here, we report the detection of GCCDC1 in four different bat species (Eonycteris spelaea, Cynopterus sphinx, Rhinolophus shameli and Rousettus sp.) in Cambodia. This finding demonstrates a much broader geographic and bat species range for this virus and indicates common cross-species transmission. Interestingly, one of the bat samples showed a co-infection with an Alpha CoV most closely related to RsYN14, a virus recently discovered in the same genus (Rhinolophus) of bat in Yunnan, China, 2020. Taken together, our latest findings highlight the need to conduct active surveillance in bats to assess the risk of emerging CoVs, especially in Southeast Asia. International audience
Viruses arrow_drop_down Mémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-IRDArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Viruses arrow_drop_down Mémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-IRDArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Other literature type , Article 2023 FrancePublisher:Elsevier BV Funded by:ARC | Discovery Projects - Gran..., ARC | Discovery Projects - Gran..., NHMRC | Repurposing and re-optimi...ARC| Discovery Projects - Grant ID: DP210100235 ,ARC| Discovery Projects - Grant ID: DP210100233 ,NHMRC| Repurposing and re-optimising drugs that disrupt glycoprotein folding to treat COVID-19Thimali Arumapperuma; Jinling Li; Bastian Hornung; Niccolay Madiedo Soler; Ethan D. Goddard-Borger; Nicolas Terrapon; Spencer J. Williams;International audience; The Carbohydrate-Active Enzyme classification groups enzymes that breakdown, assemble, or decorate glycans into protein families based on sequence similarity. The glycoside hydrolases (GH) are arranged into over 170 enzyme families, with some being very large and exhibiting distinct activities/specificities towards diverse substrates. Family GH31 is a large family that contains more than 20,000 sequences with a wide taxonomic diversity. Less than 1% of GH31 members are biochemically characterized and exhibit many different activities that include glycosidases, lyases, and transglycosidases. This diversity of activities limits our ability to predict the activities and roles of GH31 family members in their host organism and our ability to exploit these enzymes for practical purposes. Here, we established a subfamily classification using sequence similarity networks that was further validated by a structural analysis. While sequence similarity networks provide a sequence-based separation, we obtained good segregation between activities among the subfamilies. Our subclassification consists of 20 subfamilies with sixteen subfamilies containing at least one characterized member and eleven subfamilies that are monofunctional based on the available data. We also report the biochemical characterization of a member of the large subfamily 2 (GH31_2) that lacked any characterized members: RaGH31 from Rhodoferax aquaticus is an α-glucosidase with activity on a range of disaccharides including sucrose, trehalose, maltose, and nigerose. Our subclassification provides improved predictive power for the vast majority of uncharacterized proteins in family GH31 and highlights the remaining sequence space that remains to be functionally explored.
Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United Kingdom, France, FrancePublisher:American Association for the Advancement of Science (AAAS) Funded by:UKRI | Making Habitable Worlds: ..., UKRI | A pinch of salt: Earth's ..., UKRI | STFC Glasgow Earth 2019 D... +11 projectsUKRI| Making Habitable Worlds: The Formation and Evolution of Moons and Planets ,UKRI| A pinch of salt: Earth's halogen distribution and the habitability potential of planets ,UKRI| STFC Glasgow Earth 2019 DTP ,UKRI| A journey from the solar nebula to planetary bodies: cycling of heat, water and organics ,UKRI| Building Habitable Worlds ,UKRI| Planetary Science at Bristol ,UKRI| Planetary Science at Kent 2019 - 2022 ,ARC| Discovery Projects - Grant ID: DP200102073 ,UKRI| Origin