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  • COVID-19

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yan, Haiyan; Sun, Jing; Wang, Kun; Wang, Huiqiang; +19 Authors

    COVID-19 pandemic caused by SARS-CoV-2 infection severely threatens global health and economic development. No effective antiviral drug is currently available to treat COVID-19 and any other human coronavirus infections. We report herein that a CFDA-approved macrolide antibiotic, carrimycin, potently inhibited the cytopathic effects (CPE) and reduced the levels of viral protein and RNA in multiple cell types infected by human coronavirus 229E, OC43, and SARS-CoV-2. Time-of-addition and pseudotype virus infection studies indicated that carrimycin inhibited one or multiple post-entry replication events of human coronavirus infection. In support of this notion, metabolic labelling studies showed that carrimycin significantly inhibited the synthesis of viral RNA. Our studies thus strongly suggest that carrimycin is an antiviral agent against a broad-spectrum of human coronaviruses and its therapeutic efficacy to COVID-19 is currently under clinical investigation. Graphical abstract CFDA-approved drug carrimycin is repurposed as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2, through inhibition of post-entry replication events of human coronavirus infection.Image 1

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    Europe PubMed Central
    Article . 2021
    Data sources: PubMed Central
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Europe PubMed Central
      Article . 2021
      Data sources: PubMed Central
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Sparavigna, A. C.;
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Publications Open Re...arrow_drop_down
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    Authors: Beale, Sarah; Lewer, Dan; Aldridge, Robert; Johnson, Anne; +3 Authors

    These datasets comprise the main analyses for the paper “Household Transmission of Seasonal Coronavirus Infections: Results from the Flu Watch cohort study”, published in Wellcome Open Research. Details of the statistical methods are reported in the article. Datasets are given in CSV format and, where relevant, in .dta format. Descriptions for each dataset are as follows: Household_CoV_acquired.csv/dta – data required to compute the proportion of cases presumably acquired outside of the household versus and the proportion acquired from household transmission. Each row represents an anonymised PCR-confirmed seasonal coronavirus case. Household_CoV_TransmissionRisk.csv/dta – data required to compute the risk of symptomatic onward household transmission following a seasonal coronavirus index case, and perform stratified descriptive analyses. Household_CoV_SAR.csv/.dta – data required to compute the seasonal coronavirus secondary attack risk overall and by strain. Each row represents an anonymised exposed-index pair from a given outbreak. HH Transmission Serial Interval.csv – presents available, anonymised data required to compute the median clinical-onset serial interval overall and by strain for each household outbreak

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    UCL
    Dataset . 2020
    Data sources: B2FIND
    UCL Discovery
    Dataset . 2020
    License: CC BY
    Data sources: Datacite
    UCL Discovery
    Dataset . 2020
    License: CC BY
    Data sources: Datacite
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      UCL
      Dataset . 2020
      Data sources: B2FIND
      UCL Discovery
      Dataset . 2020
      License: CC BY
      Data sources: Datacite
      UCL Discovery
      Dataset . 2020
      License: CC BY
      Data sources: Datacite
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: David Pattinson; Peter Jester; Lizheng Guan; Seiya Yamayoshi; +11 Authors

    Assays using ELISA measurements on serially diluted serum samples have been heavily used to measure serum reactivity to SARS-CoV-2 antigens and are widely used in virology and elsewhere in biology. We test a method using Bayesian hierarchical modelling to reduce the workload of these assays and measure reactivity of SARS-CoV-2 and HCoV antigens to human serum samples collected before and during the COVID-19 pandemic. Inflection titers for SARS-CoV-2 full-length spike protein (S1S2), spike protein receptor-binding domain (RBD), and nucleoprotein (N) inferred from 3 spread-out dilutions correlated with those inferred from 8 consecutive dilutions with an R2 value of 0.97 or higher. We confirm existing findings showing a small proportion of pre-pandemic human serum samples contain cross-reactive antibodies to SARS-CoV-2 S1S2 and N, and that SARS-CoV-2 infection increases serum reactivity to the beta-HCoVs OC43 and HKU1 S1S2. In serial dilution assays, large savings in resources and/or increases in throughput can be achieved by reducing the number of dilutions measured and using Bayesian hierarchical modelling to infer inflection or endpoint titers. We have released software for conducting these types of analysis.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Virusesarrow_drop_down
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    Viruses
    Other literature type . Article . 2022 . Peer-reviewed
    License: CC BY
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Viruses
    Article . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Virusesarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Viruses
      Other literature type . Article . 2022 . Peer-reviewed
      License: CC BY
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Viruses
      Article . 2022
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Modeste Name Faye; Mamadou Aliou Barry; Mamadou Malado Jallow; Serigne Fallou Wade; +9 Authors

