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6 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2011
    Open Access English
    Authors:
    Chul Won Lee; Lichun Li; David P. Giedroc;

    The transcription and replication of the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is regulated by specific viral genome sequences within 5′- and 3′-untranslated regions (5′-UTR and 3′-UTR). Here we report the solution structure of 5′-UTR derived s...

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  • publication . Other literature type . Article . 2007
    Open Access
    Authors:
    Lee, Cheng-Chung; Kuo, Chih-Jung; Hsu, Min-Feng; Liang, Po-Huang; Fang, Jim-Min; Shie, Jiun-Jie; Wang, Andrew H.-J.;
    Publisher: Wiley

    Abstract Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibit...

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  • publication . Article . 2006
    Open Access
    Authors:
    Vito Graziano; William J. McGrath; Ann Marie DeGruccio; John J. Dunn; Walter F. Mangel;
    Publisher: Wiley
    Project: NIH | Antiviral agents directed... (2R01AI041599-11A2), NIH | Rapid Detection and Ident... (5U01AI056480-02)

    AbstractThe enzymatic activity of the SARS coronavirus main proteinase dimer was characterized by a sensitive, quantitative assay. The new, fluorogenic substrate, (Ala-Arg-Leu-Gln-NH)2-Rhodamine, contained a severe acute respiratory syndrome coronavirus (SARS CoV) main ...

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  • publication . Article . 2004
    Open Access English
    Authors:
    Chia-Jung Yu; Yee-Chun Chen; Cheng Hsiang Hsiao; Tse Chun Kuo; Shin C. Chang; Chun-Yi Lu; Wen Chin Wei; Chia-Huei Lee; Li-Min Huang; Ming-Fu Chang; ...
    Publisher: Published by Elsevier B.V.

    AbstractThe open reading frame 3 of the severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes a predicted protein 3a, consisting of 274 amino acids, that lacks any significant similarities to any known protein. We generated specific antibodies against ...

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  • publication . Article . Other literature type . 2006
    Open Access
    Authors:
    Kanzawa, Noriyuki; Nishigaki, Kazuo; Hayashi, Takaya; Ishii, Yuichi; Furukawa, Souichi; Niiro, Ayako; Yasui, Fumihiko; Kohara, Michinori; Morita, Kouichi; Matsushima, Kouji; ...

    AbstractSevere acute respiratory syndrome (SARS) is characterized by rapidly progressing respiratory failure resembling acute/adult respiratory distress syndrome (ARDS) associated with uncontrolled inflammatory responses. Here, we demonstrated that, among five accessory...

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  • publication . Article . 2006
    Open Access English
    Authors:
    Fanya Zeng; Chung-Chau Hon; Chi Wai Yip; Ka Man Law; Yin Shan Yeung; Kwok-Hung Chan; Joseph S. M. Peiris; Frederick C. Leung;
    Publisher: Published by Elsevier B.V.

    AbstractNeutralizing effects of antibodies targeting the C-terminal stalk (S2) subunit of the spike protein of severe acute respiratory syndrome coronavirus have previously been reported, although its mechanism remained elusive. In this study, high titered mouse antiser...

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6 research outcomes, page 1 of 1