and processing of water in the early Solar System ,UKRI| Planetary Science at The University of Manchester ,UKRI| The cosmic carbon observatory ,EC| ParisRegionFP ,UKRI| Planetary Origins and Evolution at Imperial (2019-2022) ,UKRI| UK leadership in extraterrestrial sample returnKing, Ashley J; Daly, Luke; Rowe, James; Joy, Katherine H; Greenwood, Richard C; Devillepoix, Hadrien AR; Suttle, Martin D; Chan, Queenie HS; Russell, Sara S; Bates, Helena C; Bryson, James FJ; Clay, Patricia L; Vida, Denis; Lee, Martin R; O'Brien, Áine; Hallis, Lydia J; Stephen, Natasha R; Tartèse, Romain; Sansom, Eleanor K; Towner, Martin C; Cupak, Martin; Shober, Patrick M; Bland, Phil A; Findlay, Ross; Franchi, Ian A; Verchovsky, Alexander B; Abernethy, Feargus AJ; Grady, Monica M; Floyd, Cameron J; Van Ginneken, Matthias; Bridges, John; Hicks, Leon J; Jones, Rhian H; Mitchell, Jennifer T; Genge, Matthew J; Jenkins, Laura; Martin, Pierre-Etienne; Sephton, Mark A; Watson, Jonathan S; Salge, Tobias; Shirley, Katherine A; Curtis, Rowan J; Warren, Tristram J; Bowles, Neil E; Stuart, Finlay M; Di Nicola, Luigia; Györe, Domokos; Boyce, Adrian J; Shaw, Kathryn MM; Elliott, Tim; Steele, Robert CJ; Povinec, Pavel; Laubenstein, Matthias; Sanderson, David; Cresswell, Alan; Jull, Anthony JT; Sýkora, Ivan; Sridhar, Sanjana; Harrison, Richard J; Willcocks, Francesca M; Harrison, Catherine S; Hallatt, Daniel; Wozniakiewicz, Penny J; Burchell, Mark J; Alesbrook, Luke S; Dignam, Aishling; Almeida, Natasha V; Smith, Caroline L; Clark, Brett; Humphreys-Williams, Emma R; Schofield, Paul F; Cornwell, Luke T; Spathis, Vassilia; Morgan, Geraint H; Perkins, Mark J; Kacerek, Richard; Campbell-Burns, Peter; Colas, Francois; Zanda, Brigitte; Vernazza, Pierre; Bouley, Sylvain; Jeanne, Simon; Hankey, Mike; Collins, Gareth S; Young, John S; Shaw, Clive; Horak, Jana; Jones, Dave; James, Nick; Bosley, Steve; Shuttleworth, Alan; Dickinson, Paul; McMullan, Ian; Robson, Derek; Smedley, Andrew RD; Stanley, Ben; Bassom, Richard; McIntyre, Mark; Suttle, Adam A; Fleet, Richard; Bastiaens, Luc; Ihász, Míra B; McMullan, Sarah; Boazman, Sarah J; Dickeson, Zach I; Grindrod, Peter M; Pickersgill, Annemarie E; Weir, Colin J; Suttle, Fiona M; Farrelly, Sarah; Spencer, Ieun; Naqvi, Sheeraz; Mayne, Ben; Skilton, Dan; Kirk, Dan; Mounsey, Ann; Mounsey, Sally E; Mounsey, Sarah; Godfrey, Pamela; Bond, Lachlan; Bond, Victoria; Wilcock, Cathryn; Wilcock, Hannah; Wilcock, Rob;Direct links between carbonaceous chondrites and their parent bodies in the solar system are rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite fall. Its pre-atmospheric orbit and cosmic-ray exposure age confirm that it arrived on Earth shortly after ejection from a primitive asteroid. Recovered only hours after falling, the composition of the Winchcombe meteorite is largely unmodified by the terrestrial environment. It contains abundant hydrated silicates formed during fluid-rock reactions, and carbon- and nitrogen-bearing organic matter including soluble protein amino acids. The near-pristine hydrogen isotopic composition of the Winchcombe meteorite is comparable to the terrestrial hydrosphere, providing further evidence that volatile-rich carbonaceous asteroids played an important role in the origin of Earth’s water. 8;46
Oxford University Re... arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BY NCData sources: Oxford University Research ArchiveSpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositorySt Andrews Research RepositoryArticle . 2022 . Peer-reviewedData sources: St Andrews Research RepositoryThe University of Manchester - Institutional Repository; Science AdvancesArticle . 2022 . Peer-reviewedHAL AMU; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-04259418/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 20 citations 20 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 143visibility views 143 download downloads 172 Powered bymore_vert Oxford University Re... arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BY NCData sources: Oxford University Research ArchiveSpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositorySt Andrews Research RepositoryArticle . 