    In addition to emerging coronaviruses (SARS-CoV, MERS, SARS-CoV-2), there are seasonal human coronaviruses (HCoVs): HCoV-OC43, HCoV-229E, HCoV-NL63 and HCoV-HKU1. With a wide distribution around the world, HCoVs are usually associated with mild respiratory disease. In the elderly, young children and immunocompromised patients, more severe or even fatal respiratory infections may be observed. In Africa, data on seasonal HCoV are scarce. This retrospective study investigated the epidemiology and genetic diversity of seasonal HCoVs during nine consecutive years of influenza-like illness surveillance in Senegal. Nasopharyngeal swabs were collected from ILI outpatients or from SARI hospitalized patients. HCoVs were diagnosed by qRT-PCR and the positive samples were selected for molecular characterization. Among 9337 samples tested for HCoV, 406 (4.3%) were positive: 235 (57.9%) OC43, 102 (25.1%) NL63, 58 (14.3%) 229E and 17 (4.2%) HKU1. The four types circulated during the study period and a peak was noted between November and January. Children under five were the most affected. Co-infections were observed between HCoV types (1.2%) or with other viruses (76.1%). Genetically, HCoVs types showed diversity. The results highlighted that the impact of HCoVs must be taken into account in public health; monitoring them is therefore particularly necessary both in the most sensitive populations and in animals.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Virusesarrow_drop_down
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    Viruses
    Other literature type . Article . 2022 . Peer-reviewed
    License: CC BY
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Viruses
    Article . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Virusesarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Viruses
      Other literature type . Article . 2022 . Peer-reviewed
      License: CC BY
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Viruses
      Article . 2022
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Sebastián Iglesias-Osores; Arturo Rafael-Heredia; Eric R Rojas-Tello; Washington A Ortiz-Uribe; +5 Authors

