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15 research outcomes, page 1 of 2
  • International audience; The entire process of the complete passage of a virus from animals to humans requires five phases. The first one is the unique and short-lived initial zoonotic passage in humans of an animal virus. During the second stage, the animal virus passes...

  • publication . Article . 2011
    Open Access English
    Authors:
    Ryu, H.-J.; Lee, S.-H.; Hwang, S.; BRETON, Vincent; H. Rhee, J.; Kim, D.;
    Publisher: HAL CCSD

    The 3C-like protease (3CLpro) of severe acute respiratory syndrome associated coronavirus (SARS-CoV) is vital for SARS-CoV replication and is a promising drug target. Structure based virtual screening of 308 307 chemical compounds was performed using the computation too...

  • publication . Conference object . Article . 2003
    Open Access French
    Authors:
    Charley, Bernard;
    Publisher: HAL CCSD

    National audience; Interferons are a family of molecules produced in response to a viral aggression. The author focuses here on alpha interferon, describing its biological properties (antiviral, immunomodulator, antitumoral and responsible for side effects such as fever...

  • publication . Article . 2020
    Open Access English
    Authors:
    Wilkinson, David A.; Joffrin, Léa; Lebarbenchon, Camille; Mavingui, Patrick;
    Persistent Identifiers
    Publisher: HAL CCSD

    International audience; The recent reclassification of the Riboviria, and the introduction of multiple new taxonomic categories including both subfamilies and subgenera for coronaviruses (family Coronaviridae, subfamily Orthocoronavirinae), represents a major shift in h...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Jean K. Millet; Gary R. Whittaker;
    Persistent Identifiers
    Publisher: Elsevier Inc.
    Project: NIH | Spike protein cleavage-ac... (1R21AI111085-01)

    Highlights • SARS-CoV as model for studying the coronavirus (CoV) fusion peptide (FP). • Evidence based on functional and biophysical analyses that reveal the region downstream of the coronavirus spike protein S2′ cleavage as the bona fide FP that forms an extended “fus...

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  • publication . Article . 2010
    Open Access English
    Authors:
    Antoine Flahault; Patrick Zylberman;
    Persistent Identifiers
    Publisher: HAL CCSD

    International audience; Influenza epidemics occur regularly and prediction of their conversion to pandemics and their impact is difficult. Coordination of efforts on a global scale to control or reduce the impact is fraught with potential for under and overreaction. In ...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Luca Quartuccio; Luca Semerano; Maurizio Benucci; Marie-Christophe Boissier; Salvatore De Vita;
    Persistent Identifiers
    Publisher: HAL CCSD

    International audience

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  • publication . Article . 2020
    Open Access
    Authors:
    Didac Carmona-Gutierrez; Maria A. Bauer; Andreas Zimmermann; Katharina Kainz; Sebastian J. Hofer; Guido Kroemer; Frank Madeo;
    Persistent Identifiers
    Publisher: Shared Science Publishers OG
    Project: ANR | Université de Paris (ANR-18-IDEX-0001), FWF | Pro-autophagic polyphenol... (P 27893), FWF | Causal epigenetic changes... (P 29203), FWF | Metabolic and Cardiovascu... (W 1226), FWF | Mechanisms of spermidine ... (P 29262)

    International audience; Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of v...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Dragos Horvath; Alexey A. Orlov; Dmitry I. Osolodkin; Aydar A. Ishmukhametov; Gilles Marcou; Alexandre Varnek;
    Persistent Identifiers
    Publisher: HAL CCSD

    International audience; Discovery of drugs against newly emerged pathogenic agents like the SARS-CoV-2 coronavirus (CoV) must be based on previous research against related species. Scientists need to get acquainted with and develop a global oversight over so-far tested ...

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  • publication . Other literature type . Article . 2020
    Open Access
    Authors:
    Bertrand Bryche; Audrey St Albin; Séverine Murri; Sandra Lacôte; Coralie Pulido; Meriadeg Ar Gouilh; Sandrine Lesellier; Alexandre Servat; Marine Wasniewski; Evelyne Picard-Meyer; ...
    Publisher: Cold Spring Harbor Laboratory

    Highlights • SARS-CoV-2 infects massively the olfactory mucosa in hamsters. • SARS-CoV-2 induces desquamation of the olfactory epithelium. • SARS-CoV-2 infects mainly sustentacular cells and not olfactory sensory neurons. • SARS-CoV2 infection lead to a massive recruitm...

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15 research outcomes, page 1 of 2