2022 . Peer-reviewedData sources: St Andrews Research RepositoryThe University of Manchester - Institutional Repository; Science AdvancesArticle . 2022 . Peer-reviewedHAL AMU; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-04259418/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Book , Preprint 2022 France, Italy, France, United KingdomPublisher:The Royal Society Funded by:UKRI | Investigating SARS-CoV-2 ..., WT | Immunity dynamics and epi...UKRI| Investigating SARS-CoV-2 Transmission in UK Jewish Communities ,WT| Immunity dynamics and epidemiology of cross-reactive pathogensW. Waites; M. Cavaliere; V. Danos; R. Datta; R. M. Eggo; T. B. Hallett; D. Manheim; J. Panovska-Griffiths; T. W. Russell; V. I. Zarnitsyna;Transmission models for infectious diseases are typically formulated in terms of dynamics between individuals or groups with processes such as disease progression or recovery for each individual captured phenomenologically, without reference to underlying biological processes. Furthermore, the construction of these models is often monolithic: they do not allow one to readily modify the processes involved or include the new ones, or to combine models at different scales. We show how to construct a simple model of immune response to a respiratory virus and a model of transmission using an easily modifiable set of rules allowing further refining and merging the two models together. The immune response model reproduces the expected response curve of PCR testing for COVID-19 and implies a long-tailed distribution of infectiousness reflective of individual heterogeneity. This immune response model, when combined with a transmission model, reproduces the previously reported shift in the population distribution of viral loads along an epidemic trajectory. This article is part of the theme issue ‘Technical challenges of modelling real-life epidemics and examples of overcoming these’. International audience
CORE (RIOXX-UK Aggre... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2021Data sources: arXiv.org e-Print ArchiveSpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositoryPhilosophical Transactions of the Royal Society A Mathematical Physical and Engineering SciencesArticle . 2022 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2021License: arXiv Non-Exclusive DistributionData sources: DataciteHyper Article en Ligne; Hal-DiderotOther literature type . Preprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 70visibility views 70 download downloads 64 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2021Data sources: arXiv.org e-Print ArchiveSpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositoryPhilosophical Transactions of the Royal Society A Mathematical Physical and Engineering SciencesArticle . 2022 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2021License: arXiv Non-Exclusive DistributionData sources: DataciteHyper Article en Ligne; Hal-DiderotOther literature type . Preprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 Spain, Netherlands, Italy, FrancePublisher:Wiley Funded by:EC | ARCHEC| ARCHAuthors: Pitsillidou, Christina; Alonso-Rubido, Sandra; Ávila-Ávila, Andrea; Romero-Mulero, Mari Carmen; +14 AuthorsPitsillidou, Christina; Alonso-Rubido, Sandra; Ávila-Ávila, Andrea; Romero-Mulero, Mari Carmen; Labedz, Agata; Oikonomou, Athanasios; Proietti, Ludovica; Psychoyiou, Maria Eleni; Tellez-Quijorna, Clara; Hillary, Maniriho; Fasouli, Eirini Sofia; Fernández-Rodríguez, Guillermo; Giner-Laguarda, Natalia; Skinder, Natalia; Taroni, Chiara; Strouboulis, John; Katsantoni, Eleni; Ronchi, Antonella Ellena;pmid: 35928544
pmc: PMC9345638
This project has received funding from the European Union’s Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie grant agreement no. 813091 (ARCH, age-related changes in hematopoiesis). Peer reviewed 3 p.-1 fig.