    ABSTRACT Introduction: COVID-19 has a significant impact on the hematopoietic system and hemostasis. Leukocytosis, lymphopenia, and thrombocytopenia are associated with increased severity and even death in COVID-19 cases. Objective: The aim is to examine the laboratory results of COVID-19 patients from a hospital in the Peruvian Amazon and their clinical prognosis. Material and Methods: An analytical cross-sectional study was carried out whose purpose was to identify the laboratory tests of patients with COVID-19 and mortality in a hospital in Ucayali, Peru during the period from March 13 to May 9, 2020, selecting a total of 127 with Covid-19. Mean and the standard deviation was described for age, leukocytes, neutrophils, platelets, RDW-SD; median and interquartile range for the variables lymphocyte, RN / L, fibrinogen, CRP, D-dimer, DHL, hematocrit, monocytes, eosinophils. Results: No differences were observed in this population regarding death and sex (OR: 1.31; 95% CI 0.92 to 1.87), however, it was observed that, for each one-year increase, the probability of death increased by 4% (PR: 1.04, 95% CI 1.03 to 1.05). The IRR (Incidence Risk Ratio) analysis for the numerical variables showed results strongly associated with hematological values such as Leukocytes (scaled by 2500 units) (IRR: 1.08, 95% CI 1.03 to 1.13), neutrophils (scaled by 2500 units) (IRR: 1.08; 95% CI 1.03 to 1.13), on the contrary, it is observed that the increase of 1000 units in lymphocytes, the probability of dying decreased by 48% (IRR: 0.52; 95% CI 0.38 to 071). Conclusions: Parameters such as leukocytes,neutrophils and D-dimer were statistically much higher in patients who died. RESUMEN Introducción: COVID-19 tiene un impacto significativo en el sistema hematopoyético y la hemostasia. La leucocitosis, la linfopenia y la trombocitopenia se asocian con una mayor gravedad e incluso la muerte en los casos de COVID-19. Objetivo: examinar los resultados de laboratorio de pacientes con COVID-19 de un hospital de la Amazonía peruana y su pronóstico clínico. Material y métodos: Se realizó un estudio transversal analítico cuyo propósito fue identificar las pruebas de laboratorio de pacientes con COVID-19 y mortalidad en un hospital de Ucayali, Perú durante el periodo del 13 de marzo al 9 de mayo del 2020, seleccionando un total de 127 con COVID-19. Se describió la media y la desviación estándar para edad, leucocitos, neutrófilos, plaquetas, RDW-SD; mediana y rango intercuartílico para las variables linfocito, RN/L, fibrinógeno, PCR, dímero D, DHL, hematocrito, monocitos, eosinófilos. Resultados: No se observaron diferencias en esta población en cuanto a muerte y sexo (OR: 1,31; IC 95% 0,92 a 1,87), sin embargo, se observó que, por cada aumento de un año, la probabilidad de muerte aumentaba un 4% (RP: 1,04). , IC del 95%: 1,03 a 1,05). El análisis de RIR (Razón de incidencia de riesgos) para las variables numéricas mostró resultados fuertemente asociados con valores hematológicos como Leucocitos (escala de 2500 unidades) (RRI: 1.08, 95% CI 1.03 a 1.13), neutrófilos (escala de 2500 unidades) (RRI: 1.08; IC 95% 1.03 a 1.13), por el contrario, se observa que al aumento de 1000 unidades en linfocitos, la probabilidad de morir disminuyó en un 48% (TIR: 0.52; IC 95% 0.38 a 071). Conclusiones: Parámetros tales como los leucocitos, los neutrófilos y el dímero D fueron estadísticamente mucho más altos en los pacientes que fallecieron.

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    Revista Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo
    Article . 2023 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
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      Revista Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo
      Article . 2023 . Peer-reviewed
      License: CC BY
      Data sources: Crossref
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    Authors: Choudhury, Abhigyan; Sen Gupta, Parth Sarthi; Panda, Saroj Kumar; Rana, Malay Kumar; +1 Authors

    The coronaviridae family has generated highly virulent viruses, including the ones responsible for three major pandemics in last two decades with SARS in 2002, MERS outbreak in 2012 and the current nCOVID19 crisis that has turned the world breadthless. Future outbreaks are also a plausible threat to mankind. As computational biologists, we are committed to address the need for a universal vaccine that can deter all these pathogenic viruses in a single shot. Notably, the spike proteins present in all these viruses function as credible PAMPs that are majorly sensed by human TLR4 receptors. Our study aims to recognize the amino acid sequence(s) of the viral spike proteins that are precisely responsible for interaction with human TLR4 and to screen the immunogenic epitopes present in them to develop a multi-epitope multi-target chimeric vaccine against the coronaviruses. Molecular design of the constructed vaccine peptide is qualified in silico; additionally, molecular docking and molecular dynamics simulation studies collectively reveal strong and stable interactions of the vaccine construct with TLRs and MHC receptors. In silico cloning is performed for proficient expression in bacterial systems. In silico immune simulation of the vaccine indicates highly immunogenic nature of the vaccine construct without any allergic response. The present biocomputational study hereby innovates a vaccine candidate - AbhiSCoVac hypothesized as a potent remedy to combat all the virulent forms of coronaviruses. Graphical abstract

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    Europe PubMed Central
    Article . 2022
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    Journal of Molecular Liquids
    Article . 2022 . Peer-reviewed
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      Europe PubMed Central
      Article . 2022
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Journal of Molecular Liquids
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Matteo Biolatti; Marco Blangetti; Melissa Baggieri; Antonella Marchi; +23 Authors

    The current SARS-CoV-2 pandemic and the likelihood that new coronavirus strains will emerge in the immediate future point out the urgent need to identify new pan-coronavirus inhibitors. Strigolactones (SLs) are a class of plant hormones with multifaceted activities whose roles in plant-related fields have been extensively explored. Recently, we proved that SLs also exert antiviral activity toward herpesviruses, such as human cytomegalovirus (HCMV). Here we show that the synthetic SLs TH-EGO and EDOT-EGO impair β-coronavirus replication including SARS-CoV-2 and the common cold human coronavirus HCoV-OC43. Interestingly,

