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6 research outcomes, page 1 of 1
  • publication . Article . 2017
    Open Access English
    Authors:
    Charlotte E. Melia; Hilde M. van der Schaar; Heyrhyoung Lyoo; Ronald W. A. L. Limpens; Qian Feng; Maryam Wahedi; Gijs J. Overheul; Ronald P. van Rij; Eric J. Snijder; Abraham J. Koster; ...
    Project: EC | EUVIRNA (264286), EC | VIVARNASILENCING (615680), NWO | Viral redesign of the cel... (2300174141), NWO | The +RNA virus replicatio... (2300150213), NWO | SysVirDrug: Translating S... (2300189186), EC | ANTIVIRALS (642434)

    Summary Enteroviruses reorganize cellular endomembranes into replication organelles (ROs) for genome replication. Although enterovirus replication depends on phosphatidylinositol 4-kinase type IIIβ (PI4KB), its role, and that of its product, phosphatidylinositol 4-phosp...

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  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Yingying Cong; Pauline Verlhac; Fulvio Reggiori;
    Publisher: MDPI AG
    Project: NWO | A three-dimensional look ... (2300175771), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), EC | PRONKJEWAIL (713660)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

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  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: NWO | A three-dimensional look ... (2300175771), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), EC | PRONKJEWAIL (713660)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

  • publication . Article . 2016
    Open Access
    Authors:
    Dennis Flierman; Gerbrand J. van der Heden van Noort; Reggy Ekkebus; Paul P. Geurink; Tycho E. T. Mevissen; Manuela K. Hospenthal; David Komander; Huib Ovaa;
    Project: NWO | Targeting poly-ubiquitin;... (2300185720), EC | UBICODE (281699), NWO | Covalent Enzyme Capture (2300182105), EC | UBSPECIFIC (309756)

    Deubiquitylating enzymes (DUBs) use multiple ubiquitin-binding pockets to disassemble polyubiquitin chains. Most tools probing DUB specificity target pockets adjacent to the active site. The protease-resistant diUb probes described here monitor linkage specificity of an...

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  • publication . Article . 2015 . Embargo End Date: 25 Sep 2015
    Open Access English
    Authors:
    Cristina M. Dorobantu; Lucian Albulescu; Christian Harak; Qian Feng; Mirjam van Kampen; Jeroen R.P.M. Strating; Alexander E. Gorbalenya; Volker Lohmann; Hilde M. van der Schaar; Frank J. M. van Kuppeveld;
    Publisher: ETH Zurich
    Project: NWO | Viral redesign of the cel... (2300174141), EC | EUVIRNA (264286), NWO | Greasing the viral life-c... (2300174167)

    Author Summary All positive-sense RNA viruses [(+)RNA viruses] replicate their viral genomes in tight association with reorganized membranous structures. Viruses generate these unique structures, often termed “replication organelles” (ROs), by efficiently manipulating t...

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  • publication . Review . Article . 2011
    Open Access
    Authors:
    Fulvio Reggiori; Cornelis A. M. de Haan; Maurizio Molinari;
    Persistent Identifiers
    Project: SNSF | Protein folding, quality ... (31003A_121926), NWO | The role of the Atg9 rese... (2300160019)

    Pathogens of bacterial and viral origin hijack pathways operating in eukaryotic cells in many ways in order to gain access into the host, to establish themselves and to eventually produce their progeny. The detailed molecular characterization of the subversion mechanism...

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6 research outcomes, page 1 of 1