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15 research outcomes, page 1 of 2
  • publication . Other literature type . Article . 2004
    Open Access
    Authors:
    Zeng, Fanya; Chow, Ken Yan Ching; Hon, Chung Chau; Law, Ka Man; Yip, Chi Wai; Chan, Kwok Hung; Peiris, Joseph S.Malik; Leung, Frederick Chi Ching;
    Persistent Identifiers
    Publisher: Elsevier BV

    Abstract The immunological characteristics of SARS-CoV spike protein were investigated by administering mice with plasmids encoding various S gene fragments. We showed that the secreting forms of S1, S2 subunits and the N-terminus of S1 subunit (residues 18–495) were ca...

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  • publication . Article . 2006
    Open Access
    Authors:
    Tetsuya Mizutani; Shuetsu Fukushi; Koji Ishii; Yuko Sasaki; Tsuyoshi Kenri; Masayuki Saijo; Yumi Kanaji; Kinji Shirota; Ichiro Kurane; Shigeru Morikawa;
    Persistent Identifiers
    Publisher: Elsevier BV

    Previously, we reported the establishment of cells with persistent SARS-CoV infection after apoptotic events and showed that both JNK and PI3K/Akt signaling pathways are important for persistence by treatment with inhibitors at the early stages of SARS-CoV infection. Ho...

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  • publication . Article . 2011
    Open Access English
    Authors:
    Jessica Celigoy; Susanna McReynolds; Michael Caffrey;
    Persistent Identifiers
    Publisher: Elsevier Inc.

    Highlights ► The SARS-CoV S2-HR2 helix is stabilized at pH 5, the pH of the endosome. ► The SARS-CoV S2-HR2 helix is stabilized at physiological ionic strength. ► A novel model for SARS-CoV entry is presented. ► The observations for SARS-CoV HR2 may be applicable to oth...

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  • publication . Other literature type . Article . 2005
    Open Access
    Authors:
    Fan, Keqiang; Ma, Liang; Han, Xiaofeng; Liang, Huanhuan; Wei, Ping; Liu, Ying; Lai, Luhua;
    Persistent Identifiers
    Publisher: Elsevier BV

    The 3C-like proteinase of severe acute respiratory syndrome coronavirus (SARS) has been proposed to be a key target for structural based drug design against SARS. We have designed and synthesized 34 peptide substrates and determined their hydrolysis activities. The cons...

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  • publication . Article . 2008
    Open Access English
    Authors:
    John K. Mark; Xuguang Li; Terry D. Cyr; Sylvie M. Fournier; Bozena Jaentschke; Mary Alice Hefford;
    Persistent Identifiers
    Publisher: Elsevier Inc.

    The severe acute respiratory syndrome (SARS) is a contagious disease that killed hundreds and sickened thousands of people worldwide between November 2002 and July 2003. The nucleocapsid (N) protein of the coronavirus responsible for this disease plays a critical role i...

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  • publication . Article . 2004
    Open Access
    Authors:
    Chun-Hua Hsu; Tzu-Ping Ko; Hui-Ming Yu; Tswen-Kei Tang; Shui-Tsung Chen; Andrew H.-J. Wang;
    Persistent Identifiers
    Publisher: Elsevier BV

    The SARS-CoV spike protein, a glycoprotein essential for viral entry, is a primary target for vaccine and drug development. Two peptides denoted HR-N(SN50) and HR-C(SC40), corresponding to the Leu/Ile/Val-rich heptad-repeat regions from the N-terminal and C-terminal seg...

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  • publication . Article . 2003
    Open Access English
    Authors:
    Ottavia Spiga; Andrea Bernini; Arianna Ciutti; S. Chiellini; N. Menciassi; Francesca Finetti; Vincenza Causarono; Francesca Anselmi; Filippo Prischi; Neri Niccolai;
    Persistent Identifiers
    Publisher: Elsevier Inc.

    The S1 and S2 subunits of the spike glycoprotein of the coronavirus which is responsible for the severe acute respiratory syndrome (SARS) have been modelled, even though the corresponding amino acid sequences were not suitable for tertiary structure predictions with con...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Woo, Jiwon; Lee, Eunice Yoojin; Lee, Mirae; Kim, Taeyeon; Cho, Yong-Eun;
    Persistent Identifiers
    Publisher: Elsevier Inc.
    Project: NIH | MEDICAL SCIENTIST TRAININ... (2T32GM007367-24)

    The SARS-CoV nucleocapsid (N) protein serves multiple functions in viral replication, transcription, and assembly of the viral genome complex. Coronaviruses specifically package genomic RNA into assembled virions, and in SARS-CoV, it is reported that this process is dri...

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  • publication . Other literature type . Article . 2003
    Open Access
    Authors:
    Chou, Kuo-Chen; Wei, Dong-Qing; Zhong, Wei-Zhu;
    Publisher: Elsevier BV

    In order to stimulate the development of drugs against severe acute respiratory syndrome (SARS), based on the atomic coordinates of the SARS coronavirus main proteinase determined recently [Science 13 (May) (2003) (online)], studies of docking KZ7088 (a derivative of AG...

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  • publication . Article . 2003
    Open Access
    Authors:
    Lok Ting Lau; Yin-Wan Wendy Fung; Freda Pui-Fan Wong; Selma Sau Wah Lin; Chen Ran Wang; Hui Li Li; Natalie Dillon; Richard A Collins; John S. Tam; Paul K.S. Chan; ...
    Persistent Identifiers
    Publisher: Elsevier BV

    An enhanced polymerase chain reaction (PCR) assay to detect the coronavirus associated with severe acute respiratory syndrome (SARS-CoV) was developed in which a target gene pre-amplification step preceded TaqMan real-time fluorescent PCR. Clinical samples were collecte...

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15 research outcomes, page 1 of 2