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio Istituziona...arrow_drop_down
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    ACS Infectious Diseases
    Article . 2023 . Peer-reviewed
    License: STM Policy #29
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio Istituziona...arrow_drop_down
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      ACS Infectious Diseases
      Article . 2023 . Peer-reviewed
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    Authors: Sophie Steiner; Tatjana Schwarz; Tatjana Schwarz; Victor M. Corman; +11 Authors

    Despite RT-PCR confirmed COVID-19, specific antibodies to SARS-CoV-2 spike are undetectable in serum in approximately 10% of convalescent patients after mild disease course. This raises the question of induction and persistence of SARS-CoV-2-reactive T cells in these convalescent individuals. Using flow cytometry, we assessed specific SARS-CoV-2 and human endemic coronaviruses (HCoV-229E, -OC43) reactive T cells after stimulation with spike and nucleocapsid peptide pools and analyzed cytokine polyfunctionality (IFNγ, TNFα, and IL-2) in seropositive and seronegative convalescent COVID-19 patients as well as in unexposed healthy controls. Stimulation with SARS-CoV-2 spike and nucleocapsid (NCAP) as well as HCoV spike peptide pools elicited a similar T cell response in seropositive and seronegative post COVID-19 patients. Significantly higher frequencies of polyfunctional cytokine nucleocapsid reactive CD4+ T cells (triple positive for IFNγ, TNFα, and IL-2) were observed in both, seropositive (p = 0.008) and seronegative (p = 0.04), COVID-19 convalescent compared to healthy controls and were detectable up to day 162 post RT-PCR positivity in seronegative convalescents. Our data indicate an important role of NCAP-specific T cells for viral control.

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    Frontiers in Immunology
    Article . 2021
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      Frontiers in Immunology
      Article . 2021
      Data sources: DOAJ-Articles
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: BAS, Koray; YILMAZ, Fulya;

