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70 research outcomes, page 1 of 7
  • publication . Article . 2005
    Open Access English
    Authors:
    Azizi, Ali; Aucoin, Susan; Tadesse, Helina; Frost, Rita; Ghorbani, Masoud; Soare, Catalina; Naas, Turaya; Diaz-Mitoma, Francisco;
    Persistent Identifiers

    Several studies have shown that cell-mediated immune responses play a crucial role in controlling viral replication. As such, a candidate SARS vaccine should elicit broad CD8+ T-cell immune responses. Several groups of mice were immunized alone or in combination with SA...

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  • publication . Other literature type . Article . 2020
    Open Access English
    Authors:
    Ingraham, Nicholas E.; Boulware, David; Sparks, Matthew A.; Schacker, Timothy; Benson, Bradley; Sparks, Jeffrey A.; Murray, Thomas; Connett, John; Chipman, Jeffrey G.; Charles, Anthony; ...
    Persistent Identifiers
    Publisher: BioMed Central Ltd.

    Background The 2020 COVID-19 pandemic has stunned the world, financial markets, and healthcare systems. Researchers are rushing to identify effective treatments while maintaining rigorous adherence to the scientific method. Clinicians are doing their best to provide evi...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Park, Sungha; Lee, Hae Young; Cho, Eun Joo; Sung, Ki Chul; Kim, Juhan; Kim, Dae-Hee; Ihm, Sang-Hyun; Kim, Kwang-il; Sohn, Il-Suk; Chung, Wook-Jin; ...
    Publisher: BMC

    Abstract Antihypertensive drugs are one of the most widely used pharmacologic agent in the world and it is predominantly used in the elderly subjects. Pneumonia is the most common cause of death in the extremely old subject. During infection and its complication such as...

  • publication . Article . 2020
    Open Access English
    Authors:
    Chattu, Vijay Kumar; Yaya, Sanni;
    Persistent Identifiers
    Publisher: BMC

    Abstract This century is witnessing dramatic changes in the health needs of the world’s populations. The double burden of infectious and chronic diseases constitutes major causes of morbidity and mortality. Over the last two decades, there has been a rise in infectious ...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Chen, Yu Wai; Yiu, Chin-Pang; Wong, Kwok-Yin;
    Persistent Identifiers
    Publisher: F1000 Research Limited

    We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CL (pro)) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding and dimerisation...

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  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Florian Wrensch; Michael Winkler; Stefan Pöhlmann;
    Persistent Identifiers

    The interferon-inducible transmembrane (IFITM) proteins 1, 2 and 3 inhibit the host cell entry of several enveloped viruses, potentially by promoting the accumulation of cholesterol in endosomal compartments. IFITM3 is essential for control of influenza virus infection ...

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  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Pickett, Brett; Greer, Douglas; Zhang, Yun; Stewart, Lucy; Zhou, Liwei; Sun, Guangyu; Gu, Zhiping; Kumar, Sanjeev; Zaremba, Sam; Larsen, Christopher; ...
    Persistent Identifiers
    Publisher: MDPI AG

    Several viruses within the Coronaviridae family have been categorized as either emerging or re-emerging human pathogens, with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) being the most well known. The NIAID-sponsored Virus Pathogen Database and Analysis Res...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Kai-yue Diao; Pei-lun Han; Tong Pang; Yuan Li; Zhi-gang Yang;
    Persistent Identifiers

    <jats:title>Abstract</jats:title> <jats:p>With the spread of novel coronavirus (2019-nCoV) pneumonia, chest high-resolution computed tomography (HRCT) has been one of the key diagnostic tools. To achieve early and accurate diagnostics, determining the radiological chara...

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  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Hu, Ben; Ge, Xingyi; Wang, Lin-Fa; Shi, Zhengli;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Understanding the Risk of... (5R01AI110964-05)

    Bats have been recognized as the natural reservoirs of a large variety of viruses. Special attention has been paid to bat coronaviruses as the two emerging coronaviruses which have caused unexpected human disease outbreaks in the 21st century, Severe Acute Respiratory S...

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Firas A Rabi; Mazhar S. Al Zoubi; Ghena A Kasasbeh; Dunia M Salameh; Amjad D. Al-Nasser;
    Publisher: MDPI

    <jats:p>In December 2019, a cluster of fatal pneumonia cases presented in Wuhan, China. They were caused by a previously unknown coronavirus. All patients had been associated with the Wuhan Wholefood market, where seafood and live animals are sold. The virus spread rapi...

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70 research outcomes, page 1 of 7