HemaSphere arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICOther literature type . 2023 . 2022 . Peer-reviewedBOA - Bicocca Open Archive; HemaSphereOther literature type . Article . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 13visibility views 13 download downloads 15 Powered bymore_vert HemaSphere arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICOther literature type . 2023 . 2022 . Peer-reviewedBOA - Bicocca Open Archive; HemaSphereOther literature type . Article . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/hs9.0000000000000763&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, United Kingdom, United States, FrancePublisher:Springer Science and Business Media LLC Funded by:WT | Thailand Africa and Asia ..., WT, NIH | Malaria Epidemiology in S... +1 projectsWT| Thailand Africa and Asia Programme - GBP Core ,WT ,NIH| Malaria Epidemiology in Southeast Asia: Intra- and Inter-Country Dynamics ,NHMRC| Optimising treatment and prevention strategies to accelerate malaria eliminationRae, JD; Nosten, S; Kajeechiwa, L; Wiladphaingern, J; Parker, DM; Landier, J; Thu, AM; Dah, H; Be, A; Cho, WC; Paw, KN; Paw, ES; Shee, PB; Poe, C; Nu, C; Nyaw, B; Simpson, JA; Devine, A; Maude, RJ; Moo, KL; Min, MC; Thwin, MM; Tun, SW; Nosten, FH;Background: The collection and utilization of surveillance data is essential in monitoring progress towards achieving malaria elimination, in the timely response to increases in malaria case numbers and in the assessment of programme functioning. This paper describes the surveillance activities used by the malaria elimination task force (METF) programme which operates in eastern Myanmar, and provides an analysis of data collected from weekly surveillance, case investigations, and monitoring and evaluation of programme performance.Methods: This retrospective analysis was conducted using data collected from a network of 1250 malaria posts operational between 2014 and 2021. To investigate changes in data completeness, malaria post performance, malaria case numbers, and the demographic details of malaria cases, summary statistics were used to compare data collected over space and time.Results: In the first 3 years of the METF programme, improvements in data transmission routes resulted in a 18.9% reduction in late reporting, allowing for near real-time analysis of data collected at the malaria posts. In 2020, travel restrictions were in place across Karen State in response to COVID-19, and from February 2021 the military coup in Myanmar resulted in widescale population displacement. However, over that period there has been no decline in malaria post attendance, and the majority of consultations continue to occur within 48 h of fever onset. Case investigations found that 43.8% of cases travelled away from their resident village in the 3 weeks prior to diagnosis and 36.3% reported never using a bed net whilst sleeping in their resident village, which increased to 72.2% when sleeping away from their resident village. Malaria post assessments performed in 82.3% of the METF malaria posts found malaria posts generally performed to a high standard.Conclusions: Surveillance data collected by the METF programme demonstrate that despite significant changes in the context in which the programme operates, malaria posts have remained accessible and continue to provide early diagnosis and treatment contributing to an 89.3% decrease in Plasmodium falciparum incidence between 2014 and 2021. International audience