    Aim: The 21st Century has already witnessed three outbreaks caused by the same family of coronaviruses, the Severe Acute Respiratory Syndrome (SARS), the Middle East Respiratory Syndrome (MERS) and recently, The Noval Coronavirus Disease 2019 (COVID-19). The main aim of this study is to analyze the overall scientific publications indexed in Science Citation Index Expanded (SCI-E) about these three outbreaks. And the secondary aim is to compare first scientific reactions to SARS, MERS and COVID-19 outbreaks in their early phases by using the dates of first 4 months of them.Material and Method: Web of Science (WoS) software was used for the search and the analysis. Allscientific papers, included in SCI-E, related with each outbreaks of SARS, MERS and COVID-19 from 1980 to April15.2020, were searched and analyzed by using the terms of “SARS”, “SARS-CoV” and “Severe Acute Respiratory Syndrome” for SARS; “MERS”, “MERS-CoV”, “HCoV-EMC” and “Middle East Respiratory Disease” for MERS and “COVID-19”, “2019-n-CoV”, “SARS-CoV-2”, “Coronavirus disease 19” and “2019 novel coronavirus” for COVID-19 in the topic section of the software.Results: Overall; 3690, 1517 and 730 papers, indexed by SCI-E, were found related to SARS, MERS and COVID-19 respectively. The biggest contribution for publications was from People’s Republic of China (PRC) for SARS and COVID-19 and was from The United States of America (USA) for MERS.Conclusion: In this study, it was revealed that scientific contribution to COVID-19 is faster and greatful then SARS and MERS in the early phase of the outbreak. But the pandemic potential of betacoronaviruses, especially SARS-CoV-2, remains a threat for public health globally. Therefore further research into the pathogenesis of these infections in order to find appropriate targets for treatment is imperative. Amaç: 21. yüzyıl, aynı koronavirüs ailesinin neden olduğu üç salgına, Şiddetli Akut Solunum Sendromu (SARS), Orta Doğu Solunum Sendromu (MERS) ve yakın zamanda Noval Koronavirüs Hastalığı 2019’un (COVID-19) tanık olmuştur. Bu çalışmanın amacı, bu üç salgın ile ilgili, Science Citation Index Expanded (SCI-E) dergilerde indekslenen genel bilimsel yayınları analiz etmektir. İkincil amacı ise SARS, MERS ve COVID-19 salgınlarına yönelik ilk bilimsel reaksiyonları erken evrelerinde, ilk 4 aylık süreçlerinde, karşılaştırmaktır.Materyal ve Metot: Arama ve analiz için ISI-Web of Knowledge- Web of Science (WoS) yazılımı kullanılmıştır. 1975’ten 15 Nisan 2020’ye kadar SARS, MERS ve COVID-19 salgını ile ilgili SCI-E indexlenen tüm bilimsel makaleler Şiddetli Akut Solunum Sendromu (SARS) için “SARS”, “SARS-CoV” ve “Şiddetli Akut Solunum Sendromu” terimleri kullanılarak; Orta Doğu Solunum Sendromu (MERS) için “MERS”, “MERS-CoV”, “HCoV-EMC” ve “Orta Doğu Solunum Sendromu” terimleri kullanılarak ve COVID-19 için “COVID-19”, “2019-n-CoV”, “SARS-CoV-2”, “Koronavirüs hastalığı 19” ve “2019 yeni koronavirüs” erimleri kullanılarak arştırma yapıldı.Bulgular: SCI-E tarafından indekslenen 3690 yayın SARS ile, 1517 yayın MERS ile ve 730 yayın COVID-19 ile ilgili bulunmuştur. Yayınlara en büyük katkı, SARS ve COVID-19 için Çin Halk Cumhuriyeti’nden (PRC); MERS için Amerika Birleşik Devletlerindendir (ABD).Sonuç: Bu çalışma ile, COVID-19’a bilimsel katkının salgının erken evresindeki SARS ve MERS’den daha hızlı ve daha büyük olduğunu gösterdik. Ancak, HCoV’lerin, özellikle SARS-CoV-2’nin pandemik potansiyeli, küresel olarak halk sağlığı için bir tehdit olmaya devam etmektedir. Bu nedenle, tedavi için uygun hedefleri bulmak için HCoV enfeksiyonlarının patogenezine yönelik daha fazla araştırma yapılması zorunludur.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yan, Haiyan; Sun, Jing; Wang, Kun; Wang, Huiqiang; +19 Authors

    COVID-19 pandemic caused by SARS-CoV-2 infection severely threatens global health and economic development. No effective antiviral drug is currently available to treat COVID-19 and any other human coronavirus infections. We report herein that a CFDA-approved macrolide antibiotic, carrimycin, potently inhibited the cytopathic effects (CPE) and reduced the levels of viral protein and RNA in multiple cell types infected by human coronavirus 229E, OC43, and SARS-CoV-2. Time-of-addition and pseudotype virus infection studies indicated that carrimycin inhibited one or multiple post-entry replication events of human coronavirus infection. In support of this notion, metabolic labelling studies showed that carrimycin significantly inhibited the synthesis of viral RNA. Our studies thus strongly suggest that carrimycin is an antiviral agent against a broad-spectrum of human coronaviruses and its therapeutic efficacy to COVID-19 is currently under clinical investigation. Graphical abstract CFDA-approved drug carrimycin is repurposed as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2, through inhibition of post-entry replication events of human coronavirus infection.Image 1

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    Europe PubMed Central
    Article . 2021
    Data sources: PubMed Central
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      Europe PubMed Central
      Article . 2021
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    Authors: Sparavigna, A. C.;
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    Authors: Beale, Sarah; Lewer, Dan; Aldridge, Robert; Johnson, Anne; +3 Authors

    These datasets comprise the main analyses for the paper “Household Transmission of Seasonal Coronavirus Infections: Results from the Flu Watch cohort study”, published in Wellcome Open Research. Details of the statistical methods are reported in the article. Datasets are given in CSV format and, where relevant, in .dta format. Descriptions for each dataset are as follows: Household_CoV_acquired.csv/dta – data required to compute the proportion of cases presumably acquired outside of the household versus and the proportion acquired from household transmission. Each row represents an anonymised PCR-confirmed seasonal coronavirus case. Household_CoV_TransmissionRisk.csv/dta – data required to compute the risk of symptomatic onward household transmission following a seasonal coronavirus index case, and perform stratified descriptive analyses. Household_CoV_SAR.csv/.dta – data required to compute the seasonal coronavirus secondary attack risk overall and by strain. Each row represents an anonymised exposed-index pair from a given outbreak. HH Transmission Serial Interval.csv – presents available, anonymised data required to compute the median clinical-onset serial interval overall and by strain for each household outbreak

