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4 research outcomes, page 1 of 1
  • publication . Doctoral thesis . 2012
    Closed Access English
    Authors:
    Velthuis, A.J.W. de;
    Persistent Identifiers

    This thesis discusses the purification and activities of the SARS-coronavirus (SARS-CoV) RNA-dependent RNA polymerases (RdRps) nsp12 and nsp(7+8). The first is a large monomeric RdRp, whose stability is greatly influenced by N-terminal additions. In contrast, the latter...

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  • publication . Doctoral thesis . 2006
    Open Access English
    Authors:
    Born, E. van den;
    Persistent Identifiers

    Viruses depend on their host cell for the production of their progeny. The genetic information that is required to regulate this process is contained in the viral genome. In the case of plus-stranded RNA viruses, like nidoviruses, the RNA genome is directly involved in ...

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  • publication . Doctoral thesis . 2013
    Closed Access English
    Authors:
    Wilde, A.H. de;
    Persistent Identifiers

    The interplay between nidoviruses and the infected host cell was investigated. Arterivirus RNA-synthesising activity was shown to depend on intact membranes and on a cytosolic host protein which does not cosediment with the RTC. Furthermore, the immunosuppressant drug c...

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  • publication . Doctoral thesis . 2020
    Closed Access English
    Authors:
    Knaap, R.C.M.;
    Persistent Identifiers

    <p> Replication of positive-stranded RNA viruses requires the activity of proteases that cleave the viral replicase polyproteins. For Middle East respiratory coronavirus (MERS-CoV), the virus-encoded papain-like protease (PLpro) is one of such proteases. This protease a...

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4 research outcomes, page 1 of 1