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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
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7 research outcomes, page 1 of 1
  • publication . Article . 2021
    Open Access English
    Authors:
    Elena Arutyunova; Muhammad Bashir Khan; Conrad Fischer; Jimmy Lu; Tess Lamer; Wayne Vuong; Marco J. van Belkum; Ryan T. McKay; D. Lorne Tyrrell; John C. Vederas; ...
    Persistent Identifiers
    Publisher: The Author(s). Published by Elsevier Ltd.
    Project: NSERC

    The main protease (Mpro, also known as 3CL protease) of SARS-CoV-2 is a high priority drug target in the development of antivirals to combat COVID-19 infections. A feline coronavirus antiviral drug, GC376, has been shown to be effective in inhibiting the SARS-CoV-2 main...

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  • publication . Other literature type . Article . 2006
    Open Access
    Authors:
    Bhardwaj, Kanchan; Sun, Jingchuan; Holzenburg, Andreas; Guarino, Linda A.; Kao, C. Cheng;
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: NSF | Mechanism of Viral RNA-de... (0332259)

    The emerging disease SARS is caused by a novel coronavirus that encodes several unusual RNA-processing enzymes, including non-structural protein 15 (Nsp15), a hexameric endoribonuclease that preferentially cleaves at uridine residues.1., 2., 3. How Nsp15 recognizes and ...

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  • publication . Article . 2004
    Open Access English
    Authors:
    Rong Zeng; Ruifu Yang; Mu De Shi; Man Rong Jiang; You Hua Xie; Hong Qiang Ruan; Xiao-Sheng Jiang; Lv Shi; Hu Zhou; Lei Zhang; ...
    Persistent Identifiers
    Publisher: Elsevier Ltd.

    Proteomics was used to identify a protein encoded by ORF 3a in a SARS-associated coronavirus (SARS-CoV). Immuno-blotting revealed that interchain disulfide bonds might be formed between this protein and the spike protein. ELISA indicated that sera from SARS patients hav...

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  • publication . Article . Other literature type . 2009
    Open Access
    Authors:
    Pak, John E.; Sharon, Chetna; Satkunarajah, Malathy; Auperin, Thierry C.; Cameron, Cheryl M.; Kelvin, David J.; Seetharaman, Jayaraman; Cochrane, Alan; Plummer, Francis A.; Berry, Jody D.; ...
    Persistent Identifiers
    Project: CIHR

    The spike (S) protein of the severe acute respiratory syndrome coronavirus (SARS-CoV) is responsible for host cell attachment and fusion of the viral and host cell membranes. Within S the receptor binding domain (RBD) mediates the interaction with angiotensin-converting...

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  • publication . Article . 2006
    Open Access
    Authors:
    Natalia Tarnovitski; Leslie J. Matthews; Jianhua Sui; Jonathan M. Gershoni; Wayne A. Marasco;
    Persistent Identifiers

    Rapid elucidation of neutralizing antibody epitopes on emerging viral pathogens like severe acute respiratory syndrome (SARS) coronavirus (CoV) or highly pathogenic avian influenza H5N1 virus is of great importance for rational design of vaccines against these viruses. ...

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  • publication . Article . 2007
    Open Access
    Authors:
    Jiang Yin; Chunying Niu; Maia M. Cherney; Jianmin Zhang; Carly Huitema; Lindsay D. Eltis; John C. Vederas; Michael N. G. James;
    Persistent Identifiers
    Project: NIH | Structural Cell Biology o... (5P01CA092584-10), CIHR

    Abstract The 3C-like main peptidase 3CL pro is a viral polyprotein processing enzyme essential for the viability of the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV). While it is generalized that 3CL pro and the structurally related 3C pro viral peptidases cl...

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  • publication . Article . 2007
    Open Access
    Authors:
    Claudia Diemer; Martha Schneider; Judith Seebach; Janine Quaas; Gert Frösner; Hermann M. Schätzl; Sabine Gilch;
    Persistent Identifiers
    Publisher: Elsevier BV

    The epidemic outbreak of severe acute respiratory syndrome (SARS) in 2003 was caused by a novel coronavirus (CoV), designated SARS-CoV. The RNA genome of SARS-CoV is complexed by the nucleocapsid protein (N) to form a helical nucleocapsid. Besides this primary function,...

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7 research outcomes, page 1 of 1