Mémoires en Sciences... arrow_drop_down Oxford University Research Archive; Malaria JournalArticle . 2022 . 2023 . Peer-reviewedLicense: CC BYeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!visibility 1visibility views 1 download downloads 6 Powered bymore_vert Mémoires en Sciences... arrow_drop_down Oxford University Research Archive; Malaria JournalArticle . 2022 . 2023 . Peer-reviewedLicense: CC BYeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, Belgium, Italy, Former Yugoslav Republic of Macedonia, Brazil, France, France, Netherlands, Switzerland, Turkey, Spain, Turkey, France, France, Denmark, Italy, France, BelgiumPublisher:Proceedings of the National Academy of Sciences Funded by:EC | ATAC, ANR | AABIFNCOV, EC | EASI-Genomics +12 projectsEC| ATAC ,ANR| AABIFNCOV ,EC| EASI-Genomics ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,ANR| CNSVIRGEN ,NIH| Yale Center for Mendelian Genomics ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| Characterization of host immune responses to SARS-CoV-2 ,NIH| NHGRI Genome Sequencing Program Coordinating Center ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,NIH| Host factors contributing to susceptibility to COVID-19 disease ,EC| MORE2ADA2 ,NIH| Type I interferon-stimulated genes and the antiviral immune response ,NIH| Modulation of Human Dendritic Cell Development by Adjuvants and Vaccines ,NIH| High Performance Computing Instrumentation for the Yale Center for Genome AnalysiJérémy Manry; Paul Bastard; Adrian Gervais; Tom Le Voyer; Jérémie Rosain; Quentin Philippot; Eleftherios Michailidis; Hans-Heinrich Hoffmann; Shohei Eto; Marina Garcia-Prat; Lucy Bizien; Alba Parra-Martínez; Rui Yang; Liis Haljasmägi; Mélanie Migaud; Karita Särekannu; Julia Maslovskaja; Nicolas de Prost; Yacine Tandjaoui-Lambiotte; Charles-Edouard Luyt; Blanca Amador-Borrero; Alexandre Gaudet; Julien Poissy; Pascal Morel; Pascale Richard; Fabrice Cognasse; Jesús Troya; Sophie Trouillet-Assant; Alexandre Belot; Kahina Saker; Pierre Garçon; Jacques G. Rivière; Jean-Christophe Lagier; Stéphanie Gentile; Lindsey B. Rosen; Elana Shaw; Tomohiro Morio; Junko Tanaka; David Dalmau; Pierre-Louis Tharaux; Damien Sene; Alain Stepanian; Bruno Mégarbane; Vasiliki Triantafyllia; Arnaud Fekkar; James R. Heath; José Luis Franco; Juan-Manuel Anaya; Jordi Solé-Violán; Luisa Imberti; Andrea Biondi; Paolo Bonfanti; Riccardo Castagnoli; Ottavia M. Delmonte; Yu Zhang; Andrew L. Snow; Steven M. Holland; Catherine M. Biggs; Marcela Moncada-Vélez; Andrés Augusto Arias; Lazaro Lorenzo; Soraya Boucherit; Dany Anglicheau; Anna M. Planas; Filomeen Haerynck; Sotirija Duvlis; Tayfun Ozcelik; Sevgi Keles; Ahmed A. Bousfiha; Jalila El Bakkouri; Carolina Ramirez-Santana; Stéphane Paul; Qiang Pan-Hammarström; Lennart Hammarström; Annabelle Dupont; Alina Kurolap; Christine N. Metz; Alessandro Aiuti; Giorgio Casari; Vito Lampasona; Fabio Ciceri; Lucila A. Barreiros; Elena Dominguez-Garrido; Mateus Vidigal; Mayana Zatz; Diederik van de Beek; Sabina Sahanic; Ivan Tancevski; Yurii Stepanovskyy; Oksana Boyarchuk; Yoko Nukui; Miyuki Tsumura; Loreto Vidaur; Stuart G. Tangye; Sonia Burrel; Darragh Duffy; Lluis Quintana-Murci; Adam Klocperk; Nelli Y. Kann; Anna Shcherbina; Yu-Lung Lau; Daniel Leung; Matthieu Coulongeat; Julien Marlet; Rutger Koning; Luis Felipe Reyes; Angélique Chauvineau-Grenier; Fabienne Venet; Guillaume Monneret; Michel C. Nussenzweig; Romain Arrestier; Idris Boudhabhay; Hagit Baris-Feldman; David Hagin; Joost Wauters; Isabelle Meyts; Adam H. Dyer; Sean P. Kennelly; Nollaig M. Bourke; Rabih Halwani; Fatemeh Saheb Sharif-Askari; Karim Dorgham; Jérôme Sallette; Souad Mehlal Sedkaoui; Suzan AlKhater; Raúl Rigo-Bonnin; Francisco Morandeira; Lucie Roussel; Donald C. Vinh; Christian Erikstrup; Antonio Condino-Neto; Carolina Prando; Anastasiia Bondarenko; András N. Spaan; Laurent Gilardin; Jacques Fellay; Stanislas Lyonnet; Kaya Bilguvar; Richard P. Lifton; Shrikant Mane; Mark S. Anderson; Bertrand Boisson; Vivien Béziat; Shen-Ying Zhang; Evangelos Andreakos; Olivier Hermine; Aurora Pujol; Pärt Peterson; Trine H. Mogensen; Lee Rowen; James Mond; Stéphanie Debette; Xavier de Lamballerie; Charles Burdet; Lila Bouadma; Marie Zins; Pere Soler-Palacin; Roger Colobran; Guy Gorochov; Xavier Solanich; Sophie Susen; Javier Martinez-Picado; Didier Raoult; Marc Vasse; Peter K. Gregersen; Lorenzo Piemonti; Carlos Rodríguez-Gallego; Luigi D. Notarangelo; Helen C. Su; Kai Kisand; Satoshi Okada; Anne Puel; Emmanuelle Jouanguy; Charles