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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
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10 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2021
    Open Access English
    Authors:
    V'kovski, Philip; Gultom, Mitra; Kelly, Jenna N.; Steiner, Silvio; Russeil, Julie; Mangeat, Bastien; Cora, Elisa; Pezoldt, Joern; Holwerda, Melle; Kratzel, Annika; ...
    Persistent Identifiers
    Publisher: Public Library of Science
    Country: Switzerland
    Project: SNSF | Molecular characterizatio... (310030_179260), EC | HONOURs (721367), SNSF | Viral Plasticity Underlyi... (CRSII3_160780), SNSF | Host innate immune respon... (310030_173085)

    Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major public health burden. Despite its close phylogenetic relationship to SARS-CoV, SARS-CoV-2 exhibits increased human-to-human transmis...

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  • publication . Preprint . 2020
    Open Access
    Authors:
    Philip V'kovski; Mitra Gultom; Silvio Steiner; Jenna N. Kelly; Julie Russeil; Bastien Mangeat; Elisa Cora; Joern Pezoldt; Melle Holwerda; Annika Kratzel; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | HONOURs (721367), SNSF | Host innate immune respon... (310030_173085), SNSF | Molecular characterizatio... (310030_179260), SNSF | Viral Plasticity Underlyi... (CRSII3_160780)

    Abstract The human conductive respiratory tract spans a long anatomical distance and represents an important barrier to constrain invading respiratory pathogens. The disparate ambient temperatures found in the upper and lower respiratory tract have been demonstrated to ...

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  • publication . Preprint . 2020
    Open Access
    Authors:
    Nhu Thao, Tran Thi; Labroussaa, Fabien; Ebert, Nadine; V’kovski, Philip; Stalder, Hanspeter; Portmann, Jasmine; Kelly, Jenna; Steiner, Silvio; Holwerda, Melle; Kratzel, Annika; ...
    Persistent Identifiers
    Publisher: bioRxiv
    Project: EC | HONOURs (721367), SNSF | Viral Plasticity Underlyi... (CRSII3_160780)

    AbstractReverse genetics has been an indispensable tool revolutionising our insights into viral pathogenesis and vaccine development. Large RNA virus genomes, such as from Coronaviruses, are cumbersome to clone and to manipulate in E. coli hosts due to size and occasion...

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  • publication . Other literature type . Article . 2019
    Open Access English
    Authors:
    Philip V'kovski; Markus Gerber; Jenna Kelly; Stephanie Pfaender; Nadine Ebert; Sophie Braga Lagache; Cedric Simillion; Jasmine Portmann; Hanspeter Stalder; Véronique Gaschen; ...
    Publisher: eLife Sciences Publications
    Country: Switzerland
    Project: SNSF | Viral Plasticity Underlyi... (CRSII3_160780), EC | COV RESTRIC (748627)

    eLife digest Coronaviruses can infect the nose and throat and are a main cause of the common cold. Infections are usually mild and short-lived, but sometimes they can turn nasty. In 2002 and 2012, two dangerous new coronaviruses emerged and caused diseases known as SARS...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Thiel, Volker;
    Publisher: Public Library of Science (PLoS)
    Country: Switzerland
    Project: SNSF | Viral Plasticity Underlyi... (CRSII3_160780), EC | HONOURs (721367)
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  • publication . Research . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Philip, V’kovski; Markus, Gerber; Jenna, Kelly; Stephanie, Pfaender; Nadine, Ebert; Sophie, Braga Lagache; Cedric, Simillion; Jasmine, Portmann; Hanspeter, Stalder; Véronique, Gaschen; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Country: Switzerland
    Project: SNSF | Viral Plasticity Underlyi... (CRSII3_160780), EC | COV RESTRIC (748627)

    AbstractPositive-sense RNA viruses hijack intracellular membranes that provide niches for viral RNA synthesis and a platform for interactions with host proteins. However, little is known about host factors at the interface between replicase complexes and the host cytopl...

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  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Mauthe, Mario; Orhon, Idil; Rocchi, Cecilia; Zhou, Xingdong; Luhr, Morten; Hijlkema, Kerst-Jan; Coppes, Robert P.; Engedal, Nikolai; Mari, Muriel; Reggiori, Fulvio;
    Publisher: Informa UK Limited
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and...

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  • research data . 2018
    Authors:
    Mauthe, Mario; Idil Orhon; Rocchi, Cecilia; Xingdong Zhou; Luhr, Morten; Kerst-Jan Hijlkema; Coppes, Robert P.; Engedal, Nikolai; Mari, Muriel; Reggiori, Fulvio;
    Publisher: Taylor & Francis
    Project: EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and...

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  • publication . Article . 2017
    Open Access
    Authors:
    Yingying Cong; Pauline Verlhac; Fulvio Reggiori;
    Publisher: MDPI AG
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), NWO | A three-dimensional look ... (2300175771)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

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  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Country: Netherlands
    Project: NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

10 research outcomes, page 1 of 1