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7 research outcomes, page 1 of 1
  • publication . Article . 2009
    Open Access English
    Authors:
    Cooper, BS; Fang, LQ; Zhou, JP; Feng, D; Lv, H; Wei, MT; Wang, SX; Cao, WC; de Vlas, SJ;
    Persistent Identifiers
    Publisher: Blackwell Publishing Ltd

    Summary Objective  To quantify the transmissibility of severe acute respiratory syndrome (SARS) in hospitals in mainland China and to assess the effectiveness of control measures. Methods  We report key epidemiological details of three major hospital outbreaks of SARS i...

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  • publication . Article . 2004
    Open Access English
    Authors:
    Tsang, HW; Scudds, RJ; Chan, EY;
    Persistent Identifiers
    Publisher: Centers for Disease Control and Prevention
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  • publication . Article . 2013
    Open Access English
    Authors:
    Horby, Peter W,; Pfeiffer, Dirk; Oshitani, Hitoshi;
    Persistent Identifiers
    Publisher: Centers for Disease Control and Prevention

    It is 10 years since severe acute respiratory syndrome (SARS) emerged, and East and Southeast Asia retain a reputation as a hot spot of emerging infectious diseases. The region is certainly a hot spot of socioeconomic and environmental change, and although some changes ...

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  • publication . Part of book or chapter of book . Article . 2012
    Open Access
    Authors:
    H. Rogier van Doorn; Hongjie Yu;
    Publisher: Elsevier

    Abstract Acute respiratory illnesses are the most frequently occurring illness in all age groups globally. Disease is mostly limited to the upper airways and is self-limiting, but a small percentage can progress to lower respiratory tract infections as bronchiolitis and...

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  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Adedeji, Adeyemi O.; Marchand, Bruno; te Velthuis, Aartjan J. W.; Snijder, Eric J.; Weiss, Susan; Eoff, Robert L.; Singh, Kamalendra; Sarafianos, Stefan G.;
    Publisher: Public Library of Science (PLoS)
    Project: CIHR , NIH | Microbicide properties of... (5R33AI079801-05), NIH | Ultrapotent Inhibitors of... (2R01AI076119-06A1), NIH | Gene Therapy for HIV Usin... (5R01AI074389-08), NIH | Structure-based expansion... (1R21AI094715-01A1)

    The non-structural protein 13 (nsp13) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a helicase that separates double-stranded RNA (dsRNA) or DNA (dsDNA) with a 5' → 3' polarity, using the energy of nucleotide hydrolysis. We determined the minimal mechan...

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  • publication . Article . Other literature type . 2011
    Open Access English
    Authors:
    Do, A.H.L.; van Doorn, H.R.; Nghiem, M.N.; Bryant, J.E.; Hoang, T.H.T.; Do, Q.H.; Le Van, T.; Tran, T.T.; Wills, B.; Nguyen, V.C.; ...
    Project: WT

    Background: The dominant viral etiologies responsible for acute respiratory infections (ARIs) are poorly understood, particularly among hospitalized children in resource-limited tropical countries where morbidity and mortality caused by ARIs are highest. Improved etiolo...

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  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Bertram, Stephanie; Heurich, Adeline; Lavender, Hayley; Gierer, Stefanie; Danisch, Simon; Perin, Paula; Lucas, Jared M; Nelson, Peter S; Pöhlmann, Stefan; Soilleux, Elizabeth;
    Project: NIH | Transmembrane Proteases a... (5P01CA085859-10)

    The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS-coronavirus (TMPRSS2) in cell culture and may play an important role in viral spread and pathogenesis in the infected host. However, it is at present largely unclear to wh...

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7 research outcomes, page 1 of 1