M. Rice; Pierre Tiberghien; Qian Zhang; Jean-Laurent Casanova; Laurent Abel; Aurélie Cobat; Peng Zhang; Yoann Seeleuthner; Estelle Talouarn; Astrid Marchal; Daniela Matuozzo; Aliénor de la Chapelle; Jie Chen; Maya Chrabieh; Dana Liu; Yelena Nemirowskaya; Inés Marín Cruz; Marie Materna; Sophie Pelet; Chloé Thibault; Zhiyong Liu; Jorge Abad; Giulia Accordino; Cristian Achille; Sergio Aguilera-Albesa; Aina Aguiló-Cucurull; Alessandro Aiuti; Teresa Auguet; Mateus V. Castro; Cyril Cyrus; Olov Ekwall; Jan Gunst; Mikko Seppänen; Ali Sobh; Guillaume Voiriot; Virginia Quaresima; Olivier Terrier; Laurent Renia;pmid: 36179016
pmc: PMC9173764
handle: 10261/279776 , 20.500.11768/129015 , 11693/111766 , 1854/LU-8767983 , 11443/2890 , 10281/376820
pmid: 36179016
pmc: PMC9173764
handle: 10261/279776 , 20.500.11768/129015 , 11693/111766 , 1854/LU-8767983 , 11443/2890 , 10281/376820
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged 4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death. ispartof: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol:119 issue:21 ispartof: location:United States status: published
UGD Academic Reposit... arrow_drop_down Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTABilkent University Institutional RepositoryArticle . 2022Data sources: Bilkent University Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsHAL Descartes; HAL-PasteurArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03856619/documentAcibadem University Open Access RepositoryArticle . 2022Data sources: Acibadem University Open Access Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu98 citations 98 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert UGD Academic Reposit... arrow_drop_down Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTABilkent University Institutional RepositoryArticle . 2022Data sources: Bilkent University Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsHAL Descartes; HAL-PasteurArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03856619/documentAcibadem University Open Access RepositoryArticle . 2022Data sources: Acibadem University Open Access Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 United Kingdom, FrancePublisher:Informa UK Limited Funded by:EC | JITSUVAXEC| JITSUVAXVerger, Pierre; Fressard, Lisa; Soveri, Anna; Dauby, Nicolas; Fasce, Angelo; Karlsson, Linda; Lewandowsky, Stephan; Schmid, Philipp; Dubé, Eve; Gagneur, Arnaud;pmid: 35238274
OBJECTIVES The lack of validated instruments assessing vaccine hesitancy/confidence among health care professionals (HCPs) for themselves, and their patients led us to develop and validate the Pro-VC-Be instrument to measure vaccine confidence and other psychosocial determinants of HCPs’ vaccination behavior among diverse HCPs in different countries.METHODS Cross-sectional survey in October-November 2020 among 1,249 GPs in France, 432 GPs in French-speaking parts of Belgium, and 1,055 nurses in Quebec (Canada), all participating in general population immunization. Exploratory and confirmatory factor analyses evaluated the instrument’s construct validity. We used HCPs’ self-reported vaccine recommendations to patients, general immunization activity, self-vaccination, and future COVID-19 vaccine acceptance to test criterion validity.RESULTS The final results indicated a 6-factor structure with good fit: vaccine confidence (combining complacency, perceived vaccine risks, perceived benefit-risk balance, perceived collective responsibility), trust in authorities, perceived constraints, proactive efficacy (combining commitment to vaccination and self-efficacy), reluctant trust, and openness to patients. The instrument showed good convergent and criterion validity and adequate discriminant validity.CONCLUSIONS This study found that the Pro-VC-Be is a valid instrument for measuring psychosocial determinants of HCPs’ vaccination behaviors in different settings. Its validation is currently underway in Europe among various HCPs in different languages.
