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13 research outcomes, page 1 of 2
  • publication . Article . 2021
    Open Access English
    Authors:
    Parej Nath; Nishant Ranjan Chauhan; Kautilya Kumar Jena; Ankita Datey; Nilima Dinesh Kumar; Subhash Mehto; Saikat De; Tapas Kumar Nayak; Swatismita Priyadarsini; Kshitish Rout; ...
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660)

    Abstract The type I interferon (IFN) response is the major host arsenal against invading viruses. IRGM is a negative regulator of IFN responses under basal conditions. However, the role of human IRGM during viral infection has remained unclear. In this study, we show th...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Zubaida Hassan; Nilima Dinesh Kumar; Fulvio Reggiori; Gulfaraz Khan;
    Publisher: MDPI
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660)

    Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Bram M. ter Ellen; Nilima Dinesh Kumar; Ellen M Bouma; Berit Troost; Denise P. I. van de Pol; Heidi van der Ende-Metselaar; Leonie Apperloo; Djoke van Gosliga; Maarten van den Berge; Martijn C. Nawijn; ...
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), EC | EVA-GLOBAL (871029)

    The current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has an enormous impact on human health and economy. In search for therapeutic options, researchers have proposed resveratrol, a food supplement with known antivir...

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  • publication . Article . 2021
    Open Access English
    Authors:
    I. Margineanu; Zohar Mor; D. Garcia; C. Gilpin; S. Dhawan; Nicole Ritz; Dominik Zenner;
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660)
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  • publication . Article . 2021
    Open Access English
    Authors:
    Rick Oerlemans; Angel J Ruiz-Moreno; Yingying Cong; Nilima Dinesh Kumar; Marco A. Velasco-Velázquez; Constantinos G. Neochoritis; Jolanda Smith; Fulvio Reggiori; Matthew Groves; Alexander Dömling;
    Country: Netherlands
    Project: EC | DRIVE (765912), EC | PRONKJEWAIL (713660)

    The rapid growth of COVID-19 cases is causing an increasing death toll and also paralyzing the world economy. De novo drug discovery takes years to move from idea and/or pre-clinic to market, and it is not a short-term solution for the current SARS-CoV-2 pandemic. Drug ...

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  • publication . Article . Other literature type . Review . 2020
    Open Access English
    Authors:
    Bahaa Abu-Raya; Giovanni Battista Migliori; Miguel O'Ryan; Kathryn Edwards; Antoni Torres; Jan-Willem Alffenaar; Jan-Willem Alffenaar; Jan-Willem Alffenaar; Anne-Grete Märtson; Rosella Centis; ...
    Publisher: FRONTIERS MEDIA SA
    Countries: Netherlands, Belgium
    Project: EC | PRONKJEWAIL (713660)

    Coronavirus disease 2019 (COVID-19) is a rapidly evolving, highly transmissible, and potentially lethal pandemic caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of June 11 2020, more than 7,000,000 COVID-19 cases have been...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Ong, Catherine Wei Min; Migliori, Giovanni Battista; Raviglione, Mario; MacGregor-Skinner, Gavin; Sotgiu, Giovanni; Alffenaar, Jan-Willem; Tiberi, Simon; Adlhoch, Cornelia; Alonzi, Tonino; Archuleta, Sophia; ...
    Persistent Identifiers
    Publisher: European Respiratory Society
    Project: EC | PRONKJEWAIL (713660)

    Major epidemics, including some that qualify as pandemics, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A (H1N1)pdm/09 and most recently COVID-19, affect the lung. Tuberculosis (TB) remains the top infectious ...

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  • publication . Preprint . Article . 2019
    Open Access
    Authors:
    Alessia Landi; Muriel Mari; Tobias Wolf; Svenja Kleiser; Christine Gretzmeier; Isabel Wilhelm; Dimitra Kiritsi; Roland Thuenauer; Roger Geiger; Alexander Nyström; ...
    Publisher: Cold Spring Harbor Laboratory
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771), EC | DRIVE (765912), EC | LEC&LIP2INVADE (282105)

    Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aerugi...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Mario Mauthe; Idil Orhon; Cecilia Rocchi; Xingdong Zhou; Morten Luhr; Kerst-Jan Hijlkema; Robert P. Coppes; Nikolai Engedal; Muriel Mari; Fulvio Reggiori;
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and...

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  • research data . 2018
    Open Access
    Authors:
    Mauthe, Mario; Idil Orhon; Rocchi, Cecilia; Xingdong Zhou; Luhr, Morten; Kerst-Jan Hijlkema; Coppes, Robert P.; Engedal, Nikolai; Mari, Muriel; Reggiori, Fulvio;
    Publisher: Taylor & Francis
    Project: SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), EC | PRONKJEWAIL (713660)

    Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and...

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13 research outcomes, page 1 of 2