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    UCL
    Dataset . 2020
    Data sources: B2FIND
    UCL Discovery
    Dataset . 2020
    License: CC BY
    Data sources: Datacite
    UCL Discovery
    Dataset . 2020
    License: CC BY
    Data sources: Datacite
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      UCL
      Dataset . 2020
      Data sources: B2FIND
      UCL Discovery
      Dataset . 2020
      License: CC BY
      Data sources: Datacite
      UCL Discovery
      Dataset . 2020
      License: CC BY
      Data sources: Datacite
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    Authors: David Pattinson; Peter Jester; Lizheng Guan; Seiya Yamayoshi; +11 Authors

    Assays using ELISA measurements on serially diluted serum samples have been heavily used to measure serum reactivity to SARS-CoV-2 antigens and are widely used in virology and elsewhere in biology. We test a method using Bayesian hierarchical modelling to reduce the workload of these assays and measure reactivity of SARS-CoV-2 and HCoV antigens to human serum samples collected before and during the COVID-19 pandemic. Inflection titers for SARS-CoV-2 full-length spike protein (S1S2), spike protein receptor-binding domain (RBD), and nucleoprotein (N) inferred from 3 spread-out dilutions correlated with those inferred from 8 consecutive dilutions with an R2 value of 0.97 or higher. We confirm existing findings showing a small proportion of pre-pandemic human serum samples contain cross-reactive antibodies to SARS-CoV-2 S1S2 and N, and that SARS-CoV-2 infection increases serum reactivity to the beta-HCoVs OC43 and HKU1 S1S2. In serial dilution assays, large savings in resources and/or increases in throughput can be achieved by reducing the number of dilutions measured and using Bayesian hierarchical modelling to infer inflection or endpoint titers. We have released software for conducting these types of analysis.

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    Viruses
    Other literature type . Article . 2022 . Peer-reviewed
    License: CC BY
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    Viruses
    Article . 2022
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      Viruses
      Other literature type . Article . 2022 . Peer-reviewed
      License: CC BY
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      Viruses
      Article . 2022
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    Authors: Modeste Name Faye; Mamadou Aliou Barry; Mamadou Malado Jallow; Serigne Fallou Wade; +9 Authors

    In addition to emerging coronaviruses (SARS-CoV, MERS, SARS-CoV-2), there are seasonal human coronaviruses (HCoVs): HCoV-OC43, HCoV-229E, HCoV-NL63 and HCoV-HKU1. With a wide distribution around the world, HCoVs are usually associated with mild respiratory disease. In the elderly, young children and immunocompromised patients, more severe or even fatal respiratory infections may be observed. In Africa, data on seasonal HCoV are scarce. This retrospective study investigated the epidemiology and genetic diversity of seasonal HCoVs during nine consecutive years of influenza-like illness surveillance in Senegal. Nasopharyngeal swabs were collected from ILI outpatients or from SARI hospitalized patients. HCoVs were diagnosed by qRT-PCR and the positive samples were selected for molecular characterization. Among 9337 samples tested for HCoV, 406 (4.3%) were positive: 235 (57.9%) OC43, 102 (25.1%) NL63, 58 (14.3%) 229E and 17 (4.2%) HKU1. The four types circulated during the study period and a peak was noted between November and January. Children under five were the most affected. Co-infections were observed between HCoV types (1.2%) or with other viruses (76.1%). Genetically, HCoVs types showed diversity. The results highlighted that the impact of HCoVs must be taken into account in public health; monitoring them is therefore particularly necessary both in the most sensitive populations and in animals.

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    Viruses
    Other literature type . Article . 2022 . Peer-reviewed
    License: CC BY
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    Viruses
    Article . 2022
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