Expert Review of Vac... arrow_drop_down HAL Descartes; HAL AMU; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2022License: CC BY NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Expert Review of Vac... arrow_drop_down HAL Descartes; HAL AMU; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2022License: CC BY NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, Norway, Denmark, Spain, United KingdomPublisher:Elsevier BV Funded by:ANR | AMSE (EUR), EC | DECISIONS, UKRI | PhysioWizard®- Covid-...ANR| AMSE (EUR) ,EC| DECISIONS ,UKRI| PhysioWizard®- Covid-19Hess, S; Lancsar, E; Mariel, P; Meyerhoff, J; Song, F; van den Broek-Altenburg, E; Alaba, OA; Amaris, G; Arellana, J; Basso, LJ; Benson, J; Bravo-Moncayo, L; Chanel, O; Choi, S; Crastes dit Sourd, R; Cybis, HB; Dorner, Z; Falco, P; Garzón-Pérez, L; Glass, K; Guzman, LA; Huang, Z; Huynh, E; Kim, B; Konstantinus, A; Konstantinus, I; Larranaga, AM; Longo, A; Loo, BPY; Oehlmann, M; O'Neill, V; de Dios Ortúzar, J; Sanz, MJ; Sarmiento, OL; Moyo, HT; Tucker, S; Wang, Y; Wang, Y; Webb, EJD; Zhang, J; Zuidgeest, MHP;Despite unprecedented progress in developing COVID-19 vaccines, global vaccination levels needed to reach herd immunity remain a distant target, while new variants keep emerging. Obtaining near universal vaccine uptake relies on understanding and addressing vaccine resistance. Simple questions about vaccine acceptance however ignore that the vaccines being offered vary across countries and even population subgroups, and differ in terms of efficacy and side effects. By using advanced discrete choice models estimated on stated choice data collected in 18 countries/territories across six continents, we show a substantial influence of vaccine characteristics. Uptake increases if more efficacious vaccines (95% vs 60%) are offered (mean across study areas = 3.9%, range of 0.6%–8.1%) or if vaccines offer at least 12 months of protection (mean across study areas = 2.4%, range of 0.2%–5.8%), while an increase in severe side effects (from 0.001% to 0.01%) leads to reduced uptake (mean = −1.3%, range of −0.2% to −3.9%). Additionally, a large share of individuals (mean = 55.2%, range of 28%–75.8%) would delay vaccination by 3 months to obtain a more efficacious (95% vs 60%) vaccine, where this increases further if the low efficacy vaccine has a higher risk (0.01% instead of 0.001%) of severe side effects (mean = 65.9%, range of 41.4%–86.5%). Our work highlights that careful consideration of which vaccines to offer can be beneficial. In support of this, we provide an interactive tool to predict uptake in a country as a function of the vaccines being deployed, and also depending on the levels of infectiousness and severity of circulating variants of COVID-19. International audience
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2022License: CC BY NC NDData sources: CORE (RIOXX-UK Aggregator)Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; ARCHIVO DIGITAL PARA LA DOCENCIA Y LA INVESTIGACIONArticle . 2022License: CC BY NC NDHAL Descartes; Mémoires en Sciences de l'Information et de la Communication; HAL AMUArticle . 2022License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.socscimed.2022.114800&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 23visibility views 23 download downloads 15 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2022License: CC BY NC NDData sources: CORE (RIOXX-UK Aggregator)Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; ARCHIVO DIGITAL PARA LA DOCENCIA Y LA INVESTIGACIONArticle . 2022License: CC BY NC NDHAL Descartes; Mémoires en Sciences de l'Information et de la Communication; HAL AMUArticle . 2022License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.socscimed.2022.114800&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Netherlands, France, United KingdomPublisher:Elsevier BV Prashant Nasa; Elie Azoulay; Arunaloke Chakrabarti; Jigeeshu V Divatia; Ravi Jain; Camilla Rodrigues; Victor D. Rosenthal; Waleed Alhazzani; Yaseen M. Arabi; Jan Bakker; Matteo Bassetti; Jan J. De Waele; George Dimopoulos; Bin Du; Sharon Einav; Laura Evans; Simon Finfer; Claude Guérin; Naomi E Hammond; Samir Jaber; Ruth M. Kleinpell; Younsuck Koh; Marin H. Kollef; Mitchell M. Levy; Flávia Ribeiro Machado; Jordi Mancebo; Ignacio Martin-Loeches; Mervyn Mer; Michael S. Niederman; Paolo Pelosi; Anders Perner; John Victor Peter; Jason Phua; Lise Piquilloud; Mathias W. Pletz; Andrew Rhodes; Marcus J. Schultz; Mervyn Singer; Jean-François Timsit; Balasubramanian Venkatesh; Jean Louis Vincent; Tobias Welte; Sheila Nainan Myatra;During the current COVID-19 pandemic, health-care workers and uninfected patients in intensive care units (ICUs) are at risk of being infected with SARS-CoV-2 as a result of transmission from infected patients and health-care workers. In the absence of high-quality evidence on the transmission of SARS-CoV-2, clinical practice of infection control and prevention in ICUs varies widely. Using a Delphi process, international experts in intensive care, infectious diseases, and infection control developed consensus statements on infection control for SARS-CoV-2 in an ICU. Consensus was achieved for 31 (94%) of 33 statements, from which 25 clinical practice statements were issued. These statements include guidance on ICU design and engineering, health-care worker safety, visiting policy, personal protective equipment, patients and procedures, disinfection, and sterilisation. Consensus was not reached on optimal return to work criteria for health-care workers who were infected with SARS-CoV-2 or the acceptable disinfection strategy for heat-sensitive instruments used for airway management of patients with SARS-CoV-2 infection. Well designed studies are needed to assess the effects of these practice statements and address the remaining uncertainties.
The Lancet Infectiou... arrow_drop_down The Lancet Infectious DiseasesArticle . 2021Full-Text: http://europepmc.org/articles/PMC8580499Data sources: PubMed CentralThe Lancet Infectious DiseasesOther literature type . Article . 2022 . Peer-reviewedLicense: Elsevier TDMMémoires en Sciences de l'Information et de la CommunicationArticle . 2021Full-Text: https://hal.science/hal-03430305/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s1473-3099(21)00626-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert The Lancet Infectiou... arrow_drop_down The Lancet Infectious DiseasesArticle . 2021Full-Text: http://europepmc.org/articles/PMC8580499Data sources: PubMed CentralThe Lancet Infectious DiseasesOther literature type . Article . 2022 . Peer-reviewedLicense: Elsevier TDMMémoires en Sciences de l'Information et de la CommunicationArticle . 2021Full-Text: https://hal.science/hal-03430305/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s1473-3099(21)00626-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:MDPI AG Feng Zhu; Veasna Duong; Xiao Fang Lim; Vibol Hul; Tanu Chawla; Lucy Keatts; Tracey Goldstein; Alexandre Hassanin; Vuong Tan Tu; Philippe Buchy; October M. Sessions; Lin-Fa Wang; Philippe Dussart; Danielle E. Anderson;Bats have been recognized as an exceptional viral reservoir, especially for coronaviruses. At least three bat zoonotic coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) have been shown to cause severe diseases in humans and it is expected more will emerge. One of the major features of CoVs is that they are all highly prone to recombination. An extreme example is the insertion of the P10 gene from reoviruses in the bat CoV GCCDC1, first discovered in Rousettus leschenaultii bats in China. Here, we report the detection of GCCDC1 in four different bat species (Eonycteris spelaea, Cynopterus sphinx, Rhinolophus shameli and Rousettus sp.) in Cambodia. This finding demonstrates a much broader geographic and bat species range for this virus and indicates common cross-species transmission. Interestingly, one of the bat samples showed a co-infection with an Alpha CoV most closely related to RsYN14, a virus recently discovered in the same genus (Rhinolophus) of bat in Yunnan, China, 2020. Taken together, our latest findings highlight the need to conduct active surveillance in bats to assess the risk of emerging CoVs, especially in Southeast Asia. International audience
Viruses arrow_drop_down Mémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-IRDArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/v14020176&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Viruses arrow_drop_down Mémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-IRDArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/v14020176&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu